Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD-repeat containing protein

Species:

Leishmania major

UniProt:

Q4QHK9_LEIMA

TriTrypDb:

LmjF.10.0110 , LMJLV39_100005900 , LMJSD75_100006000

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0097361	CIA complex	3	12
GO:0140535	intracellular protein-containing complex	2	12

Expansion

Sequence features

Q4QHK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK9

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.457
CLV_NRD_NRD_1	30	32	PF00675	0.503
CLV_PCSK_KEX2_1	119	121	PF00082	0.386
CLV_PCSK_KEX2_1	280	282	PF00082	0.392
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.402
CLV_PCSK_SKI1_1	299	303	PF00082	0.393
CLV_Separin_Metazoa	250	254	PF03568	0.453
DEG_Nend_UBRbox_2	1	3	PF02207	0.607
DOC_CDC14_PxL_1	12	20	PF14671	0.430
DOC_CYCLIN_RxL_1	296	305	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.433
DOC_MAPK_RevD_3	16	32	PF00069	0.434
DOC_PP1_RVXF_1	141	148	PF00149	0.459
DOC_PP1_RVXF_1	93	100	PF00149	0.427
DOC_PP2B_LxvP_1	18	21	PF13499	0.370
DOC_PP2B_LxvP_1	245	248	PF13499	0.485
DOC_PP4_FxxP_1	191	194	PF00568	0.519
DOC_USP7_MATH_1	148	152	PF00917	0.446
DOC_USP7_MATH_1	297	301	PF00917	0.352
DOC_USP7_MATH_1	315	319	PF00917	0.317
DOC_USP7_MATH_1	56	60	PF00917	0.416
DOC_WW_Pin1_4	97	102	PF00397	0.416
LIG_14-3-3_CanoR_1	253	261	PF00244	0.451
LIG_14-3-3_CanoR_1	95	100	PF00244	0.464
LIG_APCC_ABBA_1	192	197	PF00400	0.471
LIG_APCC_ABBA_1	326	331	PF00400	0.446
LIG_BRCT_BRCA1_1	274	278	PF00533	0.307
LIG_BRCT_BRCA1_1	352	356	PF00533	0.459
LIG_BRCT_BRCA1_2	274	280	PF00533	0.349
LIG_Clathr_ClatBox_1	301	305	PF01394	0.379
LIG_CtBP_PxDLS_1	248	252	PF00389	0.445
LIG_deltaCOP1_diTrp_1	41	48	PF00928	0.418
LIG_FHA_1	112	118	PF00498	0.442
LIG_FHA_1	159	165	PF00498	0.416
LIG_FHA_1	178	184	PF00498	0.457
LIG_FHA_1	209	215	PF00498	0.408
LIG_FHA_1	370	376	PF00498	0.471
LIG_FHA_1	49	55	PF00498	0.376
LIG_FHA_2	376	382	PF00498	0.519
LIG_LIR_Gen_1	222	232	PF02991	0.502
LIG_LIR_Gen_1	320	329	PF02991	0.417
LIG_LIR_Gen_1	78	86	PF02991	0.291
LIG_LIR_LC3C_4	199	204	PF02991	0.471
LIG_LIR_Nem_3	222	227	PF02991	0.443
LIG_LIR_Nem_3	320	326	PF02991	0.410
LIG_LIR_Nem_3	78	83	PF02991	0.256
LIG_MYND_1	17	21	PF01753	0.434
LIG_Pex14_2	302	306	PF04695	0.379
LIG_SH2_STAP1	127	131	PF00017	0.282
LIG_SH2_STAP1	208	212	PF00017	0.427
LIG_SH2_STAT5	105	108	PF00017	0.459
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.420
LIG_SUMO_SIM_par_1	16	23	PF11976	0.490
LIG_SUMO_SIM_par_1	199	205	PF11976	0.462
MOD_CK1_1	107	113	PF00069	0.520
MOD_CK1_1	255	261	PF00069	0.471
MOD_CK1_1	355	361	PF00069	0.482
MOD_CK1_1	59	65	PF00069	0.540
MOD_GlcNHglycan	101	104	PF01048	0.245
MOD_GlcNHglycan	155	158	PF01048	0.252
MOD_GlcNHglycan	22	25	PF01048	0.377
MOD_GlcNHglycan	293	296	PF01048	0.415
MOD_GlcNHglycan	317	320	PF01048	0.285
MOD_GlcNHglycan	390	393	PF01048	0.441
MOD_GlcNHglycan	58	61	PF01048	0.248
MOD_GlcNHglycan	71	74	PF01048	0.448
MOD_GSK3_1	107	114	PF00069	0.371
MOD_GSK3_1	148	155	PF00069	0.452
MOD_GSK3_1	233	240	PF00069	0.436
MOD_GSK3_1	268	275	PF00069	0.271
MOD_GSK3_1	3	10	PF00069	0.608
MOD_GSK3_1	315	322	PF00069	0.423
MOD_GSK3_1	56	63	PF00069	0.440
MOD_GSK3_1	78	85	PF00069	0.364
MOD_GSK3_1	95	102	PF00069	0.357
MOD_N-GLC_1	120	125	PF02516	0.427
MOD_N-GLC_2	75	77	PF02516	0.409
MOD_NEK2_1	111	116	PF00069	0.423
MOD_NEK2_1	152	157	PF00069	0.451
MOD_NEK2_1	202	207	PF00069	0.437
MOD_NEK2_1	266	271	PF00069	0.413
MOD_NEK2_1	375	380	PF00069	0.437
MOD_NEK2_2	208	213	PF00069	0.416
MOD_NEK2_2	297	302	PF00069	0.329
MOD_NEK2_2	60	65	PF00069	0.416
MOD_OFUCOSY	77	82	PF10250	0.389
MOD_PIKK_1	355	361	PF00454	0.542
MOD_PKA_2	252	258	PF00069	0.451
MOD_PKA_2	291	297	PF00069	0.435
MOD_Plk_1	158	164	PF00069	0.444
MOD_Plk_1	208	214	PF00069	0.434
MOD_Plk_1	233	239	PF00069	0.360
MOD_Plk_1	272	278	PF00069	0.329
MOD_Plk_1	297	303	PF00069	0.331
MOD_Plk_1	319	325	PF00069	0.426
MOD_Plk_1	380	386	PF00069	0.447
MOD_Plk_1	60	66	PF00069	0.441
MOD_Plk_4	113	119	PF00069	0.440
MOD_Plk_4	148	154	PF00069	0.520
MOD_Plk_4	233	239	PF00069	0.301
MOD_Plk_4	272	278	PF00069	0.318
MOD_Plk_4	380	386	PF00069	0.458
MOD_ProDKin_1	97	103	PF00069	0.416
MOD_SUMO_rev_2	136	145	PF00179	0.427
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.525
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.437
TRG_ER_diArg_1	118	120	PF00400	0.419
TRG_ER_FFAT_2	100	110	PF00635	0.471
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	23%	76%
A0A0N1ILE6	Leptomonas seymouri	73%	98%
A0A0S4JE56	Bodo saltans	40%	95%
A0A0S4JL38	Bodo saltans	28%	74%
A0A0S4JQ93	Bodo saltans	26%	71%
A0A1X0NQ54	Trypanosomatidae	53%	97%
A0A1X0NVZ7	Trypanosomatidae	23%	76%
A0A1X0P2X5	Trypanosomatidae	26%	89%
A0A3Q8IGC4	Leishmania donovani	23%	76%
A0A3R7M365	Trypanosoma rangeli	50%	94%
A0A3R7N6M9	Trypanosoma rangeli	23%	76%
A0A3S7WQZ2	Leishmania donovani	94%	100%
A1CGS0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	100%
A1CQL6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	31%	87%
A1D3I2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	30%	85%
A2QHM1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A2QPW4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	96%
A3LVM1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	26%	100%
A4H5Z3	Leishmania braziliensis	88%	100%
A4HDT7	Leishmania braziliensis	21%	76%
A4HUB8	Leishmania infantum	94%	100%
A4I135	Leishmania infantum	23%	76%
A4R7U3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	89%
A4REK3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
A5DHD2	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	100%
A5DXE2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	23%	100%
A5E2R6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	29%	95%
A6RT32	Botryotinia fuckeliana (strain B05.10)	30%	91%
A6ZYM0	Saccharomyces cerevisiae (strain YJM789)	29%	100%
A7EZJ5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	25%	87%
A7RWD2	Nematostella vectensis	34%	100%
A7TLU2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	29%	100%
A8IZG4	Chlamydomonas reinhardtii	37%	100%
A8PWQ8	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	31%	100%
A9VDW7	Monosiga brevicollis	31%	78%
B0LSW3	Felis catus	24%	96%
B0XAF3	Culex quinquefasciatus	32%	100%
B0XQ15	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	29%	86%
B3MC74	Drosophila ananassae	34%	100%
B3NQR5	Drosophila erecta	33%	100%
B3RNR8	Trichoplax adhaerens	32%	100%
B4GDM7	Drosophila persimilis	33%	100%
B4HRQ6	Drosophila sechellia	33%	100%
B4JW81	Drosophila grimshawi	31%	100%
B4KTK4	Drosophila mojavensis	32%	100%
B4LJT7	Drosophila virilis	32%	100%
B4MY77	Drosophila willistoni	32%	100%
B4P7Q3	Drosophila yakuba	32%	100%
B4QFZ8	Drosophila simulans	33%	100%
B5X212	Salmo salar	35%	100%
B5X3Z6	Salmo salar	24%	96%
B5X9P2	Salmo salar	35%	100%
B6GZD3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	23%	85%
B6H7A3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	29%	87%
B6QC56	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	25%	86%
B7QKS1	Ixodes scapularis	37%	100%
B8M0Q1	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	24%	86%
B8MWR8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	90%
B8N9H4	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	23%	87%
B9WHJ2	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	27%	100%
C7Z6H2	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	25%	88%
C9ZQJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
C9ZVH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	93%
E9AN17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	76%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	24%	76%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	79%
O76071	Homo sapiens	34%	100%
O80990	Arabidopsis thaliana	35%	100%
P0CS30	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	90%
P0CS31	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	90%
P0CS42	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	91%
P0CS43	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	91%
P16520	Homo sapiens	24%	100%
P43033	Bos taurus	24%	96%
P43034	Homo sapiens	24%	96%
P52287	Rattus norvegicus	23%	100%
P63004	Rattus norvegicus	24%	96%
P63005	Mus musculus	24%	96%
P79147	Canis lupus familiaris	23%	100%
Q00664	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	89%
Q04491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q05583	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q0CCS0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	94%
Q0CHM0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0USG2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	89%
Q17GR9	Aedes aegypti	31%	100%
Q1DR81	Coccidioides immitis (strain RS)	28%	84%
Q1DZQ0	Coccidioides immitis (strain RS)	24%	100%
Q28DW0	Xenopus tropicalis	32%	100%
Q292E8	Drosophila pseudoobscura pseudoobscura	32%	100%
Q2UG43	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q2UGU1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	87%
Q2UPI0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	90%
Q32PJ6	Bos taurus	35%	100%
Q4ICM0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	86%
Q4P5F5	Ustilago maydis (strain 521 / FGSC 9021)	29%	87%
Q4P9P9	Ustilago maydis (strain 521 / FGSC 9021)	25%	87%
Q4QAA4	Leishmania major	22%	100%
Q4RJN5	Tetraodon nigroviridis	25%	96%
Q4WNK7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q4WTL0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	86%
Q55DA2	Dictyostelium discoideum	29%	100%
Q58D20	Bos taurus	26%	81%
Q5AG86	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
Q5B563	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	100%
Q5BDJ5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	89%
Q5DFU0	Schistosoma japonicum	30%	100%
Q5FVN8	Rattus norvegicus	24%	83%
Q5IS43	Pan troglodytes	24%	96%
Q5M7T1	Rattus norvegicus	35%	100%
Q5REG7	Pongo abelii	23%	96%
Q5RFF8	Pongo abelii	25%	81%
Q61011	Mus musculus	23%	100%
Q61FW2	Caenorhabditis briggsae	26%	67%
Q6BIR9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	100%
Q6CBI8	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	100%
Q6CMA2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6CSZ5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	100%
Q6FJ73	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6GPC6	Xenopus laevis	21%	76%
Q6NZH4	Xenopus tropicalis	24%	96%
Q6P0D9	Danio rerio	36%	100%
Q75BS2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q75C26	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	100%
Q7K1Y4	Drosophila melanogaster	32%	100%
Q7PS24	Anopheles gambiae	30%	100%
Q7SZM9	Xenopus laevis	21%	76%
Q7T394	Danio rerio	25%	96%
Q7ZVF0	Danio rerio	27%	95%
Q7ZXK9	Xenopus laevis	25%	83%
Q803D2	Danio rerio	25%	96%
Q8BHJ5	Mus musculus	21%	77%
Q8HXX0	Macaca fascicularis	23%	96%
Q8VEJ4	Mus musculus	26%	81%
Q90ZL4	Xenopus laevis	24%	96%
Q99KN2	Mus musculus	34%	100%
Q9BQ87	Homo sapiens	23%	76%
Q9D0I6	Mus musculus	23%	83%
Q9FLX9	Arabidopsis thaliana	22%	84%
Q9GL51	Sus scrofa	23%	96%
Q9NVX2	Homo sapiens	25%	81%
Q9PTR5	Gallus gallus	24%	96%
Q9QXE7	Mus musculus	23%	75%
Q9VPR4	Drosophila melanogaster	25%	81%
Q9XW12	Caenorhabditis elegans	28%	100%
V5BE41	Trypanosoma cruzi	51%	93%
V5BEB2	Trypanosoma cruzi	25%	73%