This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 25 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 16 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 12 |
| NetGPI | no | yes: 0, no: 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005635 | nuclear envelope | 4 | 2 |
| GO:0005783 | endoplasmic reticulum | 5 | 2 |
| GO:0016020 | membrane | 2 | 12 |
| GO:0020016 | ciliary pocket | 2 | 2 |
| GO:0031967 | organelle envelope | 3 | 2 |
| GO:0031975 | envelope | 2 | 2 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
Related structures:
AlphaFold database: Q4QHM6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005488 | binding | 1 | 4 |
| GO:0020037 | heme binding | 4 | 4 |
| GO:0046906 | tetrapyrrole binding | 3 | 4 |
| GO:0097159 | organic cyclic compound binding | 2 | 4 |
| GO:1901363 | heterocyclic compound binding | 2 | 4 |
| GO:0043167 | ion binding | 2 | 2 |
| GO:0043169 | cation binding | 3 | 2 |
| GO:0046872 | metal ion binding | 4 | 2 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_SKI1_1 | 13 | 17 | PF00082 | 0.364 |
| CLV_PCSK_SKI1_1 | 24 | 28 | PF00082 | 0.361 |
| DOC_CYCLIN_yClb1_LxF_4 | 17 | 23 | PF00134 | 0.580 |
| DOC_USP7_MATH_1 | 108 | 112 | PF00917 | 0.458 |
| LIG_FHA_1 | 30 | 36 | PF00498 | 0.493 |
| LIG_FHA_2 | 14 | 20 | PF00498 | 0.524 |
| LIG_LIR_Gen_1 | 54 | 64 | PF02991 | 0.484 |
| LIG_LIR_Nem_3 | 111 | 115 | PF02991 | 0.491 |
| LIG_LIR_Nem_3 | 2 | 8 | PF02991 | 0.621 |
| LIG_LIR_Nem_3 | 54 | 60 | PF02991 | 0.466 |
| LIG_REV1ctd_RIR_1 | 110 | 116 | PF16727 | 0.453 |
| LIG_SH2_PTP2 | 5 | 8 | PF00017 | 0.636 |
| LIG_SH2_STAT5 | 5 | 8 | PF00017 | 0.621 |
| LIG_SH2_STAT5 | 74 | 77 | PF00017 | 0.483 |
| LIG_SH2_STAT5 | 97 | 100 | PF00017 | 0.439 |
| LIG_SUMO_SIM_par_1 | 105 | 111 | PF11976 | 0.420 |
| LIG_TRAF2_1 | 66 | 69 | PF00917 | 0.522 |
| LIG_WRC_WIRS_1 | 109 | 114 | PF05994 | 0.396 |
| MOD_CK2_1 | 6 | 12 | PF00069 | 0.550 |
| MOD_CK2_1 | 62 | 68 | PF00069 | 0.541 |
| MOD_GlcNHglycan | 64 | 67 | PF01048 | 0.293 |
| MOD_NEK2_2 | 108 | 113 | PF00069 | 0.396 |
| MOD_Plk_4 | 108 | 114 | PF00069 | 0.457 |
| MOD_Plk_4 | 41 | 47 | PF00069 | 0.507 |
| MOD_SUMO_rev_2 | 19 | 28 | PF00179 | 0.522 |
| TRG_ENDOCYTIC_2 | 5 | 8 | PF00928 | 0.621 |
| TRG_ENDOCYTIC_2 | 97 | 100 | PF00928 | 0.439 |
| TRG_NES_CRM1_1 | 19 | 30 | PF08389 | 0.580 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I073 | Leptomonas seymouri | 54% | 98% |
| A0A0N1I7S9 | Leptomonas seymouri | 77% | 99% |
| A0A0S4JCD1 | Bodo saltans | 53% | 98% |
| A0A0S4JDV3 | Bodo saltans | 38% | 100% |
| A0A0S4JHB7 | Bodo saltans | 40% | 100% |
| A0A1X0NIP9 | Trypanosomatidae | 54% | 100% |
| A0A1X0NV37 | Trypanosomatidae | 35% | 88% |
| A0A3S5ISF2 | Trypanosoma rangeli | 62% | 100% |
| A0A3S7WQX9 | Leishmania donovani | 44% | 84% |
| A0A3S7WQZ7 | Leishmania donovani | 97% | 100% |
| A0A3S7X2E8 | Leishmania donovani | 35% | 68% |
| A0A422MYR2 | Trypanosoma rangeli | 32% | 89% |
| A4H5X6 | Leishmania braziliensis | 87% | 100% |
| A4H6J2 | Leishmania braziliensis | 32% | 82% |
| A4HU71 | Leishmania infantum | 97% | 100% |
| A4HU72 | Leishmania infantum | 44% | 84% |
| B7GCG7 | Phaeodactylum tricornutum (strain CCAP 1055/1) | 36% | 88% |
| D0A7I2 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 37% | 88% |
| D0A9Q4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 50% | 98% |
| E9AN01 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 94% | 100% |
| O22704 | Arabidopsis thaliana | 40% | 97% |
| O43169 | Homo sapiens | 47% | 78% |
| O94391 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 31% | 94% |
| P00167 | Homo sapiens | 35% | 87% |
| P00168 | Alouatta seniculus | 48% | 100% |
| P00169 | Oryctolagus cuniculus | 34% | 87% |
| P00170 | Equus caballus | 34% | 87% |
| P00171 | Bos taurus | 44% | 87% |
| P00172 | Sus scrofa | 35% | 87% |
| P00173 | Rattus norvegicus | 36% | 87% |
| P00174 | Gallus gallus | 45% | 85% |
| P04166 | Rattus norvegicus | 41% | 80% |
| P40312 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 34% | 98% |
| P49096 | Musca domestica | 33% | 87% |
| P56395 | Mus musculus | 36% | 87% |
| Q4QH22 | Leishmania major | 35% | 82% |
| Q5RDJ5 | Pongo abelii | 46% | 78% |
| Q9CQX2 | Mus musculus | 38% | 80% |
| Q9HFV1 | Rhizopus stolonifer | 44% | 89% |
| Q9USM6 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 35% | 91% |
| Q9V4N3 | Drosophila melanogaster | 40% | 87% |
| Q9Y706 | Mortierella alpina | 33% | 90% |
| Q9ZNV4 | Arabidopsis thaliana | 46% | 89% |
| Q9ZWT2 | Arabidopsis thaliana | 48% | 84% |
| V5BDK0 | Trypanosoma cruzi | 58% | 100% |
| V5BNY8 | Trypanosoma cruzi | 35% | 84% |
| V5BRX2 | Trypanosoma cruzi | 32% | 88% |