Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHR0_LEIMA

TriTrypDb:

LmjF.09.1150 , LMJLV39_090018800 , LMJSD75_090018400

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	181	187	PF00089	0.664
CLV_NRD_NRD_1	173	175	PF00675	0.480
CLV_NRD_NRD_1	177	179	PF00675	0.493
CLV_NRD_NRD_1	183	185	PF00675	0.548
CLV_NRD_NRD_1	227	229	PF00675	0.610
CLV_NRD_NRD_1	230	232	PF00675	0.639
CLV_NRD_NRD_1	265	267	PF00675	0.624
CLV_NRD_NRD_1	279	281	PF00675	0.452
CLV_PCSK_FUR_1	228	232	PF00082	0.657
CLV_PCSK_KEX2_1	100	102	PF00082	0.533
CLV_PCSK_KEX2_1	166	168	PF00082	0.502
CLV_PCSK_KEX2_1	173	175	PF00082	0.477
CLV_PCSK_KEX2_1	177	179	PF00082	0.498
CLV_PCSK_KEX2_1	183	185	PF00082	0.554
CLV_PCSK_KEX2_1	229	231	PF00082	0.581
CLV_PCSK_KEX2_1	281	283	PF00082	0.712
CLV_PCSK_KEX2_1	48	50	PF00082	0.582
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.556
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.478
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.685
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.731
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.598
CLV_PCSK_PC7_1	173	179	PF00082	0.508
CLV_PCSK_PC7_1	277	283	PF00082	0.798
CLV_PCSK_PC7_1	96	102	PF00082	0.531
CLV_PCSK_SKI1_1	53	57	PF00082	0.556
CLV_Separin_Metazoa	252	256	PF03568	0.645
DEG_SCF_SKP2-CKS1_1	185	192	PF00560	0.577
DOC_USP7_MATH_1	128	132	PF00917	0.652
DOC_USP7_MATH_1	3	7	PF00917	0.571
DOC_USP7_MATH_1	36	40	PF00917	0.651
DOC_USP7_MATH_1	75	79	PF00917	0.685
DOC_USP7_UBL2_3	14	18	PF12436	0.690
DOC_WW_Pin1_4	186	191	PF00397	0.574
LIG_14-3-3_CanoR_1	145	152	PF00244	0.585
LIG_FHA_1	201	207	PF00498	0.535
LIG_FHA_1	7	13	PF00498	0.547
LIG_FHA_1	71	77	PF00498	0.560
LIG_FHA_2	145	151	PF00498	0.539
LIG_FHA_2	80	86	PF00498	0.553
LIG_LIR_Nem_3	88	94	PF02991	0.509
LIG_PDZ_Class_3	282	287	PF00595	0.780
LIG_SH2_NCK_1	94	98	PF00017	0.440
LIG_SH2_STAP1	123	127	PF00017	0.642
LIG_SH2_STAP1	256	260	PF00017	0.552
LIG_SH2_STAP1	70	74	PF00017	0.555
LIG_SH2_STAT5	70	73	PF00017	0.627
LIG_SH3_3	182	188	PF00018	0.671
LIG_SH3_3	243	249	PF00018	0.543
LIG_TRAF2_1	249	252	PF00917	0.630
LIG_TRAF2_1	82	85	PF00917	0.549
MOD_CDK_SPxK_1	186	192	PF00069	0.580
MOD_CK1_1	155	161	PF00069	0.559
MOD_CK1_1	6	12	PF00069	0.543
MOD_CK2_1	14	20	PF00069	0.635
MOD_CK2_1	144	150	PF00069	0.534
MOD_CK2_1	79	85	PF00069	0.560
MOD_Cter_Amidation	278	281	PF01082	0.759
MOD_Cter_Amidation	98	101	PF01082	0.538
MOD_GlcNHglycan	157	160	PF01048	0.530
MOD_GlcNHglycan	193	196	PF01048	0.580
MOD_GlcNHglycan	200	203	PF01048	0.525
MOD_GlcNHglycan	242	245	PF01048	0.616
MOD_GSK3_1	75	82	PF00069	0.673
MOD_N-GLC_1	116	121	PF02516	0.593
MOD_N-GLC_1	207	212	PF02516	0.541
MOD_N-GLC_1	240	245	PF02516	0.625
MOD_N-GLC_1	79	84	PF02516	0.540
MOD_NEK2_1	191	196	PF00069	0.590
MOD_NEK2_1	207	212	PF00069	0.550
MOD_NEK2_1	240	245	PF00069	0.676
MOD_PIKK_1	128	134	PF00454	0.544
MOD_PIKK_1	233	239	PF00454	0.649
MOD_PKA_1	231	237	PF00069	0.610
MOD_PKA_2	144	150	PF00069	0.543
MOD_PKA_2	254	260	PF00069	0.622
MOD_PKA_2	6	12	PF00069	0.556
MOD_Plk_1	116	122	PF00069	0.671
MOD_Plk_1	207	213	PF00069	0.535
MOD_Plk_1	79	85	PF00069	0.544
MOD_Plk_1	87	93	PF00069	0.509
MOD_Plk_2-3	79	85	PF00069	0.537
MOD_Plk_4	37	43	PF00069	0.644
MOD_ProDKin_1	186	192	PF00069	0.580
TRG_ENDOCYTIC_2	94	97	PF00928	0.583
TRG_ER_diArg_1	176	178	PF00400	0.511
TRG_ER_diArg_1	182	184	PF00400	0.514
TRG_ER_diArg_1	227	230	PF00400	0.637
TRG_ER_KDEL_1	284	287	PF00810	0.778
TRG_NLS_Bipartite_1	266	284	PF00514	0.664
TRG_NLS_MonoCore_2	227	232	PF00514	0.640
TRG_NLS_MonoCore_2	45	50	PF00514	0.701
TRG_NLS_MonoExtC_3	227	232	PF00514	0.687
TRG_NLS_MonoExtC_3	279	284	PF00514	0.756
TRG_NLS_MonoExtC_3	45	51	PF00514	0.699
TRG_NLS_MonoExtN_4	228	233	PF00514	0.705
TRG_NLS_MonoExtN_4	264	270	PF00514	0.647
TRG_NLS_MonoExtN_4	277	284	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W8	Leptomonas seymouri	84%	98%
A0A0S4JUY7	Bodo saltans	53%	100%
A0A1X0NHZ1	Trypanosomatidae	59%	93%
A0A3S7WQW2	Leishmania donovani	97%	100%
A0A422NZP9	Trypanosoma rangeli	64%	100%
A4H5U3	Leishmania braziliensis	91%	100%
A4HU37	Leishmania infantum	97%	100%
D0A9L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	95%
E9AMW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BMM5	Trypanosoma cruzi	63%	99%