O-phosphoseryl-tRNA(Sec) selenium transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

O-phosphoseryl-tRNA(Sec) selenium transferase, putative

Species:

Leishmania major

UniProt:

Q4QHS9_LEIMA

TriTrypDb:

LmjF.09.0950 , LMJLV39_090015800 , LMJSD75_090015400

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QHS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS9

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006414	translational elongation	5	2
GO:0006417	regulation of translation	6	2
GO:0006451	translational readthrough	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	12
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019222	regulation of metabolic process	3	2
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0032774	RNA biosynthetic process	5	12
GO:0034248	regulation of amide metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	12
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	12
GO:0097056	obsolete selenocysteinyl-tRNA(Sec) biosynthetic process	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:0006412	translation	4	8
GO:0006518	peptide metabolic process	4	8
GO:0019538	protein metabolic process	3	8
GO:0043043	peptide biosynthetic process	5	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016785	selenotransferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0098621	phosphoseryl-selenocysteinyl-tRNA selenium transferase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.578
CLV_C14_Caspase3-7	351	355	PF00656	0.444
CLV_C14_Caspase3-7	578	582	PF00656	0.480
CLV_NRD_NRD_1	347	349	PF00675	0.271
CLV_NRD_NRD_1	418	420	PF00675	0.292
CLV_NRD_NRD_1	446	448	PF00675	0.246
CLV_PCSK_FUR_1	444	448	PF00082	0.305
CLV_PCSK_KEX2_1	347	349	PF00082	0.249
CLV_PCSK_KEX2_1	418	420	PF00082	0.259
CLV_PCSK_KEX2_1	446	448	PF00082	0.249
CLV_PCSK_SKI1_1	174	178	PF00082	0.343
CLV_PCSK_SKI1_1	224	228	PF00082	0.310
CLV_PCSK_SKI1_1	33	37	PF00082	0.424
CLV_PCSK_SKI1_1	348	352	PF00082	0.244
CLV_PCSK_SKI1_1	371	375	PF00082	0.198
CLV_PCSK_SKI1_1	391	395	PF00082	0.111
CLV_PCSK_SKI1_1	4	8	PF00082	0.468
CLV_PCSK_SKI1_1	447	451	PF00082	0.289
CLV_PCSK_SKI1_1	534	538	PF00082	0.247
DEG_Nend_UBRbox_2	1	3	PF02207	0.385
DEG_SCF_FBW7_1	273	279	PF00400	0.488
DEG_SCF_FBW7_1	535	541	PF00400	0.444
DEG_SPOP_SBC_1	276	280	PF00917	0.601
DEG_SPOP_SBC_1	307	311	PF00917	0.409
DOC_CKS1_1	210	215	PF01111	0.380
DOC_CKS1_1	273	278	PF01111	0.505
DOC_CKS1_1	535	540	PF01111	0.444
DOC_CYCLIN_RxL_1	53	63	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.436
DOC_MAPK_DCC_7	560	568	PF00069	0.413
DOC_MAPK_gen_1	201	209	PF00069	0.538
DOC_MAPK_gen_1	432	441	PF00069	0.506
DOC_MAPK_gen_1	444	452	PF00069	0.415
DOC_MAPK_HePTP_8	113	125	PF00069	0.440
DOC_MAPK_MEF2A_6	116	125	PF00069	0.440
DOC_MAPK_MEF2A_6	400	409	PF00069	0.422
DOC_MAPK_MEF2A_6	478	487	PF00069	0.468
DOC_MAPK_MEF2A_6	560	569	PF00069	0.413
DOC_MAPK_RevD_3	332	348	PF00069	0.444
DOC_MIT_MIM_1	581	590	PF04212	0.489
DOC_PP1_RVXF_1	212	219	PF00149	0.318
DOC_PP1_RVXF_1	359	365	PF00149	0.444
DOC_PP2B_LxvP_1	207	210	PF13499	0.481
DOC_PP4_FxxP_1	373	376	PF00568	0.398
DOC_USP7_MATH_1	108	112	PF00917	0.398
DOC_USP7_MATH_1	276	280	PF00917	0.623
DOC_USP7_MATH_1	293	297	PF00917	0.340
DOC_USP7_MATH_1	495	499	PF00917	0.444
DOC_USP7_MATH_1	538	542	PF00917	0.491
DOC_USP7_UBL2_3	157	161	PF12436	0.489
DOC_USP7_UBL2_3	224	228	PF12436	0.303
DOC_USP7_UBL2_3	387	391	PF12436	0.413
DOC_WW_Pin1_4	209	214	PF00397	0.510
DOC_WW_Pin1_4	269	274	PF00397	0.752
DOC_WW_Pin1_4	401	406	PF00397	0.409
DOC_WW_Pin1_4	534	539	PF00397	0.444
LIG_14-3-3_CanoR_1	201	210	PF00244	0.552
LIG_14-3-3_CanoR_1	26	32	PF00244	0.444
LIG_14-3-3_CanoR_1	400	404	PF00244	0.429
LIG_14-3-3_CanoR_1	56	61	PF00244	0.425
LIG_14-3-3_CanoR_1	78	86	PF00244	0.454
LIG_Actin_WH2_2	139	155	PF00022	0.440
LIG_BIR_III_4	231	235	PF00653	0.455
LIG_BRCT_BRCA1_1	279	283	PF00533	0.505
LIG_FHA_1	116	122	PF00498	0.480
LIG_FHA_1	145	151	PF00498	0.433
LIG_FHA_1	26	32	PF00498	0.474
LIG_FHA_1	320	326	PF00498	0.502
LIG_FHA_1	90	96	PF00498	0.465
LIG_FHA_2	256	262	PF00498	0.518
LIG_FHA_2	349	355	PF00498	0.444
LIG_FHA_2	453	459	PF00498	0.368
LIG_LIR_Apic_2	370	376	PF02991	0.398
LIG_LIR_Apic_2	589	594	PF02991	0.437
LIG_LIR_Nem_3	550	554	PF02991	0.429
LIG_PCNA_PIPBox_1	403	412	PF02747	0.444
LIG_PCNA_PIPBox_1	584	593	PF02747	0.549
LIG_PCNA_yPIPBox_3	116	126	PF02747	0.443
LIG_Pex14_1	425	429	PF04695	0.409
LIG_PTB_Apo_2	336	343	PF02174	0.401
LIG_PTB_Phospho_1	336	342	PF10480	0.401
LIG_SH2_CRK	490	494	PF00017	0.444
LIG_SH2_SRC	17	20	PF00017	0.415
LIG_SH2_STAT3	342	345	PF00017	0.398
LIG_SH2_STAT5	17	20	PF00017	0.325
LIG_SH2_STAT5	215	218	PF00017	0.299
LIG_SH2_STAT5	328	331	PF00017	0.462
LIG_SH2_STAT5	336	339	PF00017	0.402
LIG_SH3_3	135	141	PF00018	0.422
LIG_SH3_3	207	213	PF00018	0.559
LIG_SH3_3	233	239	PF00018	0.316
LIG_SH3_3	241	247	PF00018	0.458
LIG_SH3_3	270	276	PF00018	0.536
LIG_SH3_3	295	301	PF00018	0.419
LIG_SH3_3	313	319	PF00018	0.341
LIG_SH3_3	527	533	PF00018	0.436
LIG_SH3_3	537	543	PF00018	0.456
LIG_SH3_3	559	565	PF00018	0.446
LIG_Sin3_3	135	142	PF02671	0.444
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.409
LIG_SUMO_SIM_anti_2	448	458	PF11976	0.502
LIG_SUMO_SIM_par_1	118	124	PF11976	0.508
LIG_SUMO_SIM_par_1	448	458	PF11976	0.502
LIG_TRAF2_1	188	191	PF00917	0.662
MOD_CDK_SPK_2	209	214	PF00069	0.403
MOD_CK1_1	182	188	PF00069	0.661
MOD_CK1_1	24	30	PF00069	0.516
MOD_CK1_1	269	275	PF00069	0.690
MOD_CK1_1	278	284	PF00069	0.505
MOD_CK1_1	309	315	PF00069	0.422
MOD_CK1_1	468	474	PF00069	0.413
MOD_CK1_1	528	534	PF00069	0.440
MOD_CK1_1	541	547	PF00069	0.440
MOD_CK2_1	382	388	PF00069	0.480
MOD_CK2_1	573	579	PF00069	0.442
MOD_Cter_Amidation	416	419	PF01082	0.302
MOD_DYRK1A_RPxSP_1	534	538	PF00069	0.444
MOD_GlcNHglycan	13	16	PF01048	0.453
MOD_GlcNHglycan	181	184	PF01048	0.648
MOD_GlcNHglycan	250	253	PF01048	0.652
MOD_GlcNHglycan	295	298	PF01048	0.297
MOD_GlcNHglycan	367	370	PF01048	0.227
MOD_GlcNHglycan	499	502	PF01048	0.268
MOD_GlcNHglycan	527	530	PF01048	0.232
MOD_GlcNHglycan	80	83	PF01048	0.311
MOD_GlcNHglycan	97	100	PF01048	0.157
MOD_GSK3_1	174	181	PF00069	0.475
MOD_GSK3_1	21	28	PF00069	0.402
MOD_GSK3_1	255	262	PF00069	0.686
MOD_GSK3_1	271	278	PF00069	0.628
MOD_GSK3_1	377	384	PF00069	0.500
MOD_GSK3_1	461	468	PF00069	0.474
MOD_GSK3_1	479	486	PF00069	0.406
MOD_GSK3_1	534	541	PF00069	0.449
MOD_GSK3_1	56	63	PF00069	0.398
MOD_NEK2_1	172	177	PF00069	0.474
MOD_NEK2_1	248	253	PF00069	0.555
MOD_NEK2_1	25	30	PF00069	0.437
MOD_NEK2_1	254	259	PF00069	0.526
MOD_NEK2_1	308	313	PF00069	0.424
MOD_NEK2_1	409	414	PF00069	0.410
MOD_NEK2_1	525	530	PF00069	0.440
MOD_NEK2_1	60	65	PF00069	0.271
MOD_NEK2_1	89	94	PF00069	0.460
MOD_NEK2_2	21	26	PF00069	0.449
MOD_NEK2_2	547	552	PF00069	0.413
MOD_OFUCOSY	306	313	PF10250	0.198
MOD_PIKK_1	299	305	PF00454	0.444
MOD_PIKK_1	465	471	PF00454	0.413
MOD_PKA_2	203	209	PF00069	0.527
MOD_PKA_2	21	27	PF00069	0.480
MOD_PKA_2	259	265	PF00069	0.535
MOD_PKA_2	399	405	PF00069	0.402
MOD_PKA_2	503	509	PF00069	0.381
MOD_Plk_1	2	8	PF00069	0.417
MOD_Plk_1	319	325	PF00069	0.502
MOD_Plk_1	461	467	PF00069	0.524
MOD_Plk_1	479	485	PF00069	0.398
MOD_Plk_4	109	115	PF00069	0.398
MOD_Plk_4	278	284	PF00069	0.505
MOD_Plk_4	377	383	PF00069	0.468
MOD_Plk_4	56	62	PF00069	0.387
MOD_ProDKin_1	209	215	PF00069	0.501
MOD_ProDKin_1	269	275	PF00069	0.748
MOD_ProDKin_1	401	407	PF00069	0.409
MOD_ProDKin_1	534	540	PF00069	0.444
MOD_SUMO_rev_2	453	460	PF00179	0.521
TRG_DiLeu_BaEn_1	579	584	PF01217	0.477
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.444
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.442
TRG_ER_diArg_1	347	349	PF00400	0.472
TRG_ER_diArg_1	432	435	PF00400	0.408
TRG_ER_diArg_1	84	87	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGI4	Leptomonas seymouri	64%	100%
A0A0S4KH93	Bodo saltans	41%	100%
A0A1X0NN47	Trypanosomatidae	47%	88%
A0A3R7N0G5	Trypanosoma rangeli	51%	100%
A0A3S7WQS5	Leishmania donovani	96%	100%
A4H5S3	Leishmania braziliensis	83%	92%
A4HU16	Leishmania infantum	96%	100%
D0A9I4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AMU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q28EN2	Xenopus tropicalis	34%	100%
Q54VQ6	Dictyostelium discoideum	34%	100%
Q5RAK7	Pongo abelii	34%	100%
Q6P6M7	Mus musculus	34%	100%
Q803A7	Danio rerio	34%	100%
Q9HD40	Homo sapiens	34%	100%
V5BBE8	Trypanosoma cruzi	52%	100%