Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHS1_LEIMA

TriTrypDb:

LmjF.09.1030 , LMJLV39_090017700 , LMJSD75_090017300

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.591
CLV_C14_Caspase3-7	95	99	PF00656	0.477
CLV_NRD_NRD_1	116	118	PF00675	0.542
CLV_NRD_NRD_1	171	173	PF00675	0.601
CLV_NRD_NRD_1	195	197	PF00675	0.635
CLV_NRD_NRD_1	216	218	PF00675	0.608
CLV_NRD_NRD_1	230	232	PF00675	0.510
CLV_NRD_NRD_1	36	38	PF00675	0.811
CLV_NRD_NRD_1	71	73	PF00675	0.595
CLV_PCSK_FUR_1	214	218	PF00082	0.590
CLV_PCSK_FUR_1	34	38	PF00082	0.652
CLV_PCSK_KEX2_1	116	118	PF00082	0.542
CLV_PCSK_KEX2_1	194	196	PF00082	0.600
CLV_PCSK_KEX2_1	204	206	PF00082	0.537
CLV_PCSK_KEX2_1	216	218	PF00082	0.581
CLV_PCSK_KEX2_1	230	232	PF00082	0.510
CLV_PCSK_KEX2_1	36	38	PF00082	0.808
CLV_PCSK_KEX2_1	71	73	PF00082	0.595
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.622
CLV_PCSK_SKI1_1	116	120	PF00082	0.698
CLV_PCSK_SKI1_1	246	250	PF00082	0.509
CLV_PCSK_SKI1_1	28	32	PF00082	0.585
DEG_COP1_1	157	165	PF00400	0.622
DEG_SPOP_SBC_1	18	22	PF00917	0.644
DEG_SPOP_SBC_1	223	227	PF00917	0.625
DEG_SPOP_SBC_1	82	86	PF00917	0.577
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.593
DOC_MAPK_gen_1	204	210	PF00069	0.562
DOC_PP4_FxxP_1	44	47	PF00568	0.619
DOC_USP7_MATH_1	12	16	PF00917	0.747
DOC_USP7_MATH_1	165	169	PF00917	0.630
DOC_USP7_MATH_1	222	226	PF00917	0.627
DOC_USP7_MATH_1	29	33	PF00917	0.801
DOC_USP7_MATH_1	303	307	PF00917	0.499
DOC_USP7_MATH_1	82	86	PF00917	0.559
DOC_WW_Pin1_4	10	15	PF00397	0.799
DOC_WW_Pin1_4	167	172	PF00397	0.632
DOC_WW_Pin1_4	43	48	PF00397	0.653
LIG_14-3-3_CanoR_1	16	25	PF00244	0.726
LIG_14-3-3_CanoR_1	205	211	PF00244	0.516
LIG_14-3-3_CanoR_1	246	252	PF00244	0.433
LIG_14-3-3_CanoR_1	277	286	PF00244	0.484
LIG_14-3-3_CanoR_1	37	43	PF00244	0.656
LIG_BRCT_BRCA1_1	240	244	PF00533	0.547
LIG_CaM_IQ_9	109	124	PF13499	0.414
LIG_FHA_1	174	180	PF00498	0.439
LIG_IBAR_NPY_1	54	56	PF08397	0.621
LIG_LIR_Apic_2	41	47	PF02991	0.614
LIG_NRBOX	250	256	PF00104	0.408
LIG_SH2_STAP1	102	106	PF00017	0.545
LIG_SH2_STAP1	197	201	PF00017	0.449
LIG_SH3_1	141	147	PF00018	0.579
LIG_SH3_3	141	147	PF00018	0.634
LIG_SH3_3	159	165	PF00018	0.527
LIG_SH3_3	4	10	PF00018	0.698
MOD_CDC14_SPxK_1	13	16	PF00782	0.637
MOD_CDC14_SPxK_1	170	173	PF00782	0.575
MOD_CDK_SPK_2	167	172	PF00069	0.632
MOD_CDK_SPxK_1	10	16	PF00069	0.649
MOD_CDK_SPxK_1	167	173	PF00069	0.595
MOD_CK1_1	226	232	PF00069	0.635
MOD_CK1_1	302	308	PF00069	0.652
MOD_Cter_Amidation	34	37	PF01082	0.633
MOD_Cter_Amidation	69	72	PF01082	0.553
MOD_GlcNHglycan	22	25	PF01048	0.705
MOD_GlcNHglycan	232	235	PF01048	0.633
MOD_GlcNHglycan	240	244	PF01048	0.578
MOD_GlcNHglycan	301	304	PF01048	0.628
MOD_GlcNHglycan	305	308	PF01048	0.648
MOD_GlcNHglycan	31	34	PF01048	0.610
MOD_GSK3_1	222	229	PF00069	0.679
MOD_GSK3_1	250	257	PF00069	0.498
MOD_GSK3_1	299	306	PF00069	0.660
MOD_N-GLC_1	238	243	PF02516	0.511
MOD_N-GLC_1	299	304	PF02516	0.656
MOD_NEK2_1	123	128	PF00069	0.502
MOD_NEK2_1	254	259	PF00069	0.407
MOD_NEK2_1	299	304	PF00069	0.541
MOD_NEK2_1	58	63	PF00069	0.527
MOD_NMyristoyl	1	7	PF02799	0.539
MOD_PKA_1	230	236	PF00069	0.577
MOD_PKA_2	229	235	PF00069	0.628
MOD_PKA_2	278	284	PF00069	0.633
MOD_Plk_1	239	245	PF00069	0.503
MOD_Plk_1	58	64	PF00069	0.528
MOD_Plk_4	250	256	PF00069	0.408
MOD_ProDKin_1	10	16	PF00069	0.802
MOD_ProDKin_1	167	173	PF00069	0.627
MOD_ProDKin_1	43	49	PF00069	0.652
TRG_DiLeu_BaEn_1	59	64	PF01217	0.619
TRG_ENDOCYTIC_2	197	200	PF00928	0.511
TRG_ER_diArg_1	108	111	PF00400	0.583
TRG_ER_diArg_1	193	196	PF00400	0.554
TRG_ER_diArg_1	214	217	PF00400	0.579
TRG_ER_diArg_1	277	280	PF00400	0.506
TRG_ER_diArg_1	34	37	PF00400	0.690
TRG_ER_diArg_1	60	63	PF00400	0.622
TRG_NES_CRM1_1	128	142	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQV2	Leishmania donovani	90%	100%
A4H5T2	Leishmania braziliensis	63%	76%
A4HU25	Leishmania infantum	90%	100%
E9AMV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%