Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHM9_LEIMA

TriTrypDb:

LmjF.09.1460 , LMJLV39_090022200 , LMJSD75_090021900

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHM9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004792	thiosulfate sulfurtransferase activity	5	5
GO:0016740	transferase activity	2	5
GO:0016782	transferase activity, transferring sulphur-containing groups	3	5
GO:0016783	sulfurtransferase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.380
CLV_NRD_NRD_1	3	5	PF00675	0.575
CLV_PCSK_KEX2_1	3	5	PF00082	0.514
CLV_PCSK_SKI1_1	19	23	PF00082	0.336
CLV_PCSK_SKI1_1	63	67	PF00082	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.482
DOC_CKS1_1	132	137	PF01111	0.578
DOC_CKS1_1	145	150	PF01111	0.568
DOC_USP7_MATH_1	135	139	PF00917	0.613
DOC_USP7_MATH_1	23	27	PF00917	0.381
DOC_WW_Pin1_4	131	136	PF00397	0.545
DOC_WW_Pin1_4	144	149	PF00397	0.581
LIG_14-3-3_CanoR_1	3	7	PF00244	0.572
LIG_Actin_WH2_2	48	65	PF00022	0.473
LIG_FHA_1	3	9	PF00498	0.543
LIG_FHA_1	40	46	PF00498	0.422
LIG_FHA_1	89	95	PF00498	0.496
LIG_GBD_Chelix_1	105	113	PF00786	0.266
LIG_LIR_Gen_1	112	121	PF02991	0.519
LIG_LIR_Gen_1	74	84	PF02991	0.512
LIG_LIR_Nem_3	112	118	PF02991	0.528
LIG_LIR_Nem_3	74	80	PF02991	0.512
LIG_Pex14_1	125	129	PF04695	0.443
LIG_Pex14_2	121	125	PF04695	0.436
LIG_Pex14_2	77	81	PF04695	0.422
LIG_SH2_CRK	132	136	PF00017	0.578
LIG_SH2_STAT5	96	99	PF00017	0.436
LIG_SUMO_SIM_par_1	35	42	PF11976	0.439
MOD_CDK_SPxK_1	144	150	PF00069	0.497
MOD_CK1_1	119	125	PF00069	0.541
MOD_CK1_1	144	150	PF00069	0.597
MOD_CK1_1	67	73	PF00069	0.401
MOD_CK2_1	38	44	PF00069	0.446
MOD_CK2_1	67	73	PF00069	0.528
MOD_CMANNOS	125	128	PF00535	0.287
MOD_GlcNHglycan	102	105	PF01048	0.263
MOD_GlcNHglycan	121	124	PF01048	0.213
MOD_GlcNHglycan	137	140	PF01048	0.587
MOD_GlcNHglycan	52	55	PF01048	0.332
MOD_GSK3_1	131	138	PF00069	0.597
MOD_N-GLC_1	116	121	PF02516	0.257
MOD_NEK2_1	121	126	PF00069	0.457
MOD_NEK2_1	2	7	PF00069	0.473
MOD_PIKK_1	64	70	PF00454	0.401
MOD_PIKK_1	88	94	PF00454	0.436
MOD_PKA_2	2	8	PF00069	0.554
MOD_PKA_2	39	45	PF00069	0.438
MOD_Plk_4	67	73	PF00069	0.492
MOD_ProDKin_1	131	137	PF00069	0.559
MOD_ProDKin_1	144	150	PF00069	0.582
TRG_ER_diArg_1	2	4	PF00400	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG29	Leptomonas seymouri	64%	100%
A0A1X0NHS7	Trypanosomatidae	37%	100%
A0A1X0NIC3	Trypanosomatidae	33%	100%
A0A1X0NJI4	Trypanosomatidae	27%	100%
A0A1X0NJQ7	Trypanosomatidae	52%	100%
A0A3R7LB88	Trypanosoma rangeli	32%	100%
A0A3R7P0U7	Trypanosoma rangeli	45%	100%
A0A3S7WQW6	Leishmania donovani	94%	100%
A0A3S7WQX1	Leishmania donovani	34%	100%
A4H5X3	Leishmania braziliensis	84%	100%
A4H5X4	Leishmania braziliensis	35%	100%
A4HU68	Leishmania infantum	95%	100%
A4HU69	Leishmania infantum	34%	100%
D0A9Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AMZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
P22978	Drosophila melanogaster	36%	100%
Q08742	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q4QHM8	Leishmania major	38%	100%
V5BI16	Trypanosoma cruzi	28%	93%
V5BMN5	Trypanosoma cruzi	49%	100%