RAB3GAP2_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHS8_LEIMA

TriTrypDb:

LmjF.09.0960 , LMJLV39_090015900 , LMJSD75_090015500

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.485
CLV_C14_Caspase3-7	184	188	PF00656	0.664
CLV_C14_Caspase3-7	38	42	PF00656	0.537
CLV_C14_Caspase3-7	391	395	PF00656	0.577
CLV_MEL_PAP_1	417	423	PF00089	0.617
CLV_PCSK_SKI1_1	293	297	PF00082	0.589
CLV_PCSK_SKI1_1	459	463	PF00082	0.653
CLV_PCSK_SKI1_1	464	468	PF00082	0.651
CLV_PCSK_SKI1_1	577	581	PF00082	0.757
CLV_PCSK_SKI1_1	607	611	PF00082	0.590
CLV_PCSK_SKI1_1	67	71	PF00082	0.384
DEG_ODPH_VHL_1	247	260	PF01847	0.501
DEG_SPOP_SBC_1	52	56	PF00917	0.732
DEG_SPOP_SBC_1	522	526	PF00917	0.733
DOC_MAPK_MEF2A_6	251	260	PF00069	0.517
DOC_PP1_RVXF_1	437	444	PF00149	0.638
DOC_PP2B_LxvP_1	371	374	PF13499	0.580
DOC_PP2B_LxvP_1	582	585	PF13499	0.549
DOC_USP7_MATH_1	116	120	PF00917	0.487
DOC_USP7_MATH_1	299	303	PF00917	0.614
DOC_USP7_MATH_1	376	380	PF00917	0.639
DOC_USP7_MATH_1	522	526	PF00917	0.776
DOC_USP7_MATH_1	53	57	PF00917	0.663
DOC_USP7_MATH_1	587	591	PF00917	0.656
DOC_USP7_MATH_1	612	616	PF00917	0.558
DOC_WW_Pin1_4	342	347	PF00397	0.508
DOC_WW_Pin1_4	490	495	PF00397	0.716
DOC_WW_Pin1_4	518	523	PF00397	0.730
DOC_WW_Pin1_4	57	62	PF00397	0.713
LIG_14-3-3_CanoR_1	175	181	PF00244	0.595
LIG_14-3-3_CanoR_1	220	226	PF00244	0.512
LIG_14-3-3_CanoR_1	454	458	PF00244	0.664
LIG_14-3-3_CanoR_1	577	583	PF00244	0.635
LIG_14-3-3_CanoR_1	586	592	PF00244	0.444
LIG_14-3-3_CanoR_1	67	75	PF00244	0.376
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BRCT_BRCA1_1	230	234	PF00533	0.428
LIG_BRCT_BRCA1_1	35	39	PF00533	0.613
LIG_BRCT_BRCA1_1	492	496	PF00533	0.616
LIG_Clathr_ClatBox_1	103	107	PF01394	0.424
LIG_CtBP_PxDLS_1	619	623	PF00389	0.536
LIG_deltaCOP1_diTrp_1	197	205	PF00928	0.629
LIG_DLG_GKlike_1	420	428	PF00625	0.637
LIG_FHA_1	375	381	PF00498	0.564
LIG_FHA_1	402	408	PF00498	0.554
LIG_FHA_1	495	501	PF00498	0.708
LIG_FHA_1	502	508	PF00498	0.701
LIG_FHA_1	554	560	PF00498	0.563
LIG_FHA_1	579	585	PF00498	0.686
LIG_FHA_1	98	104	PF00498	0.471
LIG_FHA_2	127	133	PF00498	0.520
LIG_FHA_2	175	181	PF00498	0.727
LIG_FHA_2	182	188	PF00498	0.651
LIG_LIR_Gen_1	288	299	PF02991	0.470
LIG_LIR_LC3C_4	259	264	PF02991	0.371
LIG_LIR_Nem_3	288	294	PF02991	0.567
LIG_LIR_Nem_3	440	446	PF02991	0.515
LIG_LIR_Nem_3	590	594	PF02991	0.620
LIG_LYPXL_SIV_4	602	610	PF13949	0.598
LIG_PDZ_Class_1	618	623	PF00595	0.529
LIG_Pex14_2	234	238	PF04695	0.359
LIG_Pex14_2	549	553	PF04695	0.471
LIG_SH2_CRK	414	418	PF00017	0.675
LIG_SH2_NCK_1	366	370	PF00017	0.481
LIG_SH2_STAP1	366	370	PF00017	0.481
LIG_SH2_STAT3	347	350	PF00017	0.545
LIG_SH2_STAT5	273	276	PF00017	0.377
LIG_SH2_STAT5	4	7	PF00017	0.700
LIG_SH2_STAT5	568	571	PF00017	0.504
LIG_SH3_3	58	64	PF00018	0.654
LIG_SH3_3	581	587	PF00018	0.655
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.463
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.348
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.673
LIG_SUMO_SIM_anti_2	556	563	PF11976	0.450
LIG_SUMO_SIM_anti_2	86	97	PF11976	0.456
LIG_SUMO_SIM_par_1	102	107	PF11976	0.478
LIG_SUMO_SIM_par_1	157	162	PF11976	0.336
LIG_SUMO_SIM_par_1	261	268	PF11976	0.345
LIG_SUMO_SIM_par_1	556	563	PF11976	0.455
LIG_TRAF2_1	13	16	PF00917	0.747
LIG_TRAF2_1	177	180	PF00917	0.741
LIG_TRAF2_2	453	458	PF00917	0.665
LIG_TRFH_1	342	346	PF08558	0.502
LIG_TYR_ITIM	412	417	PF00017	0.607
LIG_WRC_WIRS_1	588	593	PF05994	0.656
MOD_CDK_SPxxK_3	60	67	PF00069	0.473
MOD_CK1_1	170	176	PF00069	0.635
MOD_CK1_1	302	308	PF00069	0.697
MOD_CK1_1	416	422	PF00069	0.671
MOD_CK1_1	517	523	PF00069	0.743
MOD_CK1_1	526	532	PF00069	0.703
MOD_CK1_1	536	542	PF00069	0.641
MOD_CK1_1	57	63	PF00069	0.715
MOD_CK1_1	578	584	PF00069	0.661
MOD_CK1_1	590	596	PF00069	0.637
MOD_CK1_1	79	85	PF00069	0.583
MOD_CK2_1	116	122	PF00069	0.422
MOD_CK2_1	173	179	PF00069	0.744
MOD_CK2_1	234	240	PF00069	0.475
MOD_CK2_1	310	316	PF00069	0.578
MOD_CK2_1	457	463	PF00069	0.627
MOD_CK2_1	560	566	PF00069	0.512
MOD_CK2_1	590	596	PF00069	0.649
MOD_GlcNHglycan	124	127	PF01048	0.556
MOD_GlcNHglycan	153	156	PF01048	0.477
MOD_GlcNHglycan	169	172	PF01048	0.538
MOD_GlcNHglycan	207	210	PF01048	0.618
MOD_GlcNHglycan	221	224	PF01048	0.581
MOD_GlcNHglycan	267	270	PF01048	0.454
MOD_GlcNHglycan	304	307	PF01048	0.695
MOD_GlcNHglycan	31	34	PF01048	0.674
MOD_GlcNHglycan	312	315	PF01048	0.751
MOD_GlcNHglycan	318	322	PF01048	0.512
MOD_GlcNHglycan	359	362	PF01048	0.600
MOD_GlcNHglycan	458	462	PF01048	0.722
MOD_GlcNHglycan	516	519	PF01048	0.677
MOD_GlcNHglycan	535	538	PF01048	0.649
MOD_GlcNHglycan	546	549	PF01048	0.505
MOD_GlcNHglycan	562	565	PF01048	0.410
MOD_GlcNHglycan	577	580	PF01048	0.589
MOD_GlcNHglycan	70	73	PF01048	0.441
MOD_GSK3_1	122	129	PF00069	0.513
MOD_GSK3_1	167	174	PF00069	0.691
MOD_GSK3_1	199	206	PF00069	0.722
MOD_GSK3_1	29	36	PF00069	0.647
MOD_GSK3_1	298	305	PF00069	0.673
MOD_GSK3_1	317	324	PF00069	0.530
MOD_GSK3_1	374	381	PF00069	0.626
MOD_GSK3_1	416	423	PF00069	0.669
MOD_GSK3_1	453	460	PF00069	0.657
MOD_GSK3_1	486	493	PF00069	0.745
MOD_GSK3_1	510	517	PF00069	0.654
MOD_GSK3_1	518	525	PF00069	0.681
MOD_GSK3_1	53	60	PF00069	0.687
MOD_GSK3_1	79	86	PF00069	0.440
MOD_GSK3_1	93	100	PF00069	0.405
MOD_N-GLC_1	171	176	PF02516	0.661
MOD_N-GLC_1	364	369	PF02516	0.480
MOD_NEK2_1	121	126	PF00069	0.360
MOD_NEK2_1	218	223	PF00069	0.470
MOD_NEK2_1	234	239	PF00069	0.373
MOD_NEK2_1	401	406	PF00069	0.605
MOD_NEK2_1	457	462	PF00069	0.596
MOD_NEK2_1	610	615	PF00069	0.592
MOD_OFUCOSY	509	514	PF10250	0.518
MOD_PIKK_1	305	311	PF00454	0.583
MOD_PIKK_1	401	407	PF00454	0.524
MOD_PKA_2	167	173	PF00069	0.632
MOD_PKA_2	174	180	PF00069	0.667
MOD_PKA_2	219	225	PF00069	0.457
MOD_PKA_2	453	459	PF00069	0.601
MOD_Plk_1	116	122	PF00069	0.446
MOD_Plk_1	364	370	PF00069	0.480
MOD_Plk_1	457	463	PF00069	0.650
MOD_Plk_4	116	122	PF00069	0.313
MOD_Plk_4	234	240	PF00069	0.509
MOD_Plk_4	590	596	PF00069	0.599
MOD_ProDKin_1	342	348	PF00069	0.514
MOD_ProDKin_1	490	496	PF00069	0.718
MOD_ProDKin_1	518	524	PF00069	0.731
MOD_ProDKin_1	57	63	PF00069	0.700
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.548
TRG_ENDOCYTIC_2	414	417	PF00928	0.610
TRG_NES_CRM1_1	34	49	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H8	Leptomonas seymouri	48%	81%
A0A1X0NMF5	Trypanosomatidae	29%	100%
A0A3S7WQU1	Leishmania donovani	91%	100%
A4H5S4	Leishmania braziliensis	76%	85%
A4HU17	Leishmania infantum	91%	100%
D0A9I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AMU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B2B3	Trypanosoma cruzi	32%	100%