Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHQ6_LEIMA

TriTrypDb:

LmjF.09.1190 , LMJLV39_090019200 , LMJSD75_090018800

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.579
CLV_C14_Caspase3-7	482	486	PF00656	0.628
CLV_C14_Caspase3-7	572	576	PF00656	0.550
CLV_C14_Caspase3-7	72	76	PF00656	0.720
CLV_NRD_NRD_1	238	240	PF00675	0.594
CLV_NRD_NRD_1	294	296	PF00675	0.595
CLV_NRD_NRD_1	395	397	PF00675	0.585
CLV_NRD_NRD_1	399	401	PF00675	0.469
CLV_NRD_NRD_1	450	452	PF00675	0.690
CLV_NRD_NRD_1	461	463	PF00675	0.591
CLV_NRD_NRD_1	470	472	PF00675	0.787
CLV_NRD_NRD_1	86	88	PF00675	0.759
CLV_PCSK_FUR_1	396	400	PF00082	0.597
CLV_PCSK_FUR_1	468	472	PF00082	0.737
CLV_PCSK_KEX2_1	237	239	PF00082	0.601
CLV_PCSK_KEX2_1	294	296	PF00082	0.595
CLV_PCSK_KEX2_1	395	397	PF00082	0.585
CLV_PCSK_KEX2_1	398	400	PF00082	0.616
CLV_PCSK_KEX2_1	450	452	PF00082	0.707
CLV_PCSK_KEX2_1	456	458	PF00082	0.659
CLV_PCSK_KEX2_1	461	463	PF00082	0.718
CLV_PCSK_KEX2_1	468	470	PF00082	0.606
CLV_PCSK_KEX2_1	86	88	PF00082	0.589
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.696
CLV_PCSK_PC7_1	395	401	PF00082	0.499
CLV_PCSK_PC7_1	457	463	PF00082	0.579
CLV_PCSK_PC7_1	464	470	PF00082	0.578
CLV_PCSK_SKI1_1	261	265	PF00082	0.593
CLV_PCSK_SKI1_1	515	519	PF00082	0.609
CLV_PCSK_SKI1_1	86	90	PF00082	0.659
CLV_Separin_Metazoa	392	396	PF03568	0.620
DEG_APCC_DBOX_1	260	268	PF00400	0.594
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DEG_SCF_FBW7_2	13	20	PF00400	0.662
DOC_MAPK_MEF2A_6	334	343	PF00069	0.617
DOC_PP2B_LxvP_1	336	339	PF13499	0.629
DOC_PP2B_LxvP_1	410	413	PF13499	0.672
DOC_USP7_MATH_1	123	127	PF00917	0.723
DOC_USP7_MATH_1	129	133	PF00917	0.689
DOC_USP7_MATH_1	137	141	PF00917	0.539
DOC_USP7_MATH_1	15	19	PF00917	0.783
DOC_USP7_MATH_1	185	189	PF00917	0.730
DOC_USP7_MATH_1	259	263	PF00917	0.562
DOC_USP7_MATH_1	270	274	PF00917	0.507
DOC_USP7_MATH_1	315	319	PF00917	0.575
DOC_USP7_MATH_1	414	418	PF00917	0.599
DOC_USP7_MATH_1	436	440	PF00917	0.566
DOC_USP7_MATH_1	455	459	PF00917	0.638
DOC_USP7_MATH_1	486	490	PF00917	0.634
DOC_USP7_MATH_1	527	531	PF00917	0.661
DOC_USP7_MATH_1	60	64	PF00917	0.611
DOC_WW_Pin1_4	13	18	PF00397	0.830
LIG_14-3-3_CanoR_1	153	162	PF00244	0.592
LIG_14-3-3_CanoR_1	304	310	PF00244	0.590
LIG_14-3-3_CanoR_1	38	47	PF00244	0.649
LIG_14-3-3_CterR_2	587	590	PF00244	0.593
LIG_Actin_WH2_2	550	566	PF00022	0.563
LIG_BIR_III_4	94	98	PF00653	0.536
LIG_BRCT_BRCA1_1	529	533	PF00533	0.543
LIG_CtBP_PxDLS_1	340	344	PF00389	0.628
LIG_CtBP_PxDLS_1	374	378	PF00389	0.566
LIG_FHA_1	280	286	PF00498	0.524
LIG_FHA_1	300	306	PF00498	0.602
LIG_FHA_1	533	539	PF00498	0.634
LIG_FHA_2	570	576	PF00498	0.551
LIG_FHA_2	78	84	PF00498	0.623
LIG_LIR_Apic_2	20	26	PF02991	0.567
LIG_LIR_Gen_1	154	163	PF02991	0.643
LIG_LIR_Gen_1	216	226	PF02991	0.493
LIG_LIR_Gen_1	41	47	PF02991	0.590
LIG_LIR_Nem_3	154	159	PF02991	0.630
LIG_LIR_Nem_3	216	221	PF02991	0.493
LIG_LIR_Nem_3	314	319	PF02991	0.598
LIG_LIR_Nem_3	41	46	PF02991	0.593
LIG_LIR_Nem_3	530	536	PF02991	0.545
LIG_LIR_Nem_3	567	573	PF02991	0.552
LIG_PAM2_1	341	353	PF00658	0.599
LIG_Pex14_1	103	107	PF04695	0.566
LIG_Pex14_1	306	310	PF04695	0.597
LIG_Pex14_2	152	156	PF04695	0.625
LIG_Pex14_2	39	43	PF04695	0.510
LIG_Pex3_1	96	107	PF04882	0.568
LIG_SH2_CRK	223	227	PF00017	0.572
LIG_SH2_NCK_1	223	227	PF00017	0.572
LIG_SH2_STAP1	40	44	PF00017	0.507
LIG_SH2_STAP1	524	528	PF00017	0.607
LIG_SH2_STAT5	223	226	PF00017	0.497
LIG_SH2_STAT5	310	313	PF00017	0.614
LIG_SH2_STAT5	351	354	PF00017	0.419
LIG_SH2_STAT5	40	43	PF00017	0.544
LIG_SH2_STAT5	562	565	PF00017	0.546
LIG_SH3_1	176	182	PF00018	0.656
LIG_SH3_3	176	182	PF00018	0.625
LIG_SH3_3	27	33	PF00018	0.564
LIG_SH3_3	419	425	PF00018	0.677
LIG_SH3_3	542	548	PF00018	0.690
LIG_SH3_3	59	65	PF00018	0.658
LIG_SUMO_SIM_par_1	339	344	PF11976	0.631
LIG_SUMO_SIM_par_1	373	379	PF11976	0.530
LIG_TRAF2_1	117	120	PF00917	0.625
LIG_TRAF2_1	255	258	PF00917	0.574
LIG_TYR_ITIM	221	226	PF00017	0.487
MOD_CK1_1	154	160	PF00069	0.585
MOD_CK1_1	206	212	PF00069	0.595
MOD_CK1_1	405	411	PF00069	0.639
MOD_CK1_1	415	421	PF00069	0.634
MOD_CK1_1	511	517	PF00069	0.610
MOD_CK1_1	70	76	PF00069	0.839
MOD_CK2_1	251	257	PF00069	0.589
MOD_CK2_1	270	276	PF00069	0.427
MOD_CK2_1	315	321	PF00069	0.583
MOD_CK2_1	485	491	PF00069	0.627
MOD_Cter_Amidation	459	462	PF01082	0.605
MOD_GlcNHglycan	125	128	PF01048	0.671
MOD_GlcNHglycan	131	134	PF01048	0.591
MOD_GlcNHglycan	135	138	PF01048	0.485
MOD_GlcNHglycan	153	156	PF01048	0.619
MOD_GlcNHglycan	164	167	PF01048	0.589
MOD_GlcNHglycan	215	218	PF01048	0.518
MOD_GlcNHglycan	252	256	PF01048	0.740
MOD_GlcNHglycan	261	264	PF01048	0.480
MOD_GlcNHglycan	272	275	PF01048	0.476
MOD_GlcNHglycan	404	407	PF01048	0.629
MOD_GlcNHglycan	416	420	PF01048	0.676
MOD_GlcNHglycan	438	441	PF01048	0.650
MOD_GlcNHglycan	457	460	PF01048	0.602
MOD_GlcNHglycan	510	513	PF01048	0.562
MOD_GlcNHglycan	529	532	PF01048	0.586
MOD_GlcNHglycan	62	65	PF01048	0.651
MOD_GSK3_1	125	132	PF00069	0.734
MOD_GSK3_1	133	140	PF00069	0.554
MOD_GSK3_1	151	158	PF00069	0.570
MOD_GSK3_1	226	233	PF00069	0.523
MOD_GSK3_1	247	254	PF00069	0.650
MOD_GSK3_1	279	286	PF00069	0.532
MOD_GSK3_1	305	312	PF00069	0.602
MOD_GSK3_1	38	45	PF00069	0.580
MOD_GSK3_1	481	488	PF00069	0.595
MOD_GSK3_1	504	511	PF00069	0.728
MOD_GSK3_1	527	534	PF00069	0.663
MOD_GSK3_1	569	576	PF00069	0.550
MOD_N-GLC_1	564	569	PF02516	0.636
MOD_NEK2_1	151	156	PF00069	0.550
MOD_NEK2_1	172	177	PF00069	0.813
MOD_NEK2_1	221	226	PF00069	0.566
MOD_NEK2_1	230	235	PF00069	0.619
MOD_NEK2_1	305	310	PF00069	0.623
MOD_NEK2_1	341	346	PF00069	0.594
MOD_NEK2_1	573	578	PF00069	0.663
MOD_NEK2_2	299	304	PF00069	0.555
MOD_OFUCOSY	219	225	PF10250	0.562
MOD_PIKK_1	232	238	PF00454	0.601
MOD_PIKK_1	45	51	PF00454	0.589
MOD_PIKK_1	573	579	PF00454	0.541
MOD_PKA_1	86	92	PF00069	0.576
MOD_PKA_2	172	178	PF00069	0.682
MOD_PKA_2	475	481	PF00069	0.574
MOD_PKA_2	555	561	PF00069	0.593
MOD_PKA_2	573	579	PF00069	0.478
MOD_PKA_2	86	92	PF00069	0.535
MOD_PKB_1	2	10	PF00069	0.569
MOD_PKB_1	398	406	PF00069	0.513
MOD_Plk_1	352	358	PF00069	0.586
MOD_Plk_1	486	492	PF00069	0.706
MOD_Plk_2-3	481	487	PF00069	0.612
MOD_Plk_4	155	161	PF00069	0.557
MOD_Plk_4	226	232	PF00069	0.546
MOD_Plk_4	305	311	PF00069	0.648
MOD_Plk_4	341	347	PF00069	0.642
MOD_Plk_4	405	411	PF00069	0.542
MOD_Plk_4	42	48	PF00069	0.542
MOD_ProDKin_1	13	19	PF00069	0.829
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.476
TRG_ENDOCYTIC_2	223	226	PF00928	0.497
TRG_ENDOCYTIC_2	40	43	PF00928	0.511
TRG_ER_diArg_1	1	4	PF00400	0.561
TRG_ER_diArg_1	237	239	PF00400	0.528
TRG_ER_diArg_1	394	396	PF00400	0.573
TRG_ER_diArg_1	398	400	PF00400	0.611
TRG_ER_diArg_1	461	464	PF00400	0.637
TRG_ER_diArg_1	467	470	PF00400	0.710
TRG_ER_diArg_1	85	87	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	580	585	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJF6	Leptomonas seymouri	31%	94%
A0A3S7WQU0	Leishmania donovani	86%	99%
A4H5U7	Leishmania braziliensis	65%	99%
A4HU41	Leishmania infantum	86%	99%
E9AMX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%