Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHQ9_LEIMA

TriTrypDb:

LmjF.09.1160 , LMJLV39_090018900 , LMJSD75_090018500

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QHQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHQ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.639
CLV_NRD_NRD_1	166	168	PF00675	0.443
CLV_NRD_NRD_1	287	289	PF00675	0.477
CLV_NRD_NRD_1	342	344	PF00675	0.570
CLV_NRD_NRD_1	45	47	PF00675	0.484
CLV_NRD_NRD_1	480	482	PF00675	0.509
CLV_NRD_NRD_1	52	54	PF00675	0.483
CLV_NRD_NRD_1	679	681	PF00675	0.659
CLV_NRD_NRD_1	719	721	PF00675	0.663
CLV_NRD_NRD_1	73	75	PF00675	0.469
CLV_PCSK_FUR_1	288	292	PF00082	0.463
CLV_PCSK_FUR_1	677	681	PF00082	0.623
CLV_PCSK_KEX2_1	115	117	PF00082	0.319
CLV_PCSK_KEX2_1	287	289	PF00082	0.478
CLV_PCSK_KEX2_1	290	292	PF00082	0.487
CLV_PCSK_KEX2_1	45	47	PF00082	0.423
CLV_PCSK_KEX2_1	480	482	PF00082	0.504
CLV_PCSK_KEX2_1	536	538	PF00082	0.380
CLV_PCSK_KEX2_1	679	681	PF00082	0.621
CLV_PCSK_KEX2_1	719	721	PF00082	0.623
CLV_PCSK_KEX2_1	73	75	PF00082	0.469
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.319
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.493
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.423
CLV_PCSK_SKI1_1	194	198	PF00082	0.463
CLV_PCSK_SKI1_1	214	218	PF00082	0.493
CLV_PCSK_SKI1_1	287	291	PF00082	0.596
CLV_PCSK_SKI1_1	430	434	PF00082	0.418
CLV_PCSK_SKI1_1	462	466	PF00082	0.455
CLV_PCSK_SKI1_1	483	487	PF00082	0.457
CLV_PCSK_SKI1_1	59	63	PF00082	0.377
CLV_PCSK_SKI1_1	618	622	PF00082	0.484
CLV_PCSK_SKI1_1	98	102	PF00082	0.398
DEG_APCC_DBOX_1	550	558	PF00400	0.706
DEG_APCC_DBOX_1	636	644	PF00400	0.509
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DOC_ANK_TNKS_1	72	79	PF00023	0.641
DOC_CYCLIN_yCln2_LP_2	643	649	PF00134	0.372
DOC_MAPK_gen_1	115	123	PF00069	0.518
DOC_MAPK_gen_1	167	176	PF00069	0.680
DOC_MAPK_gen_1	483	491	PF00069	0.570
DOC_MAPK_gen_1	727	736	PF00069	0.445
DOC_MAPK_HePTP_8	164	176	PF00069	0.738
DOC_MAPK_MEF2A_6	167	176	PF00069	0.622
DOC_MAPK_MEF2A_6	583	591	PF00069	0.548
DOC_PP1_RVXF_1	57	64	PF00149	0.578
DOC_PP2B_LxvP_1	643	646	PF13499	0.372
DOC_PP4_FxxP_1	186	189	PF00568	0.636
DOC_USP7_MATH_1	15	19	PF00917	0.676
DOC_USP7_MATH_1	361	365	PF00917	0.669
DOC_USP7_MATH_1	464	468	PF00917	0.736
DOC_USP7_MATH_1	576	580	PF00917	0.765
DOC_USP7_UBL2_3	410	414	PF12436	0.656
DOC_USP7_UBL2_3	486	490	PF12436	0.632
DOC_USP7_UBL2_3	530	534	PF12436	0.596
DOC_WW_Pin1_4	267	272	PF00397	0.744
DOC_WW_Pin1_4	274	279	PF00397	0.740
DOC_WW_Pin1_4	280	285	PF00397	0.731
DOC_WW_Pin1_4	555	560	PF00397	0.746
DOC_WW_Pin1_4	82	87	PF00397	0.734
LIG_14-3-3_CanoR_1	20	29	PF00244	0.753
LIG_14-3-3_CanoR_1	231	237	PF00244	0.788
LIG_14-3-3_CanoR_1	343	347	PF00244	0.713
LIG_14-3-3_CanoR_1	507	513	PF00244	0.652
LIG_Actin_WH2_2	694	710	PF00022	0.323
LIG_BRCT_BRCA1_1	119	123	PF00533	0.558
LIG_BRCT_BRCA1_1	92	96	PF00533	0.649
LIG_Clathr_ClatBox_1	175	179	PF01394	0.592
LIG_CSL_BTD_1	643	646	PF09270	0.372
LIG_FHA_1	159	165	PF00498	0.667
LIG_FHA_1	42	48	PF00498	0.719
LIG_FHA_1	463	469	PF00498	0.659
LIG_FHA_1	472	478	PF00498	0.676
LIG_FHA_1	507	513	PF00498	0.676
LIG_FHA_1	83	89	PF00498	0.636
LIG_FHA_2	326	332	PF00498	0.590
LIG_FHA_2	496	502	PF00498	0.698
LIG_FHA_2	601	607	PF00498	0.621
LIG_LIR_Apic_2	202	208	PF02991	0.663
LIG_LIR_Gen_1	130	141	PF02991	0.651
LIG_LIR_Gen_1	308	319	PF02991	0.625
LIG_LIR_Gen_1	405	413	PF02991	0.560
LIG_LIR_Gen_1	416	427	PF02991	0.708
LIG_LIR_Gen_1	585	595	PF02991	0.600
LIG_LIR_Nem_3	130	136	PF02991	0.650
LIG_LIR_Nem_3	308	314	PF02991	0.596
LIG_LIR_Nem_3	331	337	PF02991	0.565
LIG_LIR_Nem_3	405	409	PF02991	0.555
LIG_LIR_Nem_3	416	422	PF02991	0.704
LIG_LIR_Nem_3	585	591	PF02991	0.603
LIG_LIR_Nem_3	60	66	PF02991	0.583
LIG_LIR_Nem_3	634	639	PF02991	0.643
LIG_LIR_Nem_3	657	661	PF02991	0.408
LIG_LIR_Nem_3	662	666	PF02991	0.334
LIG_LYPXL_yS_3	575	578	PF13949	0.713
LIG_MYND_1	555	559	PF01753	0.711
LIG_NRBOX	171	177	PF00104	0.679
LIG_NRBOX	685	691	PF00104	0.397
LIG_Pex14_1	333	337	PF04695	0.567
LIG_Pex14_2	62	66	PF04695	0.622
LIG_Pex14_2	96	100	PF04695	0.638
LIG_SH2_GRB2like	336	339	PF00017	0.652
LIG_SH2_GRB2like	639	642	PF00017	0.393
LIG_SH2_SRC	379	382	PF00017	0.764
LIG_SH2_SRC	626	629	PF00017	0.613
LIG_SH2_SRC	639	642	PF00017	0.393
LIG_SH2_STAP1	92	96	PF00017	0.692
LIG_SH2_STAT3	359	362	PF00017	0.653
LIG_SH2_STAT3	493	496	PF00017	0.672
LIG_SH2_STAT3	72	75	PF00017	0.677
LIG_SH2_STAT3	92	95	PF00017	0.576
LIG_SH2_STAT5	133	136	PF00017	0.616
LIG_SH2_STAT5	406	409	PF00017	0.556
LIG_SH2_STAT5	588	591	PF00017	0.658
LIG_SH2_STAT5	598	601	PF00017	0.635
LIG_SH2_STAT5	619	622	PF00017	0.614
LIG_SH2_STAT5	639	642	PF00017	0.389
LIG_SH3_1	291	297	PF00018	0.674
LIG_SH3_2	294	299	PF14604	0.695
LIG_SH3_3	234	240	PF00018	0.741
LIG_SH3_3	251	257	PF00018	0.661
LIG_SH3_3	278	284	PF00018	0.738
LIG_SH3_3	291	297	PF00018	0.592
LIG_SH3_3	549	555	PF00018	0.671
LIG_SUMO_SIM_par_1	221	230	PF11976	0.659
LIG_SUMO_SIM_par_1	325	331	PF11976	0.607
LIG_SUMO_SIM_par_1	605	612	PF11976	0.498
LIG_TRAF2_1	498	501	PF00917	0.661
LIG_TYR_ITIM	404	409	PF00017	0.674
LIG_UBA3_1	422	430	PF00899	0.670
LIG_UBA3_1	531	536	PF00899	0.680
LIG_WW_2	552	555	PF00397	0.730
MOD_CDK_SPxxK_3	280	287	PF00069	0.742
MOD_CK1_1	227	233	PF00069	0.720
MOD_CK1_1	277	283	PF00069	0.804
MOD_CK1_1	402	408	PF00069	0.599
MOD_CK1_1	467	473	PF00069	0.700
MOD_CK1_1	6	12	PF00069	0.755
MOD_CK2_1	230	236	PF00069	0.760
MOD_CK2_1	449	455	PF00069	0.686
MOD_CK2_1	495	501	PF00069	0.662
MOD_CK2_1	6	12	PF00069	0.615
MOD_CK2_1	600	606	PF00069	0.654
MOD_Cter_Amidation	51	54	PF01082	0.497
MOD_Cter_Amidation	728	731	PF01082	0.640
MOD_GlcNHglycan	232	235	PF01048	0.486
MOD_GlcNHglycan	30	33	PF01048	0.563
MOD_GlcNHglycan	347	350	PF01048	0.556
MOD_GlcNHglycan	401	404	PF01048	0.408
MOD_GlcNHglycan	451	454	PF01048	0.496
MOD_GlcNHglycan	50	53	PF01048	0.524
MOD_GlcNHglycan	578	581	PF01048	0.420
MOD_GlcNHglycan	6	9	PF01048	0.488
MOD_GSK3_1	2	9	PF00069	0.674
MOD_GSK3_1	462	469	PF00069	0.697
MOD_GSK3_1	471	478	PF00069	0.631
MOD_GSK3_1	512	519	PF00069	0.663
MOD_GSK3_1	714	721	PF00069	0.420
MOD_GSK3_1	77	84	PF00069	0.688
MOD_LATS_1	545	551	PF00433	0.664
MOD_N-GLC_1	699	704	PF02516	0.649
MOD_N-GLC_1	714	719	PF02516	0.724
MOD_NEK2_1	1	6	PF00069	0.793
MOD_NEK2_1	342	347	PF00069	0.704
MOD_NEK2_1	418	423	PF00069	0.729
MOD_NEK2_1	463	468	PF00069	0.655
MOD_NEK2_1	512	517	PF00069	0.687
MOD_NEK2_1	707	712	PF00069	0.495
MOD_NEK2_1	714	719	PF00069	0.383
MOD_NEK2_1	88	93	PF00069	0.540
MOD_NEK2_2	15	20	PF00069	0.708
MOD_PIKK_1	21	27	PF00454	0.717
MOD_PIKK_1	342	348	PF00454	0.654
MOD_PKA_1	719	725	PF00069	0.458
MOD_PKA_2	158	164	PF00069	0.743
MOD_PKA_2	21	27	PF00069	0.686
MOD_PKA_2	230	236	PF00069	0.788
MOD_PKA_2	342	348	PF00069	0.704
MOD_PKA_2	373	379	PF00069	0.744
MOD_PKA_2	506	512	PF00069	0.660
MOD_PKA_2	718	724	PF00069	0.421
MOD_Plk_1	714	720	PF00069	0.530
MOD_Plk_2-3	250	256	PF00069	0.586
MOD_Plk_2-3	606	612	PF00069	0.492
MOD_Plk_4	117	123	PF00069	0.623
MOD_Plk_4	136	142	PF00069	0.511
MOD_Plk_4	325	331	PF00069	0.604
MOD_Plk_4	402	408	PF00069	0.623
MOD_Plk_4	418	424	PF00069	0.623
MOD_Plk_4	631	637	PF00069	0.594
MOD_Plk_4	654	660	PF00069	0.293
MOD_ProDKin_1	267	273	PF00069	0.743
MOD_ProDKin_1	274	280	PF00069	0.741
MOD_ProDKin_1	555	561	PF00069	0.746
MOD_ProDKin_1	82	88	PF00069	0.729
MOD_SUMO_rev_2	162	169	PF00179	0.628
TRG_DiLeu_BaEn_1	527	532	PF01217	0.573
TRG_DiLeu_BaEn_4	627	633	PF01217	0.579
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.393
TRG_ENDOCYTIC_2	104	107	PF00928	0.559
TRG_ENDOCYTIC_2	133	136	PF00928	0.641
TRG_ENDOCYTIC_2	336	339	PF00928	0.612
TRG_ENDOCYTIC_2	406	409	PF00928	0.571
TRG_ENDOCYTIC_2	575	578	PF00928	0.696
TRG_ENDOCYTIC_2	588	591	PF00928	0.556
TRG_ENDOCYTIC_2	658	661	PF00928	0.494
TRG_ER_diArg_1	19	22	PF00400	0.740
TRG_ER_diArg_1	287	289	PF00400	0.677
TRG_ER_diArg_1	45	47	PF00400	0.679
TRG_ER_diArg_1	480	483	PF00400	0.705
TRG_ER_diArg_1	677	680	PF00400	0.372
TRG_ER_diArg_1	718	720	PF00400	0.424
TRG_ER_diArg_1	72	74	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTV6	Leptomonas seymouri	53%	100%
A0A0S4JUS6	Bodo saltans	23%	100%
A0A3Q8IH12	Leishmania donovani	94%	100%
A0A422NZM2	Trypanosoma rangeli	31%	100%
A4H5U4	Leishmania braziliensis	75%	100%
A4HU38	Leishmania infantum	94%	100%
E9AMW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DEB6	Trypanosoma cruzi	31%	100%