F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHN6_LEIMA

TriTrypDb:

LmjF.09.1390 , LMJLV39_090021300 , LMJSD75_090020900

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QHN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.702
CLV_NRD_NRD_1	197	199	PF00675	0.412
CLV_NRD_NRD_1	208	210	PF00675	0.425
CLV_NRD_NRD_1	40	42	PF00675	0.604
CLV_NRD_NRD_1	490	492	PF00675	0.619
CLV_PCSK_KEX2_1	208	210	PF00082	0.468
CLV_PCSK_KEX2_1	40	42	PF00082	0.593
CLV_PCSK_KEX2_1	490	492	PF00082	0.585
CLV_PCSK_KEX2_1	5	7	PF00082	0.498
CLV_PCSK_KEX2_1	506	508	PF00082	0.466
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.488
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.526
CLV_PCSK_SKI1_1	215	219	PF00082	0.427
CLV_PCSK_SKI1_1	273	277	PF00082	0.658
CLV_PCSK_SKI1_1	350	354	PF00082	0.617
CLV_PCSK_SKI1_1	390	394	PF00082	0.485
CLV_PCSK_SKI1_1	40	44	PF00082	0.504
CLV_PCSK_SKI1_1	449	453	PF00082	0.516
CLV_PCSK_SKI1_1	507	511	PF00082	0.632
DEG_SPOP_SBC_1	161	165	PF00917	0.542
DEG_SPOP_SBC_1	77	81	PF00917	0.704
DOC_CKS1_1	46	51	PF01111	0.712
DOC_MAPK_HePTP_8	592	604	PF00069	0.559
DOC_MAPK_MEF2A_6	277	284	PF00069	0.419
DOC_MAPK_MEF2A_6	595	604	PF00069	0.549
DOC_MAPK_NFAT4_5	277	285	PF00069	0.323
DOC_PP1_RVXF_1	241	248	PF00149	0.566
DOC_PP1_RVXF_1	318	325	PF00149	0.447
DOC_USP7_MATH_1	275	279	PF00917	0.425
DOC_USP7_MATH_1	368	372	PF00917	0.459
DOC_USP7_MATH_2	365	371	PF00917	0.379
DOC_WW_Pin1_4	41	46	PF00397	0.701
LIG_14-3-3_CanoR_1	390	395	PF00244	0.318
LIG_14-3-3_CanoR_1	449	455	PF00244	0.403
LIG_14-3-3_CanoR_1	507	512	PF00244	0.345
LIG_14-3-3_CanoR_1	559	563	PF00244	0.398
LIG_14-3-3_CanoR_1	6	11	PF00244	0.645
LIG_14-3-3_CanoR_1	70	78	PF00244	0.722
LIG_AP2alpha_2	455	457	PF02296	0.401
LIG_APCC_ABBA_1	157	162	PF00400	0.662
LIG_APCC_ABBA_1	421	426	PF00400	0.289
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BRCT_BRCA1_1	430	434	PF00533	0.296
LIG_BRCT_BRCA1_1	91	95	PF00533	0.675
LIG_Clathr_ClatBox_1	158	162	PF01394	0.679
LIG_Clathr_ClatBox_1	422	426	PF01394	0.322
LIG_deltaCOP1_diTrp_1	535	544	PF00928	0.347
LIG_EH1_1	204	212	PF00400	0.601
LIG_FHA_1	212	218	PF00498	0.697
LIG_FHA_1	283	289	PF00498	0.332
LIG_FHA_1	297	303	PF00498	0.292
LIG_FHA_1	316	322	PF00498	0.554
LIG_FHA_1	355	361	PF00498	0.392
LIG_FHA_1	397	403	PF00498	0.356
LIG_FHA_1	416	422	PF00498	0.244
LIG_FHA_1	46	52	PF00498	0.740
LIG_FHA_1	478	484	PF00498	0.295
LIG_FHA_1	5	11	PF00498	0.680
LIG_FHA_1	508	514	PF00498	0.336
LIG_FHA_1	605	611	PF00498	0.321
LIG_FHA_1	615	621	PF00498	0.323
LIG_FHA_1	649	655	PF00498	0.330
LIG_FHA_1	78	84	PF00498	0.710
LIG_FHA_2	110	116	PF00498	0.669
LIG_FHA_2	216	222	PF00498	0.580
LIG_FHA_2	292	298	PF00498	0.465
LIG_FHA_2	391	397	PF00498	0.325
LIG_FHA_2	450	456	PF00498	0.323
LIG_FHA_2	495	501	PF00498	0.450
LIG_FHA_2	552	558	PF00498	0.285
LIG_FHA_2	63	69	PF00498	0.664
LIG_GBD_Chelix_1	292	300	PF00786	0.425
LIG_LIR_Apic_2	498	504	PF02991	0.337
LIG_LIR_Gen_1	285	295	PF02991	0.333
LIG_LIR_Gen_1	376	384	PF02991	0.278
LIG_LIR_Gen_1	418	427	PF02991	0.258
LIG_LIR_Gen_1	510	516	PF02991	0.393
LIG_LIR_Gen_1	560	570	PF02991	0.412
LIG_LIR_Gen_1	651	659	PF02991	0.416
LIG_LIR_Nem_3	285	290	PF02991	0.427
LIG_LIR_Nem_3	376	380	PF02991	0.276
LIG_LIR_Nem_3	386	392	PF02991	0.284
LIG_LIR_Nem_3	452	457	PF02991	0.426
LIG_LIR_Nem_3	510	514	PF02991	0.384
LIG_LIR_Nem_3	567	572	PF02991	0.314
LIG_LIR_Nem_3	651	655	PF02991	0.416
LIG_MYND_1	45	49	PF01753	0.692
LIG_Pex14_1	544	548	PF04695	0.354
LIG_REV1ctd_RIR_1	1	10	PF16727	0.717
LIG_SH2_CRK	182	186	PF00017	0.664
LIG_SH2_CRK	404	408	PF00017	0.398
LIG_SH2_CRK	484	488	PF00017	0.373
LIG_SH2_GRB2like	182	185	PF00017	0.610
LIG_SH2_NCK_1	413	417	PF00017	0.407
LIG_SH2_PTP2	548	551	PF00017	0.312
LIG_SH2_PTP2	572	575	PF00017	0.349
LIG_SH2_SRC	237	240	PF00017	0.578
LIG_SH2_STAP1	182	186	PF00017	0.633
LIG_SH2_STAP1	429	433	PF00017	0.354
LIG_SH2_STAP1	450	454	PF00017	0.438
LIG_SH2_STAP1	72	76	PF00017	0.731
LIG_SH2_STAT5	160	163	PF00017	0.585
LIG_SH2_STAT5	191	194	PF00017	0.663
LIG_SH2_STAT5	206	209	PF00017	0.517
LIG_SH2_STAT5	222	225	PF00017	0.597
LIG_SH2_STAT5	237	240	PF00017	0.555
LIG_SH2_STAT5	267	270	PF00017	0.391
LIG_SH2_STAT5	404	407	PF00017	0.348
LIG_SH2_STAT5	424	427	PF00017	0.272
LIG_SH2_STAT5	548	551	PF00017	0.297
LIG_SH2_STAT5	572	575	PF00017	0.222
LIG_SH2_STAT5	632	635	PF00017	0.338
LIG_SH2_STAT5	658	661	PF00017	0.286
LIG_SH3_3	298	304	PF00018	0.305
LIG_SH3_3	375	381	PF00018	0.374
LIG_SH3_3	39	45	PF00018	0.767
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.380
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.266
LIG_SUMO_SIM_par_1	288	294	PF11976	0.314
LIG_SUMO_SIM_par_1	356	361	PF11976	0.390
LIG_SUMO_SIM_par_1	390	399	PF11976	0.366
LIG_SUMO_SIM_par_1	475	480	PF11976	0.278
LIG_SUMO_SIM_par_1	6	12	PF11976	0.663
LIG_TRFH_1	377	381	PF08558	0.363
LIG_TYR_ITIM	15	20	PF00017	0.699
LIG_TYR_ITIM	570	575	PF00017	0.416
LIG_UBA3_1	588	595	PF00899	0.490
LIG_Vh1_VBS_1	593	611	PF01044	0.317
LIG_WRC_WIRS_1	284	289	PF05994	0.374
LIG_WRC_WIRS_1	374	379	PF05994	0.425
MOD_CK1_1	109	115	PF00069	0.538
MOD_CK1_1	278	284	PF00069	0.452
MOD_CK1_1	512	518	PF00069	0.352
MOD_CK1_1	61	67	PF00069	0.663
MOD_CK1_1	9	15	PF00069	0.548
MOD_CK2_1	215	221	PF00069	0.479
MOD_CK2_1	291	297	PF00069	0.376
MOD_CK2_1	390	396	PF00069	0.431
MOD_CK2_1	551	557	PF00069	0.315
MOD_CK2_1	657	663	PF00069	0.374
MOD_DYRK1A_RPxSP_1	41	45	PF00069	0.631
MOD_GlcNHglycan	149	152	PF01048	0.596
MOD_GlcNHglycan	338	341	PF01048	0.342
MOD_GlcNHglycan	362	365	PF01048	0.516
MOD_GlcNHglycan	430	433	PF01048	0.433
MOD_GlcNHglycan	437	440	PF01048	0.415
MOD_GlcNHglycan	463	466	PF01048	0.578
MOD_GlcNHglycan	470	473	PF01048	0.595
MOD_GlcNHglycan	519	522	PF01048	0.415
MOD_GlcNHglycan	620	623	PF01048	0.327
MOD_GlcNHglycan	638	641	PF01048	0.330
MOD_GlcNHglycan	90	94	PF01048	0.612
MOD_GSK3_1	143	150	PF00069	0.603
MOD_GSK3_1	211	218	PF00069	0.629
MOD_GSK3_1	271	278	PF00069	0.507
MOD_GSK3_1	310	317	PF00069	0.596
MOD_GSK3_1	354	361	PF00069	0.512
MOD_GSK3_1	390	397	PF00069	0.402
MOD_GSK3_1	41	48	PF00069	0.657
MOD_GSK3_1	445	452	PF00069	0.406
MOD_GSK3_1	512	519	PF00069	0.345
MOD_GSK3_1	58	65	PF00069	0.537
MOD_GSK3_1	614	621	PF00069	0.404
MOD_GSK3_1	653	660	PF00069	0.383
MOD_GSK3_1	66	73	PF00069	0.633
MOD_GSK3_1	89	96	PF00069	0.635
MOD_LATS_1	87	93	PF00433	0.688
MOD_N-GLC_1	307	312	PF02516	0.415
MOD_N-GLC_1	427	432	PF02516	0.414
MOD_N-GLC_1	435	440	PF02516	0.371
MOD_N-GLC_1	468	473	PF02516	0.570
MOD_NEK2_1	271	276	PF00069	0.488
MOD_NEK2_1	282	287	PF00069	0.321
MOD_NEK2_1	296	301	PF00069	0.235
MOD_NEK2_1	309	314	PF00069	0.462
MOD_NEK2_1	329	334	PF00069	0.279
MOD_NEK2_1	341	346	PF00069	0.445
MOD_NEK2_1	360	365	PF00069	0.482
MOD_NEK2_1	4	9	PF00069	0.658
MOD_NEK2_1	516	521	PF00069	0.381
MOD_NEK2_1	551	556	PF00069	0.456
MOD_NEK2_1	60	65	PF00069	0.676
MOD_NEK2_1	618	623	PF00069	0.382
MOD_NEK2_1	653	658	PF00069	0.340
MOD_NEK2_1	95	100	PF00069	0.559
MOD_PIKK_1	396	402	PF00454	0.328
MOD_PIKK_1	477	483	PF00454	0.431
MOD_PKA_2	516	522	PF00069	0.439
MOD_PKA_2	523	529	PF00069	0.565
MOD_PKA_2	558	564	PF00069	0.414
MOD_PKB_1	388	396	PF00069	0.344
MOD_Plk_1	278	284	PF00069	0.446
MOD_Plk_1	296	302	PF00069	0.338
MOD_Plk_1	358	364	PF00069	0.492
MOD_Plk_1	435	441	PF00069	0.394
MOD_Plk_1	93	99	PF00069	0.641
MOD_Plk_2-3	354	360	PF00069	0.495
MOD_Plk_4	283	289	PF00069	0.361
MOD_Plk_4	291	297	PF00069	0.325
MOD_Plk_4	329	335	PF00069	0.392
MOD_Plk_4	373	379	PF00069	0.436
MOD_Plk_4	614	620	PF00069	0.412
MOD_Plk_4	628	634	PF00069	0.394
MOD_Plk_4	648	654	PF00069	0.150
MOD_ProDKin_1	41	47	PF00069	0.641
MOD_SUMO_for_1	227	230	PF00179	0.577
TRG_ENDOCYTIC_2	17	20	PF00928	0.705
TRG_ENDOCYTIC_2	182	185	PF00928	0.539
TRG_ENDOCYTIC_2	484	487	PF00928	0.356
TRG_ENDOCYTIC_2	548	551	PF00928	0.364
TRG_ENDOCYTIC_2	572	575	PF00928	0.329
TRG_ER_diArg_1	117	120	PF00400	0.621
TRG_ER_diArg_1	192	195	PF00400	0.490
TRG_ER_diArg_1	207	209	PF00400	0.499
TRG_ER_diArg_1	22	25	PF00400	0.725
TRG_ER_diArg_1	40	42	PF00400	0.592
TRG_ER_diArg_1	489	491	PF00400	0.397
TRG_NES_CRM1_1	152	162	PF08389	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M8	Leptomonas seymouri	65%	100%
A0A1X0NIN6	Trypanosomatidae	44%	100%
A0A3Q8I8N7	Leishmania donovani	92%	100%
A0A3R7N0K0	Trypanosoma rangeli	43%	100%
A4H5W6	Leishmania braziliensis	81%	100%
A4HU61	Leishmania infantum	92%	100%
D0A9P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AMZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BI21	Trypanosoma cruzi	41%	92%