Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHN8_LEIMA

TriTrypDb:

LmjF.09.1370 , LMJLV39_090021100 , LMJSD75_090020700

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.683
CLV_NRD_NRD_1	103	105	PF00675	0.391
CLV_NRD_NRD_1	201	203	PF00675	0.604
CLV_NRD_NRD_1	248	250	PF00675	0.689
CLV_NRD_NRD_1	263	265	PF00675	0.521
CLV_PCSK_KEX2_1	102	104	PF00082	0.449
CLV_PCSK_KEX2_1	201	203	PF00082	0.590
CLV_PCSK_KEX2_1	229	231	PF00082	0.643
CLV_PCSK_KEX2_1	248	250	PF00082	0.621
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.444
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.575
CLV_PCSK_PC7_1	225	231	PF00082	0.571
CLV_PCSK_PC7_1	244	250	PF00082	0.625
CLV_PCSK_SKI1_1	111	115	PF00082	0.493
CLV_PCSK_SKI1_1	121	125	PF00082	0.376
DEG_APCC_DBOX_1	214	222	PF00400	0.574
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.478
DOC_PP2B_LxvP_1	40	43	PF13499	0.617
DOC_USP7_MATH_1	126	130	PF00917	0.486
DOC_USP7_MATH_1	139	143	PF00917	0.457
DOC_USP7_MATH_1	67	71	PF00917	0.533
DOC_WW_Pin1_4	175	180	PF00397	0.672
DOC_WW_Pin1_4	192	197	PF00397	0.596
DOC_WW_Pin1_4	239	244	PF00397	0.622
DOC_WW_Pin1_4	253	258	PF00397	0.621
DOC_WW_Pin1_4	8	13	PF00397	0.643
LIG_14-3-3_CanoR_1	104	113	PF00244	0.383
LIG_14-3-3_CanoR_1	138	144	PF00244	0.586
LIG_14-3-3_CanoR_1	180	188	PF00244	0.644
LIG_14-3-3_CanoR_1	215	219	PF00244	0.646
LIG_14-3-3_CanoR_1	230	235	PF00244	0.558
LIG_14-3-3_CanoR_1	248	257	PF00244	0.701
LIG_14-3-3_CanoR_1	264	268	PF00244	0.511
LIG_14-3-3_CanoR_1	68	76	PF00244	0.468
LIG_Actin_WH2_2	217	234	PF00022	0.573
LIG_BIR_III_4	17	21	PF00653	0.564
LIG_CaM_IQ_9	95	111	PF13499	0.419
LIG_Clathr_ClatBox_1	112	116	PF01394	0.482
LIG_FHA_1	204	210	PF00498	0.538
LIG_FHA_2	112	118	PF00498	0.517
LIG_LIR_Apic_2	191	196	PF02991	0.667
LIG_SH2_CRK	193	197	PF00017	0.663
LIG_SH2_NCK_1	193	197	PF00017	0.595
LIG_SH3_3	9	15	PF00018	0.731
LIG_SUMO_SIM_par_1	111	118	PF11976	0.483
LIG_TRAF2_1	114	117	PF00917	0.482
LIG_TRAF2_1	217	220	PF00917	0.566
MOD_CDK_SPK_2	175	180	PF00069	0.553
MOD_CDK_SPK_2	239	244	PF00069	0.601
MOD_CDK_SPxxK_3	192	199	PF00069	0.599
MOD_CK1_1	178	184	PF00069	0.574
MOD_CK1_1	233	239	PF00069	0.612
MOD_CK1_1	253	259	PF00069	0.481
MOD_CK1_1	54	60	PF00069	0.578
MOD_CK1_1	61	67	PF00069	0.614
MOD_CK2_1	111	117	PF00069	0.520
MOD_CK2_1	178	184	PF00069	0.517
MOD_CK2_1	214	220	PF00069	0.577
MOD_GlcNHglycan	116	120	PF01048	0.566
MOD_GlcNHglycan	203	206	PF01048	0.614
MOD_GlcNHglycan	238	242	PF01048	0.587
MOD_GlcNHglycan	60	63	PF01048	0.599
MOD_GlcNHglycan	64	67	PF01048	0.552
MOD_GSK3_1	111	118	PF00069	0.472
MOD_GSK3_1	174	181	PF00069	0.533
MOD_GSK3_1	210	217	PF00069	0.616
MOD_GSK3_1	230	237	PF00069	0.600
MOD_GSK3_1	249	256	PF00069	0.613
MOD_GSK3_1	54	61	PF00069	0.638
MOD_NEK2_1	115	120	PF00069	0.390
MOD_NEK2_1	98	103	PF00069	0.436
MOD_PIKK_1	105	111	PF00454	0.417
MOD_PIKK_1	178	184	PF00454	0.572
MOD_PIKK_1	210	216	PF00454	0.658
MOD_PIKK_1	250	256	PF00454	0.679
MOD_PK_1	230	236	PF00069	0.638
MOD_PKA_1	201	207	PF00069	0.634
MOD_PKA_1	248	254	PF00069	0.686
MOD_PKA_2	201	207	PF00069	0.701
MOD_PKA_2	214	220	PF00069	0.693
MOD_PKA_2	224	230	PF00069	0.567
MOD_PKA_2	247	253	PF00069	0.623
MOD_PKA_2	67	73	PF00069	0.487
MOD_Plk_4	51	57	PF00069	0.548
MOD_ProDKin_1	175	181	PF00069	0.681
MOD_ProDKin_1	192	198	PF00069	0.599
MOD_ProDKin_1	239	245	PF00069	0.623
MOD_ProDKin_1	253	259	PF00069	0.620
MOD_ProDKin_1	8	14	PF00069	0.646
TRG_DiLeu_BaEn_4	159	165	PF01217	0.440
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.544
TRG_ER_diArg_1	103	105	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A2	Leptomonas seymouri	44%	97%
A0A3S5H6E8	Leishmania donovani	91%	100%
A4H5W4	Leishmania braziliensis	69%	100%
A4HU59	Leishmania infantum	91%	100%
E9AMY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%