LeishMANIAdb
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Putative ribosomal protein l35a

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ribosomal protein l35a
Gene product:
ribosomal protein l35a, putative
Species:
Leishmania major
UniProt:
Q4QHL3_LEIMA
TriTrypDb:
LmjF.10.0070 , LMJLV39_100005500 , LMJSD75_100005600
Length:
144

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosomal l35a

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. yes yes: 16
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 24
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0015934 large ribosomal subunit 4 2
GO:0022625 cytosolic large ribosomal subunit 5 2
GO:0032991 protein-containing complex 1 2
GO:0044391 ribosomal subunit 3 2
GO:1990904 ribonucleoprotein complex 2 2
GO:0005840 ribosome 5 15
GO:0043226 organelle 2 15
GO:0043228 non-membrane-bounded organelle 3 15
GO:0043229 intracellular organelle 3 15
GO:0043232 intracellular non-membrane-bounded organelle 4 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

Q4QHL3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHL3

PDB structure(s): 6az3_g

Function

Biological processes
Term Name Level Count
GO:0002181 cytoplasmic translation 5 2
GO:0006412 translation 4 17
GO:0006518 peptide metabolic process 4 17
GO:0006807 nitrogen compound metabolic process 2 17
GO:0008152 metabolic process 1 17
GO:0009058 biosynthetic process 2 17
GO:0009059 macromolecule biosynthetic process 4 17
GO:0009987 cellular process 1 17
GO:0019538 protein metabolic process 3 17
GO:0022613 ribonucleoprotein complex biogenesis 4 2
GO:0034641 cellular nitrogen compound metabolic process 3 17
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 17
GO:0042273 ribosomal large subunit biogenesis 5 2
GO:0043043 peptide biosynthetic process 5 17
GO:0043170 macromolecule metabolic process 3 17
GO:0043603 amide metabolic process 3 17
GO:0043604 amide biosynthetic process 4 17
GO:0044085 cellular component biogenesis 3 2
GO:0044237 cellular metabolic process 2 17
GO:0044238 primary metabolic process 2 17
GO:0044249 cellular biosynthetic process 3 17
GO:0044260 obsolete cellular macromolecule metabolic process 3 17
GO:0044271 cellular nitrogen compound biosynthetic process 4 17
GO:0071704 organic substance metabolic process 2 17
GO:0071840 cellular component organization or biogenesis 2 2
GO:1901564 organonitrogen compound metabolic process 3 17
GO:1901566 organonitrogen compound biosynthetic process 4 17
GO:1901576 organic substance biosynthetic process 3 17
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 17
GO:0005198 structural molecule activity 1 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 133 135 PF00675 0.383
CLV_NRD_NRD_1 27 29 PF00675 0.524
CLV_NRD_NRD_1 96 98 PF00675 0.348
CLV_PCSK_KEX2_1 133 135 PF00082 0.348
CLV_PCSK_KEX2_1 73 75 PF00082 0.351
CLV_PCSK_KEX2_1 85 87 PF00082 0.348
CLV_PCSK_KEX2_1 96 98 PF00082 0.348
CLV_PCSK_PC1ET2_1 73 75 PF00082 0.348
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.348
CLV_PCSK_SKI1_1 82 86 PF00082 0.470
DOC_MAPK_gen_1 133 139 PF00069 0.348
DOC_MAPK_MEF2A_6 26 35 PF00069 0.496
DOC_PP1_RVXF_1 116 122 PF00149 0.369
DOC_PP1_RVXF_1 84 91 PF00149 0.348
DOC_USP7_MATH_1 19 23 PF00917 0.682
DOC_USP7_MATH_1 95 99 PF00917 0.348
LIG_14-3-3_CanoR_1 96 104 PF00244 0.448
LIG_Clathr_ClatBox_1 55 59 PF01394 0.399
LIG_FHA_1 1 7 PF00498 0.688
LIG_FHA_1 19 25 PF00498 0.554
LIG_FHA_1 41 47 PF00498 0.360
LIG_FHA_1 51 57 PF00498 0.346
LIG_FHA_1 66 72 PF00498 0.368
LIG_FHA_1 98 104 PF00498 0.412
LIG_FHA_2 61 67 PF00498 0.352
LIG_PDZ_Class_1 139 144 PF00595 0.449
LIG_SH2_SRC 138 141 PF00017 0.412
LIG_SH2_SRC 77 80 PF00017 0.358
LIG_SH2_STAT3 140 143 PF00017 0.523
LIG_SH2_STAT5 138 141 PF00017 0.412
LIG_SH2_STAT5 42 45 PF00017 0.385
LIG_SH2_STAT5 70 73 PF00017 0.348
LIG_SH2_STAT5 77 80 PF00017 0.348
LIG_SH3_3 104 110 PF00018 0.358
MOD_CK1_1 18 24 PF00069 0.575
MOD_CK1_1 8 14 PF00069 0.600
MOD_Cter_Amidation 131 134 PF01082 0.348
MOD_Cter_Amidation 71 74 PF01082 0.348
MOD_Cter_Amidation 80 83 PF01082 0.348
MOD_GlcNHglycan 128 131 PF01048 0.450
MOD_GlcNHglycan 17 20 PF01048 0.637
MOD_GSK3_1 1 8 PF00069 0.752
MOD_GSK3_1 122 129 PF00069 0.447
MOD_GSK3_1 15 22 PF00069 0.556
MOD_NEK2_1 1 6 PF00069 0.667
MOD_NEK2_1 35 40 PF00069 0.358
MOD_PIKK_1 5 11 PF00454 0.569
MOD_PKA_1 96 102 PF00069 0.470
MOD_PKA_2 105 111 PF00069 0.379
MOD_PKA_2 88 94 PF00069 0.379
MOD_PKA_2 95 101 PF00069 0.379
MOD_Plk_1 65 71 PF00069 0.416
MOD_Plk_4 65 71 PF00069 0.444
TRG_ER_diArg_1 133 136 PF00400 0.349
TRG_NLS_MonoExtC_3 81 86 PF00514 0.470
TRG_Pf-PMV_PEXEL_1 44 49 PF00026 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P9A9 Leptomonas seymouri 94% 100%
A0A0N1P9D1 Leptomonas seymouri 93% 100%
A0A0S4KH22 Bodo saltans 72% 100%
A0A0S4KN84 Bodo saltans 72% 99%
A0A1D8PHH4 Candida albicans (strain SC5314 / ATCC MYA-2876) 37% 100%
A0A1X0NQD1 Trypanosomatidae 77% 100%
A0A1X0P9N4 Trypanosomatidae 78% 97%
A0A3Q8II82 Leishmania donovani 100% 100%
A0A3R7LBR4 Trypanosoma rangeli 80% 97%
A0A422N142 Trypanosoma rangeli 77% 100%
A4H5Y9 Leishmania braziliensis 95% 100%
A4HAV8 Leishmania braziliensis 96% 100%
A4HUB4 Leishmania infantum 100% 100%
C9ZMK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 81% 97%
E9AN13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9B533 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
O55142 Mus musculus 49% 100%
P02434 Xenopus laevis 50% 100%
P04646 Rattus norvegicus 49% 100%
P05744 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P0DJ22 Tetrahymena thermophila (strain SB210) 39% 100%
P18077 Homo sapiens 49% 100%
P41056 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 100%
P49180 Caenorhabditis elegans 48% 100%
P51422 Arabidopsis thaliana 44% 100%
P61272 Macaca fascicularis 49% 100%
Q55BN7 Dictyostelium discoideum 34% 100%
Q56JY1 Bos taurus 48% 100%
Q5R8K6 Pongo abelii 49% 100%
Q90YT3 Ictalurus punctatus 47% 100%
Q9C912 Arabidopsis thaliana 44% 100%
Q9FZH0 Arabidopsis thaliana 43% 100%
Q9LMK0 Arabidopsis thaliana 45% 100%
Q9USG6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 100%
Q9USX4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS