MSP domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHR9_LEIMA

TriTrypDb:

LmjF.09.1050 , LMJLV39_090017900 , LMJSD75_090017500

Length:

247

Annotations

LeishMANIAdb annotations

As the MSP domain is involved in providing cell motility, this protein is likely involved in the same function.. Has a number of plant (E1ZCB1_CHLVA), fungal (G8B4Z0_CANPC) and animal orthologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	10
GO:0020016	ciliary pocket	2	2
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QHR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022406	membrane docking	2	2
GO:0051179	localization	1	2
GO:0051640	organelle localization	2	2
GO:0051643	endoplasmic reticulum localization	3	2
GO:0061024	membrane organization	4	2
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090158	endoplasmic reticulum membrane organization	5	2
GO:0140056	organelle localization by membrane tethering	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.637
CLV_NRD_NRD_1	180	182	PF00675	0.569
CLV_NRD_NRD_1	199	201	PF00675	0.371
CLV_PCSK_KEX2_1	197	199	PF00082	0.451
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.490
CLV_PCSK_SKI1_1	128	132	PF00082	0.334
CLV_PCSK_SKI1_1	133	137	PF00082	0.360
CLV_PCSK_SKI1_1	182	186	PF00082	0.543
DEG_Nend_UBRbox_2	1	3	PF02207	0.703
DOC_CYCLIN_RxL_1	128	140	PF00134	0.525
DOC_MAPK_gen_1	210	219	PF00069	0.561
DOC_MAPK_MEF2A_6	213	221	PF00069	0.437
DOC_PP2B_PxIxI_1	5	11	PF00149	0.597
DOC_USP7_MATH_1	120	124	PF00917	0.620
DOC_USP7_MATH_1	138	142	PF00917	0.606
DOC_USP7_UBL2_3	148	152	PF12436	0.805
DOC_USP7_UBL2_3	55	59	PF12436	0.479
LIG_14-3-3_CanoR_1	181	189	PF00244	0.785
LIG_14-3-3_CanoR_1	40	46	PF00244	0.479
LIG_BIR_III_4	171	175	PF00653	0.678
LIG_FHA_1	24	30	PF00498	0.552
LIG_FHA_1	42	48	PF00498	0.408
LIG_FHA_1	65	71	PF00498	0.533
LIG_FHA_1	87	93	PF00498	0.562
LIG_FHA_2	191	197	PF00498	0.647
LIG_FHA_2	72	78	PF00498	0.530
LIG_LIR_Gen_1	13	21	PF02991	0.521
LIG_LIR_Nem_3	13	18	PF02991	0.496
LIG_PTB_Apo_2	28	35	PF02174	0.479
LIG_PTB_Phospho_1	28	34	PF10480	0.562
LIG_RPA_C_Fungi	208	220	PF08784	0.420
LIG_SH2_STAP1	34	38	PF00017	0.431
LIG_SH2_STAT5	129	132	PF00017	0.483
LIG_SH2_STAT5	50	53	PF00017	0.342
LIG_SH2_STAT5	85	88	PF00017	0.421
LIG_TYR_ITIM	32	37	PF00017	0.431
MOD_CK2_1	190	196	PF00069	0.562
MOD_CK2_1	71	77	PF00069	0.435
MOD_Cter_Amidation	179	182	PF01082	0.634
MOD_GlcNHglycan	178	181	PF01048	0.620
MOD_GlcNHglycan	202	205	PF01048	0.623
MOD_GlcNHglycan	62	65	PF01048	0.431
MOD_GSK3_1	176	183	PF00069	0.661
MOD_GSK3_1	23	30	PF00069	0.431
MOD_GSK3_1	60	67	PF00069	0.373
MOD_N-GLC_1	120	125	PF02516	0.552
MOD_N-GLC_1	200	205	PF02516	0.759
MOD_N-GLC_1	60	65	PF02516	0.315
MOD_NEK2_1	27	32	PF00069	0.351
MOD_NEK2_1	51	56	PF00069	0.355
MOD_NEK2_2	64	69	PF00069	0.383
MOD_PKA_2	180	186	PF00069	0.764
MOD_PKA_2	41	47	PF00069	0.388
MOD_PKA_2	83	89	PF00069	0.427
MOD_PKB_1	198	206	PF00069	0.625
MOD_Plk_1	120	126	PF00069	0.485
MOD_Plk_1	23	29	PF00069	0.340
MOD_Plk_2-3	190	196	PF00069	0.562
MOD_Plk_2-3	23	29	PF00069	0.431
MOD_Plk_4	109	115	PF00069	0.476
MOD_Plk_4	121	127	PF00069	0.437
TRG_DiLeu_BaEn_1	13	18	PF01217	0.386
TRG_ENDOCYTIC_2	34	37	PF00928	0.431
TRG_ER_diArg_1	167	170	PF00400	0.524
TRG_ER_diArg_1	198	200	PF00400	0.664
TRG_ER_diArg_1	39	42	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W8	Leptomonas seymouri	61%	98%
A0A1X0NI22	Trypanosomatidae	28%	90%
A0A3S7WQS6	Leishmania donovani	90%	99%
A0A422MXK0	Trypanosoma rangeli	30%	100%
A4H5T4	Leishmania braziliensis	76%	99%
A4HU27	Leishmania infantum	90%	99%
E9AMV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BI56	Trypanosoma cruzi	30%	100%