BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHQ8_LEIMA

TriTrypDb:

LmjF.09.1170 , LMJLV39_090019000 , LMJSD75_090018600

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	127	133	PF00089	0.447
CLV_NRD_NRD_1	163	165	PF00675	0.527
CLV_NRD_NRD_1	182	184	PF00675	0.319
CLV_PCSK_KEX2_1	182	184	PF00082	0.588
CLV_PCSK_KEX2_1	85	87	PF00082	0.333
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.426
CLV_PCSK_SKI1_1	164	168	PF00082	0.486
CLV_PCSK_SKI1_1	25	29	PF00082	0.510
CLV_PCSK_SKI1_1	69	73	PF00082	0.546
CLV_PCSK_SKI1_1	92	96	PF00082	0.467
DOC_CYCLIN_yCln2_LP_2	80	83	PF00134	0.562
DOC_MAPK_gen_1	112	122	PF00069	0.514
DOC_PP2B_LxvP_1	80	83	PF13499	0.551
LIG_14-3-3_CanoR_1	130	137	PF00244	0.432
LIG_14-3-3_CanoR_1	86	94	PF00244	0.490
LIG_Actin_WH2_2	116	132	PF00022	0.473
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_FHA_1	55	61	PF00498	0.670
LIG_FHA_1	85	91	PF00498	0.522
LIG_FHA_1	93	99	PF00498	0.485
LIG_FHA_2	172	178	PF00498	0.450
LIG_FHA_2	21	27	PF00498	0.521
LIG_GBD_Chelix_1	119	127	PF00786	0.474
LIG_NRBOX	118	124	PF00104	0.420
LIG_SH2_CRK	141	145	PF00017	0.406
LIG_SH2_CRK	78	82	PF00017	0.511
LIG_SH2_STAP1	15	19	PF00017	0.495
LIG_SH2_STAP1	187	191	PF00017	0.460
LIG_SH2_STAT5	118	121	PF00017	0.419
LIG_SH3_3	14	20	PF00018	0.432
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.475
LIG_SxIP_EBH_1	85	96	PF03271	0.516
LIG_TRAF2_1	174	177	PF00917	0.479
LIG_TRAF2_1	2	5	PF00917	0.582
LIG_TRFH_1	78	82	PF08558	0.511
MOD_CK1_1	10	16	PF00069	0.511
MOD_CK1_1	132	138	PF00069	0.472
MOD_CK2_1	171	177	PF00069	0.564
MOD_CK2_1	20	26	PF00069	0.502
MOD_GlcNHglycan	12	15	PF01048	0.567
MOD_GlcNHglycan	134	137	PF01048	0.465
MOD_GlcNHglycan	48	52	PF01048	0.768
MOD_N-GLC_1	10	15	PF02516	0.522
MOD_NEK2_1	129	134	PF00069	0.454
MOD_NEK2_1	7	12	PF00069	0.488
MOD_PIKK_1	129	135	PF00454	0.429
MOD_PIKK_1	92	98	PF00454	0.571
MOD_PK_1	86	92	PF00069	0.539
MOD_PKA_1	85	91	PF00069	0.340
MOD_PKA_2	129	135	PF00069	0.434
MOD_PKA_2	7	13	PF00069	0.521
MOD_PKA_2	85	91	PF00069	0.469
MOD_SUMO_for_1	60	63	PF00179	0.588
TRG_DiLeu_BaEn_4	176	182	PF01217	0.453
TRG_ENDOCYTIC_2	141	144	PF00928	0.445
TRG_ENDOCYTIC_2	78	81	PF00928	0.467
TRG_ER_diArg_1	181	183	PF00400	0.544
TRG_NES_CRM1_1	117	133	PF08389	0.484
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U4	Leptomonas seymouri	65%	96%
A0A0S4J983	Bodo saltans	31%	77%
A0A0S4JCU4	Bodo saltans	28%	100%
A0A1X0NIG1	Trypanosomatidae	38%	100%
A0A3S7WQT5	Leishmania donovani	97%	100%
A0A422NZK1	Trypanosoma rangeli	42%	100%
A4H5U5	Leishmania braziliensis	91%	99%
A4HU39	Leishmania infantum	97%	100%
D0A9L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AMW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BDJ1	Trypanosoma cruzi	40%	100%