PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHP5_LEIMA

TriTrypDb:

LmjF.09.1300 , LMJLV39_090020300 , LMJSD75_090019900

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHP5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0016579	protein deubiquitination	6	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044238	primary metabolic process	2	3
GO:0070646	protein modification by small protein removal	5	3
GO:0070647	protein modification by small protein conjugation or removal	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0008233	peptidase activity	3	15
GO:0016787	hydrolase activity	2	15
GO:0019783	ubiquitin-like protein peptidase activity	4	3
GO:0101005	deubiquitinase activity	5	3
GO:0140096	catalytic activity, acting on a protein	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.522
CLV_NRD_NRD_1	110	112	PF00675	0.203
CLV_PCSK_SKI1_1	157	161	PF00082	0.565
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	184	187	PF00134	0.419
DOC_MAPK_MEF2A_6	32	41	PF00069	0.292
DOC_PP2B_LxvP_1	146	149	PF13499	0.528
DOC_PP2B_LxvP_1	184	187	PF13499	0.400
DOC_PP4_FxxP_1	215	218	PF00568	0.581
DOC_USP7_MATH_1	15	19	PF00917	0.596
DOC_USP7_MATH_1	159	163	PF00917	0.643
DOC_USP7_MATH_1	187	191	PF00917	0.511
DOC_USP7_MATH_1	21	25	PF00917	0.492
DOC_USP7_MATH_1	3	7	PF00917	0.730
DOC_WW_Pin1_4	86	91	PF00397	0.487
LIG_EH_1	212	216	PF12763	0.580
LIG_eIF4E_1	179	185	PF01652	0.428
LIG_EVH1_2	90	94	PF00568	0.465
LIG_FHA_1	195	201	PF00498	0.461
LIG_LIR_Apic_2	212	218	PF02991	0.547
LIG_LIR_Gen_1	126	136	PF02991	0.494
LIG_LIR_Nem_3	126	131	PF02991	0.470
LIG_MYND_1	182	186	PF01753	0.412
LIG_Pex14_2	138	142	PF04695	0.471
LIG_Pex14_2	94	98	PF04695	0.545
LIG_SH2_CRK	128	132	PF00017	0.485
LIG_SH2_CRK	179	183	PF00017	0.423
LIG_SH2_NCK_1	27	31	PF00017	0.420
LIG_SH2_SRC	27	30	PF00017	0.428
LIG_SH2_SRC	70	73	PF00017	0.564
LIG_SH2_STAP1	195	199	PF00017	0.617
LIG_SH2_STAP1	27	31	PF00017	0.589
LIG_SH2_STAP1	66	70	PF00017	0.551
LIG_SH2_STAT5	199	202	PF00017	0.553
LIG_SH3_3	180	186	PF00018	0.411
MOD_CK1_1	190	196	PF00069	0.330
MOD_CK1_1	6	12	PF00069	0.677
MOD_CK2_1	103	109	PF00069	0.478
MOD_GlcNHglycan	105	108	PF01048	0.366
MOD_GlcNHglycan	11	14	PF01048	0.644
MOD_GlcNHglycan	165	168	PF01048	0.596
MOD_GlcNHglycan	202	205	PF01048	0.557
MOD_GlcNHglycan	23	26	PF01048	0.568
MOD_GlcNHglycan	5	8	PF01048	0.649
MOD_GlcNHglycan	76	81	PF01048	0.350
MOD_GSK3_1	11	18	PF00069	0.600
MOD_GSK3_1	119	126	PF00069	0.501
MOD_GSK3_1	155	162	PF00069	0.484
MOD_GSK3_1	190	197	PF00069	0.513
MOD_GSK3_1	3	10	PF00069	0.655
MOD_GSK3_1	46	53	PF00069	0.533
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	11	16	PF00069	0.639
MOD_PIKK_1	100	106	PF00454	0.521
MOD_PKA_2	190	196	PF00069	0.595
MOD_Plk_4	195	201	PF00069	0.567
MOD_Plk_4	46	52	PF00069	0.515
MOD_ProDKin_1	86	92	PF00069	0.487
TRG_DiLeu_BaEn_1	109	114	PF01217	0.531
TRG_ENDOCYTIC_2	128	131	PF00928	0.485
TRG_ENDOCYTIC_2	42	45	PF00928	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE7	Leptomonas seymouri	50%	89%
A0A0N1PCI8	Leptomonas seymouri	65%	97%
A0A1X0NHT4	Trypanosomatidae	41%	75%
A0A3Q8IAW2	Leishmania donovani	92%	100%
A0A3S7WQX3	Leishmania donovani	55%	86%
A0A422NZN2	Trypanosoma rangeli	42%	89%
A4H5V8	Leishmania braziliensis	75%	98%
A4HU52	Leishmania infantum	93%	100%
A4HU53	Leishmania infantum	54%	86%
D0A9N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	92%
E9AMY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AMY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	86%
Q4QHP4	Leishmania major	60%	100%