Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHN7_LEIMA

TriTrypDb:

LmjF.09.1380 , LMJLV39_090021200 , LMJSD75_090020800

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.524
CLV_NRD_NRD_1	405	407	PF00675	0.606
CLV_NRD_NRD_1	51	53	PF00675	0.683
CLV_PCSK_KEX2_1	117	119	PF00082	0.583
CLV_PCSK_KEX2_1	133	135	PF00082	0.464
CLV_PCSK_KEX2_1	405	407	PF00082	0.546
CLV_PCSK_KEX2_1	51	53	PF00082	0.683
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.659
CLV_PCSK_SKI1_1	19	23	PF00082	0.505
CLV_PCSK_SKI1_1	346	350	PF00082	0.545
CLV_PCSK_SKI1_1	375	379	PF00082	0.502
CLV_PCSK_SKI1_1	452	456	PF00082	0.628
CLV_PCSK_SKI1_1	486	490	PF00082	0.452
CLV_PCSK_SKI1_1	538	542	PF00082	0.382
CLV_PCSK_SKI1_1	568	572	PF00082	0.505
DEG_APCC_DBOX_1	345	353	PF00400	0.553
DEG_APCC_DBOX_1	374	382	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SCF_FBW7_1	542	549	PF00400	0.578
DEG_SPOP_SBC_1	67	71	PF00917	0.655
DEG_SPOP_SBC_1	72	76	PF00917	0.592
DOC_CYCLIN_RxL_1	446	458	PF00134	0.606
DOC_CYCLIN_RxL_1	483	492	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	280	283	PF00134	0.541
DOC_MAPK_gen_1	15	22	PF00069	0.514
DOC_MAPK_HePTP_8	372	384	PF00069	0.498
DOC_MAPK_MEF2A_6	15	24	PF00069	0.507
DOC_MAPK_MEF2A_6	375	384	PF00069	0.455
DOC_MAPK_MEF2A_6	431	438	PF00069	0.525
DOC_MAPK_NFAT4_5	375	383	PF00069	0.539
DOC_PP1_RVXF_1	450	456	PF00149	0.535
DOC_PP2B_LxvP_1	280	283	PF13499	0.598
DOC_PP2B_LxvP_1	326	329	PF13499	0.576
DOC_PP4_FxxP_1	348	351	PF00568	0.595
DOC_USP7_MATH_1	191	195	PF00917	0.701
DOC_USP7_MATH_1	308	312	PF00917	0.764
DOC_USP7_MATH_1	387	391	PF00917	0.576
DOC_USP7_MATH_1	68	72	PF00917	0.745
DOC_USP7_MATH_1	73	77	PF00917	0.719
DOC_USP7_MATH_1	84	88	PF00917	0.580
DOC_WW_Pin1_4	124	129	PF00397	0.656
DOC_WW_Pin1_4	298	303	PF00397	0.655
DOC_WW_Pin1_4	304	309	PF00397	0.698
DOC_WW_Pin1_4	455	460	PF00397	0.622
DOC_WW_Pin1_4	542	547	PF00397	0.578
LIG_14-3-3_CanoR_1	151	160	PF00244	0.606
LIG_14-3-3_CanoR_1	19	25	PF00244	0.496
LIG_14-3-3_CanoR_1	233	242	PF00244	0.599
LIG_14-3-3_CanoR_1	254	259	PF00244	0.721
LIG_14-3-3_CanoR_1	379	385	PF00244	0.476
LIG_14-3-3_CanoR_1	405	414	PF00244	0.487
LIG_14-3-3_CanoR_1	431	437	PF00244	0.416
LIG_14-3-3_CanoR_1	51	55	PF00244	0.643
LIG_14-3-3_CanoR_1	591	596	PF00244	0.478
LIG_14-3-3_CanoR_1	97	103	PF00244	0.578
LIG_APCC_ABBA_1	570	575	PF00400	0.375
LIG_BRCT_BRCA1_1	344	348	PF00533	0.606
LIG_BRCT_BRCA1_1	434	438	PF00533	0.517
LIG_BRCT_BRCA1_1	88	92	PF00533	0.566
LIG_CaM_NSCaTE_8	476	483	PF13499	0.547
LIG_Clathr_ClatBox_1	418	422	PF01394	0.394
LIG_Clathr_ClatBox_1	488	492	PF01394	0.403
LIG_DCNL_PONY_1	1	4	PF03556	0.497
LIG_EH1_1	447	455	PF00400	0.592
LIG_FHA_1	145	151	PF00498	0.520
LIG_FHA_1	16	22	PF00498	0.513
LIG_FHA_1	162	168	PF00498	0.635
LIG_FHA_1	213	219	PF00498	0.443
LIG_FHA_1	285	291	PF00498	0.580
LIG_FHA_1	36	42	PF00498	0.601
LIG_FHA_2	531	537	PF00498	0.491
LIG_GBD_Chelix_1	289	297	PF00786	0.544
LIG_Integrin_isoDGR_2	252	254	PF01839	0.516
LIG_LIR_Apic_2	345	351	PF02991	0.604
LIG_LIR_Apic_2	415	420	PF02991	0.493
LIG_LIR_Gen_1	139	146	PF02991	0.558
LIG_LIR_Gen_1	217	228	PF02991	0.521
LIG_LIR_Gen_1	514	519	PF02991	0.538
LIG_LIR_Nem_3	139	143	PF02991	0.510
LIG_LIR_Nem_3	217	223	PF02991	0.513
LIG_LIR_Nem_3	330	336	PF02991	0.533
LIG_LIR_Nem_3	473	479	PF02991	0.490
LIG_LIR_Nem_3	482	488	PF02991	0.342
LIG_LIR_Nem_3	596	602	PF02991	0.451
LIG_NRBOX	269	275	PF00104	0.503
LIG_PCNA_yPIPBox_3	264	274	PF02747	0.606
LIG_SH2_CRK	485	489	PF00017	0.424
LIG_SH2_NCK_1	364	368	PF00017	0.592
LIG_SH2_NCK_1	85	89	PF00017	0.511
LIG_SH2_SRC	108	111	PF00017	0.645
LIG_SH2_STAP1	414	418	PF00017	0.422
LIG_SH2_STAP1	481	485	PF00017	0.547
LIG_SH2_STAP1	515	519	PF00017	0.574
LIG_SH2_STAT3	386	389	PF00017	0.565
LIG_SH2_STAT3	481	484	PF00017	0.541
LIG_SH2_STAT5	108	111	PF00017	0.645
LIG_SH2_STAT5	334	337	PF00017	0.476
LIG_SH2_STAT5	573	576	PF00017	0.401
LIG_SH3_1	299	305	PF00018	0.638
LIG_SH3_3	242	248	PF00018	0.558
LIG_SH3_3	299	305	PF00018	0.680
LIG_SH3_5	329	333	PF00018	0.500
LIG_SUMO_SIM_anti_2	527	533	PF11976	0.573
LIG_SUMO_SIM_par_1	486	492	PF11976	0.454
LIG_TYR_ITIM	331	336	PF00017	0.546
LIG_UBA3_1	1	6	PF00899	0.499
LIG_UBA3_1	418	423	PF00899	0.463
LIG_UBA3_1	487	493	PF00899	0.502
LIG_UBA3_1	530	538	PF00899	0.536
MOD_CDK_SPK_2	304	309	PF00069	0.643
MOD_CDK_SPxK_1	542	548	PF00069	0.585
MOD_CK1_1	161	167	PF00069	0.605
MOD_CK1_1	204	210	PF00069	0.650
MOD_CK1_1	257	263	PF00069	0.676
MOD_CK1_1	342	348	PF00069	0.536
MOD_CK1_1	396	402	PF00069	0.668
MOD_CK1_1	458	464	PF00069	0.726
MOD_CK1_1	506	512	PF00069	0.583
MOD_CK1_1	7	13	PF00069	0.504
MOD_CK1_1	71	77	PF00069	0.691
MOD_CK1_1	87	93	PF00069	0.576
MOD_CK1_1	98	104	PF00069	0.629
MOD_CK2_1	241	247	PF00069	0.571
MOD_CK2_1	304	310	PF00069	0.683
MOD_CK2_1	530	536	PF00069	0.483
MOD_CK2_1	98	104	PF00069	0.568
MOD_GlcNHglycan	188	191	PF01048	0.748
MOD_GlcNHglycan	203	206	PF01048	0.600
MOD_GlcNHglycan	209	212	PF01048	0.448
MOD_GlcNHglycan	220	223	PF01048	0.362
MOD_GlcNHglycan	235	238	PF01048	0.369
MOD_GlcNHglycan	270	273	PF01048	0.496
MOD_GlcNHglycan	310	314	PF01048	0.737
MOD_GlcNHglycan	321	324	PF01048	0.533
MOD_GlcNHglycan	365	368	PF01048	0.510
MOD_GlcNHglycan	389	392	PF01048	0.545
MOD_GlcNHglycan	460	463	PF01048	0.633
MOD_GlcNHglycan	475	479	PF01048	0.488
MOD_GlcNHglycan	481	484	PF01048	0.472
MOD_GlcNHglycan	508	511	PF01048	0.605
MOD_GlcNHglycan	564	568	PF01048	0.641
MOD_GlcNHglycan	70	73	PF01048	0.744
MOD_GlcNHglycan	79	82	PF01048	0.667
MOD_GlcNHglycan	86	89	PF01048	0.529
MOD_GSK3_1	100	107	PF00069	0.550
MOD_GSK3_1	214	221	PF00069	0.541
MOD_GSK3_1	253	260	PF00069	0.718
MOD_GSK3_1	304	311	PF00069	0.684
MOD_GSK3_1	33	40	PF00069	0.606
MOD_GSK3_1	338	345	PF00069	0.625
MOD_GSK3_1	392	399	PF00069	0.716
MOD_GSK3_1	454	461	PF00069	0.626
MOD_GSK3_1	470	477	PF00069	0.526
MOD_GSK3_1	50	57	PF00069	0.642
MOD_GSK3_1	502	509	PF00069	0.598
MOD_GSK3_1	526	533	PF00069	0.454
MOD_GSK3_1	542	549	PF00069	0.425
MOD_GSK3_1	67	74	PF00069	0.695
MOD_GSK3_1	7	14	PF00069	0.504
MOD_GSK3_1	84	91	PF00069	0.575
MOD_N-GLC_1	25	30	PF02516	0.661
MOD_N-GLC_1	426	431	PF02516	0.482
MOD_N-GLC_1	502	507	PF02516	0.599
MOD_NEK2_1	142	147	PF00069	0.551
MOD_NEK2_1	160	165	PF00069	0.607
MOD_NEK2_1	214	219	PF00069	0.495
MOD_NEK2_1	25	30	PF00069	0.630
MOD_NEK2_1	33	38	PF00069	0.530
MOD_NEK2_1	380	385	PF00069	0.489
MOD_NEK2_1	4	9	PF00069	0.509
MOD_NEK2_1	41	46	PF00069	0.441
MOD_NEK2_1	421	426	PF00069	0.509
MOD_NEK2_1	434	439	PF00069	0.446
MOD_NEK2_1	453	458	PF00069	0.470
MOD_NEK2_1	530	535	PF00069	0.501
MOD_NEK2_1	563	568	PF00069	0.670
MOD_NEK2_1	92	97	PF00069	0.583
MOD_PIKK_1	41	47	PF00454	0.540
MOD_PIKK_1	54	60	PF00454	0.608
MOD_PK_1	591	597	PF00069	0.487
MOD_PKA_2	207	213	PF00069	0.614
MOD_PKA_2	253	259	PF00069	0.626
MOD_PKA_2	50	56	PF00069	0.650
MOD_Plk_1	25	31	PF00069	0.585
MOD_Plk_1	421	427	PF00069	0.532
MOD_Plk_2-3	104	110	PF00069	0.616
MOD_Plk_2-3	241	247	PF00069	0.537
MOD_Plk_4	20	26	PF00069	0.639
MOD_Plk_4	214	220	PF00069	0.522
MOD_Plk_4	241	247	PF00069	0.561
MOD_Plk_4	254	260	PF00069	0.706
MOD_Plk_4	380	386	PF00069	0.477
MOD_Plk_4	514	520	PF00069	0.514
MOD_Plk_4	526	532	PF00069	0.491
MOD_ProDKin_1	124	130	PF00069	0.647
MOD_ProDKin_1	298	304	PF00069	0.667
MOD_ProDKin_1	455	461	PF00069	0.629
MOD_ProDKin_1	542	548	PF00069	0.578
TRG_DiLeu_BaEn_1	536	541	PF01217	0.471
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.555
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.474
TRG_ENDOCYTIC_2	333	336	PF00928	0.554
TRG_ENDOCYTIC_2	485	488	PF00928	0.422
TRG_ENDOCYTIC_2	515	518	PF00928	0.477
TRG_ER_diArg_1	133	136	PF00400	0.538
TRG_ER_diArg_1	405	408	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L4	Leptomonas seymouri	55%	100%
A0A3Q8I8N5	Leishmania donovani	93%	100%
A0A3R7NSE1	Trypanosoma rangeli	29%	100%
A4H5W5	Leishmania braziliensis	82%	100%
A4HU60	Leishmania infantum	93%	100%
D0A9P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AMZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BMK0	Trypanosoma cruzi	28%	100%