Dehydrogenase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4QHL1_LEIMA

TriTrypDb:

LmjF.10.0090 , LMJLV39_100005700 , LMJSD75_100005800

Length:

412

Annotations

LeishMANIAdb annotations

Homologous to other Eukarytotic short-chain dehydrogenases.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QHL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	156	162	PF00089	0.416
CLV_NRD_NRD_1	385	387	PF00675	0.564
CLV_NRD_NRD_1	41	43	PF00675	0.383
CLV_NRD_NRD_1	62	64	PF00675	0.631
CLV_NRD_NRD_1	85	87	PF00675	0.670
CLV_PCSK_FUR_1	383	387	PF00082	0.561
CLV_PCSK_KEX2_1	211	213	PF00082	0.512
CLV_PCSK_KEX2_1	385	387	PF00082	0.564
CLV_PCSK_KEX2_1	41	43	PF00082	0.383
CLV_PCSK_KEX2_1	62	64	PF00082	0.631
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.512
CLV_PCSK_SKI1_1	262	266	PF00082	0.663
CLV_PCSK_SKI1_1	287	291	PF00082	0.509
CLV_PCSK_SKI1_1	329	333	PF00082	0.668
CLV_PCSK_SKI1_1	385	389	PF00082	0.545
CLV_PCSK_SKI1_1	42	46	PF00082	0.283
CLV_PCSK_SKI1_1	93	97	PF00082	0.673
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DOC_CYCLIN_RxL_1	281	294	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.447
DOC_MAPK_FxFP_2	336	339	PF00069	0.428
DOC_MAPK_gen_1	208	218	PF00069	0.332
DOC_MAPK_gen_1	41	49	PF00069	0.500
DOC_MAPK_gen_1	62	70	PF00069	0.427
DOC_MAPK_MEF2A_6	134	141	PF00069	0.332
DOC_MAPK_MEF2A_6	164	172	PF00069	0.281
DOC_MAPK_MEF2A_6	211	220	PF00069	0.332
DOC_MAPK_MEF2A_6	63	72	PF00069	0.431
DOC_PP1_RVXF_1	162	168	PF00149	0.318
DOC_PP1_RVXF_1	327	333	PF00149	0.348
DOC_PP2B_PxIxI_1	189	195	PF00149	0.325
DOC_PP4_FxxP_1	336	339	PF00568	0.389
DOC_USP7_MATH_1	102	106	PF00917	0.435
DOC_USP7_MATH_1	158	162	PF00917	0.327
DOC_USP7_MATH_1	77	81	PF00917	0.502
DOC_USP7_UBL2_3	398	402	PF12436	0.485
DOC_WW_Pin1_4	186	191	PF00397	0.319
DOC_WW_Pin1_4	200	205	PF00397	0.242
DOC_WW_Pin1_4	273	278	PF00397	0.461
DOC_WW_Pin1_4	369	374	PF00397	0.362
DOC_WW_Pin1_4	78	83	PF00397	0.472
DOC_WW_Pin1_4	96	101	PF00397	0.477
LIG_14-3-3_CanoR_1	20	29	PF00244	0.400
LIG_14-3-3_CanoR_1	281	286	PF00244	0.266
LIG_14-3-3_CanoR_1	71	76	PF00244	0.466
LIG_14-3-3_CanoR_1	86	95	PF00244	0.468
LIG_Actin_WH2_2	121	136	PF00022	0.383
LIG_Actin_WH2_2	6	22	PF00022	0.332
LIG_BRCT_BRCA1_1	218	222	PF00533	0.383
LIG_BRCT_BRCA1_1	356	360	PF00533	0.351
LIG_Clathr_ClatBox_1	250	254	PF01394	0.327
LIG_DLG_GKlike_1	281	288	PF00625	0.259
LIG_eIF4E_1	283	289	PF01652	0.322
LIG_FHA_1	187	193	PF00498	0.332
LIG_FHA_1	227	233	PF00498	0.303
LIG_FHA_1	292	298	PF00498	0.305
LIG_FHA_2	116	122	PF00498	0.332
LIG_FHA_2	13	19	PF00498	0.405
LIG_FHA_2	261	267	PF00498	0.376
LIG_LIR_Apic_2	334	339	PF02991	0.406
LIG_LIR_Gen_1	366	375	PF02991	0.360
LIG_LIR_Nem_3	366	370	PF02991	0.439
LIG_NRBOX	284	290	PF00104	0.354
LIG_PCNA_yPIPBox_3	281	289	PF02747	0.372
LIG_PCNA_yPIPBox_3	381	390	PF02747	0.364
LIG_Pex14_2	323	327	PF04695	0.515
LIG_Pex14_2	332	336	PF04695	0.355
LIG_REV1ctd_RIR_1	329	337	PF16727	0.406
LIG_REV1ctd_RIR_1	56	67	PF16727	0.595
LIG_SH2_CRK	348	352	PF00017	0.349
LIG_SH2_CRK	367	371	PF00017	0.389
LIG_SH2_STAP1	214	218	PF00017	0.383
LIG_SH2_STAP1	293	297	PF00017	0.305
LIG_SH2_STAP1	321	325	PF00017	0.396
LIG_SH2_STAP1	361	365	PF00017	0.381
LIG_SH2_STAP1	53	57	PF00017	0.357
LIG_SH2_STAT5	293	296	PF00017	0.324
LIG_SH2_STAT5	348	351	PF00017	0.348
LIG_SH2_STAT5	391	394	PF00017	0.365
LIG_SH2_STAT5	53	56	PF00017	0.405
LIG_SH2_STAT5	8	11	PF00017	0.484
LIG_SH3_3	254	260	PF00018	0.446
LIG_SH3_3	271	277	PF00018	0.453
LIG_SH3_3	32	38	PF00018	0.400
LIG_SH3_4	398	405	PF00018	0.476
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.383
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.396
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.309
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.244
LIG_SUMO_SIM_par_1	112	118	PF11976	0.295
LIG_SUMO_SIM_par_1	372	378	PF11976	0.400
LIG_TYR_ITIM	346	351	PF00017	0.431
LIG_TYR_ITIM	389	394	PF00017	0.529
MOD_CDK_SPK_2	186	191	PF00069	0.397
MOD_CK1_1	203	209	PF00069	0.283
MOD_CK1_1	239	245	PF00069	0.363
MOD_CK1_1	369	375	PF00069	0.464
MOD_CK1_1	397	403	PF00069	0.537
MOD_CK2_1	115	121	PF00069	0.405
MOD_CK2_1	12	18	PF00069	0.405
MOD_CK2_1	174	180	PF00069	0.244
MOD_CK2_1	77	83	PF00069	0.599
MOD_GlcNHglycan	104	107	PF01048	0.358
MOD_GlcNHglycan	198	201	PF01048	0.244
MOD_GlcNHglycan	238	241	PF01048	0.405
MOD_GlcNHglycan	356	359	PF01048	0.450
MOD_GlcNHglycan	65	68	PF01048	0.534
MOD_GlcNHglycan	88	91	PF01048	0.661
MOD_GSK3_1	196	203	PF00069	0.244
MOD_GSK3_1	273	280	PF00069	0.502
MOD_GSK3_1	303	310	PF00069	0.345
MOD_LATS_1	279	285	PF00433	0.345
MOD_N-GLC_1	196	201	PF02516	0.443
MOD_N-GLC_1	281	286	PF02516	0.547
MOD_NEK2_1	331	336	PF00069	0.585
MOD_NEK2_1	394	399	PF00069	0.591
MOD_NEK2_1	85	90	PF00069	0.598
MOD_NEK2_2	307	312	PF00069	0.316
MOD_PKA_1	86	92	PF00069	0.598
MOD_PKA_2	158	164	PF00069	0.244
MOD_PKA_2	301	307	PF00069	0.558
MOD_PKA_2	85	91	PF00069	0.582
MOD_Plk_1	174	180	PF00069	0.316
MOD_Plk_1	281	287	PF00069	0.483
MOD_Plk_2-3	174	180	PF00069	0.244
MOD_Plk_4	246	252	PF00069	0.405
MOD_Plk_4	356	362	PF00069	0.426
MOD_Plk_4	366	372	PF00069	0.432
MOD_ProDKin_1	186	192	PF00069	0.388
MOD_ProDKin_1	200	206	PF00069	0.280
MOD_ProDKin_1	273	279	PF00069	0.579
MOD_ProDKin_1	369	375	PF00069	0.443
MOD_ProDKin_1	78	84	PF00069	0.599
MOD_ProDKin_1	96	102	PF00069	0.609
TRG_DiLeu_BaEn_1	366	371	PF01217	0.558
TRG_ENDOCYTIC_2	214	217	PF00928	0.477
TRG_ENDOCYTIC_2	348	351	PF00928	0.429
TRG_ENDOCYTIC_2	367	370	PF00928	0.489
TRG_ENDOCYTIC_2	391	394	PF00928	0.452
TRG_ER_diArg_1	383	386	PF00400	0.411
TRG_ER_diArg_1	62	64	PF00400	0.544
TRG_NES_CRM1_1	382	395	PF08389	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A023I4F1	Penicillium roqueforti	25%	100%
A0A0N0P2P0	Leptomonas seymouri	65%	100%
A0A0N0P2S5	Leptomonas seymouri	27%	92%
A0A0N0P2S7	Leptomonas seymouri	25%	80%
A0A0S4IP03	Bodo saltans	27%	100%
A0A0S4ITL0	Bodo saltans	27%	100%
A0A0S4IWT0	Bodo saltans	27%	88%
A0A0S4IZG2	Bodo saltans	27%	91%
A0A0S4J1I6	Bodo saltans	24%	94%
A0A0S4JBQ4	Bodo saltans	36%	100%
A0A0U5CNP2	Aspergillus calidoustus	25%	100%
A0A1J0HSL5	Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)	25%	100%
A0A1X0NVT8	Trypanosomatidae	30%	83%
A0A1X0P5Q9	Trypanosomatidae	27%	90%
A0A1X0P5W3	Trypanosomatidae	27%	92%
A0A3Q8ID46	Leishmania donovani	28%	81%
A0A3Q8IM89	Leishmania donovani	26%	94%
A0A3R7K8J6	Trypanosoma rangeli	27%	94%
A0A3R7N7S2	Trypanosoma rangeli	29%	96%
A0A3S7WQY1	Leishmania donovani	93%	100%
A0A422N2B6	Trypanosoma rangeli	27%	86%
A2RVM0	Arabidopsis thaliana	28%	100%
A4H5Z1	Leishmania braziliensis	80%	94%
A4HMN7	Leishmania braziliensis	26%	100%
A4HUB6	Leishmania infantum	93%	100%
B2X050	Capsicum annuum	25%	100%
C8VI80	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	87%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9AF39	Leishmania major	25%	100%
E9AH89	Leishmania infantum	28%	81%
E9AHV6	Leishmania infantum	26%	100%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	81%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P48758	Mus musculus	27%	100%
P59837	Bos taurus	34%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q0V6Q2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	100%
Q17QU7	Bos taurus	33%	100%
Q17QW3	Bos taurus	33%	100%
Q42536	Arabidopsis thaliana	24%	100%
Q42850	Hordeum vulgare	26%	100%
Q4QAE9	Leishmania major	27%	81%
Q5SS80	Mus musculus	33%	100%
Q6RVV4	Pisum sativum	29%	100%
Q6UX07	Homo sapiens	33%	100%
Q803A8	Danio rerio	29%	100%
Q8BYK4	Mus musculus	35%	100%
Q8CEE7	Mus musculus	32%	100%
Q8N5I4	Homo sapiens	30%	100%
Q8NBN7	Homo sapiens	31%	100%
Q8VBZ0	Mus musculus	32%	100%
Q8W3D9	Oryza sativa subsp. japonica	25%	100%
Q91WL8	Mus musculus	26%	100%
Q96NR8	Homo sapiens	34%	100%
Q99J47	Mus musculus	25%	100%
Q9ERI6	Mus musculus	33%	100%
Q9HBH5	Homo sapiens	33%	100%
V5BAF4	Trypanosoma cruzi	28%	87%
V5BJC7	Trypanosoma cruzi	26%	93%
V5BNY6	Trypanosoma cruzi	30%	96%
W6QB10	Penicillium roqueforti (strain FM164)	25%	100%