Putative cytochrome b5-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like protein, putative

Species:

Leishmania major

UniProt:

Q4QHM6_LEIMA

TriTrypDb:

LmjF.09.1490 , LMJLV39_090022500 , LMJSD75_090022200

Length:

117

Annotations

LeishMANIAdb annotations

This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0020016	ciliary pocket	2	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

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Expansion

Sequence features

Q4QHM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHM6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.364
CLV_PCSK_SKI1_1	24	28	PF00082	0.361
DOC_CYCLIN_yClb1_LxF_4	17	23	PF00134	0.580
DOC_USP7_MATH_1	108	112	PF00917	0.458
LIG_FHA_1	30	36	PF00498	0.493
LIG_FHA_2	14	20	PF00498	0.524
LIG_LIR_Gen_1	54	64	PF02991	0.484
LIG_LIR_Nem_3	111	115	PF02991	0.491
LIG_LIR_Nem_3	2	8	PF02991	0.621
LIG_LIR_Nem_3	54	60	PF02991	0.466

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I073	Leptomonas seymouri	54%	98%
A0A0N1I7S9	Leptomonas seymouri	77%	99%
A0A0S4JCD1	Bodo saltans	53%	98%
A0A0S4JDV3	Bodo saltans	38%	100%
A0A0S4JHB7	Bodo saltans	40%	100%
A0A1X0NIP9	Trypanosomatidae	54%	100%
A0A1X0NV37	Trypanosomatidae	35%	88%
A0A3S5ISF2	Trypanosoma rangeli	62%	100%
A0A3S7WQX9	Leishmania donovani	44%	84%
A0A3S7WQZ7	Leishmania donovani	97%	100%

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