Gryzun domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gryzun, putative trafficking through Golgi, putative

Species:

Leishmania major

UniProt:

Q4QHL6_LEIMA

TriTrypDb:

LmjF.10.0040 , LMJLV39_100005200 , LMJSD75_100005300

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.413
CLV_C14_Caspase3-7	304	308	PF00656	0.429
CLV_NRD_NRD_1	120	122	PF00675	0.312
CLV_NRD_NRD_1	206	208	PF00675	0.391
CLV_NRD_NRD_1	237	239	PF00675	0.468
CLV_NRD_NRD_1	73	75	PF00675	0.355
CLV_NRD_NRD_1	77	79	PF00675	0.510
CLV_NRD_NRD_1	883	885	PF00675	0.419
CLV_PCSK_KEX2_1	73	75	PF00082	0.355
CLV_PCSK_KEX2_1	749	751	PF00082	0.372
CLV_PCSK_KEX2_1	794	796	PF00082	0.450
CLV_PCSK_KEX2_1	883	885	PF00082	0.389
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.372
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.363
CLV_PCSK_PC7_1	745	751	PF00082	0.369
CLV_PCSK_PC7_1	790	796	PF00082	0.419
CLV_PCSK_SKI1_1	121	125	PF00082	0.409
CLV_PCSK_SKI1_1	269	273	PF00082	0.433
CLV_PCSK_SKI1_1	30	34	PF00082	0.439
CLV_PCSK_SKI1_1	434	438	PF00082	0.331
CLV_PCSK_SKI1_1	457	461	PF00082	0.373
CLV_PCSK_SKI1_1	513	517	PF00082	0.490
CLV_PCSK_SKI1_1	519	523	PF00082	0.466
CLV_PCSK_SKI1_1	528	532	PF00082	0.322
CLV_PCSK_SKI1_1	694	698	PF00082	0.575
CLV_PCSK_SKI1_1	750	754	PF00082	0.372
CLV_PCSK_SKI1_1	79	83	PF00082	0.451
CLV_PCSK_SKI1_1	805	809	PF00082	0.305
CLV_PCSK_SKI1_1	89	93	PF00082	0.334
CLV_PCSK_SKI1_1	897	901	PF00082	0.448
DEG_APCC_DBOX_1	88	96	PF00400	0.321
DEG_APCC_DBOX_1	896	904	PF00400	0.454
DEG_MDM2_SWIB_1	97	105	PF02201	0.280
DEG_Nend_UBRbox_1	1	4	PF02207	0.469
DOC_CKS1_1	899	904	PF01111	0.379
DOC_CYCLIN_yClb3_PxF_3	128	136	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.447
DOC_MAPK_DCC_7	89	97	PF00069	0.312
DOC_MAPK_gen_1	238	244	PF00069	0.457
DOC_MAPK_gen_1	525	533	PF00069	0.498
DOC_MAPK_MEF2A_6	89	97	PF00069	0.404
DOC_PP1_RVXF_1	582	589	PF00149	0.463
DOC_PP1_RVXF_1	803	809	PF00149	0.485
DOC_PP1_RVXF_1	96	102	PF00149	0.280
DOC_PP2B_LxvP_1	393	396	PF13499	0.412
DOC_PP2B_LxvP_1	841	844	PF13499	0.307
DOC_PP2B_LxvP_1	90	93	PF13499	0.288
DOC_PP2B_LxvP_1	908	911	PF13499	0.387
DOC_PP4_FxxP_1	631	634	PF00568	0.449
DOC_PP4_FxxP_1	704	707	PF00568	0.579
DOC_PP4_FxxP_1	807	810	PF00568	0.497
DOC_SPAK_OSR1_1	502	506	PF12202	0.420
DOC_SPAK_OSR1_1	912	916	PF12202	0.367
DOC_USP7_MATH_1	285	289	PF00917	0.365
DOC_USP7_MATH_1	334	338	PF00917	0.453
DOC_USP7_MATH_1	511	515	PF00917	0.686
DOC_USP7_MATH_1	55	59	PF00917	0.365
DOC_USP7_MATH_1	613	617	PF00917	0.349
DOC_USP7_MATH_1	663	667	PF00917	0.419
DOC_USP7_MATH_1	678	682	PF00917	0.576
DOC_USP7_MATH_1	683	687	PF00917	0.559
DOC_USP7_MATH_1	891	895	PF00917	0.563
DOC_USP7_MATH_1	927	931	PF00917	0.576
DOC_USP7_UBL2_3	265	269	PF12436	0.378
DOC_WW_Pin1_4	342	347	PF00397	0.468
DOC_WW_Pin1_4	451	456	PF00397	0.471
DOC_WW_Pin1_4	703	708	PF00397	0.573
DOC_WW_Pin1_4	844	849	PF00397	0.427
DOC_WW_Pin1_4	898	903	PF00397	0.576
LIG_14-3-3_CanoR_1	121	127	PF00244	0.307
LIG_14-3-3_CanoR_1	347	354	PF00244	0.325
LIG_14-3-3_CanoR_1	416	422	PF00244	0.310
LIG_14-3-3_CanoR_1	434	439	PF00244	0.293
LIG_14-3-3_CanoR_1	745	752	PF00244	0.442
LIG_14-3-3_CanoR_1	816	824	PF00244	0.355
LIG_14-3-3_CanoR_1	883	887	PF00244	0.380
LIG_14-3-3_CanoR_1	922	932	PF00244	0.480
LIG_BIR_III_4	359	363	PF00653	0.471
LIG_BRCT_BRCA1_1	536	540	PF00533	0.398
LIG_BRCT_BRCA1_1	57	61	PF00533	0.375
LIG_BRCT_BRCA1_1	627	631	PF00533	0.396
LIG_BRCT_BRCA1_1	740	744	PF00533	0.403
LIG_eIF4E_1	692	698	PF01652	0.579
LIG_FHA_1	186	192	PF00498	0.443
LIG_FHA_1	207	213	PF00498	0.449
LIG_FHA_1	275	281	PF00498	0.329
LIG_FHA_1	310	316	PF00498	0.364
LIG_FHA_1	347	353	PF00498	0.373
LIG_FHA_1	485	491	PF00498	0.366
LIG_FHA_1	650	656	PF00498	0.511
LIG_FHA_1	735	741	PF00498	0.546
LIG_FHA_1	894	900	PF00498	0.375
LIG_FHA_1	918	924	PF00498	0.543
LIG_FHA_2	290	296	PF00498	0.359
LIG_FHA_2	724	730	PF00498	0.524
LIG_FHA_2	759	765	PF00498	0.477
LIG_GBD_Chelix_1	189	197	PF00786	0.418
LIG_LIR_Apic_2	628	634	PF02991	0.456
LIG_LIR_Apic_2	702	707	PF02991	0.569
LIG_LIR_Gen_1	161	171	PF02991	0.356
LIG_LIR_Gen_1	293	301	PF02991	0.341
LIG_LIR_Gen_1	339	348	PF02991	0.459
LIG_LIR_LC3C_4	616	621	PF02991	0.245
LIG_LIR_Nem_3	125	130	PF02991	0.366
LIG_LIR_Nem_3	161	167	PF02991	0.327
LIG_LIR_Nem_3	198	204	PF02991	0.301
LIG_LIR_Nem_3	261	267	PF02991	0.398
LIG_LIR_Nem_3	293	299	PF02991	0.341
LIG_LIR_Nem_3	339	344	PF02991	0.417
LIG_LIR_Nem_3	4	10	PF02991	0.554
LIG_LIR_Nem_3	641	647	PF02991	0.396
LIG_LIR_Nem_3	686	692	PF02991	0.533
LIG_LIR_Nem_3	836	842	PF02991	0.435
LIG_LYPXL_yS_3	839	842	PF13949	0.484
LIG_NRBOX	28	34	PF00104	0.403
LIG_Pex14_1	144	148	PF04695	0.306
LIG_Pex14_2	142	146	PF04695	0.378
LIG_Pex14_2	799	803	PF04695	0.431
LIG_Pex14_2	97	101	PF04695	0.282
LIG_PTB_Apo_2	797	804	PF02174	0.361
LIG_REV1ctd_RIR_1	718	727	PF16727	0.597
LIG_SH2_CRK	573	577	PF00017	0.312
LIG_SH2_CRK	644	648	PF00017	0.456
LIG_SH2_CRK	845	849	PF00017	0.388
LIG_SH2_NCK_1	606	610	PF00017	0.345
LIG_SH2_NCK_1	856	860	PF00017	0.350
LIG_SH2_SRC	164	167	PF00017	0.323
LIG_SH2_STAP1	422	426	PF00017	0.345
LIG_SH2_STAP1	692	696	PF00017	0.588
LIG_SH2_STAT5	103	106	PF00017	0.316
LIG_SH2_STAT5	204	207	PF00017	0.351
LIG_SH2_STAT5	220	223	PF00017	0.232
LIG_SH2_STAT5	296	299	PF00017	0.338
LIG_SH2_STAT5	402	405	PF00017	0.431
LIG_SH2_STAT5	481	484	PF00017	0.299
LIG_SH2_STAT5	719	722	PF00017	0.546
LIG_SH2_STAT5	827	830	PF00017	0.415
LIG_SH2_STAT5	898	901	PF00017	0.389
LIG_SH2_STAT5	931	934	PF00017	0.469
LIG_SH3_2	452	457	PF14604	0.516
LIG_SH3_3	125	131	PF00018	0.352
LIG_SH3_3	3	9	PF00018	0.481
LIG_SH3_3	449	455	PF00018	0.495
LIG_SH3_3	468	474	PF00018	0.454
LIG_SH3_3	530	536	PF00018	0.384
LIG_SH3_3	539	545	PF00018	0.349
LIG_SH3_3	574	580	PF00018	0.378
LIG_SH3_3	654	660	PF00018	0.319
LIG_SH3_3	818	824	PF00018	0.528
LIG_SH3_3	896	902	PF00018	0.333
LIG_SH3_3	934	940	PF00018	0.417
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.324
LIG_SUMO_SIM_anti_2	763	769	PF11976	0.391
LIG_SUMO_SIM_par_1	188	194	PF11976	0.348
LIG_SUMO_SIM_par_1	417	425	PF11976	0.362
LIG_SUMO_SIM_par_1	434	440	PF11976	0.271
LIG_SUMO_SIM_par_1	735	743	PF11976	0.352
LIG_SUMO_SIM_par_1	847	852	PF11976	0.564
LIG_TRAF2_1	17	20	PF00917	0.460
LIG_TRAF2_1	364	367	PF00917	0.507
LIG_TRFH_1	127	131	PF08558	0.361
LIG_TRFH_1	898	902	PF08558	0.363
LIG_UBA3_1	116	124	PF00899	0.386
LIG_WRC_WIRS_1	130	135	PF05994	0.346
LIG_WRC_WIRS_1	767	772	PF05994	0.356
MOD_CDC14_SPxK_1	454	457	PF00782	0.537
MOD_CDK_SPK_2	342	347	PF00069	0.392
MOD_CDK_SPxK_1	451	457	PF00069	0.505
MOD_CDK_SPxK_1	898	904	PF00069	0.341
MOD_CK1_1	158	164	PF00069	0.355
MOD_CK1_1	28	34	PF00069	0.387
MOD_CK1_1	289	295	PF00069	0.359
MOD_CK1_1	337	343	PF00069	0.548
MOD_CK1_1	425	431	PF00069	0.315
MOD_CK1_1	439	445	PF00069	0.446
MOD_CK1_1	534	540	PF00069	0.470
MOD_CK1_1	681	687	PF00069	0.560
MOD_CK2_1	10	16	PF00069	0.576
MOD_CK2_1	148	154	PF00069	0.477
MOD_CK2_1	156	162	PF00069	0.424
MOD_CK2_1	234	240	PF00069	0.449
MOD_CK2_1	285	291	PF00069	0.399
MOD_CK2_1	543	549	PF00069	0.382
MOD_CK2_1	587	593	PF00069	0.469
MOD_CK2_1	723	729	PF00069	0.510
MOD_CK2_1	774	780	PF00069	0.503
MOD_CK2_1	844	850	PF00069	0.359
MOD_CK2_1	923	929	PF00069	0.383
MOD_GlcNHglycan	117	120	PF01048	0.315
MOD_GlcNHglycan	260	263	PF01048	0.513
MOD_GlcNHglycan	268	272	PF01048	0.431
MOD_GlcNHglycan	336	339	PF01048	0.377
MOD_GlcNHglycan	341	344	PF01048	0.544
MOD_GlcNHglycan	39	42	PF01048	0.394
MOD_GlcNHglycan	404	409	PF01048	0.419
MOD_GlcNHglycan	413	416	PF01048	0.368
MOD_GlcNHglycan	424	427	PF01048	0.407
MOD_GlcNHglycan	439	442	PF01048	0.324
MOD_GlcNHglycan	461	464	PF01048	0.414
MOD_GlcNHglycan	477	480	PF01048	0.412
MOD_GlcNHglycan	513	516	PF01048	0.651
MOD_GlcNHglycan	522	525	PF01048	0.499
MOD_GlcNHglycan	589	592	PF01048	0.423
MOD_GlcNHglycan	627	630	PF01048	0.454
MOD_GlcNHglycan	835	838	PF01048	0.453
MOD_GlcNHglycan	925	928	PF01048	0.398
MOD_GSK3_1	10	17	PF00069	0.592
MOD_GSK3_1	21	28	PF00069	0.473
MOD_GSK3_1	263	270	PF00069	0.407
MOD_GSK3_1	285	292	PF00069	0.382
MOD_GSK3_1	321	328	PF00069	0.582
MOD_GSK3_1	342	349	PF00069	0.465
MOD_GSK3_1	37	44	PF00069	0.291
MOD_GSK3_1	417	424	PF00069	0.438
MOD_GSK3_1	511	518	PF00069	0.653
MOD_GSK3_1	520	527	PF00069	0.421
MOD_GSK3_1	531	538	PF00069	0.333
MOD_GSK3_1	645	652	PF00069	0.381
MOD_GSK3_1	681	688	PF00069	0.620
MOD_GSK3_1	703	710	PF00069	0.576
MOD_GSK3_1	719	726	PF00069	0.508
MOD_GSK3_1	734	741	PF00069	0.475
MOD_GSK3_1	878	885	PF00069	0.481
MOD_GSK3_1	923	930	PF00069	0.421
MOD_NEK2_1	109	114	PF00069	0.294
MOD_NEK2_1	137	142	PF00069	0.368
MOD_NEK2_1	148	153	PF00069	0.457
MOD_NEK2_1	191	196	PF00069	0.412
MOD_NEK2_1	267	272	PF00069	0.342
MOD_NEK2_1	32	37	PF00069	0.415
MOD_NEK2_1	421	426	PF00069	0.372
MOD_NEK2_1	436	441	PF00069	0.306
MOD_NEK2_1	461	466	PF00069	0.396
MOD_NEK2_1	531	536	PF00069	0.359
MOD_NEK2_1	61	66	PF00069	0.424
MOD_NEK2_1	619	624	PF00069	0.299
MOD_NEK2_1	685	690	PF00069	0.664
MOD_NEK2_1	740	745	PF00069	0.412
MOD_NEK2_1	851	856	PF00069	0.511
MOD_NEK2_2	613	618	PF00069	0.348
MOD_NEK2_2	649	654	PF00069	0.431
MOD_OFUCOSY	458	465	PF10250	0.366
MOD_OFUCOSY	558	564	PF10250	0.415
MOD_PIKK_1	446	452	PF00454	0.422
MOD_PKA_2	206	212	PF00069	0.445
MOD_PKA_2	21	27	PF00069	0.523
MOD_PKA_2	274	280	PF00069	0.291
MOD_PKA_2	289	295	PF00069	0.420
MOD_PKA_2	346	352	PF00069	0.350
MOD_PKA_2	744	750	PF00069	0.450
MOD_PKA_2	882	888	PF00069	0.481
MOD_Plk_1	25	31	PF00069	0.384
MOD_Plk_1	267	273	PF00069	0.433
MOD_Plk_1	61	67	PF00069	0.439
MOD_Plk_1	613	619	PF00069	0.338
MOD_Plk_1	663	669	PF00069	0.428
MOD_Plk_1	692	698	PF00069	0.538
MOD_Plk_1	734	740	PF00069	0.414
MOD_Plk_1	851	857	PF00069	0.347
MOD_Plk_1	927	933	PF00069	0.413
MOD_Plk_2-3	543	549	PF00069	0.434
MOD_Plk_2-3	774	780	PF00069	0.389
MOD_Plk_4	122	128	PF00069	0.415
MOD_Plk_4	137	143	PF00069	0.228
MOD_Plk_4	185	191	PF00069	0.476
MOD_Plk_4	322	328	PF00069	0.499
MOD_Plk_4	417	423	PF00069	0.370
MOD_Plk_4	535	541	PF00069	0.547
MOD_Plk_4	543	549	PF00069	0.558
MOD_Plk_4	55	61	PF00069	0.322
MOD_Plk_4	663	669	PF00069	0.458
MOD_Plk_4	692	698	PF00069	0.511
MOD_Plk_4	774	780	PF00069	0.512
MOD_Plk_4	783	789	PF00069	0.431
MOD_Plk_4	851	857	PF00069	0.298
MOD_Plk_4	927	933	PF00069	0.484
MOD_ProDKin_1	342	348	PF00069	0.459
MOD_ProDKin_1	451	457	PF00069	0.473
MOD_ProDKin_1	703	709	PF00069	0.573
MOD_ProDKin_1	844	850	PF00069	0.427
MOD_ProDKin_1	898	904	PF00069	0.582
MOD_SUMO_for_1	182	185	PF00179	0.433
MOD_SUMO_rev_2	71	81	PF00179	0.364
TRG_DiLeu_BaEn_1	543	548	PF01217	0.440
TRG_DiLeu_BaEn_1	615	620	PF01217	0.354
TRG_DiLeu_BaEn_2	165	171	PF01217	0.286
TRG_DiLeu_BaEn_2	294	300	PF01217	0.304
TRG_DiLeu_BaEn_2	773	779	PF01217	0.376
TRG_DiLeu_BaEn_4	774	780	PF01217	0.405
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.402
TRG_ENDOCYTIC_2	103	106	PF00928	0.327
TRG_ENDOCYTIC_2	164	167	PF00928	0.409
TRG_ENDOCYTIC_2	296	299	PF00928	0.338
TRG_ENDOCYTIC_2	573	576	PF00928	0.450
TRG_ENDOCYTIC_2	644	647	PF00928	0.399
TRG_ENDOCYTIC_2	818	821	PF00928	0.446
TRG_ENDOCYTIC_2	839	842	PF00928	0.484
TRG_ER_diArg_1	272	275	PF00400	0.349
TRG_ER_diArg_1	72	74	PF00400	0.351
TRG_NES_CRM1_1	375	387	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA1	Leptomonas seymouri	56%	100%
A0A1X0NQK5	Trypanosomatidae	24%	87%
A0A3S7WQY9	Leishmania donovani	94%	100%
A0A422N156	Trypanosoma rangeli	24%	87%
A4H5Y6	Leishmania braziliensis	79%	100%
A4HUB1	Leishmania infantum	94%	100%
E9AN10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BE46	Trypanosoma cruzi	23%	100%