RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHP6_LEIMA

TriTrypDb:

LmjF.09.1290 , LMJLV39_090020200 , LMJSD75_090019800

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.670
CLV_C14_Caspase3-7	366	370	PF00656	0.685
CLV_C14_Caspase3-7	46	50	PF00656	0.681
CLV_C14_Caspase3-7	473	477	PF00656	0.615
CLV_NRD_NRD_1	143	145	PF00675	0.745
CLV_NRD_NRD_1	196	198	PF00675	0.416
CLV_PCSK_KEX2_1	143	145	PF00082	0.745
CLV_PCSK_KEX2_1	196	198	PF00082	0.416
CLV_PCSK_KEX2_1	361	363	PF00082	0.722
CLV_PCSK_KEX2_1	576	578	PF00082	0.809
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.819
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.809
CLV_PCSK_SKI1_1	349	353	PF00082	0.624
CLV_PCSK_SKI1_1	448	452	PF00082	0.460
CLV_PCSK_SKI1_1	583	587	PF00082	0.740
DEG_COP1_1	101	111	PF00400	0.572
DEG_COP1_1	279	288	PF00400	0.841
DEG_SCF_FBW7_1	483	490	PF00400	0.624
DEG_SPOP_SBC_1	288	292	PF00917	0.836
DOC_CYCLIN_RxL_1	236	247	PF00134	0.588
DOC_MAPK_gen_1	499	507	PF00069	0.582
DOC_MAPK_MEF2A_6	399	408	PF00069	0.489
DOC_MAPK_MEF2A_6	499	507	PF00069	0.582
DOC_PP1_RVXF_1	237	244	PF00149	0.593
DOC_PP1_RVXF_1	497	503	PF00149	0.571
DOC_PP2B_LxvP_1	299	302	PF13499	0.701
DOC_PP2B_LxvP_1	505	508	PF13499	0.520
DOC_PP2B_LxvP_1	549	552	PF13499	0.516
DOC_PP4_FxxP_1	214	217	PF00568	0.732
DOC_USP7_MATH_1	14	18	PF00917	0.671
DOC_USP7_MATH_1	261	265	PF00917	0.704
DOC_USP7_MATH_1	335	339	PF00917	0.709
DOC_USP7_MATH_1	381	385	PF00917	0.491
DOC_USP7_MATH_1	48	52	PF00917	0.789
DOC_USP7_MATH_1	487	491	PF00917	0.613
DOC_USP7_MATH_1	510	514	PF00917	0.643
DOC_USP7_MATH_1	523	527	PF00917	0.518
DOC_USP7_MATH_1	553	557	PF00917	0.632
DOC_USP7_MATH_1	575	579	PF00917	0.605
DOC_USP7_MATH_1	71	75	PF00917	0.539
DOC_WW_Pin1_4	101	106	PF00397	0.584
DOC_WW_Pin1_4	213	218	PF00397	0.617
DOC_WW_Pin1_4	289	294	PF00397	0.777
DOC_WW_Pin1_4	355	360	PF00397	0.712
DOC_WW_Pin1_4	370	375	PF00397	0.647
DOC_WW_Pin1_4	483	488	PF00397	0.692
DOC_WW_Pin1_4	67	72	PF00397	0.527
DOC_WW_Pin1_4	79	84	PF00397	0.568
LIG_14-3-3_CanoR_1	228	234	PF00244	0.479
LIG_14-3-3_CanoR_1	437	442	PF00244	0.622
LIG_14-3-3_CanoR_1	577	585	PF00244	0.593
LIG_Actin_WH2_2	229	244	PF00022	0.586
LIG_BIR_III_4	457	461	PF00653	0.488
LIG_BIR_III_4	568	572	PF00653	0.800
LIG_CSL_BTD_1	402	405	PF09270	0.459
LIG_deltaCOP1_diTrp_1	160	171	PF00928	0.632
LIG_EABR_CEP55_1	15	24	PF12180	0.736
LIG_FHA_1	232	238	PF00498	0.559
LIG_FHA_1	290	296	PF00498	0.822
LIG_FHA_1	331	337	PF00498	0.589
LIG_FHA_1	546	552	PF00498	0.505
LIG_FHA_2	326	332	PF00498	0.704
LIG_FHA_2	387	393	PF00498	0.577
LIG_FHA_2	44	50	PF00498	0.672
LIG_FHA_2	484	490	PF00498	0.773
LIG_LIR_Apic_2	211	217	PF02991	0.732
LIG_LIR_Gen_1	314	321	PF02991	0.537
LIG_LIR_Gen_1	99	108	PF02991	0.693
LIG_LIR_LC3C_4	449	453	PF02991	0.443
LIG_LIR_Nem_3	161	167	PF02991	0.644
LIG_LIR_Nem_3	314	320	PF02991	0.538
LIG_LIR_Nem_3	99	103	PF02991	0.684
LIG_MAD2	407	415	PF02301	0.610
LIG_MYND_1	293	297	PF01753	0.816
LIG_NRBOX	236	242	PF00104	0.549
LIG_PDZ_Class_2	582	587	PF00595	0.737
LIG_Pex14_2	167	171	PF04695	0.585
LIG_SH2_CRK	100	104	PF00017	0.760
LIG_SH2_CRK	317	321	PF00017	0.388
LIG_SH2_NCK_1	100	104	PF00017	0.760
LIG_SH2_SRC	187	190	PF00017	0.596
LIG_SH2_STAP1	396	400	PF00017	0.475
LIG_SH2_STAP1	419	423	PF00017	0.460
LIG_SH2_STAT5	100	103	PF00017	0.755
LIG_SH2_STAT5	531	534	PF00017	0.478
LIG_SH3_3	282	288	PF00018	0.801
LIG_SH3_3	290	296	PF00018	0.643
LIG_SH3_3	298	304	PF00018	0.700
LIG_SH3_3	33	39	PF00018	0.586
LIG_SH3_3	423	429	PF00018	0.515
LIG_SUMO_SIM_anti_2	449	454	PF11976	0.443
LIG_SUMO_SIM_par_1	30	35	PF11976	0.675
LIG_TRAF2_1	254	257	PF00917	0.647
LIG_TRAF2_1	52	55	PF00917	0.800
LIG_WW_3	302	306	PF00397	0.538
MOD_CDC14_SPxK_1	358	361	PF00782	0.797
MOD_CDK_SPK_2	289	294	PF00069	0.837
MOD_CDK_SPxK_1	101	107	PF00069	0.568
MOD_CDK_SPxK_1	355	361	PF00069	0.717
MOD_CDK_SPxxK_3	355	362	PF00069	0.793
MOD_CDK_SPxxK_3	79	86	PF00069	0.538
MOD_CK1_1	173	179	PF00069	0.674
MOD_CK1_1	213	219	PF00069	0.713
MOD_CK1_1	226	232	PF00069	0.488
MOD_CK1_1	338	344	PF00069	0.658
MOD_CK1_1	40	46	PF00069	0.756
MOD_CK1_1	490	496	PF00069	0.721
MOD_CK1_1	578	584	PF00069	0.576
MOD_CK2_1	261	267	PF00069	0.694
MOD_CK2_1	48	54	PF00069	0.793
MOD_CK2_1	67	73	PF00069	0.525
MOD_CMANNOS	171	174	PF00535	0.502
MOD_Cter_Amidation	359	362	PF01082	0.810
MOD_DYRK1A_RPxSP_1	355	359	PF00069	0.780
MOD_GlcNHglycan	112	115	PF01048	0.783
MOD_GlcNHglycan	16	19	PF01048	0.654
MOD_GlcNHglycan	175	178	PF01048	0.650
MOD_GlcNHglycan	192	195	PF01048	0.389
MOD_GlcNHglycan	219	222	PF01048	0.723
MOD_GlcNHglycan	25	30	PF01048	0.608
MOD_GlcNHglycan	261	264	PF01048	0.744
MOD_GlcNHglycan	337	340	PF01048	0.693
MOD_GlcNHglycan	365	368	PF01048	0.706
MOD_GlcNHglycan	378	382	PF01048	0.591
MOD_GlcNHglycan	383	386	PF01048	0.315
MOD_GlcNHglycan	39	42	PF01048	0.609
MOD_GlcNHglycan	472	475	PF01048	0.528
MOD_GlcNHglycan	489	492	PF01048	0.680
MOD_GlcNHglycan	555	558	PF01048	0.711
MOD_GlcNHglycan	578	581	PF01048	0.683
MOD_GSK3_1	103	110	PF00069	0.732
MOD_GSK3_1	212	219	PF00069	0.660
MOD_GSK3_1	222	229	PF00069	0.550
MOD_GSK3_1	244	251	PF00069	0.514
MOD_GSK3_1	377	384	PF00069	0.655
MOD_GSK3_1	433	440	PF00069	0.649
MOD_GSK3_1	483	490	PF00069	0.774
MOD_GSK3_1	67	74	PF00069	0.525
MOD_NEK2_1	112	117	PF00069	0.737
MOD_NEK2_1	377	382	PF00069	0.688
MOD_NEK2_1	4	9	PF00069	0.700
MOD_NEK2_2	510	515	PF00069	0.584
MOD_PIKK_1	244	250	PF00454	0.514
MOD_PIKK_1	311	317	PF00454	0.566
MOD_PIKK_1	325	331	PF00454	0.488
MOD_PIKK_1	523	529	PF00454	0.461
MOD_PKA_1	349	355	PF00069	0.769
MOD_PKA_1	576	582	PF00069	0.795
MOD_PKA_2	576	582	PF00069	0.795
MOD_Plk_1	377	383	PF00069	0.655
MOD_Plk_1	98	104	PF00069	0.696
MOD_Plk_4	181	187	PF00069	0.491
MOD_Plk_4	510	516	PF00069	0.628
MOD_Plk_4	71	77	PF00069	0.527
MOD_ProDKin_1	101	107	PF00069	0.588
MOD_ProDKin_1	213	219	PF00069	0.625
MOD_ProDKin_1	289	295	PF00069	0.772
MOD_ProDKin_1	355	361	PF00069	0.717
MOD_ProDKin_1	370	376	PF00069	0.646
MOD_ProDKin_1	483	489	PF00069	0.693
MOD_ProDKin_1	67	73	PF00069	0.525
MOD_ProDKin_1	79	85	PF00069	0.581
MOD_SUMO_rev_2	366	373	PF00179	0.804
MOD_SUMO_rev_2	392	400	PF00179	0.564
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.603
TRG_ENDOCYTIC_2	100	103	PF00928	0.755
TRG_ENDOCYTIC_2	317	320	PF00928	0.468
TRG_ER_diArg_1	196	198	PF00400	0.416
TRG_ER_FFAT_2	211	220	PF00635	0.543
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D8	Leptomonas seymouri	40%	91%
A0A3Q8I7J7	Leishmania donovani	89%	100%
A4HU51	Leishmania infantum	89%	100%
E9AMY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%