Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHP2_LEIMA

TriTrypDb:

LmjF.09.1330 , LMJLV39_090020700 , LMJSD75_090020300

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 1
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QHP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	603	607	PF00656	0.502
CLV_NRD_NRD_1	2	4	PF00675	0.765
CLV_NRD_NRD_1	457	459	PF00675	0.524
CLV_NRD_NRD_1	590	592	PF00675	0.810
CLV_PCSK_SKI1_1	209	213	PF00082	0.754
DEG_APCC_DBOX_1	104	112	PF00400	0.438
DOC_CKS1_1	198	203	PF01111	0.590
DOC_MAPK_gen_1	306	314	PF00069	0.476
DOC_MAPK_gen_1	343	352	PF00069	0.461
DOC_MAPK_gen_1	523	531	PF00069	0.652
DOC_MAPK_MEF2A_6	306	314	PF00069	0.484
DOC_MAPK_MEF2A_6	346	354	PF00069	0.413
DOC_MAPK_MEF2A_6	523	531	PF00069	0.652
DOC_MAPK_MEF2A_6	58	67	PF00069	0.571
DOC_PP1_RVXF_1	317	324	PF00149	0.557
DOC_PP2B_LxvP_1	330	333	PF13499	0.528
DOC_PP2B_LxvP_1	350	353	PF13499	0.473
DOC_PP4_FxxP_1	178	181	PF00568	0.578
DOC_PP4_FxxP_1	454	457	PF00568	0.637
DOC_USP7_MATH_1	241	245	PF00917	0.462
DOC_USP7_MATH_1	381	385	PF00917	0.578
DOC_USP7_MATH_1	557	561	PF00917	0.422
DOC_USP7_MATH_1	93	97	PF00917	0.618
DOC_USP7_MATH_1	99	103	PF00917	0.556
DOC_USP7_UBL2_3	461	465	PF12436	0.754
DOC_WW_Pin1_4	177	182	PF00397	0.592
DOC_WW_Pin1_4	197	202	PF00397	0.412
DOC_WW_Pin1_4	228	233	PF00397	0.582
DOC_WW_Pin1_4	36	41	PF00397	0.536
DOC_WW_Pin1_4	453	458	PF00397	0.709
LIG_14-3-3_CanoR_1	132	140	PF00244	0.555
LIG_14-3-3_CanoR_1	196	201	PF00244	0.601
LIG_14-3-3_CanoR_1	346	351	PF00244	0.418
LIG_14-3-3_CanoR_1	48	53	PF00244	0.598
LIG_14-3-3_CanoR_1	526	532	PF00244	0.611
LIG_BRCT_BRCA1_1	448	452	PF00533	0.463
LIG_FHA_1	11	17	PF00498	0.648
LIG_FHA_1	111	117	PF00498	0.557
LIG_FHA_1	151	157	PF00498	0.501
LIG_FHA_1	347	353	PF00498	0.417
LIG_FHA_1	393	399	PF00498	0.492
LIG_FHA_1	427	433	PF00498	0.495
LIG_FHA_1	438	444	PF00498	0.347
LIG_FHA_1	469	475	PF00498	0.736
LIG_FHA_1	489	495	PF00498	0.583
LIG_FHA_1	551	557	PF00498	0.431
LIG_FHA_1	559	565	PF00498	0.431
LIG_FHA_1	73	79	PF00498	0.553
LIG_FHA_2	256	262	PF00498	0.456
LIG_FHA_2	74	80	PF00498	0.460
LIG_LIR_Apic_2	543	547	PF02991	0.760
LIG_LIR_Gen_1	21	32	PF02991	0.642
LIG_LIR_Gen_1	261	269	PF02991	0.460
LIG_LIR_Gen_1	355	366	PF02991	0.481
LIG_LIR_Gen_1	409	420	PF02991	0.496
LIG_LIR_Gen_1	530	538	PF02991	0.669
LIG_LIR_Gen_1	549	559	PF02991	0.551
LIG_LIR_Nem_3	203	208	PF02991	0.469
LIG_LIR_Nem_3	21	27	PF02991	0.628
LIG_LIR_Nem_3	261	265	PF02991	0.496
LIG_LIR_Nem_3	355	361	PF02991	0.511
LIG_LIR_Nem_3	409	415	PF02991	0.498
LIG_LIR_Nem_3	51	55	PF02991	0.420
LIG_LIR_Nem_3	518	524	PF02991	0.705
LIG_LIR_Nem_3	530	534	PF02991	0.599
LIG_LIR_Nem_3	549	555	PF02991	0.551
LIG_PCNA_yPIPBox_3	124	138	PF02747	0.530
LIG_Pex14_1	356	360	PF04695	0.476
LIG_Pex14_2	448	452	PF04695	0.459
LIG_SH2_CRK	358	362	PF00017	0.490
LIG_SH2_CRK	544	548	PF00017	0.722
LIG_SH2_CRK	552	556	PF00017	0.361
LIG_SH2_NCK_1	257	261	PF00017	0.532
LIG_SH2_PTP2	262	265	PF00017	0.545
LIG_SH2_PTP2	508	511	PF00017	0.648
LIG_SH2_SRC	508	511	PF00017	0.696
LIG_SH2_STAP1	242	246	PF00017	0.513
LIG_SH2_STAP1	55	59	PF00017	0.579
LIG_SH2_STAP1	552	556	PF00017	0.431
LIG_SH2_STAP1	581	585	PF00017	0.538
LIG_SH2_STAT5	257	260	PF00017	0.523
LIG_SH2_STAT5	262	265	PF00017	0.478
LIG_SH2_STAT5	276	279	PF00017	0.384
LIG_SH2_STAT5	303	306	PF00017	0.530
LIG_SH2_STAT5	340	343	PF00017	0.478
LIG_SH2_STAT5	414	417	PF00017	0.544
LIG_SH2_STAT5	435	438	PF00017	0.519
LIG_SH2_STAT5	478	481	PF00017	0.705
LIG_SH2_STAT5	508	511	PF00017	0.625
LIG_SH2_STAT5	552	555	PF00017	0.433
LIG_SH3_1	544	550	PF00018	0.754
LIG_SH3_3	195	201	PF00018	0.636
LIG_SH3_3	221	227	PF00018	0.602
LIG_SH3_3	34	40	PF00018	0.601
LIG_SH3_3	375	381	PF00018	0.600
LIG_SH3_3	544	550	PF00018	0.809
LIG_Sin3_3	7	14	PF02671	0.628
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.516
LIG_SUMO_SIM_par_1	107	113	PF11976	0.429
LIG_SUMO_SIM_par_1	15	22	PF11976	0.638
LIG_SUMO_SIM_par_1	489	496	PF11976	0.694
LIG_SUMO_SIM_par_1	560	566	PF11976	0.437
LIG_TRAF2_1	278	281	PF00917	0.395
LIG_TYR_ITIM	519	524	PF00017	0.690
LIG_WRC_WIRS_1	49	54	PF05994	0.423
MOD_CDC14_SPxK_1	456	459	PF00782	0.771
MOD_CDK_SPK_2	197	202	PF00069	0.482
MOD_CDK_SPK_2	453	458	PF00069	0.636
MOD_CDK_SPxK_1	453	459	PF00069	0.634
MOD_CK1_1	126	132	PF00069	0.517
MOD_CK1_1	234	240	PF00069	0.499
MOD_CK1_1	253	259	PF00069	0.362
MOD_CK1_1	264	270	PF00069	0.416
MOD_CK1_1	403	409	PF00069	0.510
MOD_CK1_1	437	443	PF00069	0.361
MOD_CK1_1	486	492	PF00069	0.729
MOD_CK1_1	73	79	PF00069	0.634
MOD_CK1_1	83	89	PF00069	0.565
MOD_CK1_1	94	100	PF00069	0.586
MOD_CK2_1	255	261	PF00069	0.457
MOD_CK2_1	263	269	PF00069	0.445
MOD_CK2_1	275	281	PF00069	0.313
MOD_GlcNHglycan	134	137	PF01048	0.724
MOD_GlcNHglycan	171	174	PF01048	0.823
MOD_GlcNHglycan	213	216	PF01048	0.683
MOD_GlcNHglycan	236	239	PF01048	0.685
MOD_GlcNHglycan	392	395	PF01048	0.726
MOD_GlcNHglycan	421	424	PF01048	0.775
MOD_GlcNHglycan	436	439	PF01048	0.664
MOD_GlcNHglycan	448	451	PF01048	0.478
MOD_GlcNHglycan	586	589	PF01048	0.636
MOD_GlcNHglycan	79	83	PF01048	0.824
MOD_GlcNHglycan	93	96	PF01048	0.789
MOD_GSK3_1	122	129	PF00069	0.561
MOD_GSK3_1	132	139	PF00069	0.553
MOD_GSK3_1	179	186	PF00069	0.516
MOD_GSK3_1	19	26	PF00069	0.570
MOD_GSK3_1	196	203	PF00069	0.537
MOD_GSK3_1	32	39	PF00069	0.560
MOD_GSK3_1	341	348	PF00069	0.448
MOD_GSK3_1	390	397	PF00069	0.518
MOD_GSK3_1	406	413	PF00069	0.562
MOD_GSK3_1	453	460	PF00069	0.567
MOD_GSK3_1	484	491	PF00069	0.672
MOD_GSK3_1	532	539	PF00069	0.659
MOD_N-GLC_1	253	258	PF02516	0.697
MOD_N-GLC_1	298	303	PF02516	0.739
MOD_N-GLC_1	346	351	PF02516	0.639
MOD_NEK2_1	18	23	PF00069	0.644
MOD_NEK2_1	184	189	PF00069	0.491
MOD_NEK2_1	283	288	PF00069	0.514
MOD_NEK2_1	304	309	PF00069	0.481
MOD_NEK2_1	321	326	PF00069	0.416
MOD_NEK2_1	367	372	PF00069	0.563
MOD_NEK2_1	392	397	PF00069	0.503
MOD_NEK2_1	434	439	PF00069	0.526
MOD_NEK2_1	452	457	PF00069	0.447
MOD_NEK2_1	492	497	PF00069	0.700
MOD_PIKK_1	110	116	PF00454	0.535
MOD_PIKK_1	222	228	PF00454	0.623
MOD_PIKK_1	281	287	PF00454	0.448
MOD_PK_1	470	476	PF00069	0.686
MOD_PKA_2	250	256	PF00069	0.541
MOD_PKA_2	345	351	PF00069	0.490
MOD_PKA_2	457	463	PF00069	0.763
MOD_PKB_1	46	54	PF00069	0.598
MOD_Plk_1	253	259	PF00069	0.499
MOD_Plk_1	298	304	PF00069	0.537
MOD_Plk_1	346	352	PF00069	0.394
MOD_Plk_1	403	409	PF00069	0.516
MOD_Plk_1	492	498	PF00069	0.691
MOD_Plk_4	126	132	PF00069	0.555
MOD_Plk_4	139	145	PF00069	0.439
MOD_Plk_4	19	25	PF00069	0.520
MOD_Plk_4	219	225	PF00069	0.590
MOD_Plk_4	299	305	PF00069	0.435
MOD_Plk_4	367	373	PF00069	0.543
MOD_Plk_4	470	476	PF00069	0.686
MOD_Plk_4	515	521	PF00069	0.749
MOD_Plk_4	550	556	PF00069	0.431
MOD_Plk_4	558	564	PF00069	0.431
MOD_ProDKin_1	177	183	PF00069	0.592
MOD_ProDKin_1	197	203	PF00069	0.410
MOD_ProDKin_1	228	234	PF00069	0.577
MOD_ProDKin_1	36	42	PF00069	0.532
MOD_ProDKin_1	453	459	PF00069	0.707
MOD_SUMO_for_1	158	161	PF00179	0.523
MOD_SUMO_for_1	469	472	PF00179	0.710
MOD_SUMO_rev_2	311	321	PF00179	0.485
TRG_DiLeu_BaEn_1	152	157	PF01217	0.477
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.559
TRG_ENDOCYTIC_2	262	265	PF00928	0.455
TRG_ENDOCYTIC_2	358	361	PF00928	0.484
TRG_ENDOCYTIC_2	402	405	PF00928	0.531
TRG_ENDOCYTIC_2	508	511	PF00928	0.638
TRG_ENDOCYTIC_2	521	524	PF00928	0.676
TRG_ENDOCYTIC_2	552	555	PF00928	0.463
TRG_ENDOCYTIC_2	573	576	PF00928	0.523
TRG_ER_diArg_1	306	309	PF00400	0.495
TRG_ER_diArg_1	46	49	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG0	Leptomonas seymouri	38%	100%
A0A3R7LBA1	Trypanosoma rangeli	24%	100%
A0A3S5H6E7	Leishmania donovani	89%	100%
A4H5W1	Leishmania braziliensis	63%	100%
A4HU56	Leishmania infantum	89%	100%
E9AMY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%