Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHQ2_LEIMA

TriTrypDb:

LmjF.09.1230 , LMJLV39_090019600 , LMJSD75_090019200

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHQ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.553
CLV_C14_Caspase3-7	128	132	PF00656	0.576
CLV_C14_Caspase3-7	191	195	PF00656	0.539
CLV_MEL_PAP_1	330	336	PF00089	0.669
CLV_NRD_NRD_1	285	287	PF00675	0.645
CLV_NRD_NRD_1	294	296	PF00675	0.662
CLV_NRD_NRD_1	332	334	PF00675	0.656
CLV_NRD_NRD_1	79	81	PF00675	0.469
CLV_PCSK_FUR_1	77	81	PF00082	0.473
CLV_PCSK_KEX2_1	123	125	PF00082	0.750
CLV_PCSK_KEX2_1	285	287	PF00082	0.645
CLV_PCSK_KEX2_1	294	296	PF00082	0.662
CLV_PCSK_KEX2_1	332	334	PF00082	0.656
CLV_PCSK_KEX2_1	79	81	PF00082	0.469
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.750
CLV_PCSK_SKI1_1	161	165	PF00082	0.721
CLV_PCSK_SKI1_1	286	290	PF00082	0.620
DEG_SPOP_SBC_1	349	353	PF00917	0.486
DEG_SPOP_SBC_1	46	50	PF00917	0.703
DOC_ANK_TNKS_1	294	301	PF00023	0.491
DOC_ANK_TNKS_1	365	372	PF00023	0.504
DOC_CDC14_PxL_1	198	206	PF14671	0.570
DOC_CDC14_PxL_1	306	314	PF14671	0.439
DOC_CYCLIN_yCln2_LP_2	200	203	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	61	64	PF00134	0.648
DOC_MAPK_gen_1	332	339	PF00069	0.483
DOC_MAPK_gen_1	77	87	PF00069	0.681
DOC_MAPK_MEF2A_6	154	162	PF00069	0.514
DOC_MAPK_MEF2A_6	263	272	PF00069	0.455
DOC_MAPK_MEF2A_6	80	89	PF00069	0.524
DOC_PP2B_LxvP_1	200	203	PF13499	0.491
DOC_PP2B_LxvP_1	36	39	PF13499	0.719
DOC_PP2B_LxvP_1	60	63	PF13499	0.727
DOC_PP4_FxxP_1	16	19	PF00568	0.726
DOC_PP4_FxxP_1	99	102	PF00568	0.528
DOC_SPAK_OSR1_1	333	337	PF12202	0.485
DOC_USP7_MATH_1	12	16	PF00917	0.789
DOC_USP7_MATH_1	135	139	PF00917	0.457
DOC_USP7_MATH_1	246	250	PF00917	0.487
DOC_USP7_MATH_1	308	312	PF00917	0.462
DOC_USP7_MATH_1	378	382	PF00917	0.514
DOC_USP7_MATH_1	432	436	PF00917	0.506
DOC_USP7_MATH_1	47	51	PF00917	0.812
DOC_USP7_UBL2_3	386	390	PF12436	0.420
DOC_WW_Pin1_4	264	269	PF00397	0.492
DOC_WW_Pin1_4	54	59	PF00397	0.727
DOC_WW_Pin1_4	8	13	PF00397	0.761
LIG_14-3-3_CanoR_1	124	130	PF00244	0.536
LIG_14-3-3_CanoR_1	7	12	PF00244	0.801
LIG_APCC_ABBA_1	160	165	PF00400	0.518
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_4	111	115	PF00653	0.574
LIG_BRCT_BRCA1_1	91	95	PF00533	0.436
LIG_eIF4E_1	276	282	PF01652	0.460
LIG_EVH1_1	201	205	PF00568	0.556
LIG_FHA_1	151	157	PF00498	0.425
LIG_FHA_1	259	265	PF00498	0.534
LIG_FHA_1	349	355	PF00498	0.520
LIG_FHA_1	362	368	PF00498	0.480
LIG_FHA_1	399	405	PF00498	0.511
LIG_FHA_1	88	94	PF00498	0.433
LIG_FHA_2	345	351	PF00498	0.407
LIG_FHA_2	81	87	PF00498	0.539
LIG_GBD_Chelix_1	24	32	PF00786	0.480
LIG_LIR_Apic_2	14	19	PF02991	0.729
LIG_LIR_Apic_2	165	170	PF02991	0.544
LIG_LIR_Apic_2	342	346	PF02991	0.456
LIG_LIR_Gen_1	267	277	PF02991	0.473
LIG_LIR_Gen_1	90	99	PF02991	0.429
LIG_LIR_Nem_3	267	272	PF02991	0.472
LIG_LIR_Nem_3	274	279	PF02991	0.466
LIG_LIR_Nem_3	413	419	PF02991	0.580
LIG_LIR_Nem_3	90	94	PF02991	0.400
LIG_LYPXL_yS_3	309	312	PF13949	0.438
LIG_MLH1_MIPbox_1	91	95	PF16413	0.436
LIG_MYND_1	199	203	PF01753	0.497
LIG_PCNA_yPIPBox_3	324	333	PF02747	0.444
LIG_Pex14_1	219	223	PF04695	0.458
LIG_Pex14_2	163	167	PF04695	0.526
LIG_Pex14_2	94	98	PF04695	0.415
LIG_Pex14_2	99	103	PF04695	0.550
LIG_PTAP_UEV_1	345	350	PF05743	0.467
LIG_PTB_Apo_2	263	270	PF02174	0.512
LIG_SH2_CRK	152	156	PF00017	0.508
LIG_SH2_CRK	276	280	PF00017	0.459
LIG_SH2_CRK	343	347	PF00017	0.466
LIG_SH2_NCK_1	343	347	PF00017	0.535
LIG_SH2_STAP1	152	156	PF00017	0.508
LIG_SH2_STAP1	321	325	PF00017	0.432
LIG_SH2_STAP1	81	85	PF00017	0.546
LIG_SH2_STAP1	91	95	PF00017	0.411
LIG_SH2_STAT3	321	324	PF00017	0.431
LIG_SH2_STAT5	152	155	PF00017	0.442
LIG_SH2_STAT5	343	346	PF00017	0.462
LIG_SH2_STAT5	355	358	PF00017	0.507
LIG_SH3_1	343	349	PF00018	0.460
LIG_SH3_2	310	315	PF14604	0.452
LIG_SH3_3	15	21	PF00018	0.743
LIG_SH3_3	152	158	PF00018	0.504
LIG_SH3_3	196	202	PF00018	0.476
LIG_SH3_3	307	313	PF00018	0.448
LIG_SH3_3	343	349	PF00018	0.460
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.474
LIG_SUMO_SIM_anti_2	56	63	PF11976	0.644
LIG_TRAF2_1	435	438	PF00917	0.457
LIG_TRAF2_1	50	53	PF00917	0.780
LIG_UBA3_1	280	289	PF00899	0.434
LIG_WW_2	202	205	PF00397	0.555
MOD_CK2_1	344	350	PF00069	0.436
MOD_CK2_1	432	438	PF00069	0.550
MOD_CK2_1	47	53	PF00069	0.838
MOD_CK2_1	80	86	PF00069	0.591
MOD_Cter_Amidation	77	80	PF01082	0.479
MOD_GlcNHglycan	137	140	PF01048	0.617
MOD_GlcNHglycan	182	185	PF01048	0.704
MOD_GlcNHglycan	236	239	PF01048	0.727
MOD_GlcNHglycan	242	247	PF01048	0.706
MOD_GlcNHglycan	421	424	PF01048	0.784
MOD_GlcNHglycan	49	52	PF01048	0.608
MOD_GSK3_1	242	249	PF00069	0.470
MOD_GSK3_1	335	342	PF00069	0.509
MOD_GSK3_1	344	351	PF00069	0.434
MOD_GSK3_1	7	14	PF00069	0.781
MOD_N-GLC_1	264	269	PF02516	0.764
MOD_NEK2_1	339	344	PF00069	0.448
MOD_NEK2_1	419	424	PF00069	0.520
MOD_NEK2_1	89	94	PF00069	0.436
MOD_PKA_2	225	231	PF00069	0.497
MOD_PKA_2	344	350	PF00069	0.457
MOD_PKA_2	378	384	PF00069	0.526
MOD_PKA_2	6	12	PF00069	0.727
MOD_Plk_1	349	355	PF00069	0.421
MOD_Plk_2-3	433	439	PF00069	0.487
MOD_Plk_4	12	18	PF00069	0.738
MOD_Plk_4	323	329	PF00069	0.412
MOD_Plk_4	350	356	PF00069	0.526
MOD_Plk_4	89	95	PF00069	0.398
MOD_ProDKin_1	264	270	PF00069	0.491
MOD_ProDKin_1	54	60	PF00069	0.727
MOD_ProDKin_1	8	14	PF00069	0.759
MOD_SUMO_for_1	367	370	PF00179	0.497
MOD_SUMO_for_1	405	408	PF00179	0.443
TRG_DiLeu_BaEn_1	275	280	PF01217	0.425
TRG_DiLeu_BaEn_1	56	61	PF01217	0.654
TRG_DiLeu_BaEn_2	29	35	PF01217	0.714
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.516
TRG_ENDOCYTIC_2	152	155	PF00928	0.400
TRG_ENDOCYTIC_2	276	279	PF00928	0.467
TRG_ENDOCYTIC_2	309	312	PF00928	0.438
TRG_ENDOCYTIC_2	91	94	PF00928	0.513
TRG_ER_diArg_1	284	286	PF00400	0.444
TRG_ER_diArg_1	331	333	PF00400	0.460
TRG_ER_diArg_1	376	379	PF00400	0.596
TRG_ER_diArg_1	76	79	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.754
TRG_PTS1	438	441	PF00515	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P570	Leptomonas seymouri	42%	100%
A0A3S7WQU3	Leishmania donovani	91%	100%
A4H5V1	Leishmania braziliensis	65%	100%
A4HU45	Leishmania infantum	91%	100%
E9AMX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%