Putative mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

Q4QHP8_LEIMA

TriTrypDb:

LmjF.09.1270 , LMJLV39_090020000 , LMJSD75_090019600

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QHP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHP8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0022857	transmembrane transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.635
CLV_PCSK_KEX2_1	340	342	PF00082	0.648
CLV_PCSK_KEX2_1	99	101	PF00082	0.253
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.590
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.253
CLV_PCSK_SKI1_1	20	24	PF00082	0.519
DEG_SPOP_SBC_1	246	250	PF00917	0.455
DOC_CKS1_1	8	13	PF01111	0.399
DOC_CYCLIN_RxL_1	97	108	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.518
DOC_MAPK_MEF2A_6	87	95	PF00069	0.440
DOC_PP1_RVXF_1	214	221	PF00149	0.312
DOC_PP1_RVXF_1	98	105	PF00149	0.287
DOC_PP4_FxxP_1	236	239	PF00568	0.382
DOC_USP7_MATH_1	117	121	PF00917	0.442
DOC_USP7_MATH_1	240	244	PF00917	0.558
DOC_USP7_MATH_1	271	275	PF00917	0.439
DOC_USP7_MATH_1	4	8	PF00917	0.498
DOC_USP7_MATH_1	98	102	PF00917	0.437
DOC_WW_Pin1_4	7	12	PF00397	0.412
LIG_14-3-3_CanoR_1	188	198	PF00244	0.460
LIG_14-3-3_CanoR_1	260	265	PF00244	0.397
LIG_BRCT_BRCA1_1	100	104	PF00533	0.287
LIG_BRCT_BRCA1_1	151	155	PF00533	0.282
LIG_Clathr_ClatBox_1	281	285	PF01394	0.396
LIG_deltaCOP1_diTrp_1	108	113	PF00928	0.270
LIG_FHA_1	192	198	PF00498	0.469
LIG_FHA_1	275	281	PF00498	0.273
LIG_FHA_1	41	47	PF00498	0.238
LIG_FHA_1	51	57	PF00498	0.530
LIG_FHA_1	8	14	PF00498	0.506
LIG_FHA_2	181	187	PF00498	0.406
LIG_FHA_2	242	248	PF00498	0.503
LIG_LIR_Apic_2	233	239	PF02991	0.347
LIG_LIR_Apic_2	5	11	PF02991	0.393
LIG_LIR_Gen_1	18	29	PF02991	0.483
LIG_LIR_Gen_1	217	228	PF02991	0.208
LIG_LIR_Nem_3	18	24	PF02991	0.491
LIG_LIR_Nem_3	201	207	PF02991	0.494
LIG_LIR_Nem_3	222	227	PF02991	0.231
LIG_LIR_Nem_3	277	281	PF02991	0.277
LIG_LIR_Nem_3	83	89	PF02991	0.427
LIG_PCNA_yPIPBox_3	99	110	PF02747	0.347
LIG_Pex14_1	109	113	PF04695	0.270
LIG_Pex14_1	278	282	PF04695	0.253
LIG_Pex14_2	206	210	PF04695	0.396
LIG_SH2_CRK	228	232	PF00017	0.318
LIG_SH2_CRK	310	314	PF00017	0.416
LIG_SH2_CRK	86	90	PF00017	0.411
LIG_SH2_STAT5	224	227	PF00017	0.216
LIG_SH3_3	23	29	PF00018	0.308
LIG_SH3_3	3	9	PF00018	0.415
LIG_SH3_3	86	92	PF00018	0.411
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.324
LIG_TYR_ITIM	308	313	PF00017	0.518
LIG_UBA3_1	23	28	PF00899	0.378
LIG_UBA3_1	280	288	PF00899	0.254
MOD_CK1_1	241	247	PF00069	0.475
MOD_CK1_1	259	265	PF00069	0.330
MOD_CK1_1	274	280	PF00069	0.211
MOD_CK1_1	7	13	PF00069	0.469
MOD_CK2_1	241	247	PF00069	0.486
MOD_GlcNHglycan	116	120	PF01048	0.625
MOD_GlcNHglycan	240	243	PF01048	0.696
MOD_GlcNHglycan	268	271	PF01048	0.362
MOD_GlcNHglycan	323	326	PF01048	0.343
MOD_GlcNHglycan	59	62	PF01048	0.335
MOD_GSK3_1	176	183	PF00069	0.432
MOD_GSK3_1	189	196	PF00069	0.437
MOD_GSK3_1	241	248	PF00069	0.472
MOD_GSK3_1	249	256	PF00069	0.464
MOD_GSK3_1	62	69	PF00069	0.426
MOD_GSK3_1	72	79	PF00069	0.386
MOD_NEK2_1	313	318	PF00069	0.287
MOD_NEK2_2	193	198	PF00069	0.453
MOD_NEK2_2	219	224	PF00069	0.208
MOD_NEK2_2	283	288	PF00069	0.253
MOD_PIKK_1	176	182	PF00454	0.416
MOD_PKA_1	260	266	PF00069	0.450
MOD_PKA_2	256	262	PF00069	0.458
MOD_PKA_2	66	72	PF00069	0.470
MOD_Plk_4	151	157	PF00069	0.288
MOD_Plk_4	163	169	PF00069	0.226
MOD_Plk_4	219	225	PF00069	0.246
MOD_Plk_4	27	33	PF00069	0.357
MOD_Plk_4	286	292	PF00069	0.483
MOD_Plk_4	313	319	PF00069	0.268
MOD_Plk_4	41	47	PF00069	0.231
MOD_Plk_4	69	75	PF00069	0.458
MOD_Plk_4	81	87	PF00069	0.439
MOD_ProDKin_1	7	13	PF00069	0.409
MOD_SUMO_rev_2	17	22	PF00179	0.318
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.289
TRG_ENDOCYTIC_2	207	210	PF00928	0.299
TRG_ENDOCYTIC_2	224	227	PF00928	0.271
TRG_ENDOCYTIC_2	228	231	PF00928	0.259
TRG_ENDOCYTIC_2	310	313	PF00928	0.416
TRG_ENDOCYTIC_2	86	89	PF00928	0.411
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	23%	100%
A0A0N0P7X0	Leptomonas seymouri	24%	100%
A0A0N0P7Y4	Leptomonas seymouri	22%	100%
A0A0N1HX25	Leptomonas seymouri	61%	96%
A0A0N1IMA2	Leptomonas seymouri	22%	100%
A0A0S4IV98	Bodo saltans	25%	100%
A0A0S4IZG7	Bodo saltans	24%	99%
A0A0S4J045	Bodo saltans	24%	97%
A0A0S4JIA4	Bodo saltans	26%	81%
A0A0S4JM95	Bodo saltans	23%	100%
A0A0S4JQI3	Bodo saltans	39%	96%
A0A1X0NFT4	Trypanosomatidae	25%	100%
A0A1X0NIA3	Trypanosomatidae	48%	100%
A0A1X0NJD2	Trypanosomatidae	25%	100%
A0A1X0NLW7	Trypanosomatidae	25%	100%
A0A1X0P4Q9	Trypanosomatidae	25%	100%
A0A3R7KGU8	Trypanosoma rangeli	24%	100%
A0A3R7N0M4	Trypanosoma rangeli	49%	99%
A0A3R7RT89	Trypanosoma rangeli	24%	100%
A0A3S5H6E6	Leishmania donovani	91%	100%
A0A3S7WYS1	Leishmania donovani	22%	100%
A0A422NF39	Trypanosoma rangeli	23%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	25%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	100%
A2ASZ8	Mus musculus	23%	74%
A2CEQ0	Danio rerio	22%	74%
A2R5A0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	100%
A3LVX1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	23%	100%
A4H5V5	Leishmania braziliensis	75%	99%
A4H8E6	Leishmania braziliensis	21%	100%
A4HU49	Leishmania infantum	91%	100%
A4I163	Leishmania infantum	22%	100%
A4QNX2	Danio rerio	25%	100%
A4RPU0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	100%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	24%	99%
A6RF73	Ajellomyces capsulatus (strain NAm1 / WU24)	26%	100%
A7TIQ0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	24%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	22%	100%
B2VSU4	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	25%	100%
B8ZHC9	Rattus norvegicus	23%	100%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZYS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A728	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A9N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AMX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AX97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
F1R4U0	Danio rerio	21%	100%
O94370	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
O97562	Sus scrofa	24%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P38087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P55916	Homo sapiens	22%	100%
P56499	Rattus norvegicus	23%	100%
P56500	Rattus norvegicus	26%	100%
P56501	Mus musculus	23%	100%
P70406	Mus musculus	26%	100%
Q08DK7	Bos taurus	25%	100%
Q0CEN9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0UUH1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	100%
Q0V7M4	Bos taurus	24%	74%
Q10248	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	24%	99%
Q1E7P0	Coccidioides immitis (strain RS)	26%	100%
Q1LZB3	Bos taurus	23%	100%
Q23125	Caenorhabditis elegans	23%	100%
Q287T7	Danio rerio	24%	100%
Q29RM1	Bos taurus	23%	100%
Q2H608	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	22%	100%
Q3SZI5	Bos taurus	25%	100%
Q3TZX3	Mus musculus	21%	100%
Q4QA75	Leishmania major	23%	93%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	22%	100%
Q54BM3	Dictyostelium discoideum	22%	100%
Q54FE6	Dictyostelium discoideum	22%	100%
Q54S10	Dictyostelium discoideum	21%	88%
Q55E45	Dictyostelium discoideum	23%	100%
Q55E85	Dictyostelium discoideum	22%	100%
Q59Q36	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	100%
Q5AVW1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5B717	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5HZE0	Rattus norvegicus	24%	100%
Q5XH95	Xenopus tropicalis	23%	67%
Q5XHA0	Xenopus tropicalis	23%	73%
Q66H23	Rattus norvegicus	22%	100%
Q6C6I3	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q6CNY8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6FR88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q6GQS1	Mus musculus	24%	74%
Q6KCM7	Homo sapiens	24%	74%
Q6NYZ6	Danio rerio	23%	74%
Q74Z23	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
Q75EP3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q7K566	Drosophila melanogaster	23%	100%
Q7S2H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q7T0U6	Xenopus laevis	23%	73%
Q7T292	Danio rerio	23%	92%
Q7ZY36	Xenopus laevis	23%	73%
Q7ZYD5	Xenopus laevis	23%	67%
Q86AV5	Dictyostelium discoideum	23%	100%
Q86HN8	Dictyostelium discoideum	25%	79%
Q8BL03	Mus musculus	24%	100%
Q8BMD8	Mus musculus	22%	73%
Q8BVN7	Mus musculus	22%	100%
Q8BW66	Mus musculus	22%	100%
Q8BZ09	Mus musculus	23%	100%
Q8K3P6	Rattus norvegicus	23%	74%
Q8N5S1	Homo sapiens	24%	93%
Q8N8R3	Homo sapiens	24%	100%
Q8R0Z5	Mus musculus	24%	95%
Q920G8	Mus musculus	22%	100%
Q96A46	Homo sapiens	24%	95%
Q96U08	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	99%
Q9BSK2	Homo sapiens	23%	100%
Q9BV35	Homo sapiens	25%	74%
Q9BXI2	Homo sapiens	25%	100%
Q9CA93	Arabidopsis thaliana	27%	100%
Q9FLS8	Arabidopsis thaliana	23%	72%
Q9GMZ1	Canis lupus familiaris	24%	100%
Q9LJX5	Arabidopsis thaliana	21%	99%
Q9LY28	Arabidopsis thaliana	22%	72%
Q9N2J1	Canis lupus familiaris	25%	100%
Q9NYZ2	Homo sapiens	23%	100%
Q9P3T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9VAY3	Drosophila melanogaster	23%	91%
Q9VQG4	Drosophila melanogaster	24%	100%
Q9W720	Danio rerio	25%	100%
Q9W725	Cyprinus carpio	24%	100%
Q9WVD5	Mus musculus	23%	100%
Q9Y619	Homo sapiens	24%	100%
V5BDR1	Trypanosoma cruzi	24%	100%
V5BI33	Trypanosoma cruzi	51%	100%
V5BSW1	Trypanosoma cruzi	23%	100%
V5BVW0	Trypanosoma cruzi	25%	100%