Putative eukaryotic translation initiation factor 2 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 2 subunit, putative

Species:

Leishmania major

UniProt:

Q4QHR7_LEIMA

TriTrypDb:

LmjF.09.1070 , LMJLV39_090018100 , LMJSD75_090017700

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005850	eukaryotic translation initiation factor 2 complex	2	3
GO:0032991	protein-containing complex	1	3
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QHR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR7

Function

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Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	3
GO:0006417	regulation of translation	6	3
GO:0006450	regulation of translational fidelity	3	3
GO:0009889	regulation of biosynthetic process	4	3
GO:0009891	positive regulation of biosynthetic process	5	3
GO:0009893	positive regulation of metabolic process	4	3
GO:0009987	cellular process	1	3
GO:0010468	regulation of gene expression	5	3
GO:0010556	regulation of macromolecule biosynthetic process	5	3
GO:0010557	positive regulation of macromolecule biosynthetic process	6	3

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Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	11
GO:0000166	nucleotide binding	3	15
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	11
GO:0003743	translation initiation factor activity	4	15
GO:0003746	translation elongation factor activity	4	1
GO:0003824	catalytic activity	1	15
GO:0003924	GTPase activity	7	15
GO:0005488	binding	1	15
GO:0005525	GTP binding	5	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.614
CLV_NRD_NRD_1	470	472	PF00675	0.465
CLV_PCSK_KEX2_1	131	133	PF00082	0.296
CLV_PCSK_KEX2_1	232	234	PF00082	0.275
CLV_PCSK_KEX2_1	401	403	PF00082	0.364
CLV_PCSK_KEX2_1	470	472	PF00082	0.406
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.296
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.267
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.332
CLV_PCSK_SKI1_1	250	254	PF00082	0.514

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q3	Leptomonas seymouri	24%	100%
A0A0S4J558	Bodo saltans	25%	100%
A0A0S4JVP8	Bodo saltans	50%	100%
A0A1X0NJD8	Trypanosomatidae	75%	100%
A0A1X0NJL3	Trypanosomatidae	55%	96%
A0A1X0P746	Trypanosomatidae	25%	100%
A0A3S7WQT0	Leishmania donovani	100%	100%
A0A3S7WV40	Leishmania donovani	26%	100%
A0A422MTH4	Trypanosoma rangeli	71%	100%
A0A422P1Y0	Trypanosoma rangeli	26%	100%

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