Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 10

Species:

Leishmania major

UniProt:

Q4QHS3_LEIMA

TriTrypDb:

LmjF.09.1010 , LMJLV39_090016900 , LMJSD75_090016500

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0005929	cilium	4	2
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031514	motile cilium	5	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QHS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.568
CLV_NRD_NRD_1	151	153	PF00675	0.431
CLV_NRD_NRD_1	246	248	PF00675	0.451
CLV_NRD_NRD_1	384	386	PF00675	0.451
CLV_NRD_NRD_1	595	597	PF00675	0.395
CLV_PCSK_KEX2_1	138	140	PF00082	0.597
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.526
CLV_PCSK_SKI1_1	139	143	PF00082	0.607
CLV_PCSK_SKI1_1	258	262	PF00082	0.337
CLV_PCSK_SKI1_1	302	306	PF00082	0.355
CLV_PCSK_SKI1_1	406	410	PF00082	0.317
CLV_PCSK_SKI1_1	434	438	PF00082	0.366
DEG_APCC_DBOX_1	170	178	PF00400	0.675
DEG_SCF_FBW7_1	312	319	PF00400	0.635
DEG_SCF_FBW7_2	439	444	PF00400	0.654
DOC_CKS1_1	313	318	PF01111	0.639
DOC_MAPK_gen_1	152	160	PF00069	0.571
DOC_MAPK_gen_1	365	371	PF00069	0.519
DOC_MAPK_gen_1	385	395	PF00069	0.465
DOC_MAPK_MEF2A_6	153	162	PF00069	0.560
DOC_PP4_FxxP_1	41	44	PF00568	0.733
DOC_USP7_MATH_1	109	113	PF00917	0.785
DOC_USP7_MATH_1	126	130	PF00917	0.628
DOC_USP7_MATH_1	316	320	PF00917	0.637
DOC_USP7_MATH_1	435	439	PF00917	0.661
DOC_USP7_MATH_1	44	48	PF00917	0.825
DOC_USP7_MATH_1	63	67	PF00917	0.819
DOC_USP7_MATH_1	68	72	PF00917	0.840
DOC_USP7_MATH_1	73	77	PF00917	0.854
DOC_USP7_UBL2_3	134	138	PF12436	0.775
DOC_USP7_UBL2_3	223	227	PF12436	0.525
DOC_WW_Pin1_4	172	177	PF00397	0.584
DOC_WW_Pin1_4	312	317	PF00397	0.624
DOC_WW_Pin1_4	437	442	PF00397	0.598
DOC_WW_Pin1_4	494	499	PF00397	0.749
DOC_WW_Pin1_4	560	565	PF00397	0.636
LIG_14-3-3_CanoR_1	125	135	PF00244	0.772
LIG_14-3-3_CanoR_1	152	156	PF00244	0.618
LIG_14-3-3_CanoR_1	302	312	PF00244	0.618
LIG_14-3-3_CanoR_1	434	440	PF00244	0.639
LIG_14-3-3_CanoR_1	579	588	PF00244	0.551
LIG_APCC_ABBA_1	267	272	PF00400	0.578
LIG_BRCT_BRCA1_1	320	324	PF00533	0.564
LIG_BRCT_BRCA1_1	607	611	PF00533	0.520
LIG_deltaCOP1_diTrp_1	337	342	PF00928	0.549
LIG_eIF4E_1	410	416	PF01652	0.546
LIG_FHA_1	20	26	PF00498	0.413
LIG_FHA_1	236	242	PF00498	0.648
LIG_FHA_1	327	333	PF00498	0.522
LIG_FHA_1	460	466	PF00498	0.534
LIG_FHA_1	502	508	PF00498	0.575
LIG_FHA_1	524	530	PF00498	0.573
LIG_FHA_1	53	59	PF00498	0.730
LIG_FHA_1	580	586	PF00498	0.524
LIG_FHA_1	8	14	PF00498	0.434
LIG_FHA_2	313	319	PF00498	0.620
LIG_FHA_2	368	374	PF00498	0.576
LIG_FHA_2	407	413	PF00498	0.480
LIG_FHA_2	512	518	PF00498	0.619
LIG_FHA_2	73	79	PF00498	0.807
LIG_IRF3_LxIS_1	155	161	PF10401	0.596
LIG_LIR_Apic_2	339	345	PF02991	0.533
LIG_LIR_Apic_2	38	44	PF02991	0.731
LIG_LIR_Gen_1	154	162	PF02991	0.599
LIG_LIR_Gen_1	189	198	PF02991	0.679
LIG_LIR_Gen_1	412	419	PF02991	0.593
LIG_LIR_Gen_1	462	471	PF02991	0.580
LIG_LIR_Gen_1	607	615	PF02991	0.619
LIG_LIR_LC3C_4	412	417	PF02991	0.511
LIG_LIR_Nem_3	154	158	PF02991	0.547
LIG_LIR_Nem_3	189	193	PF02991	0.630
LIG_LIR_Nem_3	254	260	PF02991	0.624
LIG_LIR_Nem_3	321	327	PF02991	0.604
LIG_LIR_Nem_3	407	413	PF02991	0.550
LIG_LIR_Nem_3	462	466	PF02991	0.658
LIG_LIR_Nem_3	592	598	PF02991	0.594
LIG_LIR_Nem_3	607	612	PF02991	0.511
LIG_PDZ_Class_3	610	615	PF00595	0.639
LIG_Pex14_1	186	190	PF04695	0.644
LIG_Pex14_1	340	344	PF04695	0.541
LIG_Pex14_2	605	609	PF04695	0.554
LIG_PTB_Apo_2	184	191	PF02174	0.644
LIG_REV1ctd_RIR_1	322	330	PF16727	0.568
LIG_SH2_CRK	301	305	PF00017	0.625
LIG_SH2_CRK	413	417	PF00017	0.523
LIG_SH2_STAP1	263	267	PF00017	0.515
LIG_SH2_STAP1	461	465	PF00017	0.554
LIG_SH2_STAP1	598	602	PF00017	0.635
LIG_SH2_STAT3	287	290	PF00017	0.495
LIG_SH2_STAT3	483	486	PF00017	0.610
LIG_SH2_STAT5	287	290	PF00017	0.509
LIG_SH2_STAT5	413	416	PF00017	0.529
LIG_SH2_STAT5	426	429	PF00017	0.516
LIG_SH2_STAT5	461	464	PF00017	0.577
LIG_SH3_2	489	494	PF14604	0.720
LIG_SH3_3	120	126	PF00018	0.790
LIG_SH3_3	182	188	PF00018	0.611
LIG_SH3_3	238	244	PF00018	0.660
LIG_SH3_3	310	316	PF00018	0.627
LIG_SH3_3	413	419	PF00018	0.511
LIG_SH3_3	442	448	PF00018	0.625
LIG_SH3_3	479	485	PF00018	0.575
LIG_SH3_3	486	492	PF00018	0.658
LIG_SH3_3	98	104	PF00018	0.695
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.567
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.595
LIG_SUMO_SIM_par_1	202	208	PF11976	0.529
LIG_SUMO_SIM_par_1	5	10	PF11976	0.321
LIG_TRAF2_1	129	132	PF00917	0.833
LIG_TRAF2_1	251	254	PF00917	0.610
LIG_TRAF2_1	497	500	PF00917	0.699
LIG_TRAF2_1	521	524	PF00917	0.602
LIG_TRAF2_1	75	78	PF00917	0.656
LIG_WRC_WIRS_1	606	611	PF05994	0.561
MOD_CDK_SPK_2	560	565	PF00069	0.636
MOD_CDK_SPxxK_3	560	567	PF00069	0.636
MOD_CK1_1	137	143	PF00069	0.811
MOD_CK1_1	425	431	PF00069	0.675
MOD_CK1_1	46	52	PF00069	0.738
MOD_CK1_1	490	496	PF00069	0.724
MOD_CK1_1	71	77	PF00069	0.806
MOD_CK2_1	109	115	PF00069	0.676
MOD_CK2_1	126	132	PF00069	0.650
MOD_CK2_1	248	254	PF00069	0.607
MOD_CK2_1	367	373	PF00069	0.552
MOD_CK2_1	494	500	PF00069	0.736
MOD_CK2_1	518	524	PF00069	0.568
MOD_CK2_1	560	566	PF00069	0.669
MOD_CK2_1	72	78	PF00069	0.676
MOD_GlcNHglycan	128	131	PF01048	0.620
MOD_GlcNHglycan	396	399	PF01048	0.388
MOD_GlcNHglycan	441	444	PF01048	0.368
MOD_GlcNHglycan	589	592	PF01048	0.403
MOD_GlcNHglycan	94	98	PF01048	0.586
MOD_GSK3_1	126	133	PF00069	0.724
MOD_GSK3_1	19	26	PF00069	0.448
MOD_GSK3_1	223	230	PF00069	0.632
MOD_GSK3_1	312	319	PF00069	0.584
MOD_GSK3_1	326	333	PF00069	0.530
MOD_GSK3_1	336	343	PF00069	0.567
MOD_GSK3_1	435	442	PF00069	0.544
MOD_GSK3_1	44	51	PF00069	0.799
MOD_GSK3_1	466	473	PF00069	0.638
MOD_GSK3_1	490	497	PF00069	0.708
MOD_GSK3_1	587	594	PF00069	0.593
MOD_GSK3_1	59	66	PF00069	0.753
MOD_GSK3_1	68	75	PF00069	0.772
MOD_N-GLC_1	477	482	PF02516	0.446
MOD_N-GLC_1	534	539	PF02516	0.473
MOD_N-GLC_1	579	584	PF02516	0.381
MOD_NEK2_1	158	163	PF00069	0.560
MOD_NEK2_1	19	24	PF00069	0.261
MOD_NEK2_1	235	240	PF00069	0.566
MOD_NEK2_1	261	266	PF00069	0.551
MOD_NEK2_1	271	276	PF00069	0.497
MOD_NEK2_1	317	322	PF00069	0.576
MOD_NEK2_1	360	365	PF00069	0.551
MOD_NEK2_1	48	53	PF00069	0.703
MOD_NEK2_1	605	610	PF00069	0.527
MOD_NEK2_1	7	12	PF00069	0.385
MOD_NEK2_2	503	508	PF00069	0.556
MOD_PIKK_1	261	267	PF00454	0.571
MOD_PIKK_1	303	309	PF00454	0.545
MOD_PIKK_1	399	405	PF00454	0.647
MOD_PIKK_1	46	52	PF00454	0.731
MOD_PIKK_1	73	79	PF00454	0.816
MOD_PIKK_1	83	89	PF00454	0.815
MOD_PK_1	248	254	PF00069	0.632
MOD_PKA_1	247	253	PF00069	0.647
MOD_PKA_1	30	36	PF00069	0.793
MOD_PKA_2	151	157	PF00069	0.623
MOD_PKA_2	63	69	PF00069	0.746
MOD_Plk_1	227	233	PF00069	0.608
MOD_Plk_1	248	254	PF00069	0.607
MOD_Plk_1	271	277	PF00069	0.572
MOD_Plk_1	317	323	PF00069	0.590
MOD_Plk_1	336	342	PF00069	0.427
MOD_Plk_1	367	373	PF00069	0.524
MOD_Plk_1	386	392	PF00069	0.592
MOD_Plk_2-3	151	157	PF00069	0.521
MOD_Plk_2-3	367	373	PF00069	0.577
MOD_Plk_4	109	115	PF00069	0.741
MOD_Plk_4	181	187	PF00069	0.564
MOD_Plk_4	271	277	PF00069	0.606
MOD_Plk_4	477	483	PF00069	0.608
MOD_Plk_4	550	556	PF00069	0.555
MOD_Plk_4	581	587	PF00069	0.516
MOD_ProDKin_1	172	178	PF00069	0.582
MOD_ProDKin_1	312	318	PF00069	0.633
MOD_ProDKin_1	437	443	PF00069	0.604
MOD_ProDKin_1	494	500	PF00069	0.748
MOD_ProDKin_1	560	566	PF00069	0.636
MOD_SUMO_for_1	364	367	PF00179	0.563
MOD_SUMO_rev_2	129	136	PF00179	0.831
MOD_SUMO_rev_2	148	155	PF00179	0.663
MOD_SUMO_rev_2	400	408	PF00179	0.598
MOD_SUMO_rev_2	94	104	PF00179	0.772
TRG_DiLeu_BaEn_1	215	220	PF01217	0.558
TRG_DiLeu_BaEn_2	549	555	PF01217	0.541
TRG_DiLeu_BaEn_2	606	612	PF01217	0.575
TRG_ENDOCYTIC_2	301	304	PF00928	0.573
TRG_ENDOCYTIC_2	413	416	PF00928	0.511
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUN6	Leptomonas seymouri	69%	99%
A0A0S4JT82	Bodo saltans	45%	100%
A0A1X0NI07	Trypanosomatidae	47%	100%
A0A3R7MXK0	Trypanosoma rangeli	44%	100%
A0A3S7WQS4	Leishmania donovani	95%	100%
A4H5S9	Leishmania braziliensis	84%	100%
A4HU23	Leishmania infantum	95%	100%
D0A9K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AMV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5CK09	Trypanosoma cruzi	52%	100%