Dual specificity protein phosphatase 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHQ0_LEIMA

TriTrypDb:

LmjF.09.1250 , LMJLV39_090019800 , LMJSD75_090019400

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHQ0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.603
CLV_PCSK_KEX2_1	70	72	PF00082	0.602
CLV_PCSK_SKI1_1	65	69	PF00082	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.741
DOC_CKS1_1	153	158	PF01111	0.403
DOC_MAPK_gen_1	45	54	PF00069	0.388
DOC_PP4_FxxP_1	99	102	PF00568	0.355
DOC_USP7_MATH_1	115	119	PF00917	0.534
DOC_USP7_MATH_1	179	183	PF00917	0.688
DOC_USP7_MATH_1	25	29	PF00917	0.678
DOC_USP7_MATH_1	74	78	PF00917	0.629
DOC_USP7_MATH_1	9	13	PF00917	0.694
DOC_WW_Pin1_4	102	107	PF00397	0.422
DOC_WW_Pin1_4	152	157	PF00397	0.386
DOC_WW_Pin1_4	169	174	PF00397	0.504
LIG_FHA_1	103	109	PF00498	0.530
LIG_FHA_2	28	34	PF00498	0.657
LIG_LIR_Apic_2	96	102	PF02991	0.367
LIG_SH2_STAT5	128	131	PF00017	0.383
LIG_SH3_3	118	124	PF00018	0.560
LIG_SH3_3	19	25	PF00018	0.673
LIG_SH3_3	53	59	PF00018	0.482
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.314
MOD_CDK_SPxxK_3	152	159	PF00069	0.398
MOD_CK1_1	146	152	PF00069	0.374
MOD_CK2_1	87	93	PF00069	0.589
MOD_GlcNHglycan	11	14	PF01048	0.597
MOD_GlcNHglycan	117	120	PF01048	0.468
MOD_GlcNHglycan	174	177	PF01048	0.676
MOD_GlcNHglycan	4	7	PF01048	0.706
MOD_GlcNHglycan	85	88	PF01048	0.636
MOD_GlcNHglycan	89	92	PF01048	0.563
MOD_GSK3_1	139	146	PF00069	0.394
MOD_GSK3_1	168	175	PF00069	0.587
MOD_GSK3_1	83	90	PF00069	0.597
MOD_N-GLC_1	115	120	PF02516	0.571
MOD_N-GLC_1	63	68	PF02516	0.652
MOD_N-GLC_1	82	87	PF02516	0.496
MOD_NEK2_1	168	173	PF00069	0.626
MOD_NEK2_2	179	184	PF00069	0.626
MOD_NEK2_2	63	68	PF00069	0.659
MOD_PIKK_1	143	149	PF00454	0.458
MOD_Plk_1	63	69	PF00069	0.614
MOD_Plk_4	123	129	PF00069	0.408
MOD_Plk_4	94	100	PF00069	0.380
MOD_ProDKin_1	102	108	PF00069	0.420
MOD_ProDKin_1	152	158	PF00069	0.380
MOD_ProDKin_1	169	175	PF00069	0.511
TRG_ER_diArg_1	132	135	PF00400	0.469
TRG_ER_diArg_1	45	48	PF00400	0.390
TRG_ER_diArg_1	69	71	PF00400	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S9	Leptomonas seymouri	64%	100%
A0A0S4JFW8	Bodo saltans	42%	100%
A0A1X0NI01	Trypanosomatidae	52%	100%
A0A3S7WQX0	Leishmania donovani	91%	100%
A0A422NZK2	Trypanosoma rangeli	52%	100%
A4H5V3	Leishmania braziliensis	74%	99%
A4HU47	Leishmania infantum	91%	100%
D0A9M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	93%
E9AMX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q570P7	Arabidopsis thaliana	26%	100%
V5BMP4	Trypanosoma cruzi	52%	100%