SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHN4_LEIMA

TriTrypDb:

LmjF.09.1410 , LMJLV39_090021500 , LMJSD75_090021200

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN4

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018026	peptidyl-lysine monomethylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.588
CLV_NRD_NRD_1	175	177	PF00675	0.524
CLV_NRD_NRD_1	189	191	PF00675	0.361
CLV_NRD_NRD_1	229	231	PF00675	0.478
CLV_NRD_NRD_1	531	533	PF00675	0.539
CLV_NRD_NRD_1	79	81	PF00675	0.603
CLV_PCSK_KEX2_1	165	167	PF00082	0.579
CLV_PCSK_KEX2_1	175	177	PF00082	0.495
CLV_PCSK_KEX2_1	189	191	PF00082	0.365
CLV_PCSK_KEX2_1	229	231	PF00082	0.478
CLV_PCSK_KEX2_1	440	442	PF00082	0.510
CLV_PCSK_KEX2_1	531	533	PF00082	0.555
CLV_PCSK_KEX2_1	64	66	PF00082	0.478
CLV_PCSK_KEX2_1	79	81	PF00082	0.568
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.608
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.440
CLV_PCSK_SKI1_1	129	133	PF00082	0.389
CLV_PCSK_SKI1_1	176	180	PF00082	0.451
CLV_PCSK_SKI1_1	19	23	PF00082	0.480
CLV_PCSK_SKI1_1	565	569	PF00082	0.635
DOC_CYCLIN_RxL_1	186	197	PF00134	0.584
DOC_MAPK_DCC_7	342	351	PF00069	0.498
DOC_MAPK_HePTP_8	126	138	PF00069	0.353
DOC_MAPK_HePTP_8	339	351	PF00069	0.534
DOC_MAPK_MEF2A_6	129	138	PF00069	0.336
DOC_MAPK_MEF2A_6	342	351	PF00069	0.464
DOC_PP2B_LxvP_1	119	122	PF13499	0.524
DOC_PP2B_LxvP_1	297	300	PF13499	0.470
DOC_PP2B_LxvP_1	541	544	PF13499	0.448
DOC_PP4_MxPP_1	1	4	PF00568	0.595
DOC_USP7_MATH_1	207	211	PF00917	0.489
DOC_USP7_MATH_1	410	414	PF00917	0.574
DOC_USP7_MATH_1	463	467	PF00917	0.654
DOC_WW_Pin1_4	140	145	PF00397	0.479
DOC_WW_Pin1_4	151	156	PF00397	0.477
DOC_WW_Pin1_4	235	240	PF00397	0.521
DOC_WW_Pin1_4	34	39	PF00397	0.632
DOC_WW_Pin1_4	459	464	PF00397	0.718
LIG_14-3-3_CanoR_1	111	116	PF00244	0.438
LIG_14-3-3_CanoR_1	175	179	PF00244	0.610
LIG_14-3-3_CanoR_1	283	293	PF00244	0.563
LIG_APCC_ABBAyCdc20_2	402	408	PF00400	0.532
LIG_BIR_III_2	161	165	PF00653	0.479
LIG_BRCT_BRCA1_1	463	467	PF00533	0.733
LIG_CtBP_PxDLS_1	389	395	PF00389	0.534
LIG_deltaCOP1_diTrp_1	492	501	PF00928	0.353
LIG_EH1_1	287	295	PF00400	0.474
LIG_FHA_1	133	139	PF00498	0.326
LIG_FHA_1	195	201	PF00498	0.457
LIG_FHA_1	236	242	PF00498	0.477
LIG_FHA_1	285	291	PF00498	0.510
LIG_FHA_1	49	55	PF00498	0.404
LIG_Pex14_1	495	499	PF04695	0.347
LIG_SH2_GRB2like	33	36	PF00017	0.567
LIG_SH2_NCK_1	396	400	PF00017	0.643
LIG_SH2_STAT5	139	142	PF00017	0.374
LIG_SH2_STAT5	245	248	PF00017	0.645
LIG_SH3_3	161	167	PF00018	0.442
LIG_SH3_3	341	347	PF00018	0.566
LIG_SH3_3	409	415	PF00018	0.729
LIG_SH3_3	475	481	PF00018	0.556
LIG_SH3_3	564	570	PF00018	0.539
LIG_SUMO_SIM_par_1	295	301	PF11976	0.513
LIG_TRAF2_1	388	391	PF00917	0.450
LIG_TRAF2_1	504	507	PF00917	0.621
LIG_TYR_ITIM	394	399	PF00017	0.400
LIG_UBA3_1	405	414	PF00899	0.504
MOD_CDC14_SPxK_1	154	157	PF00782	0.399
MOD_CDK_SPxK_1	151	157	PF00069	0.424
MOD_CK1_1	110	116	PF00069	0.516
MOD_CK1_1	117	123	PF00069	0.493
MOD_CK1_1	177	183	PF00069	0.578
MOD_CK1_1	251	257	PF00069	0.607
MOD_CK1_1	301	307	PF00069	0.368
MOD_CK1_1	34	40	PF00069	0.620
MOD_CK1_1	413	419	PF00069	0.596
MOD_CK1_1	67	73	PF00069	0.514
MOD_CK2_1	304	310	PF00069	0.280
MOD_CK2_1	501	507	PF00069	0.432
MOD_GlcNHglycan	116	119	PF01048	0.545
MOD_GlcNHglycan	250	253	PF01048	0.565
MOD_GlcNHglycan	314	317	PF01048	0.377
MOD_GlcNHglycan	321	325	PF01048	0.400
MOD_GlcNHglycan	373	377	PF01048	0.319
MOD_GlcNHglycan	424	427	PF01048	0.639
MOD_GSK3_1	107	114	PF00069	0.460
MOD_GSK3_1	378	385	PF00069	0.311
MOD_GSK3_1	44	51	PF00069	0.495
MOD_GSK3_1	459	466	PF00069	0.672
MOD_GSK3_1	468	475	PF00069	0.496
MOD_N-GLC_1	34	39	PF02516	0.676
MOD_N-GLC_1	358	363	PF02516	0.286
MOD_NEK2_1	132	137	PF00069	0.339
MOD_NEK2_1	138	143	PF00069	0.350
MOD_NEK2_1	174	179	PF00069	0.583
MOD_NEK2_1	26	31	PF00069	0.479
MOD_NEK2_1	331	336	PF00069	0.260
MOD_NEK2_1	358	363	PF00069	0.298
MOD_NEK2_1	467	472	PF00069	0.700
MOD_NEK2_1	514	519	PF00069	0.642
MOD_PIKK_1	251	257	PF00454	0.555
MOD_PIKK_1	72	78	PF00454	0.505
MOD_PIKK_1	84	90	PF00454	0.533
MOD_PK_1	64	70	PF00069	0.391
MOD_PKA_1	64	70	PF00069	0.312
MOD_PKA_2	110	116	PF00069	0.536
MOD_PKA_2	174	180	PF00069	0.616
MOD_PKA_2	248	254	PF00069	0.540
MOD_PKA_2	257	263	PF00069	0.555
MOD_PKA_2	410	416	PF00069	0.585
MOD_PKA_2	422	428	PF00069	0.611
MOD_PKA_2	64	70	PF00069	0.536
MOD_PKA_2	72	78	PF00069	0.481
MOD_PKA_2	8	14	PF00069	0.630
MOD_Plk_1	320	326	PF00069	0.427
MOD_Plk_4	237	243	PF00069	0.519
MOD_Plk_4	347	353	PF00069	0.406
MOD_Plk_4	64	70	PF00069	0.493
MOD_ProDKin_1	140	146	PF00069	0.478
MOD_ProDKin_1	151	157	PF00069	0.477
MOD_ProDKin_1	235	241	PF00069	0.516
MOD_ProDKin_1	34	40	PF00069	0.635
MOD_ProDKin_1	459	465	PF00069	0.712
TRG_ENDOCYTIC_2	396	399	PF00928	0.523
TRG_ENDOCYTIC_2	443	446	PF00928	0.617
TRG_ER_diArg_1	164	166	PF00400	0.591
TRG_ER_diArg_1	174	176	PF00400	0.529
TRG_ER_diArg_1	188	190	PF00400	0.384
TRG_ER_diArg_1	228	230	PF00400	0.495
TRG_ER_diArg_1	421	424	PF00400	0.674
TRG_ER_diArg_1	520	523	PF00400	0.487
TRG_ER_diArg_1	530	532	PF00400	0.492
TRG_ER_diArg_1	559	562	PF00400	0.451
TRG_ER_diArg_1	78	80	PF00400	0.613
TRG_NLS_MonoExtC_3	531	536	PF00514	0.530
TRG_NLS_MonoExtN_4	531	536	PF00514	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB06	Leptomonas seymouri	61%	99%
A0A0S4JCA3	Bodo saltans	28%	92%
A0A1X0NHU4	Trypanosomatidae	38%	100%
A0A3S7WQW9	Leishmania donovani	96%	100%
A0A422NZM7	Trypanosoma rangeli	40%	100%
A4H5W8	Leishmania braziliensis	82%	100%
A4HU63	Leishmania infantum	96%	100%
D0A9P4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
E9AMZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AY09	Trypanosoma cruzi	38%	100%