LEM3 (Ligand-effect modulator 3) / CDC50 family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LEM3 (ligand-effect modulator 3) family / CDC50 family, putative

Species:

Leishmania major

UniProt:

Q4QHS2_LEIMA

TriTrypDb:

LmjF.09.1020 , LMJLV39_090017600 , LMJSD75_090017200

Length:

597

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	3
GO:0005794	Golgi apparatus	5	3
GO:0005886	plasma membrane	3	3
GO:0016020	membrane	2	19
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3

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Expansion

Sequence features

Q4QHS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS2

Function

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Biological processes
Term	Name	Level	Count
GO:0033036	macromolecule localization	2	19
GO:0051179	localization	1	19

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.305
CLV_C14_Caspase3-7	68	72	PF00656	0.794
CLV_NRD_NRD_1	324	326	PF00675	0.439
CLV_NRD_NRD_1	449	451	PF00675	0.459
CLV_NRD_NRD_1	480	482	PF00675	0.501
CLV_NRD_NRD_1	560	562	PF00675	0.398
CLV_NRD_NRD_1	571	573	PF00675	0.370
CLV_PCSK_FUR_1	530	534	PF00082	0.329
CLV_PCSK_FUR_1	558	562	PF00082	0.392
CLV_PCSK_KEX2_1	532	534	PF00082	0.437

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U8	Leptomonas seymouri	66%	95%
A0A0S4IMK4	Bodo saltans	31%	100%
A0A0S4JQR9	Bodo saltans	36%	100%
A0A1X0NHQ5	Trypanosomatidae	45%	100%
A0A1X0P5L3	Trypanosomatidae	34%	100%
A0A3Q8IBY5	Leishmania donovani	91%	100%
A0A3R7LIN7	Trypanosoma rangeli	46%	100%
A0A3S7X9N4	Leishmania donovani	35%	100%
A0A422NR22	Trypanosoma rangeli	31%	100%
A4H5T1	Leishmania braziliensis	80%	97%

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