Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHS6_LEIMA

TriTrypDb:

LmjF.09.0980 , LMJLV39_090016100 , LMJSD75_090015700

Length:

1004

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.633
CLV_C14_Caspase3-7	283	287	PF00656	0.543
CLV_C14_Caspase3-7	623	627	PF00656	0.660
CLV_C14_Caspase3-7	749	753	PF00656	0.580
CLV_NRD_NRD_1	194	196	PF00675	0.677
CLV_NRD_NRD_1	240	242	PF00675	0.582
CLV_NRD_NRD_1	424	426	PF00675	0.493
CLV_NRD_NRD_1	581	583	PF00675	0.716
CLV_NRD_NRD_1	6	8	PF00675	0.541
CLV_NRD_NRD_1	738	740	PF00675	0.760
CLV_PCSK_FUR_1	238	242	PF00082	0.575
CLV_PCSK_KEX2_1	105	107	PF00082	0.781
CLV_PCSK_KEX2_1	196	198	PF00082	0.677
CLV_PCSK_KEX2_1	207	209	PF00082	0.686
CLV_PCSK_KEX2_1	240	242	PF00082	0.582
CLV_PCSK_KEX2_1	423	425	PF00082	0.494
CLV_PCSK_KEX2_1	581	583	PF00082	0.718
CLV_PCSK_KEX2_1	6	8	PF00082	0.528
CLV_PCSK_KEX2_1	738	740	PF00082	0.760
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.718
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.659
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.670
CLV_PCSK_PC7_1	419	425	PF00082	0.609
CLV_PCSK_SKI1_1	294	298	PF00082	0.597
CLV_PCSK_SKI1_1	371	375	PF00082	0.602
CLV_PCSK_SKI1_1	440	444	PF00082	0.497
CLV_PCSK_SKI1_1	6	10	PF00082	0.536
CLV_PCSK_SKI1_1	680	684	PF00082	0.560
CLV_PCSK_SKI1_1	874	878	PF00082	0.666
CLV_PCSK_SKI1_1	892	896	PF00082	0.647
CLV_Separin_Metazoa	368	372	PF03568	0.594
CLV_Separin_Metazoa	80	84	PF03568	0.685
DEG_APCC_DBOX_1	679	687	PF00400	0.561
DEG_Nend_UBRbox_3	1	3	PF02207	0.562
DEG_SCF_FBW7_1	113	118	PF00400	0.723
DEG_SCF_FBW7_1	740	747	PF00400	0.696
DEG_SCF_FBW7_2	115	122	PF00400	0.787
DEG_SPOP_SBC_1	265	269	PF00917	0.725
DEG_SPOP_SBC_1	321	325	PF00917	0.744
DEG_SPOP_SBC_1	459	463	PF00917	0.670
DEG_SPOP_SBC_1	799	803	PF00917	0.805
DEG_SPOP_SBC_1	934	938	PF00917	0.624
DEG_SPOP_SBC_1	981	985	PF00917	0.652
DEG_SPOP_SBC_1	987	991	PF00917	0.656
DOC_CKS1_1	116	121	PF01111	0.790
DOC_CKS1_1	170	175	PF01111	0.725
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	89	92	PF00134	0.692
DOC_MAPK_gen_1	824	832	PF00069	0.779
DOC_PP2B_LxvP_1	125	128	PF13499	0.581
DOC_PP2B_LxvP_1	488	491	PF13499	0.673
DOC_PP2B_LxvP_1	67	70	PF13499	0.580
DOC_PP2B_LxvP_1	726	729	PF13499	0.673
DOC_PP2B_LxvP_1	89	92	PF13499	0.692
DOC_PP2B_LxvP_1	932	935	PF13499	0.591
DOC_PP2B_PxIxI_1	478	484	PF00149	0.664
DOC_PP4_FxxP_1	573	576	PF00568	0.660
DOC_PP4_FxxP_1	923	926	PF00568	0.631
DOC_USP7_MATH_1	135	139	PF00917	0.790
DOC_USP7_MATH_1	177	181	PF00917	0.678
DOC_USP7_MATH_1	200	204	PF00917	0.683
DOC_USP7_MATH_1	214	218	PF00917	0.814
DOC_USP7_MATH_1	246	250	PF00917	0.779
DOC_USP7_MATH_1	266	270	PF00917	0.512
DOC_USP7_MATH_1	330	334	PF00917	0.658
DOC_USP7_MATH_1	384	388	PF00917	0.633
DOC_USP7_MATH_1	492	496	PF00917	0.706
DOC_USP7_MATH_1	518	522	PF00917	0.742
DOC_USP7_MATH_1	537	541	PF00917	0.575
DOC_USP7_MATH_1	60	64	PF00917	0.718
DOC_USP7_MATH_1	656	660	PF00917	0.701
DOC_USP7_MATH_1	722	726	PF00917	0.657
DOC_USP7_MATH_1	74	78	PF00917	0.610
DOC_USP7_MATH_1	748	752	PF00917	0.783
DOC_USP7_MATH_1	902	906	PF00917	0.656
DOC_USP7_MATH_1	917	921	PF00917	0.587
DOC_USP7_MATH_1	935	939	PF00917	0.648
DOC_USP7_MATH_1	953	957	PF00917	0.559
DOC_USP7_MATH_1	987	991	PF00917	0.592
DOC_WW_Pin1_4	109	114	PF00397	0.824
DOC_WW_Pin1_4	115	120	PF00397	0.720
DOC_WW_Pin1_4	151	156	PF00397	0.788
DOC_WW_Pin1_4	169	174	PF00397	0.550
DOC_WW_Pin1_4	218	223	PF00397	0.662
DOC_WW_Pin1_4	252	257	PF00397	0.679
DOC_WW_Pin1_4	333	338	PF00397	0.794
DOC_WW_Pin1_4	360	365	PF00397	0.603
DOC_WW_Pin1_4	43	48	PF00397	0.690
DOC_WW_Pin1_4	466	471	PF00397	0.558
DOC_WW_Pin1_4	568	573	PF00397	0.665
DOC_WW_Pin1_4	603	608	PF00397	0.586
DOC_WW_Pin1_4	705	710	PF00397	0.649
DOC_WW_Pin1_4	717	722	PF00397	0.714
DOC_WW_Pin1_4	732	737	PF00397	0.705
DOC_WW_Pin1_4	740	745	PF00397	0.628
DOC_WW_Pin1_4	793	798	PF00397	0.678
DOC_WW_Pin1_4	860	865	PF00397	0.723
DOC_WW_Pin1_4	921	926	PF00397	0.658
DOC_WW_Pin1_4	936	941	PF00397	0.667
LIG_14-3-3_CanoR_1	304	310	PF00244	0.664
LIG_14-3-3_CanoR_1	512	520	PF00244	0.717
LIG_14-3-3_CanoR_1	637	647	PF00244	0.675
LIG_14-3-3_CanoR_1	800	805	PF00244	0.800
LIG_14-3-3_CanoR_1	826	831	PF00244	0.780
LIG_14-3-3_CanoR_1	843	853	PF00244	0.536
LIG_AP2alpha_2	952	954	PF02296	0.565
LIG_BIR_III_2	733	737	PF00653	0.591
LIG_BRCT_BRCA1_1	919	923	PF00533	0.597
LIG_deltaCOP1_diTrp_1	952	960	PF00928	0.553
LIG_FHA_1	199	205	PF00498	0.776
LIG_FHA_1	304	310	PF00498	0.620
LIG_FHA_1	314	320	PF00498	0.590
LIG_FHA_1	324	330	PF00498	0.731
LIG_FHA_1	342	348	PF00498	0.551
LIG_FHA_1	461	467	PF00498	0.688
LIG_FHA_1	642	648	PF00498	0.656
LIG_FHA_1	668	674	PF00498	0.623
LIG_FHA_1	721	727	PF00498	0.662
LIG_FHA_1	755	761	PF00498	0.712
LIG_FHA_1	827	833	PF00498	0.842
LIG_FHA_1	99	105	PF00498	0.668
LIG_FHA_2	142	148	PF00498	0.716
LIG_FHA_2	159	165	PF00498	0.693
LIG_FHA_2	173	179	PF00498	0.585
LIG_FHA_2	341	347	PF00498	0.681
LIG_FHA_2	407	413	PF00498	0.573
LIG_FHA_2	621	627	PF00498	0.743
LIG_FHA_2	763	769	PF00498	0.601
LIG_IBAR_NPY_1	549	551	PF08397	0.551
LIG_LIR_Apic_2	474	479	PF02991	0.635
LIG_LIR_Apic_2	571	576	PF02991	0.657
LIG_LIR_Apic_2	920	926	PF02991	0.590
LIG_LIR_Gen_1	372	381	PF02991	0.697
LIG_LIR_Gen_1	76	82	PF02991	0.598
LIG_LIR_Gen_1	956	961	PF02991	0.537
LIG_LIR_Gen_1	968	977	PF02991	0.521
LIG_LIR_Nem_3	372	377	PF02991	0.665
LIG_LIR_Nem_3	634	639	PF02991	0.534
LIG_LIR_Nem_3	76	81	PF02991	0.601
LIG_LIR_Nem_3	952	957	PF02991	0.563
LIG_LIR_Nem_3	968	974	PF02991	0.531
LIG_PAM2_1	828	840	PF00658	0.774
LIG_Pex14_1	569	573	PF04695	0.661
LIG_Pex14_2	608	612	PF04695	0.616
LIG_PTAP_UEV_1	715	720	PF05743	0.605
LIG_SH2_CRK	476	480	PF00017	0.666
LIG_SH2_CRK	545	549	PF00017	0.677
LIG_SH2_CRK	971	975	PF00017	0.538
LIG_SH2_GRB2like	971	974	PF00017	0.634
LIG_SH2_SRC	971	974	PF00017	0.634
LIG_SH2_STAP1	957	961	PF00017	0.546
LIG_SH2_STAT3	427	430	PF00017	0.465
LIG_SH2_STAT5	299	302	PF00017	0.489
LIG_SH2_STAT5	427	430	PF00017	0.465
LIG_SH3_1	819	825	PF00018	0.589
LIG_SH3_2	887	892	PF14604	0.762
LIG_SH3_3	101	107	PF00018	0.643
LIG_SH3_3	113	119	PF00018	0.666
LIG_SH3_3	304	310	PF00018	0.633
LIG_SH3_3	326	332	PF00018	0.690
LIG_SH3_3	559	565	PF00018	0.623
LIG_SH3_3	601	607	PF00018	0.786
LIG_SH3_3	610	616	PF00018	0.510
LIG_SH3_3	68	74	PF00018	0.573
LIG_SH3_3	707	713	PF00018	0.673
LIG_SH3_3	716	722	PF00018	0.658
LIG_SH3_3	819	825	PF00018	0.744
LIG_SH3_3	833	839	PF00018	0.627
LIG_SH3_3	872	878	PF00018	0.629
LIG_SH3_3	884	890	PF00018	0.645
LIG_SH3_3	895	901	PF00018	0.579
LIG_SH3_3	937	943	PF00018	0.815
LIG_SH3_3	947	953	PF00018	0.591
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.471
LIG_SUMO_SIM_par_1	305	312	PF11976	0.549
LIG_SUMO_SIM_par_1	409	414	PF11976	0.586
LIG_SUMO_SIM_par_1	670	676	PF11976	0.614
LIG_TRAF2_1	120	123	PF00917	0.795
LIG_TRAF2_1	162	165	PF00917	0.808
LIG_TRAF2_1	233	236	PF00917	0.576
LIG_TRAF2_1	676	679	PF00917	0.642
LIG_UBA3_1	432	440	PF00899	0.570
LIG_WW_3	735	739	PF00397	0.685
MOD_CDK_SPxK_1	732	738	PF00069	0.597
MOD_CDK_SPxK_1	860	866	PF00069	0.745
MOD_CDK_SPxxK_3	732	739	PF00069	0.729
MOD_CDK_SPxxK_3	793	800	PF00069	0.681
MOD_CDK_SPxxK_3	941	948	PF00069	0.657
MOD_CK1_1	179	185	PF00069	0.770
MOD_CK1_1	198	204	PF00069	0.730
MOD_CK1_1	213	219	PF00069	0.597
MOD_CK1_1	322	328	PF00069	0.746
MOD_CK1_1	333	339	PF00069	0.666
MOD_CK1_1	340	346	PF00069	0.485
MOD_CK1_1	494	500	PF00069	0.703
MOD_CK1_1	592	598	PF00069	0.634
MOD_CK1_1	63	69	PF00069	0.640
MOD_CK1_1	652	658	PF00069	0.792
MOD_CK1_1	663	669	PF00069	0.611
MOD_CK1_1	769	775	PF00069	0.773
MOD_CK1_1	798	804	PF00069	0.702
MOD_CK1_1	846	852	PF00069	0.653
MOD_CK1_1	862	868	PF00069	0.745
MOD_CK1_1	924	930	PF00069	0.669
MOD_CK1_1	988	994	PF00069	0.768
MOD_CK2_1	141	147	PF00069	0.749
MOD_CK2_1	151	157	PF00069	0.688
MOD_CK2_1	158	164	PF00069	0.763
MOD_CK2_1	230	236	PF00069	0.587
MOD_CK2_1	321	327	PF00069	0.769
MOD_CK2_1	340	346	PF00069	0.695
MOD_CK2_1	406	412	PF00069	0.585
MOD_CK2_1	454	460	PF00069	0.618
MOD_CK2_1	518	524	PF00069	0.731
MOD_CK2_1	656	662	PF00069	0.786
MOD_CK2_1	673	679	PF00069	0.476
MOD_CK2_1	74	80	PF00069	0.655
MOD_CK2_1	762	768	PF00069	0.593
MOD_GlcNHglycan	137	140	PF01048	0.788
MOD_GlcNHglycan	14	17	PF01048	0.573
MOD_GlcNHglycan	178	182	PF01048	0.788
MOD_GlcNHglycan	183	186	PF01048	0.723
MOD_GlcNHglycan	211	215	PF01048	0.762
MOD_GlcNHglycan	216	219	PF01048	0.840
MOD_GlcNHglycan	248	251	PF01048	0.677
MOD_GlcNHglycan	268	271	PF01048	0.571
MOD_GlcNHglycan	286	289	PF01048	0.502
MOD_GlcNHglycan	332	335	PF01048	0.698
MOD_GlcNHglycan	384	387	PF01048	0.598
MOD_GlcNHglycan	456	459	PF01048	0.586
MOD_GlcNHglycan	463	466	PF01048	0.682
MOD_GlcNHglycan	502	505	PF01048	0.752
MOD_GlcNHglycan	514	517	PF01048	0.547
MOD_GlcNHglycan	526	529	PF01048	0.533
MOD_GlcNHglycan	62	65	PF01048	0.722
MOD_GlcNHglycan	622	626	PF01048	0.668
MOD_GlcNHglycan	667	670	PF01048	0.723
MOD_GlcNHglycan	752	755	PF01048	0.782
MOD_GlcNHglycan	797	800	PF01048	0.708
MOD_GlcNHglycan	850	853	PF01048	0.608
MOD_GlcNHglycan	878	881	PF01048	0.639
MOD_GlcNHglycan	92	95	PF01048	0.772
MOD_GlcNHglycan	927	930	PF01048	0.678
MOD_GlcNHglycan	990	993	PF01048	0.789
MOD_GSK3_1	107	114	PF00069	0.839
MOD_GSK3_1	149	156	PF00069	0.725
MOD_GSK3_1	168	175	PF00069	0.574
MOD_GSK3_1	177	184	PF00069	0.640
MOD_GSK3_1	209	216	PF00069	0.614
MOD_GSK3_1	220	227	PF00069	0.640
MOD_GSK3_1	242	249	PF00069	0.654
MOD_GSK3_1	305	312	PF00069	0.603
MOD_GSK3_1	319	326	PF00069	0.724
MOD_GSK3_1	333	340	PF00069	0.656
MOD_GSK3_1	454	461	PF00069	0.705
MOD_GSK3_1	568	575	PF00069	0.711
MOD_GSK3_1	59	66	PF00069	0.691
MOD_GSK3_1	617	624	PF00069	0.675
MOD_GSK3_1	646	653	PF00069	0.656
MOD_GSK3_1	656	663	PF00069	0.601
MOD_GSK3_1	720	727	PF00069	0.690
MOD_GSK3_1	740	747	PF00069	0.826
MOD_GSK3_1	750	757	PF00069	0.669
MOD_GSK3_1	762	769	PF00069	0.617
MOD_GSK3_1	795	802	PF00069	0.839
MOD_GSK3_1	844	851	PF00069	0.658
MOD_GSK3_1	856	863	PF00069	0.749
MOD_GSK3_1	876	883	PF00069	0.623
MOD_GSK3_1	917	924	PF00069	0.667
MOD_GSK3_1	981	988	PF00069	0.728
MOD_N-GLC_1	241	246	PF02516	0.608
MOD_N-GLC_1	284	289	PF02516	0.569
MOD_N-GLC_1	358	363	PF02516	0.585
MOD_N-GLC_1	880	885	PF02516	0.578
MOD_NEK2_1	638	643	PF00069	0.553
MOD_NEK2_1	667	672	PF00069	0.707
MOD_NEK2_1	856	861	PF00069	0.562
MOD_NEK2_2	552	557	PF00069	0.588
MOD_PIKK_1	166	172	PF00454	0.858
MOD_PIKK_1	276	282	PF00454	0.765
MOD_PIKK_1	338	344	PF00454	0.623
MOD_PIKK_1	441	447	PF00454	0.567
MOD_PIKK_1	45	51	PF00454	0.611
MOD_PIKK_1	494	500	PF00454	0.671
MOD_PIKK_1	555	561	PF00454	0.611
MOD_PIKK_1	638	644	PF00454	0.665
MOD_PIKK_1	646	652	PF00454	0.668
MOD_PIKK_1	656	662	PF00454	0.544
MOD_PIKK_1	673	679	PF00454	0.534
MOD_PIKK_1	762	768	PF00454	0.712
MOD_PIKK_1	769	775	PF00454	0.750
MOD_PKA_1	195	201	PF00069	0.796
MOD_PKA_2	242	248	PF00069	0.639
MOD_PKA_2	303	309	PF00069	0.655
MOD_PKA_2	799	805	PF00069	0.800
MOD_PKA_2	825	831	PF00069	0.777
MOD_Plk_1	284	290	PF00069	0.567
MOD_Plk_1	302	308	PF00069	0.605
MOD_Plk_1	358	364	PF00069	0.581
MOD_Plk_1	661	667	PF00069	0.785
MOD_Plk_1	774	780	PF00069	0.683
MOD_Plk_1	880	886	PF00069	0.578
MOD_Plk_4	406	412	PF00069	0.502
MOD_Plk_4	552	558	PF00069	0.590
MOD_Plk_4	774	780	PF00069	0.651
MOD_Plk_4	881	887	PF00069	0.676
MOD_Plk_4	99	105	PF00069	0.718
MOD_ProDKin_1	109	115	PF00069	0.821
MOD_ProDKin_1	151	157	PF00069	0.791
MOD_ProDKin_1	169	175	PF00069	0.548
MOD_ProDKin_1	218	224	PF00069	0.661
MOD_ProDKin_1	252	258	PF00069	0.677
MOD_ProDKin_1	333	339	PF00069	0.790
MOD_ProDKin_1	360	366	PF00069	0.598
MOD_ProDKin_1	43	49	PF00069	0.693
MOD_ProDKin_1	466	472	PF00069	0.555
MOD_ProDKin_1	568	574	PF00069	0.665
MOD_ProDKin_1	603	609	PF00069	0.588
MOD_ProDKin_1	705	711	PF00069	0.651
MOD_ProDKin_1	717	723	PF00069	0.716
MOD_ProDKin_1	732	738	PF00069	0.707
MOD_ProDKin_1	740	746	PF00069	0.628
MOD_ProDKin_1	793	799	PF00069	0.678
MOD_ProDKin_1	860	866	PF00069	0.725
MOD_ProDKin_1	921	927	PF00069	0.661
MOD_ProDKin_1	936	942	PF00069	0.665
MOD_SUMO_rev_2	19	27	PF00179	0.592
TRG_DiLeu_BaEn_3	810	816	PF01217	0.594
TRG_DiLeu_BaEn_4	678	684	PF01217	0.621
TRG_DiLeu_BaEn_4	811	817	PF01217	0.598
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.579
TRG_ENDOCYTIC_2	551	554	PF00928	0.572
TRG_ENDOCYTIC_2	957	960	PF00928	0.544
TRG_ENDOCYTIC_2	971	974	PF00928	0.534
TRG_ER_diArg_1	194	197	PF00400	0.681
TRG_ER_diArg_1	237	240	PF00400	0.575
TRG_ER_diArg_1	423	425	PF00400	0.498
TRG_ER_diArg_1	5	7	PF00400	0.549
TRG_ER_diArg_1	581	584	PF00400	0.716
TRG_ER_diArg_1	737	739	PF00400	0.752
TRG_NLS_MonoCore_2	104	109	PF00514	0.663
TRG_NLS_MonoExtC_3	194	199	PF00514	0.659
TRG_NLS_MonoExtN_4	195	200	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAC9	Leptomonas seymouri	39%	97%
A0A3S7WQR9	Leishmania donovani	89%	100%
A4H5S6	Leishmania braziliensis	62%	92%
A4HU20	Leishmania infantum	89%	100%
E9AMV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%