GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHM1_LEIMA

TriTrypDb:

LmjF.09.1540 , LMJLV39_090023000 , LMJSD75_090022700

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.561
CLV_C14_Caspase3-7	525	529	PF00656	0.555
CLV_NRD_NRD_1	235	237	PF00675	0.461
CLV_NRD_NRD_1	433	435	PF00675	0.391
CLV_NRD_NRD_1	532	534	PF00675	0.614
CLV_NRD_NRD_1	75	77	PF00675	0.424
CLV_NRD_NRD_1	84	86	PF00675	0.435
CLV_PCSK_FUR_1	131	135	PF00082	0.418
CLV_PCSK_KEX2_1	133	135	PF00082	0.621
CLV_PCSK_KEX2_1	234	236	PF00082	0.490
CLV_PCSK_KEX2_1	433	435	PF00082	0.446
CLV_PCSK_KEX2_1	45	47	PF00082	0.566
CLV_PCSK_KEX2_1	532	534	PF00082	0.614
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.479
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.565
CLV_PCSK_SKI1_1	10	14	PF00082	0.503
CLV_PCSK_SKI1_1	204	208	PF00082	0.584
CLV_PCSK_SKI1_1	215	219	PF00082	0.479
CLV_PCSK_SKI1_1	521	525	PF00082	0.591
CLV_PCSK_SKI1_1	593	597	PF00082	0.515
DEG_APCC_DBOX_1	203	211	PF00400	0.523
DEG_APCC_DBOX_1	214	222	PF00400	0.461
DEG_Nend_UBRbox_1	1	4	PF02207	0.494
DEG_SPOP_SBC_1	175	179	PF00917	0.446
DOC_CKS1_1	156	161	PF01111	0.475
DOC_MAPK_gen_1	588	596	PF00069	0.455
DOC_MAPK_gen_1	83	92	PF00069	0.546
DOC_MAPK_MEF2A_6	409	417	PF00069	0.408
DOC_PP1_RVXF_1	496	502	PF00149	0.358
DOC_USP7_MATH_1	11	15	PF00917	0.502
DOC_USP7_MATH_1	443	447	PF00917	0.572
DOC_USP7_MATH_1	56	60	PF00917	0.472
DOC_USP7_MATH_2	159	165	PF00917	0.524
DOC_USP7_UBL2_3	48	52	PF12436	0.563
DOC_WW_Pin1_4	155	160	PF00397	0.543
LIG_14-3-3_CanoR_1	10	20	PF00244	0.552
LIG_14-3-3_CanoR_1	103	108	PF00244	0.527
LIG_14-3-3_CanoR_1	139	145	PF00244	0.702
LIG_14-3-3_CanoR_1	162	172	PF00244	0.640
LIG_14-3-3_CanoR_1	2	7	PF00244	0.617
LIG_14-3-3_CanoR_1	31	36	PF00244	0.615
LIG_14-3-3_CanoR_1	317	323	PF00244	0.436
LIG_14-3-3_CanoR_1	498	502	PF00244	0.461
LIG_14-3-3_CanoR_1	543	547	PF00244	0.580
LIG_14-3-3_CanoR_1	555	563	PF00244	0.438
LIG_14-3-3_CterR_2	604	607	PF00244	0.587
LIG_BRCT_BRCA1_1	373	377	PF00533	0.410
LIG_CaM_IQ_9	396	411	PF13499	0.455
LIG_FHA_1	140	146	PF00498	0.650
LIG_FHA_1	155	161	PF00498	0.507
LIG_FHA_1	412	418	PF00498	0.525
LIG_FHA_2	142	148	PF00498	0.566
LIG_FHA_2	156	162	PF00498	0.562
LIG_FHA_2	176	182	PF00498	0.436
LIG_FHA_2	228	234	PF00498	0.490
LIG_FHA_2	258	264	PF00498	0.540
LIG_Integrin_RGD_1	37	39	PF01839	0.464
LIG_LIR_Gen_1	3	12	PF02991	0.502
LIG_LIR_Nem_3	3	9	PF02991	0.512
LIG_NRBOX	188	194	PF00104	0.550
LIG_SH2_GRB2like	422	425	PF00017	0.426
LIG_SH2_SRC	6	9	PF00017	0.633
LIG_SH2_STAP1	16	20	PF00017	0.561
LIG_SH2_STAP1	301	305	PF00017	0.528
LIG_SH2_STAP1	345	349	PF00017	0.384
LIG_SH2_STAT5	398	401	PF00017	0.398
LIG_SUMO_SIM_par_1	219	224	PF11976	0.587
LIG_SUMO_SIM_par_1	413	419	PF11976	0.528
LIG_SUMO_SIM_par_1	522	528	PF11976	0.660
LIG_TRAF2_1	179	182	PF00917	0.587
LIG_TRAF2_1	364	367	PF00917	0.447
LIG_TRAF2_1	391	394	PF00917	0.532
LIG_TRAF2_1	580	583	PF00917	0.507
LIG_TRAF2_1	95	98	PF00917	0.509
MOD_CDK_SPxxK_3	155	162	PF00069	0.539
MOD_CK1_1	141	147	PF00069	0.705
MOD_CK1_1	155	161	PF00069	0.585
MOD_CK1_1	188	194	PF00069	0.459
MOD_CK1_1	257	263	PF00069	0.539
MOD_CK1_1	467	473	PF00069	0.481
MOD_CK1_1	59	65	PF00069	0.489
MOD_CK2_1	11	17	PF00069	0.572
MOD_CK2_1	141	147	PF00069	0.590
MOD_CK2_1	148	154	PF00069	0.589
MOD_CK2_1	155	161	PF00069	0.576
MOD_CK2_1	175	181	PF00069	0.396
MOD_CK2_1	188	194	PF00069	0.447
MOD_CK2_1	257	263	PF00069	0.474
MOD_CK2_1	282	288	PF00069	0.431
MOD_CK2_1	367	373	PF00069	0.477
MOD_CK2_1	388	394	PF00069	0.470
MOD_CK2_1	462	468	PF00069	0.431
MOD_CK2_1	577	583	PF00069	0.494
MOD_CK2_1	92	98	PF00069	0.534
MOD_GlcNHglycan	178	181	PF01048	0.614
MOD_GlcNHglycan	208	213	PF01048	0.472
MOD_GlcNHglycan	308	311	PF01048	0.618
MOD_GlcNHglycan	358	361	PF01048	0.397
MOD_GSK3_1	137	144	PF00069	0.599
MOD_GSK3_1	148	155	PF00069	0.579
MOD_GSK3_1	367	374	PF00069	0.554
MOD_GSK3_1	388	395	PF00069	0.468
MOD_GSK3_1	577	584	PF00069	0.604
MOD_GSK3_1	92	99	PF00069	0.526
MOD_N-GLC_1	243	248	PF02516	0.526
MOD_N-GLC_1	367	372	PF02516	0.522
MOD_N-GLC_1	477	482	PF02516	0.469
MOD_NEK2_1	163	168	PF00069	0.617
MOD_NEK2_1	221	226	PF00069	0.447
MOD_NEK2_1	30	35	PF00069	0.754
MOD_NEK2_1	308	313	PF00069	0.462
MOD_NEK2_1	371	376	PF00069	0.514
MOD_NEK2_1	462	467	PF00069	0.418
MOD_NEK2_1	563	568	PF00069	0.628
MOD_NEK2_1	577	582	PF00069	0.417
MOD_NEK2_1	96	101	PF00069	0.657
MOD_NEK2_2	16	21	PF00069	0.468
MOD_PIKK_1	11	17	PF00454	0.580
MOD_PIKK_1	115	121	PF00454	0.617
MOD_PIKK_1	152	158	PF00454	0.586
MOD_PIKK_1	161	167	PF00454	0.541
MOD_PIKK_1	282	288	PF00454	0.437
MOD_PIKK_1	371	377	PF00454	0.401
MOD_PKA_2	102	108	PF00069	0.572
MOD_PKA_2	138	144	PF00069	0.702
MOD_PKA_2	161	167	PF00069	0.650
MOD_PKA_2	254	260	PF00069	0.540
MOD_PKA_2	30	36	PF00069	0.610
MOD_PKA_2	497	503	PF00069	0.426
MOD_PKA_2	542	548	PF00069	0.677
MOD_PKB_1	121	129	PF00069	0.425
MOD_PKB_1	484	492	PF00069	0.427
MOD_Plk_1	16	22	PF00069	0.605
MOD_Plk_1	208	214	PF00069	0.491
MOD_Plk_1	243	249	PF00069	0.529
MOD_Plk_1	282	288	PF00069	0.435
MOD_Plk_1	367	373	PF00069	0.524
MOD_Plk_1	392	398	PF00069	0.475
MOD_Plk_1	477	483	PF00069	0.584
MOD_Plk_1	577	583	PF00069	0.532
MOD_Plk_1	59	65	PF00069	0.480
MOD_Plk_2-3	367	373	PF00069	0.529
MOD_Plk_2-3	416	422	PF00069	0.405
MOD_Plk_2-3	522	528	PF00069	0.660
MOD_Plk_4	188	194	PF00069	0.464
MOD_Plk_4	367	373	PF00069	0.529
MOD_Plk_4	477	483	PF00069	0.628
MOD_Plk_4	486	492	PF00069	0.493
MOD_ProDKin_1	155	161	PF00069	0.542
MOD_SUMO_rev_2	188	197	PF00179	0.490
MOD_SUMO_rev_2	437	446	PF00179	0.473
TRG_DiLeu_BaEn_1	367	372	PF01217	0.522
TRG_DiLeu_BaEn_1	447	452	PF01217	0.483
TRG_DiLeu_BaEn_2	372	378	PF01217	0.524
TRG_DiLeu_BaEn_3	275	281	PF01217	0.437
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.467
TRG_ENDOCYTIC_2	6	9	PF00928	0.509
TRG_ER_diArg_1	234	236	PF00400	0.576
TRG_ER_diArg_1	483	486	PF00400	0.439
TRG_NES_CRM1_1	464	479	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGV3	Leptomonas seymouri	55%	92%
A0A1X0NJR6	Trypanosomatidae	41%	81%
A0A3Q8IH29	Leishmania donovani	91%	100%
A0A422NZK3	Trypanosoma rangeli	39%	80%
A4H5Y1	Leishmania braziliensis	81%	92%
A4HU77	Leishmania infantum	91%	100%
D0A9Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	81%
E9AN07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BI13	Trypanosoma cruzi	38%	81%