Putative DNA-directed RNA polymerase III subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase III subunit, putative

Species:

Leishmania major

UniProt:

Q4QHR8_LEIMA

TriTrypDb:

LmjF.09.1060 , LMJLV39_090018000 , LMJSD75_090017600

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	9
GO:0005666	RNA polymerase III complex	4	2
GO:0016020	membrane	2	2
GO:0030880	RNA polymerase complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	9
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9

Expansion

Sequence features

Q4QHR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006352	DNA-templated transcription initiation	6	9
GO:0006384	transcription initiation at RNA polymerase III promoter	7	2
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009059	macromolecule biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0018130	heterocycle biosynthetic process	4	9
GO:0019438	aromatic compound biosynthetic process	4	9
GO:0032774	RNA biosynthetic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034654	nucleobase-containing compound biosynthetic process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044271	cellular nitrogen compound biosynthetic process	4	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901362	organic cyclic compound biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.626
CLV_C14_Caspase3-7	224	228	PF00656	0.746
CLV_C14_Caspase3-7	230	234	PF00656	0.653
CLV_PCSK_SKI1_1	31	35	PF00082	0.508
DEG_SPOP_SBC_1	184	188	PF00917	0.655
DOC_CDC14_PxL_1	112	120	PF14671	0.491
DOC_PP4_FxxP_1	117	120	PF00568	0.357
DOC_USP7_MATH_1	15	19	PF00917	0.717
DOC_USP7_MATH_1	179	183	PF00917	0.718
DOC_USP7_MATH_1	184	188	PF00917	0.613
DOC_USP7_MATH_1	70	74	PF00917	0.561
LIG_14-3-3_CanoR_1	129	137	PF00244	0.409
LIG_14-3-3_CanoR_1	37	43	PF00244	0.424
LIG_BIR_III_2	156	160	PF00653	0.544
LIG_BIR_III_4	225	229	PF00653	0.667
LIG_BIR_III_4	249	253	PF00653	0.528
LIG_eIF4E_1	106	112	PF01652	0.491
LIG_FHA_1	106	112	PF00498	0.430
LIG_FHA_1	12	18	PF00498	0.643
LIG_FHA_1	77	83	PF00498	0.502
LIG_FHA_2	27	33	PF00498	0.454
LIG_LIR_Gen_1	110	120	PF02991	0.368
LIG_LIR_Gen_1	73	82	PF02991	0.481
LIG_LIR_Nem_3	110	115	PF02991	0.372
LIG_LIR_Nem_3	73	78	PF02991	0.503
LIG_MYND_1	116	120	PF01753	0.438
LIG_PDZ_Class_3	258	263	PF00595	0.689
LIG_SH2_STAP1	26	30	PF00017	0.561
LIG_SH2_STAT5	106	109	PF00017	0.391
LIG_SH2_STAT5	138	141	PF00017	0.392
LIG_SH2_STAT5	42	45	PF00017	0.441
LIG_SH3_3	110	116	PF00018	0.438
LIG_SH3_3	81	87	PF00018	0.422
MOD_CK1_1	128	134	PF00069	0.491
MOD_CK1_1	183	189	PF00069	0.682
MOD_CK1_1	216	222	PF00069	0.583
MOD_CK1_1	63	69	PF00069	0.490
MOD_CK1_1	9	15	PF00069	0.733
MOD_CK2_1	218	224	PF00069	0.624
MOD_CK2_1	252	258	PF00069	0.603
MOD_GlcNHglycan	130	133	PF01048	0.491
MOD_GlcNHglycan	150	154	PF01048	0.450
MOD_GlcNHglycan	182	185	PF01048	0.720
MOD_GlcNHglycan	220	223	PF01048	0.639
MOD_GlcNHglycan	229	232	PF01048	0.603
MOD_GlcNHglycan	61	65	PF01048	0.465
MOD_GlcNHglycan	72	75	PF01048	0.449
MOD_GlcNHglycan	8	11	PF01048	0.697
MOD_GSK3_1	1	8	PF00069	0.632
MOD_GSK3_1	11	18	PF00069	0.635
MOD_GSK3_1	179	186	PF00069	0.685
MOD_GSK3_1	70	77	PF00069	0.465
MOD_N-GLC_2	23	25	PF02516	0.563
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	180	185	PF00069	0.745
MOD_NEK2_1	242	247	PF00069	0.557
MOD_NEK2_1	60	65	PF00069	0.446
MOD_NEK2_1	76	81	PF00069	0.498
MOD_NEK2_2	26	31	PF00069	0.509
MOD_PKA_2	128	134	PF00069	0.409
MOD_PKA_2	242	248	PF00069	0.504
MOD_PKA_2	36	42	PF00069	0.432
MOD_Plk_1	216	222	PF00069	0.583
MOD_Plk_4	242	248	PF00069	0.415
MOD_Plk_4	252	258	PF00069	0.603
TRG_ENDOCYTIC_2	106	109	PF00928	0.438
TRG_ENDOCYTIC_2	138	141	PF00928	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P336	Leptomonas seymouri	56%	80%
A0A1X0NIF1	Trypanosomatidae	36%	86%
A0A3Q8I7I6	Leishmania donovani	96%	89%
A4H5T5	Leishmania braziliensis	82%	89%
A4HU28	Leishmania infantum	96%	89%
D0A9K8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AMV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	89%