Putative phospholipid:diacylglycerol acyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipid:diacylglycerol acyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QHS0_LEIMA

TriTrypDb:

LmjF.09.1040 , LMJLV39_090017800 , LMJSD75_090017400

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	9

Expansion

Sequence features

Q4QHS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHS0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008080	N-acetyltransferase activity	6	7
GO:0008374	O-acyltransferase activity	5	12
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0046027	phospholipid:diacylglycerol acyltransferase activity	7	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.225
CLV_NRD_NRD_1	175	177	PF00675	0.486
CLV_NRD_NRD_1	29	31	PF00675	0.537
CLV_NRD_NRD_1	317	319	PF00675	0.509
CLV_NRD_NRD_1	389	391	PF00675	0.516
CLV_NRD_NRD_1	45	47	PF00675	0.429
CLV_NRD_NRD_1	631	633	PF00675	0.626
CLV_NRD_NRD_1	653	655	PF00675	0.584
CLV_NRD_NRD_1	93	95	PF00675	0.373
CLV_PCSK_KEX2_1	121	123	PF00082	0.413
CLV_PCSK_KEX2_1	175	177	PF00082	0.487
CLV_PCSK_KEX2_1	29	31	PF00082	0.579
CLV_PCSK_KEX2_1	317	319	PF00082	0.484
CLV_PCSK_KEX2_1	321	323	PF00082	0.505
CLV_PCSK_KEX2_1	631	633	PF00082	0.626
CLV_PCSK_KEX2_1	93	95	PF00082	0.442
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.508
CLV_PCSK_PC7_1	317	323	PF00082	0.376
CLV_PCSK_SKI1_1	203	207	PF00082	0.634
CLV_PCSK_SKI1_1	390	394	PF00082	0.414
CLV_PCSK_SKI1_1	556	560	PF00082	0.414
CLV_PCSK_SKI1_1	658	662	PF00082	0.638
DEG_APCC_DBOX_1	122	130	PF00400	0.458
DEG_APCC_DBOX_1	308	316	PF00400	0.238
DEG_Kelch_Keap1_1	620	625	PF01344	0.531
DEG_SCF_TRCP1_1	251	256	PF00400	0.316
DOC_CDC14_PxL_1	468	476	PF14671	0.269
DOC_CYCLIN_yClb1_LxF_4	309	315	PF00134	0.316
DOC_CYCLIN_yClb5_NLxxxL_5	644	653	PF00134	0.294
DOC_MAPK_gen_1	121	130	PF00069	0.438
DOC_MAPK_gen_1	175	181	PF00069	0.250
DOC_MAPK_gen_1	317	326	PF00069	0.283
DOC_MAPK_gen_1	43	51	PF00069	0.777
DOC_MAPK_gen_1	93	104	PF00069	0.678
DOC_MAPK_MEF2A_6	121	130	PF00069	0.426
DOC_MAPK_MEF2A_6	175	182	PF00069	0.337
DOC_MAPK_NFAT4_5	123	131	PF00069	0.289
DOC_PP2B_LxvP_1	102	105	PF13499	0.564
DOC_PP4_FxxP_1	79	82	PF00568	0.618
DOC_USP7_MATH_1	103	107	PF00917	0.579
DOC_USP7_MATH_1	23	27	PF00917	0.718
DOC_USP7_MATH_1	536	540	PF00917	0.294
DOC_USP7_UBL2_3	578	582	PF12436	0.266
DOC_WW_Pin1_4	16	21	PF00397	0.700
DOC_WW_Pin1_4	291	296	PF00397	0.225
DOC_WW_Pin1_4	506	511	PF00397	0.266
DOC_WW_Pin1_4	78	83	PF00397	0.626
LIG_14-3-3_CanoR_1	157	163	PF00244	0.364
LIG_14-3-3_CanoR_1	201	206	PF00244	0.381
LIG_14-3-3_CanoR_1	309	313	PF00244	0.325
LIG_14-3-3_CanoR_1	407	416	PF00244	0.231
LIG_14-3-3_CanoR_1	46	52	PF00244	0.768
LIG_14-3-3_CanoR_1	527	535	PF00244	0.316
LIG_14-3-3_CanoR_1	61	66	PF00244	0.643
LIG_14-3-3_CanoR_1	636	645	PF00244	0.279
LIG_14-3-3_CanoR_1	93	99	PF00244	0.636
LIG_Actin_WH2_2	559	577	PF00022	0.266
LIG_APCC_Cbox_2	351	357	PF00515	0.316
LIG_BIR_III_2	155	159	PF00653	0.310
LIG_BRCT_BRCA1_1	310	314	PF00533	0.305
LIG_BRCT_BRCA1_1	514	518	PF00533	0.266
LIG_BRCT_BRCA1_1	63	67	PF00533	0.675
LIG_EH1_1	589	597	PF00400	0.268
LIG_FHA_1	185	191	PF00498	0.301
LIG_FHA_1	331	337	PF00498	0.241
LIG_FHA_1	380	386	PF00498	0.253
LIG_FHA_1	439	445	PF00498	0.317
LIG_FHA_1	478	484	PF00498	0.179
LIG_FHA_1	507	513	PF00498	0.308
LIG_FHA_1	532	538	PF00498	0.235
LIG_FHA_1	624	630	PF00498	0.495
LIG_FHA_2	149	155	PF00498	0.364
LIG_FHA_2	237	243	PF00498	0.214
LIG_FHA_2	465	471	PF00498	0.330
LIG_FHA_2	617	623	PF00498	0.426
LIG_FXI_DFP_1	72	76	PF00024	0.421
LIG_GBD_Chelix_1	126	134	PF00786	0.343
LIG_HP1_1	178	182	PF01393	0.247
LIG_Integrin_RGD_1	168	170	PF01839	0.543
LIG_LIR_Apic_2	256	262	PF02991	0.310
LIG_LIR_Apic_2	76	82	PF02991	0.614
LIG_LIR_Gen_1	251	262	PF02991	0.288
LIG_LIR_Gen_1	406	417	PF02991	0.283
LIG_LIR_Gen_1	57	67	PF02991	0.666
LIG_LIR_Gen_1	635	645	PF02991	0.282
LIG_LIR_Gen_1	70	80	PF02991	0.648
LIG_LIR_Nem_3	161	166	PF02991	0.389
LIG_LIR_Nem_3	204	209	PF02991	0.409
LIG_LIR_Nem_3	251	257	PF02991	0.288
LIG_LIR_Nem_3	302	308	PF02991	0.214
LIG_LIR_Nem_3	406	412	PF02991	0.266
LIG_LIR_Nem_3	421	427	PF02991	0.250
LIG_LIR_Nem_3	57	62	PF02991	0.666
LIG_LIR_Nem_3	635	641	PF02991	0.286
LIG_LIR_Nem_3	70	75	PF02991	0.698
LIG_NRP_CendR_1	684	685	PF00754	0.572
LIG_OCRL_FandH_1	348	360	PF00620	0.316
LIG_PCNA_TLS_4	390	397	PF02747	0.248
LIG_Pex14_1	229	233	PF04695	0.316
LIG_Pex14_2	205	209	PF04695	0.358
LIG_Pex14_2	75	79	PF04695	0.733
LIG_REV1ctd_RIR_1	160	169	PF16727	0.394
LIG_REV1ctd_RIR_1	336	344	PF16727	0.316
LIG_SH2_GRB2like	357	360	PF00017	0.305
LIG_SH2_GRB2like	618	621	PF00017	0.401
LIG_SH2_NCK_1	618	622	PF00017	0.403
LIG_SH2_NCK_1	638	642	PF00017	0.220
LIG_SH2_PTP2	357	360	PF00017	0.316
LIG_SH2_SRC	357	360	PF00017	0.316
LIG_SH2_STAP1	289	293	PF00017	0.223
LIG_SH2_STAT3	279	282	PF00017	0.225
LIG_SH2_STAT5	172	175	PF00017	0.413
LIG_SH2_STAT5	220	223	PF00017	0.303
LIG_SH2_STAT5	259	262	PF00017	0.305
LIG_SH2_STAT5	357	360	PF00017	0.274
LIG_SH2_STAT5	497	500	PF00017	0.248
LIG_SH2_STAT5	511	514	PF00017	0.316
LIG_SH2_STAT5	618	621	PF00017	0.432
LIG_SH3_1	656	662	PF00018	0.397
LIG_SH3_2	82	87	PF14604	0.586
LIG_SH3_3	133	139	PF00018	0.453
LIG_SH3_3	17	23	PF00018	0.712
LIG_SH3_3	177	183	PF00018	0.320
LIG_SH3_3	469	475	PF00018	0.241
LIG_SH3_3	485	491	PF00018	0.216
LIG_SH3_3	605	611	PF00018	0.426
LIG_SH3_3	656	662	PF00018	0.397
LIG_SH3_3	79	85	PF00018	0.698
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.293
LIG_SUMO_SIM_par_1	14	19	PF11976	0.751
LIG_UBA3_1	232	238	PF00899	0.238
LIG_UBA3_1	592	598	PF00899	0.271
LIG_WRC_WIRS_1	393	398	PF05994	0.305
LIG_WRC_WIRS_1	461	466	PF05994	0.375
LIG_WRC_WIRS_1	62	67	PF05994	0.605
MOD_CDC14_SPxK_1	294	297	PF00782	0.238
MOD_CDK_SPxK_1	291	297	PF00069	0.238
MOD_CK1_1	204	210	PF00069	0.349
MOD_CK1_1	567	573	PF00069	0.317
MOD_CK1_1	672	678	PF00069	0.491
MOD_CK2_1	148	154	PF00069	0.368
MOD_CK2_1	449	455	PF00069	0.299
MOD_CK2_1	460	466	PF00069	0.287
MOD_GlcNHglycan	206	209	PF01048	0.621
MOD_GlcNHglycan	25	28	PF01048	0.536
MOD_GlcNHglycan	251	254	PF01048	0.477
MOD_GlcNHglycan	371	374	PF01048	0.416
MOD_GlcNHglycan	451	454	PF01048	0.484
MOD_GlcNHglycan	51	54	PF01048	0.474
MOD_GlcNHglycan	566	569	PF01048	0.492
MOD_GlcNHglycan	579	582	PF01048	0.373
MOD_GlcNHglycan	600	603	PF01048	0.474
MOD_GlcNHglycan	674	677	PF01048	0.676
MOD_GlcNHglycan	76	79	PF01048	0.481
MOD_GSK3_1	249	256	PF00069	0.297
MOD_GSK3_1	326	333	PF00069	0.256
MOD_GSK3_1	403	410	PF00069	0.334
MOD_GSK3_1	431	438	PF00069	0.332
MOD_GSK3_1	460	467	PF00069	0.338
MOD_GSK3_1	564	571	PF00069	0.322
MOD_GSK3_1	610	617	PF00069	0.427
MOD_GSK3_1	620	627	PF00069	0.391
MOD_GSK3_1	644	651	PF00069	0.312
MOD_GSK3_1	674	681	PF00069	0.485
MOD_GSK3_1	74	81	PF00069	0.611
MOD_GSK3_1	88	95	PF00069	0.646
MOD_LATS_1	634	640	PF00433	0.354
MOD_N-GLC_1	243	248	PF02516	0.419
MOD_N-GLC_1	431	436	PF02516	0.495
MOD_N-GLC_1	513	518	PF02516	0.475
MOD_N-GLC_1	519	524	PF02516	0.492
MOD_N-GLC_1	562	567	PF02516	0.559
MOD_NEK2_1	392	397	PF00069	0.238
MOD_NEK2_1	405	410	PF00069	0.289
MOD_NEK2_1	49	54	PF00069	0.787
MOD_NEK2_1	562	567	PF00069	0.266
MOD_NEK2_1	616	621	PF00069	0.538
MOD_NEK2_2	158	163	PF00069	0.366
MOD_NEK2_2	513	518	PF00069	0.288
MOD_NEK2_2	568	573	PF00069	0.177
MOD_PIKK_1	395	401	PF00454	0.316
MOD_PIKK_1	88	94	PF00454	0.671
MOD_PK_1	47	53	PF00069	0.587
MOD_PKA_2	308	314	PF00069	0.325
MOD_PKA_2	379	385	PF00069	0.266
MOD_PKA_2	438	444	PF00069	0.323
MOD_PKA_2	526	532	PF00069	0.316
MOD_PKA_2	92	98	PF00069	0.635
MOD_Plk_1	193	199	PF00069	0.370
MOD_Plk_1	3	9	PF00069	0.648
MOD_Plk_1	513	519	PF00069	0.275
MOD_Plk_1	531	537	PF00069	0.308
MOD_Plk_1	562	568	PF00069	0.323
MOD_Plk_1	614	620	PF00069	0.411
MOD_Plk_1	624	630	PF00069	0.396
MOD_Plk_1	669	675	PF00069	0.329
MOD_Plk_4	103	109	PF00069	0.643
MOD_Plk_4	158	164	PF00069	0.337
MOD_Plk_4	168	174	PF00069	0.397
MOD_Plk_4	201	207	PF00069	0.367
MOD_Plk_4	392	398	PF00069	0.306
MOD_Plk_4	411	417	PF00069	0.287
MOD_Plk_4	425	431	PF00069	0.279
MOD_Plk_4	460	466	PF00069	0.346
MOD_Plk_4	478	484	PF00069	0.156
MOD_Plk_4	513	519	PF00069	0.316
MOD_Plk_4	669	675	PF00069	0.329
MOD_ProDKin_1	16	22	PF00069	0.700
MOD_ProDKin_1	291	297	PF00069	0.225
MOD_ProDKin_1	506	512	PF00069	0.266
MOD_ProDKin_1	78	84	PF00069	0.626
MOD_SUMO_rev_2	242	248	PF00179	0.346
TRG_ENDOCYTIC_2	220	223	PF00928	0.284
TRG_ENDOCYTIC_2	357	360	PF00928	0.287
TRG_ENDOCYTIC_2	496	499	PF00928	0.357
TRG_ENDOCYTIC_2	590	593	PF00928	0.289
TRG_ENDOCYTIC_2	638	641	PF00928	0.278
TRG_ER_diArg_1	121	123	PF00400	0.559
TRG_ER_diArg_1	174	176	PF00400	0.309
TRG_ER_diArg_1	209	212	PF00400	0.280
TRG_ER_diArg_1	317	320	PF00400	0.160
TRG_ER_diArg_1	60	63	PF00400	0.677
TRG_ER_diArg_1	631	633	PF00400	0.426
TRG_NLS_MonoExtC_3	653	658	PF00514	0.404
TRG_NLS_MonoExtN_4	317	324	PF00514	0.307
TRG_NLS_MonoExtN_4	654	659	PF00514	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU70	Leptomonas seymouri	64%	90%
A0A0S4J6G5	Bodo saltans	37%	100%
A0A1X0NHY0	Trypanosomatidae	45%	86%
A0A3R7KCW2	Trypanosoma rangeli	43%	100%
A0A3S7WQS8	Leishmania donovani	95%	100%
A4H5T3	Leishmania braziliensis	85%	95%
A4HU26	Leishmania infantum	95%	100%
D0A9K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
O94680	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P40345	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4VCM1	Arabidopsis thaliana	22%	100%
V5BDI6	Trypanosoma cruzi	43%	100%