SRP40_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SRP40, C-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHL0_LEIMA

TriTrypDb:

LmjF.10.0100 , LMJLV39_100005800 , LMJSD75_100005900

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QHL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.716
CLV_NRD_NRD_1	170	172	PF00675	0.678
CLV_NRD_NRD_1	183	185	PF00675	0.327
CLV_NRD_NRD_1	24	26	PF00675	0.726
CLV_NRD_NRD_1	93	95	PF00675	0.732
CLV_PCSK_KEX2_1	146	148	PF00082	0.647
CLV_PCSK_KEX2_1	170	172	PF00082	0.678
CLV_PCSK_KEX2_1	183	185	PF00082	0.327
CLV_PCSK_KEX2_1	93	95	PF00082	0.576
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.647
CLV_PCSK_SKI1_1	119	123	PF00082	0.596
CLV_PCSK_SKI1_1	78	82	PF00082	0.745
CLV_Separin_Metazoa	217	221	PF03568	0.430
DEG_SPOP_SBC_1	113	117	PF00917	0.798
DEG_SPOP_SBC_1	28	32	PF00917	0.525
DEG_SPOP_SBC_1	80	84	PF00917	0.773
DOC_MAPK_gen_1	204	212	PF00069	0.424
DOC_PP1_RVXF_1	190	196	PF00149	0.376
DOC_USP7_MATH_1	126	130	PF00917	0.653
DOC_USP7_MATH_1	139	143	PF00917	0.715
DOC_USP7_MATH_1	80	84	PF00917	0.773
DOC_USP7_UBL2_3	119	123	PF12436	0.647
DOC_USP7_UBL2_3	224	228	PF12436	0.395
DOC_USP7_UBL2_3	230	234	PF12436	0.304
DOC_WW_Pin1_4	114	119	PF00397	0.660
DOC_WW_Pin1_4	169	174	PF00397	0.772
DOC_WW_Pin1_4	29	34	PF00397	0.643
DOC_WW_Pin1_4	54	59	PF00397	0.603
DOC_WW_Pin1_4	81	86	PF00397	0.750
LIG_14-3-3_CanoR_1	52	58	PF00244	0.700
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	116	120	PF00533	0.557
LIG_CtBP_PxDLS_1	241	247	PF00389	0.424
LIG_FHA_1	30	36	PF00498	0.528
LIG_FHA_1	55	61	PF00498	0.518
LIG_FHA_2	161	167	PF00498	0.728
LIG_FHA_2	63	69	PF00498	0.662
LIG_LIR_Nem_3	179	185	PF02991	0.629
LIG_MYND_1	34	38	PF01753	0.490
LIG_SH2_STAT3	51	54	PF00017	0.702
LIG_SH2_STAT5	12	15	PF00017	0.553
LIG_SxIP_EBH_1	81	94	PF03271	0.806
LIG_TRAF2_1	43	46	PF00917	0.573
MOD_CDK_SPK_2	114	119	PF00069	0.678
MOD_CDK_SPxxK_3	34	41	PF00069	0.647
MOD_CDK_SPxxK_3	83	90	PF00069	0.722
MOD_CK1_1	129	135	PF00069	0.759
MOD_CK1_1	76	82	PF00069	0.790
MOD_CK1_1	83	89	PF00069	0.637
MOD_CK2_1	100	106	PF00069	0.724
MOD_CK2_1	128	134	PF00069	0.770
MOD_CK2_1	160	166	PF00069	0.704
MOD_CK2_1	251	257	PF00069	0.603
MOD_CK2_1	40	46	PF00069	0.594
MOD_Cter_Amidation	144	147	PF01082	0.709
MOD_Cter_Amidation	39	42	PF01082	0.700
MOD_GlcNHglycan	104	109	PF01048	0.626
MOD_GlcNHglycan	142	145	PF01048	0.820
MOD_GSK3_1	100	107	PF00069	0.753
MOD_GSK3_1	76	83	PF00069	0.809
MOD_N-GLC_1	140	145	PF02516	0.722
MOD_N-GLC_1	62	67	PF02516	0.697
MOD_NEK2_1	218	223	PF00069	0.440
MOD_PKA_2	73	79	PF00069	0.746
MOD_Plk_1	242	248	PF00069	0.430
MOD_Plk_2-3	100	106	PF00069	0.724
MOD_ProDKin_1	114	120	PF00069	0.658
MOD_ProDKin_1	169	175	PF00069	0.762
MOD_ProDKin_1	29	35	PF00069	0.645
MOD_ProDKin_1	54	60	PF00069	0.607
MOD_ProDKin_1	81	87	PF00069	0.749
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.508
TRG_ER_diArg_1	182	184	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8F0	Bodo saltans	42%	100%
A0A1X0NQ23	Trypanosomatidae	50%	100%
A0A3S5H6F2	Leishmania donovani	90%	100%
A4H5Z2	Leishmania braziliensis	76%	100%
A4HUB7	Leishmania infantum	90%	100%
E9AN16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%