Putative ef-hand protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ef-hand protein 5, putative

Species:

Leishmania major

UniProt:

Q4QHT4_LEIMA

TriTrypDb:

LmjF.09.0900 , LMJLV39_090015200 , LMJSD75_090015000

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHT4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0030234	enzyme regulator activity	2	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	15	17	PF00082	0.614
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.659
CLV_PCSK_SKI1_1	119	123	PF00082	0.462
CLV_PCSK_SKI1_1	136	140	PF00082	0.451
CLV_PCSK_SKI1_1	33	37	PF00082	0.620
CLV_PCSK_SKI1_1	49	53	PF00082	0.430
CLV_PCSK_SKI1_1	63	67	PF00082	0.384
DOC_MAPK_gen_1	135	143	PF00069	0.588
DOC_MAPK_MEF2A_6	174	183	PF00069	0.534
DOC_USP7_MATH_1	161	165	PF00917	0.593
DOC_USP7_MATH_1	7	11	PF00917	0.652
DOC_USP7_UBL2_3	63	67	PF12436	0.447
DOC_WW_Pin1_4	5	10	PF00397	0.701
LIG_14-3-3_CanoR_1	119	125	PF00244	0.631
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_FHA_1	105	111	PF00498	0.432
LIG_FHA_1	128	134	PF00498	0.460
LIG_FHA_1	92	98	PF00498	0.484
LIG_FHA_2	161	167	PF00498	0.616
LIG_FHA_2	74	80	PF00498	0.495
LIG_LIR_Gen_1	120	126	PF02991	0.630
LIG_LIR_Gen_1	171	180	PF02991	0.417
LIG_LIR_Gen_1	98	106	PF02991	0.458
LIG_LIR_Nem_3	120	125	PF02991	0.484
LIG_LIR_Nem_3	171	175	PF02991	0.430
LIG_LIR_Nem_3	46	51	PF02991	0.460
LIG_LIR_Nem_3	64	69	PF02991	0.402
LIG_LIR_Nem_3	98	102	PF02991	0.456
LIG_NRBOX	178	184	PF00104	0.464
LIG_Pex14_2	138	142	PF04695	0.468
LIG_SH2_CRK	172	176	PF00017	0.494
LIG_SH2_CRK	48	52	PF00017	0.552
LIG_SH2_STAP1	172	176	PF00017	0.453
LIG_SUMO_SIM_anti_2	155	166	PF11976	0.543
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.559
LIG_TRAF2_1	114	117	PF00917	0.541
LIG_TRAF2_1	150	153	PF00917	0.509
LIG_TRAF2_1	163	166	PF00917	0.508
LIG_TRAF2_1	76	79	PF00917	0.495
LIG_TYR_ITIM	170	175	PF00017	0.512
LIG_UBA3_1	103	108	PF00899	0.587
MOD_CK1_1	120	126	PF00069	0.541
MOD_CK1_1	25	31	PF00069	0.605
MOD_CK2_1	111	117	PF00069	0.518
MOD_CK2_1	141	147	PF00069	0.513
MOD_CK2_1	160	166	PF00069	0.568
MOD_CK2_1	73	79	PF00069	0.462
MOD_GlcNHglycan	119	122	PF01048	0.518
MOD_GlcNHglycan	144	147	PF01048	0.686
MOD_GlcNHglycan	149	152	PF01048	0.604
MOD_GlcNHglycan	24	27	PF01048	0.588
MOD_GlcNHglycan	28	31	PF01048	0.534
MOD_GlcNHglycan	38	41	PF01048	0.596
MOD_GlcNHglycan	52	55	PF01048	0.457
MOD_GSK3_1	120	127	PF00069	0.470
MOD_GSK3_1	142	149	PF00069	0.630
MOD_GSK3_1	22	29	PF00069	0.581
MOD_GSK3_1	5	12	PF00069	0.659
MOD_N-GLC_1	127	132	PF02516	0.590
MOD_N-GLC_1	36	41	PF02516	0.526
MOD_NEK2_1	141	146	PF00069	0.484
MOD_NEK2_1	36	41	PF00069	0.557
MOD_PIKK_1	9	15	PF00454	0.646
MOD_Plk_1	111	117	PF00069	0.550
MOD_Plk_1	91	97	PF00069	0.590
MOD_Plk_2-3	111	117	PF00069	0.656
MOD_ProDKin_1	5	11	PF00069	0.702
MOD_SUMO_rev_2	109	115	PF00179	0.602
TRG_DiLeu_BaEn_1	101	106	PF01217	0.541
TRG_DiLeu_BaEn_1	153	158	PF01217	0.488
TRG_DiLeu_BaEn_1	178	183	PF01217	0.459
TRG_DiLeu_BaEn_1	80	85	PF01217	0.553
TRG_DiLeu_BaEn_2	97	103	PF01217	0.570
TRG_DiLeu_BaEn_4	155	161	PF01217	0.606
TRG_ENDOCYTIC_2	172	175	PF00928	0.427
TRG_ENDOCYTIC_2	48	51	PF00928	0.543
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	28%	100%
A0A0N0P2H6	Leptomonas seymouri	74%	100%
A0A0S4IS38	Bodo saltans	28%	100%
A0A0S4J1R1	Bodo saltans	35%	100%
A0A0S4J7U6	Bodo saltans	26%	100%
A0A0S4JFC8	Bodo saltans	28%	100%
A0A1X0NEW2	Trypanosomatidae	29%	97%
A0A1X0NMM5	Trypanosomatidae	28%	100%
A0A1X0NN63	Trypanosomatidae	47%	96%
A0A3R7LX73	Trypanosoma rangeli	44%	92%
A0A3S5H6E1	Leishmania donovani	98%	100%
A0A422N5Z1	Trypanosoma rangeli	30%	98%
A2WN93	Oryza sativa subsp. indica	28%	100%
A2WNH1	Oryza sativa subsp. indica	26%	100%
A2Y609	Oryza sativa subsp. indica	29%	100%
A4H5R8	Leishmania braziliensis	81%	100%
A4H5R9	Leishmania braziliensis	28%	100%
A4HU12	Leishmania infantum	99%	100%
A4HU13	Leishmania infantum	28%	100%
B1PSN3	Leishmania donovani	28%	100%
D0A9H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	95%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AMU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O02367	Ciona intestinalis	27%	100%
O16305	Caenorhabditis elegans	26%	100%
O23320	Arabidopsis thaliana	26%	100%
O82018	Mougeotia scalaris	26%	100%
O82659	Arabidopsis thaliana	28%	100%
O96081	Halocynthia roretzi	26%	100%
O96102	Physarum polycephalum	27%	100%
O97341	Suberites domuncula	27%	100%
P02585	Homo sapiens	28%	100%
P02586	Oryctolagus cuniculus	28%	100%
P02587	Sus scrofa	27%	100%
P02588	Gallus gallus	26%	100%
P02589	Pelophylax lessonae	28%	100%
P02591	Oryctolagus cuniculus	26%	100%
P02594	Electrophorus electricus	27%	100%
P02595	Patinopecten sp.	26%	100%
P02597	Gallus gallus	26%	100%
P02599	Dictyostelium discoideum	27%	100%
P04352	Chlamydomonas reinhardtii	29%	100%
P04353	Spinacia oleracea	28%	100%
P04464	Triticum aestivum	28%	100%
P04630	Caenorhabditis elegans	28%	100%
P05434	Chlamydomonas reinhardtii	29%	100%
P05932	Arbacia punctulata	26%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P05936	Coturnix japonica	25%	100%
P09860	Gallus gallus	25%	100%
P0DP23	Homo sapiens	26%	100%
P0DP24	Homo sapiens	26%	100%
P0DP25	Homo sapiens	26%	100%
P0DP26	Mus musculus	26%	100%
P0DP27	Mus musculus	26%	100%
P0DP28	Mus musculus	26%	100%
P0DP29	Rattus norvegicus	26%	100%
P0DP30	Rattus norvegicus	26%	100%
P0DP31	Rattus norvegicus	26%	100%
P0DP33	Xenopus laevis	26%	100%
P0DP34	Xenopus laevis	26%	100%
P0DP35	Xenopus laevis	26%	100%
P10246	Meleagris gallopavo	26%	100%
P11118	Euglena gracilis	29%	100%
P11121	Pyuridae sp.	26%	100%
P13868	Solanum tuberosum	26%	100%
P18061	Trypanosoma cruzi	28%	100%
P19123	Mus musculus	26%	100%
P20801	Mus musculus	28%	100%
P21251	Stichopus japonicus	26%	100%
P23286	Candida albicans	27%	100%
P25027	Trypanosoma brucei brucei	41%	97%
P27161	Solanum lycopersicum	26%	100%
P27165	Phytophthora infestans	27%	100%
P27166	Stylonychia lemnae	28%	100%
P41040	Zea mays	28%	100%
P41041	Pneumocystis carinii	26%	100%
P41045	Leishmania tarentolae	87%	100%
P41048	Trypanosoma cruzi	44%	89%
P41049	Trypanosoma cruzi	43%	89%
P41210	Atriplex nummularia	26%	100%
P43646	Tetraselmis striata	27%	100%
P53440	Naegleria gruberi	26%	100%
P54213	Dunaliella salina	30%	100%
P62144	Anas platyrhynchos	26%	100%
P62145	Aplysia californica	26%	100%
P62147	Branchiostoma floridae	26%	100%
P62148	Branchiostoma lanceolatum	26%	100%
P62149	Gallus gallus	26%	100%
P62150	Oryzias latipes	26%	100%
P62151	Tetronarce californica	26%	100%
P62152	Drosophila melanogaster	26%	100%
P62153	Halocynthia roretzi	26%	100%
P62154	Locusta migratoria	26%	100%
P62156	Oncorhynchus sp.	26%	100%
P62157	Bos taurus	26%	100%
P62160	Oryctolagus cuniculus	26%	100%
P62162	Hordeum vulgare	28%	100%
P62163	Glycine max	28%	100%
P62184	Renilla reniformis	26%	100%
P63315	Bos taurus	26%	100%
P63316	Homo sapiens	26%	100%
P63317	Sus scrofa	26%	100%
P69097	Trypanosoma brucei brucei	28%	100%
P69098	Trypanosoma brucei gambiense	28%	100%
P81660	Anguilla anguilla	29%	100%
Q06827	Scherffelia dubia	28%	100%
Q0JNL7	Oryza sativa subsp. japonica	27%	100%
Q0JNS6	Oryza sativa subsp. japonica	28%	100%
Q2R1Z5	Oryza sativa subsp. japonica	24%	100%
Q2TBN3	Bos taurus	28%	100%
Q338P8	Oryza sativa subsp. japonica	26%	97%
Q40302	Macrocystis pyrifera	27%	100%
Q4QHT2	Leishmania major	27%	100%
Q5RAD2	Pongo abelii	26%	100%
Q5U206	Rattus norvegicus	26%	100%
Q6F332	Oryza sativa subsp. japonica	29%	100%
Q6IT78	Ctenopharyngodon idella	26%	100%
Q6PI52	Danio rerio	26%	100%
Q6YNX6	Ovis aries	26%	100%
Q71UH5	Globisporangium splendens	27%	100%
Q71UH6	Perca flavescens	26%	100%
Q7F0J0	Oryza sativa subsp. japonica	28%	100%
Q7T3T2	Epinephelus akaara	26%	100%
Q8S1Y9	Oryza sativa subsp. japonica	28%	99%
Q8STF0	Strongylocentrotus intermedius	26%	100%
Q95NI4	Halichondria okadai	27%	100%
Q95NR9	Metridium senile	26%	100%
Q9CQ46	Mus musculus	27%	100%
Q9D6P8	Mus musculus	25%	100%
Q9GRJ1	Lumbricus rubellus	26%	100%
Q9LIK5	Arabidopsis thaliana	24%	100%
Q9R1K9	Mus musculus	27%	100%
Q9U6D3	Myxine glutinosa	26%	100%
Q9UB37	Branchiostoma lanceolatum	26%	100%
Q9XZP2	Branchiostoma floridae	27%	100%
V5DQ66	Trypanosoma cruzi	30%	98%