PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHS4_LEIMA

TriTrypDb:

LmjF.09.1000 , LMJLV39_090016300 , LMJSD75_090015900

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.572
CLV_NRD_NRD_1	181	183	PF00675	0.449
CLV_NRD_NRD_1	31	33	PF00675	0.317
CLV_PCSK_KEX2_1	159	161	PF00082	0.647
CLV_PCSK_KEX2_1	31	33	PF00082	0.287
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.717
CLV_PCSK_SKI1_1	183	187	PF00082	0.441
CLV_PCSK_SKI1_1	233	237	PF00082	0.496
CLV_PCSK_SKI1_1	295	299	PF00082	0.566
CLV_PCSK_SKI1_1	31	35	PF00082	0.303
CLV_PCSK_SKI1_1	47	51	PF00082	0.262
DEG_APCC_DBOX_1	30	38	PF00400	0.292
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DOC_CYCLIN_RxL_1	178	188	PF00134	0.450
DOC_MAPK_gen_1	31	39	PF00069	0.319
DOC_MAPK_HePTP_8	29	41	PF00069	0.352
DOC_MAPK_MEF2A_6	32	41	PF00069	0.394
DOC_PP1_RVXF_1	270	277	PF00149	0.371
DOC_PP4_FxxP_1	41	44	PF00568	0.406
DOC_USP7_MATH_1	162	166	PF00917	0.650
DOC_USP7_UBL2_3	291	295	PF12436	0.448
DOC_USP7_UBL2_3	50	54	PF12436	0.406
DOC_WW_Pin1_4	86	91	PF00397	0.251
LIG_14-3-3_CanoR_1	182	186	PF00244	0.406
LIG_14-3-3_CanoR_1	58	64	PF00244	0.329
LIG_BRCT_BRCA1_1	266	270	PF00533	0.500
LIG_BRCT_BRCA1_1	73	77	PF00533	0.406
LIG_BRCT_BRCA1_2	266	272	PF00533	0.498
LIG_FHA_1	141	147	PF00498	0.731
LIG_FHA_1	186	192	PF00498	0.410
LIG_FHA_1	246	252	PF00498	0.530
LIG_FHA_1	296	302	PF00498	0.513
LIG_FHA_1	58	64	PF00498	0.386
LIG_FHA_2	165	171	PF00498	0.605
LIG_HCF-1_HBM_1	256	259	PF13415	0.344
LIG_Integrin_isoDGR_2	284	286	PF01839	0.579
LIG_LIR_Apic_2	40	44	PF02991	0.406
LIG_LIR_Gen_1	224	235	PF02991	0.367
LIG_LIR_Gen_1	69	78	PF02991	0.380
LIG_LIR_Nem_3	224	230	PF02991	0.328
LIG_LIR_Nem_3	69	75	PF02991	0.305
LIG_LIR_Nem_3	8	13	PF02991	0.555
LIG_NRBOX	33	39	PF00104	0.352
LIG_PDZ_Class_2	307	312	PF00595	0.377
LIG_PTB_Apo_2	190	197	PF02174	0.409
LIG_REV1ctd_RIR_1	193	203	PF16727	0.475
LIG_SH2_CRK	261	265	PF00017	0.398
LIG_SH2_STAP1	237	241	PF00017	0.332
LIG_SH2_STAT5	102	105	PF00017	0.525
LIG_SH2_STAT5	302	305	PF00017	0.461
LIG_SH3_3	1	7	PF00018	0.476
LIG_TRAF2_1	153	156	PF00917	0.600
LIG_TYR_ITIM	235	240	PF00017	0.360
MOD_CK1_1	89	95	PF00069	0.341
MOD_CK2_1	162	168	PF00069	0.668
MOD_CK2_1	98	104	PF00069	0.391
MOD_GlcNHglycan	164	167	PF01048	0.658
MOD_GlcNHglycan	243	246	PF01048	0.485
MOD_GlcNHglycan	266	269	PF01048	0.467
MOD_GSK3_1	177	184	PF00069	0.411
MOD_GSK3_1	241	248	PF00069	0.414
MOD_GSK3_1	260	267	PF00069	0.376
MOD_GSK3_1	9	16	PF00069	0.585
MOD_NEK2_1	140	145	PF00069	0.638
MOD_NEK2_1	185	190	PF00069	0.451
MOD_NEK2_1	59	64	PF00069	0.370
MOD_NEK2_1	70	75	PF00069	0.259
MOD_PIKK_1	146	152	PF00454	0.681
MOD_PK_1	199	205	PF00069	0.402
MOD_PKA_2	181	187	PF00069	0.412
MOD_PKA_2	57	63	PF00069	0.386
MOD_Plk_1	103	109	PF00069	0.465
MOD_Plk_1	199	205	PF00069	0.532
MOD_Plk_4	181	187	PF00069	0.490
MOD_Plk_4	98	104	PF00069	0.495
MOD_ProDKin_1	86	92	PF00069	0.251
TRG_DiLeu_BaEn_1	283	288	PF01217	0.523
TRG_DiLeu_BaEn_4	8	14	PF01217	0.502
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.415
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.292
TRG_ENDOCYTIC_2	237	240	PF00928	0.353
TRG_ENDOCYTIC_2	261	264	PF00928	0.394
TRG_ER_diArg_1	30	32	PF00400	0.273
TRG_NES_CRM1_1	118	131	PF08389	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ0	Leptomonas seymouri	60%	100%
A0A1X0NI65	Trypanosomatidae	39%	100%
A0A3S7WQS2	Leishmania donovani	90%	100%
A0A422N3Q8	Trypanosoma rangeli	39%	100%
A4H5S8	Leishmania braziliensis	74%	100%
A4HU22	Leishmania infantum	91%	100%
D0A9J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AMV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5D6M9	Trypanosoma cruzi	41%	100%