Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHR4_LEIMA

TriTrypDb:

LmjF.09.1110 , LMJLV39_090018400 , LMJSD75_090018000

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.615
CLV_NRD_NRD_1	185	187	PF00675	0.705
CLV_NRD_NRD_1	200	202	PF00675	0.520
CLV_NRD_NRD_1	221	223	PF00675	0.625
CLV_NRD_NRD_1	243	245	PF00675	0.654
CLV_NRD_NRD_1	276	278	PF00675	0.561
CLV_NRD_NRD_1	305	307	PF00675	0.652
CLV_NRD_NRD_1	341	343	PF00675	0.638
CLV_NRD_NRD_1	35	37	PF00675	0.708
CLV_NRD_NRD_1	357	359	PF00675	0.713
CLV_NRD_NRD_1	38	40	PF00675	0.712
CLV_NRD_NRD_1	397	399	PF00675	0.831
CLV_NRD_NRD_1	424	426	PF00675	0.777
CLV_PCSK_FUR_1	36	40	PF00082	0.611
CLV_PCSK_KEX2_1	185	187	PF00082	0.705
CLV_PCSK_KEX2_1	200	202	PF00082	0.520
CLV_PCSK_KEX2_1	221	223	PF00082	0.629
CLV_PCSK_KEX2_1	243	245	PF00082	0.654
CLV_PCSK_KEX2_1	276	278	PF00082	0.613
CLV_PCSK_KEX2_1	305	307	PF00082	0.652
CLV_PCSK_KEX2_1	341	343	PF00082	0.638
CLV_PCSK_KEX2_1	357	359	PF00082	0.713
CLV_PCSK_KEX2_1	37	39	PF00082	0.721
CLV_PCSK_KEX2_1	396	398	PF00082	0.821
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.610
CLV_PCSK_SKI1_1	287	291	PF00082	0.601
DEG_Nend_Nbox_1	1	3	PF02207	0.686
DEG_SPOP_SBC_1	154	158	PF00917	0.776
DEG_SPOP_SBC_1	21	25	PF00917	0.609
DOC_CDC14_PxL_1	112	120	PF14671	0.580
DOC_CKS1_1	67	72	PF01111	0.759
DOC_MAPK_gen_1	406	415	PF00069	0.679
DOC_PP2B_LxvP_1	118	121	PF13499	0.712
DOC_PP4_FxxP_1	149	152	PF00568	0.743
DOC_PP4_FxxP_1	330	333	PF00568	0.730
DOC_USP7_MATH_1	248	252	PF00917	0.605
DOC_USP7_MATH_1	257	261	PF00917	0.509
DOC_USP7_MATH_1	289	293	PF00917	0.588
DOC_WW_Pin1_4	150	155	PF00397	0.747
DOC_WW_Pin1_4	346	351	PF00397	0.662
DOC_WW_Pin1_4	358	363	PF00397	0.783
DOC_WW_Pin1_4	370	375	PF00397	0.689
DOC_WW_Pin1_4	389	394	PF00397	0.787
DOC_WW_Pin1_4	398	403	PF00397	0.692
DOC_WW_Pin1_4	438	443	PF00397	0.690
DOC_WW_Pin1_4	66	71	PF00397	0.809
LIG_14-3-3_CanoR_1	139	144	PF00244	0.726
LIG_14-3-3_CanoR_1	162	167	PF00244	0.696
LIG_14-3-3_CanoR_1	200	206	PF00244	0.586
LIG_14-3-3_CanoR_1	357	362	PF00244	0.681
LIG_14-3-3_CanoR_1	36	44	PF00244	0.711
LIG_14-3-3_CanoR_1	388	393	PF00244	0.819
LIG_14-3-3_CanoR_1	396	402	PF00244	0.807
LIG_14-3-3_CanoR_1	446	454	PF00244	0.675
LIG_14-3-3_CanoR_1	5	11	PF00244	0.712
LIG_BRCT_BRCA1_1	250	254	PF00533	0.463
LIG_DLG_GKlike_1	164	171	PF00625	0.767
LIG_FHA_1	155	161	PF00498	0.800
LIG_FHA_1	186	192	PF00498	0.643
LIG_FHA_1	399	405	PF00498	0.729
LIG_FHA_1	446	452	PF00498	0.745
LIG_FHA_2	121	127	PF00498	0.845
LIG_FHA_2	225	231	PF00498	0.578
LIG_FHA_2	292	298	PF00498	0.439
LIG_FHA_2	38	44	PF00498	0.760
LIG_FHA_2	382	388	PF00498	0.719
LIG_FHA_2	67	73	PF00498	0.756
LIG_IBAR_NPY_1	332	334	PF08397	0.724
LIG_LIR_Apic_2	146	152	PF02991	0.747
LIG_LIR_Apic_2	416	421	PF02991	0.636
LIG_RPA_C_Fungi	190	202	PF08784	0.623
LIG_SH2_NCK_1	216	220	PF00017	0.640
LIG_SH2_STAP1	334	338	PF00017	0.541
LIG_SH2_STAP1	343	347	PF00017	0.648
LIG_SH2_STAT3	242	245	PF00017	0.655
LIG_SH2_STAT5	216	219	PF00017	0.638
LIG_SH2_STAT5	274	277	PF00017	0.570
LIG_SH3_2	421	426	PF14604	0.721
LIG_SH3_3	113	119	PF00018	0.737
LIG_SH3_3	418	424	PF00018	0.711
LIG_SH3_3	64	70	PF00018	0.810
LIG_TRAF2_1	13	16	PF00917	0.824
LIG_TRAF2_1	294	297	PF00917	0.435
LIG_WW_3	422	426	PF00397	0.645
MOD_CDK_SPK_2	150	155	PF00069	0.747
MOD_CDK_SPK_2	370	375	PF00069	0.696
MOD_CDK_SPK_2	66	71	PF00069	0.759
MOD_CDK_SPxxK_3	358	365	PF00069	0.707
MOD_CDK_SPxxK_3	389	396	PF00069	0.809
MOD_CK1_1	144	150	PF00069	0.740
MOD_CK1_1	153	159	PF00069	0.773
MOD_CK1_1	169	175	PF00069	0.639
MOD_CK1_1	220	226	PF00069	0.729
MOD_CK1_1	291	297	PF00069	0.435
MOD_CK1_1	360	366	PF00069	0.785
MOD_CK1_1	373	379	PF00069	0.608
MOD_CK1_1	392	398	PF00069	0.814
MOD_CK1_1	400	406	PF00069	0.671
MOD_CK1_1	428	434	PF00069	0.715
MOD_CK2_1	120	126	PF00069	0.755
MOD_CK2_1	169	175	PF00069	0.629
MOD_CK2_1	20	26	PF00069	0.769
MOD_CK2_1	224	230	PF00069	0.586
MOD_CK2_1	291	297	PF00069	0.467
MOD_CK2_1	317	323	PF00069	0.642
MOD_CK2_1	56	62	PF00069	0.756
MOD_CK2_1	66	72	PF00069	0.633
MOD_DYRK1A_RPxSP_1	358	362	PF00069	0.654
MOD_DYRK1A_RPxSP_1	398	402	PF00069	0.736
MOD_GlcNHglycan	106	109	PF01048	0.717
MOD_GlcNHglycan	157	160	PF01048	0.747
MOD_GlcNHglycan	168	171	PF01048	0.590
MOD_GlcNHglycan	192	195	PF01048	0.578
MOD_GlcNHglycan	197	200	PF01048	0.554
MOD_GlcNHglycan	223	226	PF01048	0.567
MOD_GlcNHglycan	249	253	PF01048	0.563
MOD_GlcNHglycan	366	369	PF01048	0.596
MOD_GlcNHglycan	375	378	PF01048	0.627
MOD_GlcNHglycan	40	43	PF01048	0.745
MOD_GlcNHglycan	432	436	PF01048	0.770
MOD_GlcNHglycan	52	56	PF01048	0.657
MOD_GlcNHglycan	6	9	PF01048	0.778
MOD_GSK3_1	139	146	PF00069	0.723
MOD_GSK3_1	150	157	PF00069	0.743
MOD_GSK3_1	158	165	PF00069	0.622
MOD_GSK3_1	186	193	PF00069	0.552
MOD_GSK3_1	217	224	PF00069	0.605
MOD_GSK3_1	357	364	PF00069	0.737
MOD_GSK3_1	388	395	PF00069	0.742
MOD_GSK3_1	396	403	PF00069	0.821
MOD_GSK3_1	47	54	PF00069	0.725
MOD_GSK3_1	56	63	PF00069	0.702
MOD_LATS_1	18	24	PF00433	0.615
MOD_N-GLC_1	134	139	PF02516	0.640
MOD_N-GLC_1	381	386	PF02516	0.688
MOD_NEK2_1	104	109	PF00069	0.581
MOD_NEK2_1	288	293	PF00069	0.665
MOD_NEK2_1	317	322	PF00069	0.640
MOD_NEK2_1	60	65	PF00069	0.719
MOD_PIKK_1	134	140	PF00454	0.653
MOD_PK_1	186	192	PF00069	0.699
MOD_PK_1	201	207	PF00069	0.521
MOD_PK_1	341	347	PF00069	0.746
MOD_PKA_1	185	191	PF00069	0.698
MOD_PKA_1	200	206	PF00069	0.519
MOD_PKA_1	221	227	PF00069	0.588
MOD_PKA_1	341	347	PF00069	0.732
MOD_PKA_1	357	363	PF00069	0.578
MOD_PKA_1	37	43	PF00069	0.679
MOD_PKA_1	396	402	PF00069	0.745
MOD_PKA_1	425	431	PF00069	0.767
MOD_PKA_2	154	160	PF00069	0.772
MOD_PKA_2	185	191	PF00069	0.622
MOD_PKA_2	200	206	PF00069	0.488
MOD_PKA_2	220	226	PF00069	0.406
MOD_PKA_2	257	263	PF00069	0.512
MOD_PKA_2	297	303	PF00069	0.590
MOD_PKA_2	341	347	PF00069	0.725
MOD_PKA_2	357	363	PF00069	0.581
MOD_PKA_2	364	370	PF00069	0.728
MOD_PKA_2	37	43	PF00069	0.761
MOD_PKA_2	387	393	PF00069	0.748
MOD_PKA_2	396	402	PF00069	0.820
MOD_PKA_2	4	10	PF00069	0.817
MOD_PKA_2	445	451	PF00069	0.693
MOD_PKB_1	139	147	PF00069	0.753
MOD_PKB_1	162	170	PF00069	0.775
MOD_PKB_1	36	44	PF00069	0.606
MOD_PKB_1	438	446	PF00069	0.530
MOD_Plk_4	186	192	PF00069	0.619
MOD_Plk_4	257	263	PF00069	0.518
MOD_Plk_4	270	276	PF00069	0.543
MOD_Plk_4	317	323	PF00069	0.564
MOD_ProDKin_1	150	156	PF00069	0.747
MOD_ProDKin_1	346	352	PF00069	0.664
MOD_ProDKin_1	358	364	PF00069	0.784
MOD_ProDKin_1	370	376	PF00069	0.690
MOD_ProDKin_1	389	395	PF00069	0.787
MOD_ProDKin_1	398	404	PF00069	0.691
MOD_ProDKin_1	438	444	PF00069	0.688
MOD_ProDKin_1	66	72	PF00069	0.810
TRG_ENDOCYTIC_2	318	321	PF00928	0.586
TRG_ENDOCYTIC_2	334	337	PF00928	0.508
TRG_ER_diArg_1	184	186	PF00400	0.652
TRG_ER_diArg_1	242	244	PF00400	0.658
TRG_ER_diArg_1	275	277	PF00400	0.621
TRG_ER_diArg_1	313	316	PF00400	0.662
TRG_ER_diArg_1	341	343	PF00400	0.638
TRG_ER_diArg_1	36	39	PF00400	0.612
TRG_ER_diArg_1	396	398	PF00400	0.829
TRG_NLS_MonoCore_2	35	40	PF00514	0.609
TRG_NLS_MonoExtN_4	36	41	PF00514	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG0	Leptomonas seymouri	39%	100%
A0A3S7WQV1	Leishmania donovani	89%	100%
A4H5T9	Leishmania braziliensis	63%	87%
A4HU33	Leishmania infantum	89%	100%
E9AMW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%