PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHP4_LEIMA

TriTrypDb:

LmjF.09.1310 , LMJLV39_090020400 , LMJSD75_090020000

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QHP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHP4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0016579	protein deubiquitination	6	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044238	primary metabolic process	2	3
GO:0070646	protein modification by small protein removal	5	3
GO:0070647	protein modification by small protein conjugation or removal	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0008233	peptidase activity	3	18
GO:0016787	hydrolase activity	2	18
GO:0019783	ubiquitin-like protein peptidase activity	4	3
GO:0101005	deubiquitinase activity	5	3
GO:0140096	catalytic activity, acting on a protein	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.473
CLV_C14_Caspase3-7	7	11	PF00656	0.634
CLV_NRD_NRD_1	159	161	PF00675	0.633
CLV_PCSK_KEX2_1	159	161	PF00082	0.598
DEG_APCC_DBOX_1	17	25	PF00400	0.459
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DOC_CYCLIN_yCln2_LP_2	148	151	PF00134	0.502
DOC_MAPK_MEF2A_6	169	177	PF00069	0.588
DOC_MAPK_MEF2A_6	181	188	PF00069	0.442
DOC_PP1_RVXF_1	120	126	PF00149	0.405
DOC_PP1_RVXF_1	20	27	PF00149	0.429
DOC_PP2B_LxvP_1	148	151	PF13499	0.503
DOC_USP7_MATH_1	204	208	PF00917	0.557
DOC_WW_Pin1_4	240	245	PF00397	0.793
DOC_WW_Pin1_4	88	93	PF00397	0.452
LIG_14-3-3_CanoR_1	18	22	PF00244	0.616
LIG_14-3-3_CanoR_1	181	185	PF00244	0.561
LIG_14-3-3_CanoR_1	240	244	PF00244	0.554
LIG_14-3-3_CanoR_1	47	53	PF00244	0.514
LIG_14-3-3_CterR_2	251	254	PF00244	0.510
LIG_BRCT_BRCA1_1	215	219	PF00533	0.583
LIG_FHA_2	230	236	PF00498	0.553
LIG_FHA_2	93	99	PF00498	0.509
LIG_LIR_Gen_1	128	138	PF02991	0.468
LIG_LIR_LC3C_4	113	117	PF02991	0.405
LIG_LIR_Nem_3	128	133	PF02991	0.429
LIG_MLH1_MIPbox_1	215	219	PF16413	0.393
LIG_MYND_1	185	189	PF01753	0.375
LIG_Pex14_2	140	144	PF04695	0.429
LIG_SH2_CRK	130	134	PF00017	0.434
LIG_SH2_SRC	72	75	PF00017	0.545
LIG_SH2_STAP1	198	202	PF00017	0.492
LIG_SH2_STAT3	96	99	PF00017	0.536
LIG_SH2_STAT5	202	205	PF00017	0.536
LIG_SH3_3	183	189	PF00018	0.356
LIG_SUMO_SIM_par_1	171	176	PF11976	0.435
MOD_CK1_1	217	223	PF00069	0.502
MOD_CK2_1	105	111	PF00069	0.482
MOD_CK2_1	217	223	PF00069	0.586
MOD_CK2_1	92	98	PF00069	0.509
MOD_DYRK1A_RPxSP_1	240	244	PF00069	0.554
MOD_GlcNHglycan	107	110	PF01048	0.353
MOD_GlcNHglycan	14	17	PF01048	0.622
MOD_GlcNHglycan	2	5	PF01048	0.675
MOD_GSK3_1	213	220	PF00069	0.534
MOD_GSK3_1	235	242	PF00069	0.727
MOD_GSK3_1	48	55	PF00069	0.510
MOD_GSK3_1	88	95	PF00069	0.463
MOD_N-GLC_1	238	243	PF02516	0.772
MOD_NEK2_1	102	107	PF00069	0.419
MOD_NEK2_1	180	185	PF00069	0.332
MOD_NEK2_1	214	219	PF00069	0.589
MOD_NEK2_1	52	57	PF00069	0.482
MOD_NEK2_2	82	87	PF00069	0.405
MOD_PIKK_1	102	108	PF00454	0.496
MOD_PIKK_1	164	170	PF00454	0.640
MOD_PIKK_1	31	37	PF00454	0.369
MOD_PKA_2	17	23	PF00069	0.604
MOD_PKA_2	180	186	PF00069	0.532
MOD_PKA_2	239	245	PF00069	0.713
MOD_PKA_2	46	52	PF00069	0.372
MOD_Plk_1	214	220	PF00069	0.600
MOD_Plk_4	214	220	PF00069	0.567
MOD_Plk_4	48	54	PF00069	0.522
MOD_ProDKin_1	240	246	PF00069	0.792
MOD_ProDKin_1	88	94	PF00069	0.452
TRG_DiLeu_BaEn_1	111	116	PF01217	0.509
TRG_ENDOCYTIC_2	130	133	PF00928	0.434
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE7	Leptomonas seymouri	55%	100%
A0A0N1PCI8	Leptomonas seymouri	55%	100%
A0A0S4JCD5	Bodo saltans	25%	93%
A0A1X0NHT4	Trypanosomatidae	40%	88%
A0A3Q8IAW2	Leishmania donovani	59%	100%
A0A3S7WQX3	Leishmania donovani	93%	100%
A0A422NZN2	Trypanosoma rangeli	41%	100%
A4H5V8	Leishmania braziliensis	56%	100%
A4HU52	Leishmania infantum	59%	100%
A4HU53	Leishmania infantum	93%	100%
D0A9M8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	76%
D0A9N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9AMY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QHP5	Leishmania major	60%	100%
V5BMK8	Trypanosoma cruzi	41%	77%