RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QHQ4_LEIMA

TriTrypDb:

LmjF.09.1210 , LMJLV39_090019400 , LMJSD75_090019000

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QHQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.725
CLV_NRD_NRD_1	139	141	PF00675	0.393
CLV_NRD_NRD_1	145	147	PF00675	0.362
CLV_NRD_NRD_1	381	383	PF00675	0.549
CLV_PCSK_FUR_1	365	369	PF00082	0.516
CLV_PCSK_KEX2_1	139	141	PF00082	0.391
CLV_PCSK_KEX2_1	147	149	PF00082	0.345
CLV_PCSK_KEX2_1	203	205	PF00082	0.332
CLV_PCSK_KEX2_1	367	369	PF00082	0.518
CLV_PCSK_KEX2_1	381	383	PF00082	0.532
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.368
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.317
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.518
CLV_PCSK_SKI1_1	147	151	PF00082	0.389
CLV_PCSK_SKI1_1	157	161	PF00082	0.345
CLV_PCSK_SKI1_1	212	216	PF00082	0.392
CLV_PCSK_SKI1_1	227	231	PF00082	0.370
DEG_APCC_DBOX_1	145	153	PF00400	0.505
DEG_SPOP_SBC_1	85	89	PF00917	0.413
DOC_CKS1_1	51	56	PF01111	0.487
DOC_CYCLIN_RxL_1	144	155	PF00134	0.596
DOC_CYCLIN_RxL_1	224	234	PF00134	0.607
DOC_MAPK_gen_1	146	152	PF00069	0.508
DOC_PP1_RVXF_1	128	135	PF00149	0.468
DOC_PP4_FxxP_1	219	222	PF00568	0.589
DOC_USP7_MATH_1	103	107	PF00917	0.423
DOC_USP7_MATH_1	292	296	PF00917	0.791
DOC_USP7_MATH_1	345	349	PF00917	0.726
DOC_USP7_MATH_1	413	417	PF00917	0.764
DOC_WW_Pin1_4	187	192	PF00397	0.532
DOC_WW_Pin1_4	247	252	PF00397	0.763
DOC_WW_Pin1_4	324	329	PF00397	0.688
DOC_WW_Pin1_4	374	379	PF00397	0.755
DOC_WW_Pin1_4	388	393	PF00397	0.716
DOC_WW_Pin1_4	50	55	PF00397	0.488
LIG_14-3-3_CanoR_1	18	26	PF00244	0.483
LIG_14-3-3_CanoR_1	329	333	PF00244	0.767
LIG_14-3-3_CanoR_1	368	378	PF00244	0.707
LIG_Actin_RPEL_3	123	142	PF02755	0.467
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_EH_1	343	347	PF12763	0.742
LIG_EH1_1	21	29	PF00400	0.254
LIG_EH1_1	223	231	PF00400	0.600
LIG_eIF4E_1	145	151	PF01652	0.584
LIG_eIF4E_1	224	230	PF01652	0.595
LIG_FHA_1	18	24	PF00498	0.485
LIG_FHA_1	384	390	PF00498	0.747
LIG_FHA_1	406	412	PF00498	0.710
LIG_FHA_1	51	57	PF00498	0.487
LIG_FHA_1	92	98	PF00498	0.562
LIG_FHA_2	285	291	PF00498	0.749
LIG_LIR_Gen_1	115	125	PF02991	0.256
LIG_LIR_Gen_1	348	355	PF02991	0.718
LIG_LIR_Gen_1	416	423	PF02991	0.644
LIG_LIR_Gen_1	58	66	PF02991	0.483
LIG_LIR_Nem_3	115	120	PF02991	0.275
LIG_LIR_Nem_3	348	353	PF02991	0.718
LIG_LIR_Nem_3	416	422	PF02991	0.747
LIG_NRBOX	22	28	PF00104	0.254
LIG_PCNA_PIPBox_1	125	134	PF02747	0.467
LIG_SH2_CRK	350	354	PF00017	0.750
LIG_SH2_CRK	51	55	PF00017	0.501
LIG_SH2_NCK_1	350	354	PF00017	0.750
LIG_SH2_PTP2	419	422	PF00017	0.641
LIG_SH2_SRC	38	41	PF00017	0.428
LIG_SH2_STAT3	225	228	PF00017	0.595
LIG_SH2_STAT5	225	228	PF00017	0.595
LIG_SH2_STAT5	419	422	PF00017	0.641
LIG_SH2_STAT5	48	51	PF00017	0.492
LIG_SH3_3	386	392	PF00018	0.762
LIG_SH3_3	62	68	PF00018	0.547
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.368
LIG_TRAF2_1	270	273	PF00917	0.725
LIG_TRAF2_1	400	403	PF00917	0.733
MOD_CDK_SPK_2	324	329	PF00069	0.666
MOD_CDK_SPxxK_3	374	381	PF00069	0.725
MOD_CK1_1	247	253	PF00069	0.750
MOD_CK1_1	255	261	PF00069	0.687
MOD_CK1_1	299	305	PF00069	0.698
MOD_CK1_1	308	314	PF00069	0.669
MOD_CK1_1	327	333	PF00069	0.708
MOD_CK1_1	335	341	PF00069	0.711
MOD_CK1_1	348	354	PF00069	0.742
MOD_CK1_1	372	378	PF00069	0.661
MOD_CK1_1	391	397	PF00069	0.685
MOD_CK2_1	228	234	PF00069	0.581
MOD_CK2_1	247	253	PF00069	0.732
MOD_GlcNHglycan	125	128	PF01048	0.484
MOD_GlcNHglycan	2	5	PF01048	0.506
MOD_GlcNHglycan	212	215	PF01048	0.348
MOD_GlcNHglycan	230	233	PF01048	0.412
MOD_GlcNHglycan	246	249	PF01048	0.501
MOD_GlcNHglycan	260	263	PF01048	0.441
MOD_GlcNHglycan	294	297	PF01048	0.557
MOD_GlcNHglycan	32	35	PF01048	0.368
MOD_GlcNHglycan	334	337	PF01048	0.497
MOD_GlcNHglycan	374	377	PF01048	0.548
MOD_GlcNHglycan	408	411	PF01048	0.585
MOD_GlcNHglycan	78	81	PF01048	0.690
MOD_GSK3_1	119	126	PF00069	0.385
MOD_GSK3_1	249	256	PF00069	0.750
MOD_GSK3_1	258	265	PF00069	0.675
MOD_GSK3_1	292	299	PF00069	0.726
MOD_GSK3_1	304	311	PF00069	0.656
MOD_GSK3_1	320	327	PF00069	0.738
MOD_GSK3_1	328	335	PF00069	0.701
MOD_GSK3_1	368	375	PF00069	0.838
MOD_N-GLC_1	304	309	PF02516	0.436
MOD_N-GLC_1	91	96	PF02516	0.675
MOD_NEK2_1	112	117	PF00069	0.449
MOD_NEK2_1	119	124	PF00069	0.434
MOD_NEK2_1	22	27	PF00069	0.359
MOD_NEK2_1	30	35	PF00069	0.337
MOD_NEK2_1	332	337	PF00069	0.684
MOD_NEK2_1	369	374	PF00069	0.680
MOD_NEK2_2	328	333	PF00069	0.688
MOD_OFUCOSY	83	90	PF10250	0.668
MOD_PKA_2	17	23	PF00069	0.532
MOD_PKA_2	328	334	PF00069	0.754
MOD_PKA_2	348	354	PF00069	0.799
MOD_Plk_1	171	177	PF00069	0.550
MOD_Plk_1	252	258	PF00069	0.648
MOD_Plk_4	103	109	PF00069	0.299
MOD_Plk_4	112	118	PF00069	0.294
MOD_Plk_4	119	125	PF00069	0.256
MOD_Plk_4	22	28	PF00069	0.345
MOD_Plk_4	9	15	PF00069	0.634
MOD_Plk_4	93	99	PF00069	0.412
MOD_ProDKin_1	187	193	PF00069	0.532
MOD_ProDKin_1	247	253	PF00069	0.764
MOD_ProDKin_1	324	330	PF00069	0.689
MOD_ProDKin_1	374	380	PF00069	0.755
MOD_ProDKin_1	388	394	PF00069	0.716
MOD_ProDKin_1	50	56	PF00069	0.487
MOD_SUMO_for_1	159	162	PF00179	0.622
MOD_SUMO_rev_2	162	171	PF00179	0.631
MOD_SUMO_rev_2	64	73	PF00179	0.447
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.553
TRG_ENDOCYTIC_2	350	353	PF00928	0.750
TRG_ENDOCYTIC_2	419	422	PF00928	0.669
TRG_ENDOCYTIC_2	59	62	PF00928	0.586
TRG_ER_diArg_1	139	141	PF00400	0.600
TRG_ER_diArg_1	145	148	PF00400	0.561
TRG_ER_diArg_1	346	349	PF00400	0.744
TRG_ER_diArg_1	380	382	PF00400	0.731
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQW1	Leishmania donovani	91%	100%
A4H5U9	Leishmania braziliensis	66%	100%
A4HU43	Leishmania infantum	91%	100%
E9AMX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%