Putative paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania major

UniProt:

Q4QHP3_LEIMA

TriTrypDb:

LmjF.09.1320 , LMJLV39_090020600 , LMJSD75_090020200

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	25
GO:0031514	motile cilium	5	25
GO:0042995	cell projection	2	25
GO:0043226	organelle	2	25
GO:0043227	membrane-bounded organelle	3	25
GO:0110165	cellular anatomical entity	1	25
GO:0120025	plasma membrane bounded cell projection	3	25
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

Q4QHP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	25
GO:0005515	protein binding	2	25
GO:0005516	calmodulin binding	3	25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.546
CLV_C14_Caspase3-7	457	461	PF00656	0.289
CLV_NRD_NRD_1	329	331	PF00675	0.337
CLV_NRD_NRD_1	372	374	PF00675	0.377
CLV_PCSK_FUR_1	370	374	PF00082	0.231
CLV_PCSK_KEX2_1	226	228	PF00082	0.325
CLV_PCSK_KEX2_1	352	354	PF00082	0.327
CLV_PCSK_KEX2_1	372	374	PF00082	0.252
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.351
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.359
CLV_PCSK_SKI1_1	103	107	PF00082	0.488
CLV_PCSK_SKI1_1	182	186	PF00082	0.431
CLV_PCSK_SKI1_1	269	273	PF00082	0.332
CLV_PCSK_SKI1_1	337	341	PF00082	0.315
CLV_PCSK_SKI1_1	352	356	PF00082	0.323
CLV_PCSK_SKI1_1	390	394	PF00082	0.450
CLV_PCSK_SKI1_1	540	544	PF00082	0.268
DEG_APCC_DBOX_1	469	477	PF00400	0.226
DEG_Nend_UBRbox_3	1	3	PF02207	0.488
DOC_CYCLIN_RxL_1	121	134	PF00134	0.365
DOC_CYCLIN_RxL_1	223	234	PF00134	0.432
DOC_MAPK_gen_1	421	429	PF00069	0.243
DOC_PP1_RVXF_1	224	231	PF00149	0.411
DOC_PP4_FxxP_1	519	522	PF00568	0.348
DOC_USP7_MATH_1	267	271	PF00917	0.335
DOC_USP7_MATH_1	407	411	PF00917	0.386
DOC_USP7_MATH_1	586	590	PF00917	0.566
DOC_USP7_UBL2_3	265	269	PF12436	0.456
LIG_14-3-3_CanoR_1	337	344	PF00244	0.314
LIG_14-3-3_CanoR_1	353	361	PF00244	0.188
LIG_14-3-3_CanoR_1	575	582	PF00244	0.564
LIG_14-3-3_CanoR_1	91	100	PF00244	0.340
LIG_Actin_WH2_2	315	332	PF00022	0.289
LIG_BRCT_BRCA1_1	415	419	PF00533	0.204
LIG_BRCT_BRCA1_2	415	421	PF00533	0.191
LIG_DLG_GKlike_1	455	462	PF00625	0.269
LIG_FHA_1	164	170	PF00498	0.499
LIG_FHA_1	338	344	PF00498	0.347
LIG_FHA_1	436	442	PF00498	0.410
LIG_FHA_1	533	539	PF00498	0.324
LIG_FHA_2	117	123	PF00498	0.431
LIG_FHA_2	183	189	PF00498	0.493
LIG_FHA_2	232	238	PF00498	0.628
LIG_FHA_2	35	41	PF00498	0.411
LIG_FHA_2	353	359	PF00498	0.295
LIG_FHA_2	360	366	PF00498	0.291
LIG_FHA_2	42	48	PF00498	0.408
LIG_FHA_2	508	514	PF00498	0.309
LIG_FHA_2	91	97	PF00498	0.392
LIG_LIR_Apic_2	516	522	PF02991	0.365
LIG_LIR_Gen_1	358	368	PF02991	0.302
LIG_LIR_Gen_1	498	509	PF02991	0.231
LIG_LIR_Gen_1	525	533	PF02991	0.198
LIG_LIR_Nem_3	358	363	PF02991	0.302
LIG_LIR_Nem_3	40	45	PF02991	0.463
LIG_LIR_Nem_3	463	469	PF02991	0.363
LIG_LIR_Nem_3	498	504	PF02991	0.231
LIG_LIR_Nem_3	525	531	PF02991	0.198
LIG_PCNA_yPIPBox_3	315	327	PF02747	0.281
LIG_PDZ_Class_2	600	605	PF00595	0.614
LIG_PTB_Apo_2	110	117	PF02174	0.327
LIG_PTB_Phospho_1	110	116	PF10480	0.326
LIG_SH2_NCK_1	528	532	PF00017	0.408
LIG_SH2_SRC	45	48	PF00017	0.468
LIG_SH2_SRC	544	547	PF00017	0.513
LIG_SH2_STAP1	183	187	PF00017	0.401
LIG_SH2_STAP1	194	198	PF00017	0.379
LIG_SH2_STAP1	218	222	PF00017	0.342
LIG_SH2_STAP1	528	532	PF00017	0.390
LIG_SH2_STAT3	183	186	PF00017	0.325
LIG_SH2_STAT3	297	300	PF00017	0.291
LIG_SH2_STAT5	128	131	PF00017	0.456
LIG_SH2_STAT5	220	223	PF00017	0.437
LIG_SH2_STAT5	224	227	PF00017	0.446
LIG_SH2_STAT5	377	380	PF00017	0.235
LIG_SH2_STAT5	391	394	PF00017	0.246
LIG_SH2_STAT5	544	547	PF00017	0.399
LIG_SH3_2	9	14	PF14604	0.458
LIG_SH3_3	137	143	PF00018	0.428
LIG_SH3_3	6	12	PF00018	0.451
LIG_SUMO_SIM_par_1	201	207	PF11976	0.368
LIG_TRAF2_1	165	168	PF00917	0.447
LIG_TRAF2_1	233	236	PF00917	0.575
LIG_TRAF2_1	346	349	PF00917	0.287
LIG_TRAF2_1	356	359	PF00917	0.292
LIG_TRAF2_1	503	506	PF00917	0.269
LIG_TRAF2_1	522	525	PF00917	0.288
LIG_TRAF2_1	93	96	PF00917	0.431
LIG_WW_1	8	11	PF00397	0.473
MOD_CK1_1	307	313	PF00069	0.218
MOD_CK1_1	458	464	PF00069	0.289
MOD_CK2_1	229	235	PF00069	0.522
MOD_CK2_1	307	313	PF00069	0.437
MOD_CK2_1	352	358	PF00069	0.281
MOD_CK2_1	41	47	PF00069	0.508
MOD_CK2_1	500	506	PF00069	0.262
MOD_CK2_1	507	513	PF00069	0.257
MOD_CK2_1	90	96	PF00069	0.510
MOD_GlcNHglycan	107	111	PF01048	0.577
MOD_GlcNHglycan	269	272	PF01048	0.238
MOD_GlcNHglycan	3	6	PF01048	0.577
MOD_GlcNHglycan	577	580	PF01048	0.570
MOD_GSK3_1	171	178	PF00069	0.372
MOD_GSK3_1	231	238	PF00069	0.504
MOD_GSK3_1	431	438	PF00069	0.303
MOD_GSK3_1	454	461	PF00069	0.232
MOD_GSK3_1	508	515	PF00069	0.224
MOD_LATS_1	453	459	PF00433	0.269
MOD_N-GLC_1	1	6	PF02516	0.452
MOD_N-GLC_1	538	543	PF02516	0.365
MOD_NEK2_1	1	6	PF00069	0.565
MOD_NEK2_1	106	111	PF00069	0.469
MOD_NEK2_1	131	136	PF00069	0.558
MOD_NEK2_1	304	309	PF00069	0.241
MOD_NEK2_1	507	512	PF00069	0.388
MOD_NEK2_2	431	436	PF00069	0.243
MOD_PIKK_1	175	181	PF00454	0.387
MOD_PIKK_1	182	188	PF00454	0.445
MOD_PIKK_1	337	343	PF00454	0.361
MOD_PIKK_1	490	496	PF00454	0.223
MOD_PKA_1	352	358	PF00069	0.324
MOD_PKA_2	352	358	PF00069	0.251
MOD_PKA_2	454	460	PF00069	0.233
MOD_PKA_2	90	96	PF00069	0.338
MOD_Plk_1	106	112	PF00069	0.544
MOD_Plk_1	304	310	PF00069	0.237
MOD_Plk_1	431	437	PF00069	0.243
MOD_Plk_1	455	461	PF00069	0.282
MOD_Plk_1	538	544	PF00069	0.238
MOD_Plk_2-3	359	365	PF00069	0.324
MOD_Plk_2-3	413	419	PF00069	0.211
MOD_Plk_4	111	117	PF00069	0.375
MOD_Plk_4	143	149	PF00069	0.540
MOD_Plk_4	220	226	PF00069	0.274
MOD_Plk_4	307	313	PF00069	0.367
MOD_Plk_4	407	413	PF00069	0.223
MOD_SUMO_for_1	169	172	PF00179	0.502
MOD_SUMO_rev_2	262	267	PF00179	0.390
MOD_SUMO_rev_2	307	316	PF00179	0.391
MOD_SUMO_rev_2	349	354	PF00179	0.217
TRG_DiLeu_BaEn_1	561	566	PF01217	0.402
TRG_DiLeu_BaEn_2	414	420	PF01217	0.226
TRG_DiLeu_BaEn_4	95	101	PF01217	0.374
TRG_ENDOCYTIC_2	128	131	PF00928	0.456
TRG_ENDOCYTIC_2	218	221	PF00928	0.286
TRG_ENDOCYTIC_2	423	426	PF00928	0.325
TRG_ENDOCYTIC_2	528	531	PF00928	0.198
TRG_ER_diArg_1	124	127	PF00400	0.379
TRG_ER_diArg_1	370	373	PF00400	0.379
TRG_ER_diArg_1	534	537	PF00400	0.243
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P573	Leptomonas seymouri	62%	99%
A0A0S4IPM7	Bodo saltans	31%	100%
A0A1X0NI51	Trypanosomatidae	43%	100%
A0A381MH18	Leishmania infantum	22%	100%
A0A381MN58	Leishmania infantum	24%	100%
A0A3Q8IAP5	Leishmania donovani	22%	100%
A0A3Q8IEH2	Leishmania donovani	24%	100%
A0A3R7P0W8	Trypanosoma rangeli	45%	100%
A0A3S7WQV4	Leishmania donovani	96%	100%
A0A3S7X2K1	Leishmania donovani	23%	100%
A4H5W0	Leishmania braziliensis	79%	100%
A4HIY0	Leishmania braziliensis	22%	100%
A4HU55	Leishmania infantum	96%	100%
A4HX40	Leishmania infantum	22%	100%
D0A9N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AE36	Leishmania major	24%	100%
E9AE37	Leishmania major	24%	100%
E9AHJ2	Leishmania infantum	23%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEM2	Leishmania major	22%	100%
V5BDF9	Trypanosoma cruzi	46%	100%