Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHL2_LEIMA

TriTrypDb:

LmjF.10.0080 , LMJLV39_100005600 , LMJSD75_100005700

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.644
CLV_NRD_NRD_1	137	139	PF00675	0.789
CLV_NRD_NRD_1	219	221	PF00675	0.524
CLV_PCSK_KEX2_1	137	139	PF00082	0.789
CLV_PCSK_KEX2_1	219	221	PF00082	0.468
CLV_PCSK_SKI1_1	241	245	PF00082	0.581
CLV_PCSK_SKI1_1	63	67	PF00082	0.638
DEG_APCC_DBOX_1	60	68	PF00400	0.747
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SPOP_SBC_1	328	332	PF00917	0.511
DOC_CYCLIN_yClb5_NLxxxL_5	187	196	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.511
DOC_MAPK_gen_1	219	229	PF00069	0.522
DOC_MAPK_gen_1	61	69	PF00069	0.648
DOC_PP1_RVXF_1	135	142	PF00149	0.556
DOC_USP7_MATH_1	71	75	PF00917	0.679
LIG_14-3-3_CanoR_1	118	124	PF00244	0.732
LIG_14-3-3_CanoR_1	143	147	PF00244	0.566
LIG_14-3-3_CanoR_1	171	175	PF00244	0.663
LIG_14-3-3_CanoR_1	220	229	PF00244	0.607
LIG_14-3-3_CanoR_1	241	247	PF00244	0.576
LIG_14-3-3_CanoR_1	282	286	PF00244	0.588
LIG_14-3-3_CanoR_1	327	337	PF00244	0.530
LIG_14-3-3_CanoR_1	63	68	PF00244	0.617
LIG_14-3-3_CanoR_1	72	77	PF00244	0.575
LIG_BRCT_BRCA1_1	74	78	PF00533	0.736
LIG_Clathr_ClatBox_1	64	68	PF01394	0.639
LIG_FHA_1	15	21	PF00498	0.709
LIG_FHA_1	177	183	PF00498	0.573
LIG_FHA_1	203	209	PF00498	0.547
LIG_FHA_1	286	292	PF00498	0.368
LIG_FHA_1	64	70	PF00498	0.625
LIG_FHA_2	243	249	PF00498	0.484
LIG_FHA_2	310	316	PF00498	0.651
LIG_Integrin_isoDGR_2	33	35	PF01839	0.507
LIG_LIR_Apic_2	19	25	PF02991	0.608
LIG_LIR_Gen_1	269	279	PF02991	0.522
LIG_LIR_Gen_1	292	303	PF02991	0.594
LIG_LIR_Gen_1	75	82	PF02991	0.640
LIG_LIR_Nem_3	269	275	PF02991	0.530
LIG_LIR_Nem_3	292	298	PF02991	0.573
LIG_LIR_Nem_3	75	81	PF02991	0.642
LIG_LIR_Nem_3	9	15	PF02991	0.621
LIG_RPA_C_Fungi	215	227	PF08784	0.496
LIG_SH2_CRK	12	16	PF00017	0.622
LIG_SH2_CRK	22	26	PF00017	0.610
LIG_SH2_STAP1	135	139	PF00017	0.673
LIG_SH2_STAP1	250	254	PF00017	0.565
LIG_SH2_STAP1	338	342	PF00017	0.452
LIG_SH2_STAT3	164	167	PF00017	0.473
LIG_SH2_STAT5	124	127	PF00017	0.663
LIG_SH2_STAT5	250	253	PF00017	0.468
LIG_SH2_STAT5	272	275	PF00017	0.458
LIG_SH2_STAT5	97	100	PF00017	0.787
LIG_SH3_3	257	263	PF00018	0.515
LIG_SUMO_SIM_par_1	197	205	PF11976	0.470
LIG_SUMO_SIM_par_1	87	92	PF11976	0.661
LIG_WRC_WIRS_1	243	248	PF05994	0.570
LIG_WRC_WIRS_1	50	55	PF05994	0.719
MOD_CK1_1	145	151	PF00069	0.536
MOD_CK1_1	173	179	PF00069	0.697
MOD_CK1_1	183	189	PF00069	0.466
MOD_CK1_1	202	208	PF00069	0.262
MOD_CK1_1	289	295	PF00069	0.579
MOD_CK1_1	309	315	PF00069	0.656
MOD_CK1_1	331	337	PF00069	0.521
MOD_CK1_1	74	80	PF00069	0.723
MOD_CK2_1	242	248	PF00069	0.558
MOD_CK2_1	96	102	PF00069	0.774
MOD_GlcNHglycan	107	110	PF01048	0.567
MOD_GlcNHglycan	188	191	PF01048	0.559
MOD_GlcNHglycan	259	263	PF01048	0.597
MOD_GlcNHglycan	268	271	PF01048	0.541
MOD_GlcNHglycan	308	311	PF01048	0.547
MOD_GlcNHglycan	333	336	PF01048	0.467
MOD_GlcNHglycan	68	72	PF01048	0.624
MOD_GSK3_1	105	112	PF00069	0.546
MOD_GSK3_1	172	179	PF00069	0.629
MOD_GSK3_1	182	189	PF00069	0.542
MOD_GSK3_1	274	281	PF00069	0.520
MOD_GSK3_1	285	292	PF00069	0.382
MOD_GSK3_1	29	36	PF00069	0.652
MOD_GSK3_1	298	305	PF00069	0.491
MOD_GSK3_1	327	334	PF00069	0.525
MOD_GSK3_1	63	70	PF00069	0.729
MOD_GSK3_1	96	103	PF00069	0.704
MOD_NEK2_1	150	155	PF00069	0.556
MOD_NEK2_1	227	232	PF00069	0.532
MOD_NEK2_1	265	270	PF00069	0.412
MOD_NEK2_1	298	303	PF00069	0.513
MOD_NEK2_1	67	72	PF00069	0.700
MOD_NEK2_1	8	13	PF00069	0.559
MOD_NEK2_1	81	86	PF00069	0.594
MOD_NEK2_2	119	124	PF00069	0.635
MOD_PK_1	72	78	PF00069	0.746
MOD_PKA_2	117	123	PF00069	0.723
MOD_PKA_2	142	148	PF00069	0.605
MOD_PKA_2	170	176	PF00069	0.659
MOD_PKA_2	221	227	PF00069	0.608
MOD_PKA_2	281	287	PF00069	0.590
MOD_PKA_2	29	35	PF00069	0.585
MOD_PKA_2	71	77	PF00069	0.749
MOD_PKB_1	61	69	PF00069	0.640
MOD_Plk_1	183	189	PF00069	0.632
MOD_Plk_1	202	208	PF00069	0.262
MOD_Plk_1	248	254	PF00069	0.582
MOD_Plk_4	119	125	PF00069	0.640
MOD_Plk_4	145	151	PF00069	0.536
MOD_Plk_4	183	189	PF00069	0.632
MOD_Plk_4	268	274	PF00069	0.538
MOD_Plk_4	281	287	PF00069	0.488
MOD_Plk_4	309	315	PF00069	0.576
MOD_Plk_4	74	80	PF00069	0.596
MOD_SUMO_for_1	275	278	PF00179	0.526
TRG_DiLeu_BaEn_1	203	208	PF01217	0.533
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.650
TRG_ENDOCYTIC_2	12	15	PF00928	0.628
TRG_ENDOCYTIC_2	272	275	PF00928	0.517
TRG_ER_diArg_1	137	139	PF00400	0.691
TRG_ER_diArg_1	219	222	PF00400	0.634
TRG_ER_diArg_1	61	64	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ49	Leptomonas seymouri	46%	100%
A0A3S7WQY3	Leishmania donovani	93%	100%
A4H5Z0	Leishmania braziliensis	80%	100%
A4HUB5	Leishmania infantum	93%	100%
E9AN14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%