MMS19 nucleotide excision repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dos2-interacting transcription regulator of RNA-Pol-II, putative

Species:

Leishmania major

UniProt:

Q4QHL5_LEIMA

TriTrypDb:

LmjF.10.0050 , LMJLV39_100005300 , LMJSD75_100005400

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0097361	CIA complex	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0140535	intracellular protein-containing complex	2	8

Expansion

Sequence features

Q4QHL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHL5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006790	sulfur compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0016226	iron-sulfur cluster assembly	4	8
GO:0019538	protein metabolic process	3	8
GO:0022607	cellular component assembly	4	8
GO:0031163	metallo-sulfur cluster assembly	5	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051604	protein maturation	4	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.356
CLV_C14_Caspase3-7	372	376	PF00656	0.637
CLV_C14_Caspase3-7	450	454	PF00656	0.559
CLV_C14_Caspase3-7	692	696	PF00656	0.692
CLV_MEL_PAP_1	279	285	PF00089	0.628
CLV_MEL_PAP_1	668	674	PF00089	0.433
CLV_NRD_NRD_1	615	617	PF00675	0.446
CLV_NRD_NRD_1	645	647	PF00675	0.412
CLV_NRD_NRD_1	657	659	PF00675	0.433
CLV_NRD_NRD_1	796	798	PF00675	0.464
CLV_NRD_NRD_1	903	905	PF00675	0.431
CLV_NRD_NRD_1	95	97	PF00675	0.519
CLV_PCSK_KEX2_1	192	194	PF00082	0.524
CLV_PCSK_KEX2_1	615	617	PF00082	0.446
CLV_PCSK_KEX2_1	645	647	PF00082	0.412
CLV_PCSK_KEX2_1	895	897	PF00082	0.422
CLV_PCSK_KEX2_1	902	904	PF00082	0.427
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.556
CLV_PCSK_PC1ET2_1	895	897	PF00082	0.422
CLV_PCSK_PC1ET2_1	902	904	PF00082	0.427
CLV_PCSK_PC7_1	188	194	PF00082	0.524
CLV_PCSK_SKI1_1	152	156	PF00082	0.607
CLV_PCSK_SKI1_1	271	275	PF00082	0.645
CLV_PCSK_SKI1_1	34	38	PF00082	0.556
CLV_PCSK_SKI1_1	502	506	PF00082	0.314
CLV_PCSK_SKI1_1	547	551	PF00082	0.340
CLV_PCSK_SKI1_1	658	662	PF00082	0.430
CLV_PCSK_SKI1_1	797	801	PF00082	0.473
CLV_PCSK_SKI1_1	812	816	PF00082	0.279
CLV_PCSK_SKI1_1	830	834	PF00082	0.275
CLV_PCSK_SKI1_1	866	870	PF00082	0.462
DEG_APCC_DBOX_1	615	623	PF00400	0.651
DEG_APCC_DBOX_1	811	819	PF00400	0.587
DEG_APCC_DBOX_1	865	873	PF00400	0.613
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DEG_SCF_FBW7_2	77	84	PF00400	0.324
DEG_SCF_TRCP1_1	695	700	PF00400	0.610
DOC_CDC14_PxL_1	734	742	PF14671	0.656
DOC_CKS1_1	5	10	PF01111	0.520
DOC_CKS1_1	78	83	PF01111	0.351
DOC_CYCLIN_RxL_1	188	198	PF00134	0.251
DOC_CYCLIN_RxL_1	268	278	PF00134	0.445
DOC_CYCLIN_RxL_1	808	819	PF00134	0.597
DOC_CYCLIN_RxL_1	853	863	PF00134	0.648
DOC_MAPK_gen_1	192	199	PF00069	0.349
DOC_MAPK_gen_1	885	893	PF00069	0.620
DOC_MAPK_HePTP_8	672	684	PF00069	0.493
DOC_MAPK_JIP1_4	747	753	PF00069	0.618
DOC_MAPK_MEF2A_6	192	199	PF00069	0.354
DOC_MAPK_MEF2A_6	220	228	PF00069	0.332
DOC_MAPK_MEF2A_6	30	37	PF00069	0.407
DOC_MAPK_MEF2A_6	675	684	PF00069	0.606
DOC_MAPK_MEF2A_6	747	755	PF00069	0.581
DOC_MAPK_NFAT4_5	192	200	PF00069	0.356
DOC_MAPK_NFAT4_5	30	38	PF00069	0.351
DOC_PP1_RVXF_1	32	38	PF00149	0.407
DOC_PP1_RVXF_1	810	817	PF00149	0.580
DOC_PP1_RVXF_1	828	835	PF00149	0.634
DOC_PP2B_LxvP_1	203	206	PF13499	0.407
DOC_PP4_FxxP_1	174	177	PF00568	0.317
DOC_USP7_MATH_1	147	151	PF00917	0.407
DOC_USP7_MATH_1	213	217	PF00917	0.356
DOC_USP7_MATH_1	315	319	PF00917	0.376
DOC_USP7_MATH_1	365	369	PF00917	0.623
DOC_USP7_MATH_1	446	450	PF00917	0.646
DOC_USP7_MATH_1	511	515	PF00917	0.589
DOC_USP7_MATH_1	611	615	PF00917	0.605
DOC_USP7_MATH_1	92	96	PF00917	0.351
DOC_USP7_MATH_2	704	710	PF00917	0.613
DOC_WW_Pin1_4	211	216	PF00397	0.317
DOC_WW_Pin1_4	391	396	PF00397	0.635
DOC_WW_Pin1_4	4	9	PF00397	0.532
DOC_WW_Pin1_4	717	722	PF00397	0.609
DOC_WW_Pin1_4	77	82	PF00397	0.351
LIG_14-3-3_CanoR_1	564	572	PF00244	0.604
LIG_14-3-3_CanoR_1	615	622	PF00244	0.659
LIG_14-3-3_CanoR_1	671	678	PF00244	0.573
LIG_14-3-3_CanoR_1	854	859	PF00244	0.577
LIG_14-3-3_CanoR_1	866	872	PF00244	0.608
LIG_14-3-3_CanoR_1	906	913	PF00244	0.590
LIG_AP2alpha_1	522	526	PF02296	0.624
LIG_APCC_ABBA_1	197	202	PF00400	0.356
LIG_APCC_ABBA_1	519	524	PF00400	0.649
LIG_APCC_ABBAyCdc20_2	830	836	PF00400	0.658
LIG_BIR_III_2	375	379	PF00653	0.598
LIG_BRCT_BRCA1_1	103	107	PF00533	0.407
LIG_BRCT_BRCA1_1	166	170	PF00533	0.317
LIG_BRCT_BRCA1_1	339	343	PF00533	0.501
LIG_BRCT_BRCA1_1	830	834	PF00533	0.615
LIG_Clathr_ClatBox_1	815	819	PF01394	0.579
LIG_CSL_BTD_1	441	444	PF09270	0.613
LIG_eIF4E_1	234	240	PF01652	0.351
LIG_EVH1_2	575	579	PF00568	0.553
LIG_FAT_LD_1	303	311	PF03623	0.281
LIG_FHA_1	109	115	PF00498	0.356
LIG_FHA_1	268	274	PF00498	0.457
LIG_FHA_1	320	326	PF00498	0.433
LIG_FHA_1	392	398	PF00498	0.621
LIG_FHA_1	461	467	PF00498	0.658
LIG_FHA_1	49	55	PF00498	0.349
LIG_FHA_1	564	570	PF00498	0.632
LIG_FHA_1	651	657	PF00498	0.592
LIG_FHA_1	663	669	PF00498	0.666
LIG_FHA_1	81	87	PF00498	0.407
LIG_FHA_2	155	161	PF00498	0.380
LIG_FHA_2	181	187	PF00498	0.317
LIG_FHA_2	227	233	PF00498	0.349
LIG_FHA_2	289	295	PF00498	0.459
LIG_FHA_2	527	533	PF00498	0.615
LIG_FHA_2	635	641	PF00498	0.626
LIG_GBD_Chelix_1	302	310	PF00786	0.474
LIG_GBD_Chelix_1	338	346	PF00786	0.424
LIG_IRF3_LxIS_1	56	62	PF10401	0.351
LIG_LIR_Gen_1	153	163	PF02991	0.342
LIG_LIR_Gen_1	340	350	PF02991	0.509
LIG_LIR_Gen_1	418	428	PF02991	0.586
LIG_LIR_Gen_1	476	485	PF02991	0.650
LIG_LIR_Gen_1	710	721	PF02991	0.681
LIG_LIR_Gen_1	732	740	PF02991	0.596
LIG_LIR_Gen_1	83	93	PF02991	0.379
LIG_LIR_Nem_3	153	158	PF02991	0.329
LIG_LIR_Nem_3	160	166	PF02991	0.303
LIG_LIR_Nem_3	167	173	PF02991	0.289
LIG_LIR_Nem_3	198	203	PF02991	0.240
LIG_LIR_Nem_3	229	234	PF02991	0.356
LIG_LIR_Nem_3	297	302	PF02991	0.378
LIG_LIR_Nem_3	340	346	PF02991	0.492
LIG_LIR_Nem_3	476	480	PF02991	0.654
LIG_LIR_Nem_3	71	77	PF02991	0.318
LIG_LIR_Nem_3	710	716	PF02991	0.639
LIG_LIR_Nem_3	732	737	PF02991	0.592
LIG_LIR_Nem_3	80	85	PF02991	0.316
LIG_LIR_Nem_3	915	919	PF02991	0.601
LIG_MLH1_MIPbox_1	166	170	PF16413	0.317
LIG_NRBOX	119	125	PF00104	0.317
LIG_NRBOX	223	229	PF00104	0.407
LIG_NRBOX	488	494	PF00104	0.600
LIG_NRBOX	514	520	PF00104	0.641
LIG_NRBOX	55	61	PF00104	0.296
LIG_NRBOX	750	756	PF00104	0.627
LIG_NRBOX	788	794	PF00104	0.659
LIG_PCNA_yPIPBox_3	784	793	PF02747	0.624
LIG_Pex14_2	170	174	PF04695	0.317
LIG_Pex14_2	522	526	PF04695	0.652
LIG_PTAP_UEV_1	495	500	PF05743	0.616
LIG_REV1ctd_RIR_1	37	47	PF16727	0.317
LIG_SH2_NCK_1	477	481	PF00017	0.649
LIG_SH2_PTP2	85	88	PF00017	0.351
LIG_SH2_STAT3	234	237	PF00017	0.407
LIG_SH2_STAT5	162	165	PF00017	0.351
LIG_SH2_STAT5	169	172	PF00017	0.356
LIG_SH2_STAT5	341	344	PF00017	0.376
LIG_SH2_STAT5	736	739	PF00017	0.592
LIG_SH2_STAT5	85	88	PF00017	0.351
LIG_SH3_3	435	441	PF00018	0.602
LIG_SH3_3	493	499	PF00018	0.648
LIG_SH3_3	569	575	PF00018	0.503
LIG_SH3_3	75	81	PF00018	0.356
LIG_Sin3_3	516	523	PF02671	0.474
LIG_SUMO_SIM_anti_2	221	229	PF11976	0.358
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.325
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.558
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.496
LIG_SUMO_SIM_anti_2	888	894	PF11976	0.603
LIG_SUMO_SIM_par_1	108	119	PF11976	0.377
LIG_SUMO_SIM_par_1	122	128	PF11976	0.344
LIG_SUMO_SIM_par_1	462	467	PF11976	0.584
LIG_SUMO_SIM_par_1	788	794	PF11976	0.548
LIG_SUMO_SIM_par_1	888	894	PF11976	0.613
LIG_TRAF2_1	45	48	PF00917	0.400
LIG_TRAF2_1	729	732	PF00917	0.656
LIG_TRAF2_1	876	879	PF00917	0.653
LIG_TYR_ITSM	81	88	PF00017	0.351
LIG_UBA3_1	102	110	PF00899	0.345
LIG_UBA3_1	792	798	PF00899	0.599
LIG_UBA3_1	890	895	PF00899	0.554
LIG_WRC_WIRS_1	102	107	PF05994	0.356
LIG_WRC_WIRS_1	257	262	PF05994	0.435
LIG_WRC_WIRS_1	708	713	PF05994	0.684
MOD_CDK_SPxK_1	4	10	PF00069	0.527
MOD_CK1_1	165	171	PF00069	0.317
MOD_CK1_1	214	220	PF00069	0.321
MOD_CK1_1	265	271	PF00069	0.440
MOD_CK1_1	288	294	PF00069	0.412
MOD_CK1_1	587	593	PF00069	0.657
MOD_CK1_1	614	620	PF00069	0.648
MOD_CK1_1	696	702	PF00069	0.678
MOD_CK1_1	757	763	PF00069	0.683
MOD_CK2_1	128	134	PF00069	0.326
MOD_CK2_1	147	153	PF00069	0.317
MOD_CK2_1	288	294	PF00069	0.432
MOD_CK2_1	385	391	PF00069	0.643
MOD_CK2_1	526	532	PF00069	0.573
MOD_CK2_1	757	763	PF00069	0.721
MOD_CK2_1	799	805	PF00069	0.605
MOD_CK2_1	873	879	PF00069	0.618
MOD_GlcNHglycan	310	313	PF01048	0.587
MOD_GlcNHglycan	317	320	PF01048	0.573
MOD_GlcNHglycan	367	370	PF01048	0.375
MOD_GlcNHglycan	435	438	PF01048	0.416
MOD_GlcNHglycan	465	469	PF01048	0.374
MOD_GlcNHglycan	496	499	PF01048	0.481
MOD_GlcNHglycan	537	540	PF01048	0.321
MOD_GlcNHglycan	589	592	PF01048	0.420
MOD_GlcNHglycan	695	698	PF01048	0.474
MOD_GlcNHglycan	770	773	PF01048	0.434
MOD_GlcNHglycan	801	804	PF01048	0.472
MOD_GlcNHglycan	824	827	PF01048	0.451
MOD_GlcNHglycan	908	911	PF01048	0.388
MOD_GSK3_1	101	108	PF00069	0.356
MOD_GSK3_1	207	214	PF00069	0.356
MOD_GSK3_1	226	233	PF00069	0.196
MOD_GSK3_1	281	288	PF00069	0.377
MOD_GSK3_1	315	322	PF00069	0.369
MOD_GSK3_1	337	344	PF00069	0.420
MOD_GSK3_1	386	393	PF00069	0.650
MOD_GSK3_1	460	467	PF00069	0.600
MOD_GSK3_1	48	55	PF00069	0.340
MOD_GSK3_1	667	674	PF00069	0.657
MOD_GSK3_1	693	700	PF00069	0.698
MOD_GSK3_1	867	874	PF00069	0.571
MOD_N-GLC_1	265	270	PF02516	0.635
MOD_N-GLC_1	587	592	PF02516	0.467
MOD_N-GLC_1	834	839	PF02516	0.462
MOD_N-GLC_2	333	335	PF02516	0.410
MOD_NEK2_1	114	119	PF00069	0.305
MOD_NEK2_1	17	22	PF00069	0.319
MOD_NEK2_1	195	200	PF00069	0.372
MOD_NEK2_1	207	212	PF00069	0.346
MOD_NEK2_1	306	311	PF00069	0.434
MOD_NEK2_1	328	333	PF00069	0.413
MOD_NEK2_1	337	342	PF00069	0.445
MOD_NEK2_1	433	438	PF00069	0.579
MOD_NEK2_1	49	54	PF00069	0.394
MOD_NEK2_1	510	515	PF00069	0.532
MOD_NEK2_1	526	531	PF00069	0.515
MOD_NEK2_1	584	589	PF00069	0.597
MOD_NEK2_1	707	712	PF00069	0.597
MOD_NEK2_1	739	744	PF00069	0.619
MOD_NEK2_1	799	804	PF00069	0.600
MOD_NEK2_1	828	833	PF00069	0.609
MOD_NEK2_1	834	839	PF00069	0.614
MOD_NEK2_1	860	865	PF00069	0.577
MOD_NEK2_1	871	876	PF00069	0.584
MOD_NEK2_1	891	896	PF00069	0.629
MOD_NEK2_2	849	854	PF00069	0.663
MOD_OFUCOSY	272	277	PF10250	0.566
MOD_PIKK_1	172	178	PF00454	0.301
MOD_PIKK_1	233	239	PF00454	0.407
MOD_PIKK_1	288	294	PF00454	0.468
MOD_PIKK_1	402	408	PF00454	0.612
MOD_PIKK_1	662	668	PF00454	0.660
MOD_PIKK_1	739	745	PF00454	0.628
MOD_PIKK_1	757	763	PF00454	0.487
MOD_PIKK_1	873	879	PF00454	0.705
MOD_PK_1	285	291	PF00069	0.322
MOD_PKA_1	797	803	PF00069	0.687
MOD_PKA_2	148	154	PF00069	0.342
MOD_PKA_2	262	268	PF00069	0.451
MOD_PKA_2	281	287	PF00069	0.435
MOD_PKA_2	386	392	PF00069	0.688
MOD_PKA_2	563	569	PF00069	0.618
MOD_PKA_2	614	620	PF00069	0.639
MOD_PKA_2	670	676	PF00069	0.641
MOD_PKA_2	746	752	PF00069	0.592
MOD_PKB_1	904	912	PF00069	0.682
MOD_Plk_1	108	114	PF00069	0.356
MOD_Plk_1	115	121	PF00069	0.356
MOD_Plk_1	265	271	PF00069	0.433
MOD_Plk_1	418	424	PF00069	0.562
MOD_Plk_1	834	840	PF00069	0.616
MOD_Plk_2-3	128	134	PF00069	0.317
MOD_Plk_2-3	778	784	PF00069	0.604
MOD_Plk_4	101	107	PF00069	0.342
MOD_Plk_4	154	160	PF00069	0.344
MOD_Plk_4	165	171	PF00069	0.297
MOD_Plk_4	195	201	PF00069	0.407
MOD_Plk_4	242	248	PF00069	0.263
MOD_Plk_4	319	325	PF00069	0.342
MOD_Plk_4	337	343	PF00069	0.376
MOD_Plk_4	52	58	PF00069	0.398
MOD_Plk_4	602	608	PF00069	0.564
MOD_Plk_4	707	713	PF00069	0.624
MOD_Plk_4	746	752	PF00069	0.674
MOD_Plk_4	791	797	PF00069	0.490
MOD_Plk_4	867	873	PF00069	0.588
MOD_ProDKin_1	211	217	PF00069	0.317
MOD_ProDKin_1	391	397	PF00069	0.629
MOD_ProDKin_1	4	10	PF00069	0.527
MOD_ProDKin_1	717	723	PF00069	0.614
MOD_ProDKin_1	77	83	PF00069	0.351
MOD_SUMO_for_1	250	253	PF00179	0.356
MOD_SUMO_rev_2	874	881	PF00179	0.644
TRG_DiLeu_BaEn_1	580	585	PF01217	0.633
TRG_DiLeu_BaEn_4	878	884	PF01217	0.635
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.403
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.586
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.592
TRG_ENDOCYTIC_2	169	172	PF00928	0.317
TRG_ENDOCYTIC_2	200	203	PF00928	0.356
TRG_ENDOCYTIC_2	320	323	PF00928	0.344
TRG_ENDOCYTIC_2	477	480	PF00928	0.650
TRG_ENDOCYTIC_2	713	716	PF00928	0.644
TRG_ENDOCYTIC_2	736	739	PF00928	0.589
TRG_ENDOCYTIC_2	85	88	PF00928	0.395
TRG_ER_diArg_1	644	646	PF00400	0.620
TRG_ER_diArg_1	853	856	PF00400	0.636
TRG_ER_diArg_1	903	906	PF00400	0.664
TRG_NES_CRM1_1	563	577	PF08389	0.561
TRG_NLS_MonoExtC_3	901	906	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	896	900	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU9	Leptomonas seymouri	53%	95%
A0A1X0NRK4	Trypanosomatidae	26%	97%
A0A3S7WQY6	Leishmania donovani	91%	100%
A4H5Y7	Leishmania braziliensis	78%	97%
A4HUB2	Leishmania infantum	91%	100%
E9AN11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%