Alpha-1,2-Mannosidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHN5_LEIMA

TriTrypDb:

LmjF.09.1400 , LMJLV39_090021400 , LMJSD75_090021000

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QHN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0004559	alpha-mannosidase activity	6	7
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	8	7
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0015923	mannosidase activity	5	7
GO:0015924	mannosyl-oligosaccharide mannosidase activity	7	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.459
CLV_NRD_NRD_1	11	13	PF00675	0.483
CLV_NRD_NRD_1	236	238	PF00675	0.663
CLV_NRD_NRD_1	288	290	PF00675	0.710
CLV_NRD_NRD_1	395	397	PF00675	0.647
CLV_NRD_NRD_1	470	472	PF00675	0.742
CLV_NRD_NRD_1	482	484	PF00675	0.573
CLV_PCSK_KEX2_1	10	12	PF00082	0.491
CLV_PCSK_KEX2_1	288	290	PF00082	0.651
CLV_PCSK_KEX2_1	482	484	PF00082	0.623
CLV_PCSK_SKI1_1	136	140	PF00082	0.654
CLV_PCSK_SKI1_1	162	166	PF00082	0.601
CLV_PCSK_SKI1_1	185	189	PF00082	0.722
CLV_PCSK_SKI1_1	277	281	PF00082	0.577
CLV_PCSK_SKI1_1	314	318	PF00082	0.615
CLV_PCSK_SKI1_1	88	92	PF00082	0.525
DEG_APCC_DBOX_1	13	21	PF00400	0.670
DEG_APCC_DBOX_1	184	192	PF00400	0.524
DEG_SPOP_SBC_1	222	226	PF00917	0.408
DOC_CKS1_1	338	343	PF01111	0.427
DOC_CKS1_1	532	537	PF01111	0.514
DOC_MAPK_gen_1	10	19	PF00069	0.657
DOC_MAPK_gen_1	396	404	PF00069	0.470
DOC_MAPK_gen_1	482	493	PF00069	0.381
DOC_MAPK_MEF2A_6	277	284	PF00069	0.361
DOC_MAPK_MEF2A_6	486	495	PF00069	0.352
DOC_MAPK_NFAT4_5	277	285	PF00069	0.380
DOC_PP1_RVXF_1	20	27	PF00149	0.569
DOC_PP4_FxxP_1	243	246	PF00568	0.498
DOC_USP7_MATH_1	152	156	PF00917	0.445
DOC_USP7_MATH_1	164	168	PF00917	0.318
DOC_USP7_MATH_1	201	205	PF00917	0.491
DOC_USP7_MATH_1	239	243	PF00917	0.546
DOC_USP7_MATH_1	263	267	PF00917	0.502
DOC_USP7_MATH_1	302	306	PF00917	0.436
DOC_USP7_MATH_1	363	367	PF00917	0.485
DOC_USP7_MATH_1	55	59	PF00917	0.577
DOC_USP7_MATH_1	65	69	PF00917	0.465
DOC_WW_Pin1_4	129	134	PF00397	0.491
DOC_WW_Pin1_4	337	342	PF00397	0.439
DOC_WW_Pin1_4	476	481	PF00397	0.416
DOC_WW_Pin1_4	519	524	PF00397	0.394
DOC_WW_Pin1_4	531	536	PF00397	0.479
LIG_14-3-3_CanoR_1	237	246	PF00244	0.567
LIG_14-3-3_CanoR_1	314	323	PF00244	0.464
LIG_14-3-3_CanoR_1	369	376	PF00244	0.445
LIG_14-3-3_CanoR_1	396	404	PF00244	0.454
LIG_14-3-3_CanoR_1	426	430	PF00244	0.465
LIG_APCC_ABBA_1	387	392	PF00400	0.419
LIG_BRCT_BRCA1_1	239	243	PF00533	0.472
LIG_BRCT_BRCA1_1	321	325	PF00533	0.356
LIG_CSL_BTD_1	243	246	PF09270	0.498
LIG_deltaCOP1_diTrp_1	71	79	PF00928	0.502
LIG_EH1_1	495	503	PF00400	0.466
LIG_FHA_1	106	112	PF00498	0.448
LIG_FHA_1	224	230	PF00498	0.469
LIG_FHA_1	311	317	PF00498	0.413
LIG_FHA_1	488	494	PF00498	0.442
LIG_FHA_1	515	521	PF00498	0.402
LIG_FHA_1	523	529	PF00498	0.404
LIG_FHA_1	64	70	PF00498	0.529
LIG_FHA_1	96	102	PF00498	0.396
LIG_FHA_2	132	138	PF00498	0.412
LIG_FHA_2	369	375	PF00498	0.337
LIG_FHA_2	444	450	PF00498	0.462
LIG_LIR_Apic_2	240	246	PF02991	0.506
LIG_LIR_Gen_1	204	213	PF02991	0.460
LIG_LIR_Gen_1	21	31	PF02991	0.498
LIG_LIR_Gen_1	266	276	PF02991	0.433
LIG_LIR_Gen_1	322	332	PF02991	0.348
LIG_LIR_Gen_1	427	437	PF02991	0.487
LIG_LIR_Gen_1	490	498	PF02991	0.368
LIG_LIR_Nem_3	204	209	PF02991	0.447
LIG_LIR_Nem_3	21	26	PF02991	0.506
LIG_LIR_Nem_3	212	217	PF02991	0.418
LIG_LIR_Nem_3	266	272	PF02991	0.451
LIG_LIR_Nem_3	322	328	PF02991	0.361
LIG_LIR_Nem_3	384	390	PF02991	0.398
LIG_LIR_Nem_3	427	432	PF02991	0.481
LIG_LIR_Nem_3	438	444	PF02991	0.319
LIG_LIR_Nem_3	490	495	PF02991	0.363
LIG_PCNA_PIPBox_1	304	313	PF02747	0.436
LIG_SH2_CRK	269	273	PF00017	0.421
LIG_SH2_NCK_1	390	394	PF00017	0.432
LIG_SH2_NCK_1	413	417	PF00017	0.609
LIG_SH2_PTP2	34	37	PF00017	0.512
LIG_SH2_SRC	390	393	PF00017	0.424
LIG_SH2_STAP1	269	273	PF00017	0.421
LIG_SH2_STAP1	299	303	PF00017	0.404
LIG_SH2_STAP1	312	316	PF00017	0.436
LIG_SH2_STAP1	413	417	PF00017	0.447
LIG_SH2_STAT5	23	26	PF00017	0.352
LIG_SH2_STAT5	312	315	PF00017	0.510
LIG_SH2_STAT5	34	37	PF00017	0.352
LIG_SH2_STAT5	370	373	PF00017	0.366
LIG_SH2_STAT5	403	406	PF00017	0.481
LIG_SH2_STAT5	413	416	PF00017	0.537
LIG_SH2_STAT5	429	432	PF00017	0.427
LIG_SH2_STAT5	96	99	PF00017	0.405
LIG_SH3_3	191	197	PF00018	0.477
LIG_SH3_3	335	341	PF00018	0.446
LIG_SH3_3	359	365	PF00018	0.534
LIG_SH3_3	526	532	PF00018	0.437
LIG_SH3_3	70	76	PF00018	0.474
LIG_SH3_3	77	83	PF00018	0.435
LIG_SH3_CIN85_PxpxPR_1	337	342	PF14604	0.511
LIG_Sin3_3	332	339	PF02671	0.542
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.379
LIG_SUMO_SIM_anti_2	456	461	PF11976	0.386
LIG_SUMO_SIM_par_1	120	125	PF11976	0.362
LIG_SUMO_SIM_par_1	34	39	PF11976	0.499
LIG_WRC_WIRS_1	437	442	PF05994	0.369
MOD_CDK_SPK_2	337	342	PF00069	0.439
MOD_CDK_SPxK_1	476	482	PF00069	0.415
MOD_CDK_SPxxK_3	129	136	PF00069	0.487
MOD_CDK_SPxxK_3	476	483	PF00069	0.412
MOD_CK1_1	151	157	PF00069	0.447
MOD_CK1_1	204	210	PF00069	0.452
MOD_CK1_1	215	221	PF00069	0.489
MOD_CK1_1	223	229	PF00069	0.544
MOD_CK1_1	424	430	PF00069	0.475
MOD_CK1_1	506	512	PF00069	0.464
MOD_CK1_1	522	528	PF00069	0.401
MOD_CK2_1	131	137	PF00069	0.405
MOD_CK2_1	327	333	PF00069	0.509
MOD_CK2_1	436	442	PF00069	0.369
MOD_CK2_1	55	61	PF00069	0.583
MOD_CK2_1	65	71	PF00069	0.463
MOD_Cter_Amidation	286	289	PF01082	0.623
MOD_Cter_Amidation	394	397	PF01082	0.667
MOD_GlcNHglycan	150	153	PF01048	0.769
MOD_GlcNHglycan	166	169	PF01048	0.647
MOD_GlcNHglycan	206	209	PF01048	0.643
MOD_GlcNHglycan	265	268	PF01048	0.744
MOD_GlcNHglycan	399	402	PF01048	0.696
MOD_GlcNHglycan	406	409	PF01048	0.689
MOD_GlcNHglycan	420	424	PF01048	0.720
MOD_GlcNHglycan	476	479	PF01048	0.716
MOD_GlcNHglycan	57	60	PF01048	0.729
MOD_GSK3_1	122	129	PF00069	0.415
MOD_GSK3_1	148	155	PF00069	0.530
MOD_GSK3_1	197	204	PF00069	0.555
MOD_GSK3_1	221	228	PF00069	0.497
MOD_GSK3_1	310	317	PF00069	0.396
MOD_GSK3_1	319	326	PF00069	0.405
MOD_GSK3_1	364	371	PF00069	0.455
MOD_GSK3_1	421	428	PF00069	0.505
MOD_GSK3_1	470	477	PF00069	0.477
MOD_GSK3_1	95	102	PF00069	0.479
MOD_N-GLC_1	323	328	PF02516	0.619
MOD_N-GLC_2	3	5	PF02516	0.482
MOD_NEK2_1	122	127	PF00069	0.361
MOD_NEK2_1	256	261	PF00069	0.539
MOD_NEK2_1	310	315	PF00069	0.430
MOD_NEK2_1	323	328	PF00069	0.419
MOD_NEK2_1	36	41	PF00069	0.396
MOD_NEK2_1	382	387	PF00069	0.380
MOD_NEK2_1	425	430	PF00069	0.511
MOD_NEK2_1	436	441	PF00069	0.320
MOD_NEK2_1	443	448	PF00069	0.275
MOD_NEK2_2	232	237	PF00069	0.466
MOD_NEK2_2	421	426	PF00069	0.510
MOD_PIKK_1	3	9	PF00454	0.691
MOD_PKA_1	237	243	PF00069	0.484
MOD_PKA_1	288	294	PF00069	0.455
MOD_PKA_2	215	221	PF00069	0.433
MOD_PKA_2	288	294	PF00069	0.455
MOD_PKA_2	363	369	PF00069	0.559
MOD_PKA_2	425	431	PF00069	0.453
MOD_PKA_2	470	476	PF00069	0.540
MOD_PKA_2	503	509	PF00069	0.476
MOD_Plk_1	323	329	PF00069	0.381
MOD_Plk_4	239	245	PF00069	0.552
MOD_Plk_4	302	308	PF00069	0.410
MOD_Plk_4	36	42	PF00069	0.376
MOD_Plk_4	436	442	PF00069	0.369
MOD_Plk_4	516	522	PF00069	0.400
MOD_ProDKin_1	129	135	PF00069	0.484
MOD_ProDKin_1	337	343	PF00069	0.433
MOD_ProDKin_1	476	482	PF00069	0.415
MOD_ProDKin_1	519	525	PF00069	0.396
MOD_ProDKin_1	531	537	PF00069	0.488
TRG_DiLeu_BaEn_2	182	188	PF01217	0.421
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.372
TRG_ENDOCYTIC_2	23	26	PF00928	0.352
TRG_ENDOCYTIC_2	269	272	PF00928	0.429
TRG_ENDOCYTIC_2	34	37	PF00928	0.352
TRG_ENDOCYTIC_2	429	432	PF00928	0.499
TRG_ER_diArg_1	10	12	PF00400	0.691
TRG_ER_diArg_1	481	483	PF00400	0.423
TRG_NES_CRM1_1	449	463	PF08389	0.402
TRG_NLS_MonoExtN_4	393	400	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A3	Leptomonas seymouri	53%	97%
A0A3Q8I8J9	Leishmania donovani	92%	82%
A4H5W7	Leishmania braziliensis	76%	100%
A4HU62	Leishmania infantum	92%	100%
E9AMZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%