Dynactin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHR5_LEIMA

TriTrypDb:

LmjF.09.1100 , LMJLV39_090018300 , LMJSD75_090017900

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.562
CLV_PCSK_KEX2_1	122	124	PF00082	0.598
CLV_PCSK_KEX2_1	137	139	PF00082	0.465
CLV_PCSK_KEX2_1	195	197	PF00082	0.563
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.582
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.474
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.609
CLV_PCSK_SKI1_1	108	112	PF00082	0.625
CLV_PCSK_SKI1_1	196	200	PF00082	0.580
DEG_APCC_KENBOX_2	45	49	PF00400	0.562
DEG_SPOP_SBC_1	97	101	PF00917	0.630
DOC_PP2B_LxvP_1	167	170	PF13499	0.627
DOC_USP7_MATH_1	214	218	PF00917	0.638
DOC_USP7_MATH_1	75	79	PF00917	0.573
DOC_USP7_MATH_1	97	101	PF00917	0.625
DOC_USP7_UBL2_3	195	199	PF12436	0.585
DOC_WW_Pin1_4	224	229	PF00397	0.710
DOC_WW_Pin1_4	23	28	PF00397	0.768
LIG_14-3-3_CanoR_1	151	160	PF00244	0.573
LIG_14-3-3_CanoR_1	168	174	PF00244	0.543
LIG_14-3-3_CanoR_1	216	221	PF00244	0.557
LIG_14-3-3_CanoR_1	76	80	PF00244	0.541
LIG_Actin_WH2_2	174	192	PF00022	0.647
LIG_BIR_II_1	1	5	PF00653	0.722
LIG_FHA_1	162	168	PF00498	0.629
LIG_FHA_1	225	231	PF00498	0.620
LIG_FHA_1	39	45	PF00498	0.590
LIG_FHA_1	99	105	PF00498	0.599
LIG_FHA_2	134	140	PF00498	0.570
LIG_LIR_Gen_1	109	118	PF02991	0.515
LIG_LIR_Gen_1	240	249	PF02991	0.348
LIG_LIR_Nem_3	109	114	PF02991	0.539
LIG_LIR_Nem_3	240	244	PF02991	0.353
LIG_MYND_1	187	191	PF01753	0.689
LIG_SH2_CRK	239	243	PF00017	0.497
LIG_SH2_STAT5	239	242	PF00017	0.422
LIG_SH3_3	227	233	PF00018	0.595
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.437
LIG_SUMO_SIM_anti_2	240	247	PF11976	0.487
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.564
LIG_UBA3_1	245	250	PF00899	0.492
LIG_WRC_WIRS_1	238	243	PF05994	0.343
MOD_CK1_1	125	131	PF00069	0.582
MOD_CK1_1	95	101	PF00069	0.640
MOD_CK2_1	133	139	PF00069	0.529
MOD_CK2_1	67	73	PF00069	0.429
MOD_GlcNHglycan	144	147	PF01048	0.521
MOD_GlcNHglycan	222	225	PF01048	0.619
MOD_GlcNHglycan	27	30	PF01048	0.621
MOD_GSK3_1	142	149	PF00069	0.522
MOD_GSK3_1	169	176	PF00069	0.576
MOD_GSK3_1	21	28	PF00069	0.562
MOD_GSK3_1	216	223	PF00069	0.626
MOD_GSK3_1	240	247	PF00069	0.500
MOD_GSK3_1	5	12	PF00069	0.696
MOD_GSK3_1	81	88	PF00069	0.520
MOD_GSK3_1	91	98	PF00069	0.541
MOD_LATS_1	23	29	PF00433	0.556
MOD_NEK2_1	142	147	PF00069	0.578
MOD_NEK2_1	173	178	PF00069	0.496
MOD_NEK2_1	51	56	PF00069	0.545
MOD_PIKK_1	151	157	PF00454	0.552
MOD_PIKK_1	85	91	PF00454	0.665
MOD_PK_1	216	222	PF00069	0.499
MOD_PKA_1	122	128	PF00069	0.635
MOD_PKA_2	122	128	PF00069	0.603
MOD_PKA_2	215	221	PF00069	0.548
MOD_PKA_2	67	73	PF00069	0.493
MOD_PKA_2	75	81	PF00069	0.550
MOD_Plk_1	38	44	PF00069	0.649
MOD_Plk_4	169	175	PF00069	0.517
MOD_Plk_4	216	222	PF00069	0.616
MOD_Plk_4	237	243	PF00069	0.590
MOD_Plk_4	244	250	PF00069	0.537
MOD_ProDKin_1	224	230	PF00069	0.705
MOD_ProDKin_1	23	29	PF00069	0.766
MOD_SUMO_for_1	249	252	PF00179	0.593
TRG_DiLeu_BaEn_1	158	163	PF01217	0.633
TRG_ENDOCYTIC_2	239	242	PF00928	0.499
TRG_NLS_MonoExtC_3	194	199	PF00514	0.582
TRG_NLS_MonoExtN_4	194	199	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA21	Leptomonas seymouri	65%	93%
A0A3S7WQT3	Leishmania donovani	93%	100%
A0A422MTH2	Trypanosoma rangeli	28%	83%
A4H5T8	Leishmania braziliensis	82%	100%
A4HU32	Leishmania infantum	93%	100%
E9AMW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%