Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHM0_LEIMA

TriTrypDb:

LmjF.09.1550 , LMJLV39_090023100 , LMJSD75_090022800

Length:

181

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QHM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.508
CLV_NRD_NRD_1	87	89	PF00675	0.410
CLV_PCSK_KEX2_1	161	163	PF00082	0.538
CLV_PCSK_KEX2_1	86	88	PF00082	0.418
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.548
CLV_PCSK_SKI1_1	161	165	PF00082	0.533
CLV_PCSK_SKI1_1	68	72	PF00082	0.456
CLV_PCSK_SKI1_1	87	91	PF00082	0.394
CLV_PCSK_SKI1_1	95	99	PF00082	0.439
DOC_MAPK_gen_1	126	135	PF00069	0.591
DOC_MAPK_gen_1	7	16	PF00069	0.633
DOC_MAPK_MEF2A_6	128	137	PF00069	0.466
DOC_MAPK_MEF2A_6	7	16	PF00069	0.602
DOC_MAPK_RevD_3	109	124	PF00069	0.657
DOC_PP4_FxxP_1	122	125	PF00568	0.657
DOC_USP7_MATH_1	12	16	PF00917	0.747
DOC_USP7_MATH_1	154	158	PF00917	0.459
DOC_USP7_UBL2_3	161	165	PF12436	0.345
DOC_WW_Pin1_4	19	24	PF00397	0.725
DOC_WW_Pin1_4	39	44	PF00397	0.666
DOC_WW_Pin1_4	8	13	PF00397	0.714
LIG_14-3-3_CanoR_1	95	103	PF00244	0.627
LIG_BRCT_BRCA1_1	133	137	PF00533	0.317
LIG_FHA_1	43	49	PF00498	0.632
LIG_FHA_1	9	15	PF00498	0.648
LIG_LIR_Gen_1	117	125	PF02991	0.661
LIG_LIR_LC3C_4	31	34	PF02991	0.650
LIG_LIR_Nem_3	117	122	PF02991	0.732
LIG_LYPXL_L_2	61	70	PF13949	0.639
LIG_NRP_CendR_1	180	181	PF00754	0.685
LIG_Pex14_2	137	141	PF04695	0.379
LIG_SH2_SRC	19	22	PF00017	0.684
LIG_SH2_STAT5	73	76	PF00017	0.620
LIG_SH3_3	11	17	PF00018	0.706
LIG_SH3_3	143	149	PF00018	0.403
LIG_SH3_3	37	43	PF00018	0.699
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.636
MOD_CK1_1	157	163	PF00069	0.384
MOD_CK1_1	3	9	PF00069	0.687
MOD_CK1_1	42	48	PF00069	0.684
MOD_CK2_1	19	25	PF00069	0.673
MOD_GlcNHglycan	116	119	PF01048	0.479
MOD_GlcNHglycan	34	37	PF01048	0.473
MOD_GSK3_1	19	26	PF00069	0.695
MOD_GSK3_1	8	15	PF00069	0.718
MOD_NEK2_1	1	6	PF00069	0.671
MOD_NEK2_1	32	37	PF00069	0.694
MOD_NMyristoyl	1	7	PF02799	0.698
MOD_ProDKin_1	19	25	PF00069	0.727
MOD_ProDKin_1	39	45	PF00069	0.665
MOD_ProDKin_1	8	14	PF00069	0.715
MOD_SUMO_rev_2	64	70	PF00179	0.679
TRG_DiLeu_BaEn_1	44	49	PF01217	0.632
TRG_ER_diArg_1	125	128	PF00400	0.643
TRG_ER_diArg_1	86	88	PF00400	0.676
TRG_NLS_MonoCore_2	122	127	PF00514	0.668
TRG_NLS_MonoExtC_3	160	165	PF00514	0.359
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JHE9	Bodo saltans	62%	100%
A0A1X0NID1	Trypanosomatidae	63%	96%
A0A3R7KNE8	Trypanosoma rangeli	62%	96%
A0A3S5H6F1	Leishmania donovani	92%	100%
A4H5Y2	Leishmania braziliensis	84%	100%
A4HU78	Leishmania infantum	91%	100%
D0A9R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	73%
E9AN08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%