J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHN1_LEIMA

TriTrypDb:

LmjF.09.1440 , LMJLV39_090022000 , LMJSD75_090021700

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0009987	cellular process	1	2
GO:0042026	protein refolding	3	2
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.722
CLV_NRD_NRD_1	103	105	PF00675	0.633
CLV_NRD_NRD_1	153	155	PF00675	0.475
CLV_NRD_NRD_1	260	262	PF00675	0.667
CLV_NRD_NRD_1	270	272	PF00675	0.543
CLV_NRD_NRD_1	362	364	PF00675	0.664
CLV_NRD_NRD_1	382	384	PF00675	0.472
CLV_NRD_NRD_1	40	42	PF00675	0.533
CLV_NRD_NRD_1	5	7	PF00675	0.609
CLV_PCSK_KEX2_1	103	105	PF00082	0.633
CLV_PCSK_KEX2_1	153	155	PF00082	0.475
CLV_PCSK_KEX2_1	260	262	PF00082	0.609
CLV_PCSK_KEX2_1	270	272	PF00082	0.672
CLV_PCSK_KEX2_1	382	384	PF00082	0.627
CLV_PCSK_KEX2_1	5	7	PF00082	0.600
CLV_PCSK_KEX2_1	60	62	PF00082	0.279
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.297
CLV_PCSK_SKI1_1	103	107	PF00082	0.657
CLV_PCSK_SKI1_1	262	266	PF00082	0.606
DEG_SPOP_SBC_1	207	211	PF00917	0.421
DEG_SPOP_SBC_1	78	82	PF00917	0.428
DOC_CYCLIN_RxL_1	99	109	PF00134	0.550
DOC_MAPK_gen_1	41	49	PF00069	0.468
DOC_MAPK_gen_1	5	11	PF00069	0.557
DOC_PP4_FxxP_1	170	173	PF00568	0.500
DOC_USP7_MATH_1	112	116	PF00917	0.704
DOC_USP7_MATH_1	117	121	PF00917	0.740
DOC_USP7_MATH_1	15	19	PF00917	0.521
DOC_USP7_MATH_1	188	192	PF00917	0.757
DOC_USP7_MATH_1	71	75	PF00917	0.357
DOC_USP7_MATH_1	78	82	PF00917	0.357
DOC_WW_Pin1_4	203	208	PF00397	0.594
DOC_WW_Pin1_4	283	288	PF00397	0.551
DOC_WW_Pin1_4	330	335	PF00397	0.647
LIG_14-3-3_CanoR_1	14	20	PF00244	0.540
LIG_14-3-3_CanoR_1	251	258	PF00244	0.561
LIG_14-3-3_CanoR_1	29	35	PF00244	0.501
LIG_14-3-3_CanoR_1	363	370	PF00244	0.622
LIG_14-3-3_CanoR_1	84	92	PF00244	0.410
LIG_AP2alpha_2	313	315	PF02296	0.585
LIG_APCC_ABBA_1	221	226	PF00400	0.396
LIG_BRCT_BRCA1_1	21	25	PF00533	0.535
LIG_BRCT_BRCA1_1	228	232	PF00533	0.396
LIG_FHA_2	209	215	PF00498	0.470
LIG_FHA_2	34	40	PF00498	0.428
LIG_FHA_2	52	58	PF00498	0.322
LIG_LIR_Apic_2	168	173	PF02991	0.662
LIG_LIR_Apic_2	175	180	PF02991	0.662
LIG_LIR_Apic_2	323	328	PF02991	0.615
LIG_LIR_Gen_1	229	237	PF02991	0.389
LIG_LIR_Gen_1	293	303	PF02991	0.579
LIG_LIR_Nem_3	229	233	PF02991	0.388
LIG_LIR_Nem_3	289	295	PF02991	0.548
LIG_LIR_Nem_3	313	318	PF02991	0.696
LIG_LIR_Nem_3	333	338	PF02991	0.757
LIG_SH2_CRK	325	329	PF00017	0.733
LIG_SH2_CRK	44	48	PF00017	0.279
LIG_SH2_CRK	92	96	PF00017	0.318
LIG_SH2_NCK_1	325	329	PF00017	0.610
LIG_SH2_SRC	224	227	PF00017	0.439
LIG_SH2_STAP1	145	149	PF00017	0.437
LIG_SH2_STAT3	126	129	PF00017	0.607
LIG_SH2_STAT5	329	332	PF00017	0.572
LIG_TRAF2_1	307	310	PF00917	0.634
LIG_WW_3	178	182	PF00397	0.686
MOD_CK1_1	115	121	PF00069	0.603
MOD_CK1_1	124	130	PF00069	0.622
MOD_CK1_1	191	197	PF00069	0.713
MOD_CK1_1	206	212	PF00069	0.608
MOD_CK1_1	308	314	PF00069	0.481
MOD_CK1_1	405	411	PF00069	0.608
MOD_CK1_1	74	80	PF00069	0.410
MOD_CK2_1	208	214	PF00069	0.590
MOD_CK2_1	283	289	PF00069	0.617
MOD_CK2_1	304	310	PF00069	0.632
MOD_Cter_Amidation	101	104	PF01082	0.484
MOD_Cter_Amidation	202	205	PF01082	0.652
MOD_GlcNHglycan	114	117	PF01048	0.601
MOD_GlcNHglycan	130	133	PF01048	0.544
MOD_GlcNHglycan	184	187	PF01048	0.773
MOD_GlcNHglycan	19	22	PF01048	0.626
MOD_GlcNHglycan	191	194	PF01048	0.582
MOD_GlcNHglycan	240	243	PF01048	0.540
MOD_GlcNHglycan	25	28	PF01048	0.663
MOD_GlcNHglycan	309	313	PF01048	0.614
MOD_GlcNHglycan	318	321	PF01048	0.559
MOD_GlcNHglycan	393	396	PF01048	0.738
MOD_GlcNHglycan	399	402	PF01048	0.739
MOD_GlcNHglycan	407	410	PF01048	0.761
MOD_GlcNHglycan	51	54	PF01048	0.393
MOD_GlcNHglycan	76	79	PF01048	0.366
MOD_GSK3_1	115	122	PF00069	0.618
MOD_GSK3_1	124	131	PF00069	0.600
MOD_GSK3_1	15	22	PF00069	0.608
MOD_GSK3_1	188	195	PF00069	0.626
MOD_GSK3_1	203	210	PF00069	0.554
MOD_GSK3_1	304	311	PF00069	0.487
MOD_GSK3_1	359	366	PF00069	0.719
MOD_GSK3_1	49	56	PF00069	0.475
MOD_GSK3_1	73	80	PF00069	0.366
MOD_N-GLC_1	112	117	PF02516	0.628
MOD_N-GLC_1	182	187	PF02516	0.774
MOD_N-GLC_1	359	364	PF02516	0.733
MOD_N-GLC_1	74	79	PF02516	0.369
MOD_NEK2_1	106	111	PF00069	0.674
MOD_NEK2_1	19	24	PF00069	0.656
MOD_NEK2_2	91	96	PF00069	0.357
MOD_PKA_1	363	369	PF00069	0.774
MOD_PKA_2	188	194	PF00069	0.687
MOD_PKA_2	197	203	PF00069	0.457
MOD_PKA_2	250	256	PF00069	0.448
MOD_PKA_2	83	89	PF00069	0.410
MOD_PKB_1	187	195	PF00069	0.672
MOD_Plk_1	157	163	PF00069	0.593
MOD_Plk_1	74	80	PF00069	0.197
MOD_Plk_2-3	226	232	PF00069	0.402
MOD_Plk_2-3	305	311	PF00069	0.675
MOD_Plk_4	121	127	PF00069	0.591
MOD_Plk_4	19	25	PF00069	0.463
MOD_ProDKin_1	203	209	PF00069	0.585
MOD_ProDKin_1	283	289	PF00069	0.551
MOD_ProDKin_1	330	336	PF00069	0.649
TRG_ENDOCYTIC_2	137	140	PF00928	0.506
TRG_ENDOCYTIC_2	145	148	PF00928	0.404
TRG_ENDOCYTIC_2	295	298	PF00928	0.673
TRG_ENDOCYTIC_2	348	351	PF00928	0.589
TRG_ENDOCYTIC_2	44	47	PF00928	0.279
TRG_ENDOCYTIC_2	62	65	PF00928	0.279
TRG_ENDOCYTIC_2	92	95	PF00928	0.318
TRG_ER_diArg_1	103	105	PF00400	0.637
TRG_ER_diArg_1	152	154	PF00400	0.474
TRG_ER_diArg_1	270	273	PF00400	0.613
TRG_ER_diArg_1	382	384	PF00400	0.634
TRG_ER_diArg_1	4	6	PF00400	0.584
TRG_ER_diArg_1	7	10	PF00400	0.586
TRG_NLS_Bipartite_1	41	63	PF00514	0.355
TRG_NLS_MonoExtC_3	58	64	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I106	Leptomonas seymouri	56%	98%
A0A1X0NII8	Trypanosomatidae	40%	100%
A0A3Q8IC04	Leishmania donovani	94%	100%
A0A3R7KNF9	Trypanosoma rangeli	40%	100%
A4H5X1	Leishmania braziliensis	81%	100%
A4HU66	Leishmania infantum	94%	100%
D0A9P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BMJ5	Trypanosoma cruzi	38%	100%