LeishMANIAdb
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LEM3 (Ligand-effect modulator 3) / CDC50 family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
LEM3 (Ligand-effect modulator 3) / CDC50 family protein
Gene product:
LEM3 (ligand-effect modulator 3) family / CDC50 family, putative
Species:
Leishmania major
UniProt:
Q4QHS2_LEIMA
TriTrypDb:
LmjF.09.1020 , LMJLV39_090017600 * , LMJSD75_090017200 *
Length:
597

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005783 endoplasmic reticulum 5 3
GO:0005794 Golgi apparatus 5 3
GO:0005886 plasma membrane 3 3
GO:0016020 membrane 2 19
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 19

Expansion

Sequence features

Q4QHS2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS2

Function

Biological processes
Term Name Level Count
GO:0033036 macromolecule localization 2 19
GO:0051179 localization 1 19
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 288 292 PF00656 0.305
CLV_C14_Caspase3-7 68 72 PF00656 0.794
CLV_NRD_NRD_1 324 326 PF00675 0.439
CLV_NRD_NRD_1 449 451 PF00675 0.459
CLV_NRD_NRD_1 480 482 PF00675 0.501
CLV_NRD_NRD_1 560 562 PF00675 0.398
CLV_NRD_NRD_1 571 573 PF00675 0.370
CLV_PCSK_FUR_1 530 534 PF00082 0.329
CLV_PCSK_FUR_1 558 562 PF00082 0.392
CLV_PCSK_KEX2_1 532 534 PF00082 0.437
CLV_PCSK_KEX2_1 538 540 PF00082 0.422
CLV_PCSK_KEX2_1 560 562 PF00082 0.364
CLV_PCSK_PC1ET2_1 532 534 PF00082 0.437
CLV_PCSK_PC1ET2_1 538 540 PF00082 0.422
CLV_PCSK_SKI1_1 325 329 PF00082 0.528
DEG_ODPH_VHL_1 311 323 PF01847 0.290
DEG_SPOP_SBC_1 347 351 PF00917 0.319
DEG_SPOP_SBC_1 42 46 PF00917 0.756
DEG_SPOP_SBC_1 53 57 PF00917 0.742
DEG_SPOP_SBC_1 58 62 PF00917 0.726
DOC_CYCLIN_yCln2_LP_2 157 163 PF00134 0.359
DOC_CYCLIN_yCln2_LP_2 269 275 PF00134 0.214
DOC_MAPK_FxFP_2 142 145 PF00069 0.621
DOC_MAPK_gen_1 103 111 PF00069 0.662
DOC_MAPK_gen_1 389 398 PF00069 0.320
DOC_MAPK_gen_1 450 460 PF00069 0.249
DOC_MAPK_gen_1 479 486 PF00069 0.316
DOC_MAPK_MEF2A_6 218 225 PF00069 0.259
DOC_MAPK_MEF2A_6 495 503 PF00069 0.251
DOC_PP1_RVXF_1 200 207 PF00149 0.350
DOC_PP1_RVXF_1 387 394 PF00149 0.281
DOC_PP2B_LxvP_1 157 160 PF13499 0.343
DOC_PP4_FxxP_1 142 145 PF00568 0.621
DOC_USP7_MATH_1 192 196 PF00917 0.331
DOC_USP7_MATH_1 335 339 PF00917 0.330
DOC_USP7_MATH_1 430 434 PF00917 0.254
DOC_USP7_MATH_1 53 57 PF00917 0.671
DOC_USP7_MATH_1 537 541 PF00917 0.621
DOC_USP7_MATH_1 58 62 PF00917 0.650
DOC_USP7_MATH_1 93 97 PF00917 0.698
DOC_USP7_UBL2_3 261 265 PF12436 0.164
DOC_WW_Pin1_4 282 287 PF00397 0.302
DOC_WW_Pin1_4 325 330 PF00397 0.325
DOC_WW_Pin1_4 348 353 PF00397 0.304
DOC_WW_Pin1_4 37 42 PF00397 0.632
LIG_14-3-3_CanoR_1 259 268 PF00244 0.344
LIG_14-3-3_CanoR_1 299 304 PF00244 0.367
LIG_14-3-3_CanoR_1 442 452 PF00244 0.242
LIG_14-3-3_CanoR_1 479 485 PF00244 0.303
LIG_14-3-3_CanoR_1 6 14 PF00244 0.696
LIG_14-3-3_CanoR_1 64 70 PF00244 0.643
LIG_Actin_WH2_2 556 574 PF00022 0.635
LIG_AP2alpha_1 317 321 PF02296 0.248
LIG_BIR_II_1 1 5 PF00653 0.577
LIG_BIR_III_4 291 295 PF00653 0.195
LIG_EH1_1 516 524 PF00400 0.335
LIG_eIF4E_1 461 467 PF01652 0.189
LIG_FHA_1 164 170 PF00498 0.273
LIG_FHA_1 318 324 PF00498 0.256
LIG_FHA_1 335 341 PF00498 0.256
LIG_FHA_1 462 468 PF00498 0.343
LIG_FHA_1 514 520 PF00498 0.336
LIG_FHA_2 217 223 PF00498 0.249
LIG_FHA_2 286 292 PF00498 0.303
LIG_FHA_2 326 332 PF00498 0.309
LIG_FHA_2 395 401 PF00498 0.239
LIG_FHA_2 409 415 PF00498 0.290
LIG_Integrin_isoDGR_2 251 253 PF01839 0.513
LIG_LIR_Apic_2 404 410 PF02991 0.287
LIG_LIR_Gen_1 174 182 PF02991 0.375
LIG_LIR_Gen_1 217 225 PF02991 0.326
LIG_LIR_Gen_1 390 398 PF02991 0.253
LIG_LIR_Gen_1 470 478 PF02991 0.326
LIG_LIR_Nem_3 174 178 PF02991 0.307
LIG_LIR_Nem_3 179 185 PF02991 0.294
LIG_LIR_Nem_3 217 223 PF02991 0.293
LIG_LIR_Nem_3 274 278 PF02991 0.239
LIG_LIR_Nem_3 302 306 PF02991 0.246
LIG_LIR_Nem_3 319 324 PF02991 0.220
LIG_LIR_Nem_3 390 396 PF02991 0.263
LIG_LIR_Nem_3 400 406 PF02991 0.231
LIG_LIR_Nem_3 446 452 PF02991 0.237
LIG_LIR_Nem_3 470 476 PF02991 0.225
LIG_LIR_Nem_3 540 544 PF02991 0.605
LIG_LIR_Nem_3 548 554 PF02991 0.541
LIG_LYPXL_L_2 460 469 PF13949 0.189
LIG_Pex14_1 402 406 PF04695 0.236
LIG_Pex14_2 317 321 PF04695 0.248
LIG_PTB_Apo_2 415 422 PF02174 0.211
LIG_PTB_Phospho_1 415 421 PF10480 0.214
LIG_SH2_CRK 188 192 PF00017 0.318
LIG_SH2_CRK 273 277 PF00017 0.326
LIG_SH2_CRK 324 328 PF00017 0.301
LIG_SH2_CRK 453 457 PF00017 0.274
LIG_SH2_CRK 473 477 PF00017 0.158
LIG_SH2_CRK 531 535 PF00017 0.534
LIG_SH2_NCK_1 473 477 PF00017 0.326
LIG_SH2_SRC 188 191 PF00017 0.315
LIG_SH2_SRC 69 72 PF00017 0.587
LIG_SH2_STAP1 435 439 PF00017 0.235
LIG_SH2_STAT3 268 271 PF00017 0.189
LIG_SH2_STAT5 155 158 PF00017 0.373
LIG_SH2_STAT5 190 193 PF00017 0.352
LIG_SH2_STAT5 268 271 PF00017 0.316
LIG_SH2_STAT5 273 276 PF00017 0.295
LIG_SH2_STAT5 303 306 PF00017 0.330
LIG_SH2_STAT5 415 418 PF00017 0.277
LIG_SH2_STAT5 421 424 PF00017 0.277
LIG_SH2_STAT5 465 468 PF00017 0.266
LIG_SH2_STAT5 542 545 PF00017 0.547
LIG_SH3_3 294 300 PF00018 0.321
LIG_SH3_3 456 462 PF00018 0.328
LIG_SH3_3 540 546 PF00018 0.647
LIG_SUMO_SIM_anti_2 166 171 PF11976 0.177
LIG_SUMO_SIM_par_1 284 291 PF11976 0.239
LIG_SUMO_SIM_par_1 464 471 PF11976 0.277
LIG_TRFH_1 148 152 PF08558 0.403
LIG_TYR_ITIM 322 327 PF00017 0.326
LIG_UBA3_1 163 171 PF00899 0.177
LIG_WRC_WIRS_1 475 480 PF05994 0.234
MOD_CK1_1 102 108 PF00069 0.650
MOD_CK1_1 134 140 PF00069 0.639
MOD_CK1_1 193 199 PF00069 0.231
MOD_CK1_1 28 34 PF00069 0.738
MOD_CK1_1 302 308 PF00069 0.164
MOD_CK1_1 444 450 PF00069 0.245
MOD_CK1_1 52 58 PF00069 0.772
MOD_CK1_1 60 66 PF00069 0.775
MOD_CK2_1 216 222 PF00069 0.249
MOD_CK2_1 325 331 PF00069 0.305
MOD_CK2_1 394 400 PF00069 0.280
MOD_CK2_1 408 414 PF00069 0.324
MOD_CK2_1 69 75 PF00069 0.794
MOD_Cter_Amidation 479 482 PF01082 0.490
MOD_GlcNHglycan 17 20 PF01048 0.570
MOD_GlcNHglycan 337 340 PF01048 0.509
MOD_GlcNHglycan 51 54 PF01048 0.579
MOD_GlcNHglycan 56 59 PF01048 0.587
MOD_GlcNHglycan 8 11 PF01048 0.409
MOD_GlcNHglycan 81 84 PF01048 0.560
MOD_GlcNHglycan 95 98 PF01048 0.557
MOD_GSK3_1 23 30 PF00069 0.753
MOD_GSK3_1 295 302 PF00069 0.350
MOD_GSK3_1 347 354 PF00069 0.272
MOD_GSK3_1 37 44 PF00069 0.772
MOD_GSK3_1 4 11 PF00069 0.757
MOD_GSK3_1 49 56 PF00069 0.727
MOD_GSK3_1 58 65 PF00069 0.807
MOD_N-GLC_1 193 198 PF02516 0.658
MOD_N-GLC_1 223 228 PF02516 0.510
MOD_N-GLC_1 317 322 PF02516 0.456
MOD_N-GLC_1 335 340 PF02516 0.333
MOD_N-GLC_1 357 362 PF02516 0.455
MOD_N-GLC_1 394 399 PF02516 0.526
MOD_N-GLC_1 58 63 PF02516 0.432
MOD_N-GLC_2 376 378 PF02516 0.414
MOD_NEK2_1 25 30 PF00069 0.688
MOD_NEK2_1 317 322 PF00069 0.256
MOD_NEK2_1 369 374 PF00069 0.214
MOD_NEK2_1 381 386 PF00069 0.214
MOD_NEK2_1 43 48 PF00069 0.604
MOD_NEK2_1 441 446 PF00069 0.262
MOD_NEK2_1 513 518 PF00069 0.360
MOD_NEK2_2 123 128 PF00069 0.646
MOD_NEK2_2 260 265 PF00069 0.164
MOD_PIKK_1 131 137 PF00454 0.636
MOD_PIKK_1 253 259 PF00454 0.239
MOD_PIKK_1 44 50 PF00454 0.601
MOD_PKA_2 102 108 PF00069 0.707
MOD_PKA_2 441 447 PF00069 0.260
MOD_PKA_2 480 486 PF00069 0.279
MOD_PKA_2 63 69 PF00069 0.668
MOD_Plk_1 180 186 PF00069 0.377
MOD_Plk_1 193 199 PF00069 0.270
MOD_Plk_1 317 323 PF00069 0.263
MOD_Plk_1 394 400 PF00069 0.326
MOD_Plk_4 163 169 PF00069 0.391
MOD_Plk_4 299 305 PF00069 0.351
MOD_Plk_4 317 323 PF00069 0.229
MOD_Plk_4 351 357 PF00069 0.202
MOD_Plk_4 461 467 PF00069 0.348
MOD_Plk_4 480 486 PF00069 0.172
MOD_Plk_4 507 513 PF00069 0.367
MOD_ProDKin_1 282 288 PF00069 0.302
MOD_ProDKin_1 325 331 PF00069 0.325
MOD_ProDKin_1 348 354 PF00069 0.304
MOD_ProDKin_1 37 43 PF00069 0.634
TRG_ENDOCYTIC_2 155 158 PF00928 0.420
TRG_ENDOCYTIC_2 175 178 PF00928 0.201
TRG_ENDOCYTIC_2 182 185 PF00928 0.251
TRG_ENDOCYTIC_2 188 191 PF00928 0.262
TRG_ENDOCYTIC_2 236 239 PF00928 0.255
TRG_ENDOCYTIC_2 275 278 PF00928 0.239
TRG_ENDOCYTIC_2 324 327 PF00928 0.326
TRG_ENDOCYTIC_2 453 456 PF00928 0.299
TRG_ENDOCYTIC_2 473 476 PF00928 0.133
TRG_ENDOCYTIC_2 531 534 PF00928 0.655
TRG_ENDOCYTIC_2 554 557 PF00928 0.548
TRG_ER_diArg_1 478 481 PF00400 0.294
TRG_ER_diArg_1 557 560 PF00400 0.608
TRG_ER_diArg_1 76 79 PF00400 0.612
TRG_Pf-PMV_PEXEL_1 532 536 PF00026 0.347

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U8 Leptomonas seymouri 66% 95%
A0A0S4IMK4 Bodo saltans 31% 100%
A0A0S4JQR9 Bodo saltans 36% 100%
A0A1X0NHQ5 Trypanosomatidae 45% 100%
A0A1X0P5L3 Trypanosomatidae 34% 100%
A0A3Q8IBY5 Leishmania donovani 91% 100%
A0A3R7LIN7 Trypanosoma rangeli 46% 100%
A0A3S7X9N4 Leishmania donovani 35% 100%
A0A422NR22 Trypanosoma rangeli 31% 100%
A4H5T1 Leishmania braziliensis 80% 97%
A4HN07 Leishmania braziliensis 36% 100%
A4HU24 Leishmania infantum 91% 100%
A4IBN0 Leishmania infantum 35% 100%
D0A9K3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AFG4 Leishmania major 35% 100%
E9AMV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9B6L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P42838 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS