Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHR1_LEIMA

TriTrypDb:

LmjF.09.1140 , LMJLV39_090018700 , LMJSD75_090018300

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	11
GO:0030992	intraciliary transport particle B	2	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

Q4QHR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.520
CLV_NRD_NRD_1	55	57	PF00675	0.494
CLV_PCSK_KEX2_1	43	45	PF00082	0.555
CLV_PCSK_SKI1_1	128	132	PF00082	0.443
CLV_PCSK_SKI1_1	56	60	PF00082	0.635
DEG_APCC_DBOX_1	42	50	PF00400	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DOC_MAPK_gen_1	116	124	PF00069	0.493
DOC_MAPK_gen_1	190	199	PF00069	0.361
DOC_MAPK_MEF2A_6	116	124	PF00069	0.493
DOC_MAPK_MEF2A_6	190	199	PF00069	0.383
DOC_PP1_RVXF_1	188	195	PF00149	0.497
DOC_PP1_RVXF_1	64	70	PF00149	0.464
DOC_USP7_MATH_1	12	16	PF00917	0.606
DOC_USP7_MATH_1	152	156	PF00917	0.526
DOC_USP7_MATH_1	20	24	PF00917	0.557
DOC_USP7_MATH_1	62	66	PF00917	0.589
DOC_WW_Pin1_4	136	141	PF00397	0.538
DOC_WW_Pin1_4	14	19	PF00397	0.530
DOC_WW_Pin1_4	159	164	PF00397	0.641
DOC_WW_Pin1_4	5	10	PF00397	0.550
LIG_14-3-3_CanoR_1	111	120	PF00244	0.516
LIG_BIR_III_4	213	217	PF00653	0.494
LIG_FHA_1	91	97	PF00498	0.450
LIG_FHA_2	139	145	PF00498	0.496
LIG_FHA_2	226	232	PF00498	0.471
LIG_FHA_2	50	56	PF00498	0.488
LIG_LIR_Gen_1	141	151	PF02991	0.431
LIG_LIR_Gen_1	191	200	PF02991	0.387
LIG_LIR_Gen_1	201	210	PF02991	0.315
LIG_LIR_Gen_1	70	81	PF02991	0.411
LIG_LIR_Nem_3	191	197	PF02991	0.390
LIG_LIR_Nem_3	201	206	PF02991	0.328
LIG_LIR_Nem_3	65	71	PF02991	0.408
LIG_Pex14_2	69	73	PF04695	0.455
LIG_SH2_STAP1	203	207	PF00017	0.408
LIG_SH2_STAP1	210	214	PF00017	0.403
LIG_SH2_STAT5	68	71	PF00017	0.429
LIG_SH3_3	170	176	PF00018	0.547
LIG_SH3_3	86	92	PF00018	0.495
LIG_TRFH_1	181	185	PF08558	0.496
LIG_WRC_WIRS_1	73	78	PF05994	0.392
MOD_CK1_1	118	124	PF00069	0.490
MOD_CK1_1	13	19	PF00069	0.640
MOD_CK1_1	159	165	PF00069	0.704
MOD_CK1_1	201	207	PF00069	0.383
MOD_CK1_1	21	27	PF00069	0.583
MOD_CK1_1	84	90	PF00069	0.514
MOD_CK2_1	138	144	PF00069	0.536
MOD_CK2_1	225	231	PF00069	0.540
MOD_CK2_1	49	55	PF00069	0.455
MOD_GlcNHglycan	113	116	PF01048	0.399
MOD_GlcNHglycan	163	166	PF01048	0.714
MOD_GlcNHglycan	200	203	PF01048	0.366
MOD_GlcNHglycan	5	8	PF01048	0.531
MOD_GlcNHglycan	83	86	PF01048	0.374
MOD_GSK3_1	1	8	PF00069	0.552
MOD_GSK3_1	10	17	PF00069	0.520
MOD_GSK3_1	107	114	PF00069	0.412
MOD_GSK3_1	152	159	PF00069	0.549
MOD_GSK3_1	33	40	PF00069	0.572
MOD_GSK3_1	91	98	PF00069	0.472
MOD_N-GLC_1	159	164	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	60	65	PF00069	0.559
MOD_NEK2_1	95	100	PF00069	0.410
MOD_PIKK_1	216	222	PF00454	0.471
MOD_PIKK_1	34	40	PF00454	0.570
MOD_PIKK_1	49	55	PF00454	0.446
MOD_PKA_2	152	158	PF00069	0.634
MOD_PKA_2	195	201	PF00069	0.455
MOD_Plk_1	147	153	PF00069	0.496
MOD_Plk_4	195	201	PF00069	0.449
MOD_Plk_4	91	97	PF00069	0.456
MOD_ProDKin_1	136	142	PF00069	0.540
MOD_ProDKin_1	14	20	PF00069	0.531
MOD_ProDKin_1	159	165	PF00069	0.644
MOD_ProDKin_1	5	11	PF00069	0.554
MOD_SUMO_rev_2	121	130	PF00179	0.435
MOD_SUMO_rev_2	84	92	PF00179	0.485
TRG_ENDOCYTIC_2	203	206	PF00928	0.422
TRG_ENDOCYTIC_2	68	71	PF00928	0.385
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A8	Leptomonas seymouri	72%	100%
A0A1X0NHU5	Trypanosomatidae	43%	100%
A0A3S5H6E4	Leishmania donovani	86%	100%
A0A3S5ISF4	Trypanosoma rangeli	42%	100%
A4H5U2	Leishmania braziliensis	73%	97%
A4HU36	Leishmania infantum	86%	100%
D0A9L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AMW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5AY45	Trypanosoma cruzi	43%	100%