Rhodanese domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHN0_LEIMA

TriTrypDb:

LmjF.09.1450 , LMJLV39_090022100 , LMJSD75_090021800

Length:

131

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004792	thiosulfate sulfurtransferase activity	5	3
GO:0016740	transferase activity	2	3
GO:0016782	transferase activity, transferring sulphur-containing groups	3	3
GO:0016783	sulfurtransferase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.555
CLV_NRD_NRD_1	70	72	PF00675	0.277
CLV_NRD_NRD_1	75	77	PF00675	0.265
DOC_MAPK_gen_1	104	112	PF00069	0.574
DOC_MAPK_gen_1	76	86	PF00069	0.473
DOC_PP1_RVXF_1	105	112	PF00149	0.466
DOC_USP7_MATH_1	114	118	PF00917	0.506
DOC_USP7_UBL2_3	77	81	PF12436	0.513
LIG_14-3-3_CanoR_1	104	110	PF00244	0.506
LIG_14-3-3_CanoR_1	93	101	PF00244	0.473
LIG_APCC_ABBAyCdc20_2	107	113	PF00400	0.466
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BRCT_BRCA1_1	107	111	PF00533	0.497
LIG_LIR_Gen_1	57	64	PF02991	0.501
LIG_LIR_Nem_3	7	13	PF02991	0.479
LIG_PDZ_Class_3	126	131	PF00595	0.539
LIG_Pex14_2	6	10	PF04695	0.428
LIG_SH2_CRK	106	110	PF00017	0.481
LIG_SH2_SRC	119	122	PF00017	0.431
LIG_SH2_STAP1	13	17	PF00017	0.396
LIG_SH2_STAT3	13	16	PF00017	0.392
LIG_SH2_STAT5	100	103	PF00017	0.543
LIG_SH2_STAT5	119	122	PF00017	0.272
LIG_SH2_STAT5	31	34	PF00017	0.518
LIG_SH2_STAT5	54	57	PF00017	0.450
LIG_SH3_3	72	78	PF00018	0.483
LIG_SH3_4	77	84	PF00018	0.510
LIG_SUMO_SIM_par_1	31	38	PF11976	0.510
MOD_CK1_1	96	102	PF00069	0.522
MOD_GlcNHglycan	25	28	PF01048	0.298
MOD_GlcNHglycan	66	69	PF01048	0.327
MOD_GlcNHglycan	95	98	PF01048	0.346
MOD_GSK3_1	92	99	PF00069	0.466
MOD_NEK2_1	120	125	PF00069	0.573
MOD_NEK2_1	64	69	PF00069	0.497
MOD_PIKK_1	120	126	PF00454	0.519
MOD_PKA_2	64	70	PF00069	0.523
MOD_PKA_2	92	98	PF00069	0.501
MOD_Plk_4	105	111	PF00069	0.458
MOD_Plk_4	96	102	PF00069	0.495
MOD_SUMO_rev_2	108	117	PF00179	0.466
TRG_ENDOCYTIC_2	106	109	PF00928	0.501
TRG_ENDOCYTIC_2	59	62	PF00928	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P899	Leptomonas seymouri	56%	100%
A0A0N0P8M5	Leptomonas seymouri	35%	100%
A0A1X0NHS7	Trypanosomatidae	31%	100%
A0A1X0NJI4	Trypanosomatidae	34%	96%
A0A3Q8I7K7	Leishmania donovani	100%	100%
A0A3R7LB88	Trypanosoma rangeli	27%	100%
A0A3R7MT99	Trypanosoma rangeli	27%	96%
A0A3S7WQX1	Leishmania donovani	31%	100%
A4H5X2	Leishmania braziliensis	79%	100%
A4HU67	Leishmania infantum	100%	100%
A4HU69	Leishmania infantum	31%	100%
D0A9P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	96%
E9AMZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AMZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
P22978	Drosophila melanogaster	31%	100%
Q4QHM8	Leishmania major	30%	100%
V5BI16	Trypanosoma cruzi	31%	81%