EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Radial spoke protein 11

Species:

Leishmania major

UniProt:

Q4QHM2_LEIMA

TriTrypDb:

LmjF.09.1530 , LMJLV39_090022900 , LMJSD75_090022600

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHM2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.568
CLV_PCSK_KEX2_1	96	98	PF00082	0.561
CLV_PCSK_SKI1_1	152	156	PF00082	0.408
DEG_Nend_UBRbox_3	1	3	PF02207	0.598
DOC_MAPK_MEF2A_6	70	77	PF00069	0.472
DOC_USP7_MATH_1	138	142	PF00917	0.397
DOC_USP7_MATH_1	52	56	PF00917	0.444
DOC_USP7_UBL2_3	21	25	PF12436	0.400
LIG_14-3-3_CanoR_1	119	125	PF00244	0.625
LIG_14-3-3_CanoR_1	70	74	PF00244	0.490
LIG_BRCT_BRCA1_1	38	42	PF00533	0.333
LIG_CtBP_PxDLS_1	13	17	PF00389	0.412
LIG_FHA_1	22	28	PF00498	0.385
LIG_FHA_1	70	76	PF00498	0.636
LIG_FHA_1	89	95	PF00498	0.428
LIG_LIR_Apic_2	103	108	PF02991	0.486
LIG_LIR_Apic_2	47	52	PF02991	0.528
LIG_LIR_Nem_3	39	45	PF02991	0.484
LIG_NRBOX	150	156	PF00104	0.512
LIG_SH2_CRK	49	53	PF00017	0.430
LIG_SH2_NCK_1	49	53	PF00017	0.430
LIG_SH2_STAP1	23	27	PF00017	0.412
LIG_SH2_STAP1	38	42	PF00017	0.383
LIG_SH2_STAT5	23	26	PF00017	0.380
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.388
MOD_CK1_1	68	74	PF00069	0.559
MOD_CK1_1	76	82	PF00069	0.649
MOD_CK2_1	120	126	PF00069	0.550
MOD_CK2_1	76	82	PF00069	0.619
MOD_GlcNHglycan	130	133	PF01048	0.556
MOD_GlcNHglycan	140	143	PF01048	0.606
MOD_GlcNHglycan	38	41	PF01048	0.351
MOD_GlcNHglycan	46	49	PF01048	0.460
MOD_GlcNHglycan	5	8	PF01048	0.554
MOD_GSK3_1	65	72	PF00069	0.644
MOD_GSK3_1	84	91	PF00069	0.438
MOD_N-GLC_1	120	125	PF02516	0.575
MOD_NEK2_1	155	160	PF00069	0.431
MOD_PIKK_1	84	90	PF00454	0.665
MOD_PKA_2	69	75	PF00069	0.490
MOD_Plk_1	120	126	PF00069	0.515
MOD_Plk_4	15	21	PF00069	0.415
MOD_SUMO_rev_2	123	129	PF00179	0.614
TRG_DiLeu_BaEn_1	110	115	PF01217	0.528
TRG_DiLeu_BaEn_1	150	155	PF01217	0.461
TRG_ER_diArg_1	95	97	PF00400	0.562
TRG_NES_CRM1_1	113	128	PF08389	0.427
TRG_NES_CRM1_1	147	157	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R7	Leptomonas seymouri	64%	99%
A0A0S4JCS1	Bodo saltans	42%	93%
A0A1X0NI72	Trypanosomatidae	41%	96%
A0A3R7KW38	Trypanosoma rangeli	42%	93%
A0A3S7WQX2	Leishmania donovani	89%	100%
A4H5Y0	Leishmania braziliensis	76%	100%
A4HU76	Leishmania infantum	90%	100%
D0A9Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	82%
E9AN06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DED0	Trypanosoma cruzi	41%	98%