PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania major

UniProt:

Q4QHK8_LEIMA

TriTrypDb:

LmjF.10.0120 , LMJLV39_100006000 , LMJSD75_100006100

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QHK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.286
CLV_NRD_NRD_1	339	341	PF00675	0.567
CLV_NRD_NRD_1	358	360	PF00675	0.694
CLV_NRD_NRD_1	88	90	PF00675	0.691
CLV_PCSK_FUR_1	337	341	PF00082	0.564
CLV_PCSK_KEX2_1	20	22	PF00082	0.542
CLV_PCSK_KEX2_1	336	338	PF00082	0.537
CLV_PCSK_KEX2_1	339	341	PF00082	0.555
CLV_PCSK_KEX2_1	357	359	PF00082	0.472
CLV_PCSK_KEX2_1	88	90	PF00082	0.691
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.567
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.577
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.634
CLV_PCSK_PC7_1	353	359	PF00082	0.624
CLV_PCSK_SKI1_1	236	240	PF00082	0.551
CLV_PCSK_SKI1_1	292	296	PF00082	0.380
CLV_PCSK_SKI1_1	89	93	PF00082	0.676
DEG_Nend_UBRbox_3	1	3	PF02207	0.539
DEG_SCF_FBW7_1	69	75	PF00400	0.560
DOC_CKS1_1	69	74	PF01111	0.645
DOC_CYCLIN_RxL_1	86	95	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.345
DOC_MAPK_gen_1	133	141	PF00069	0.574
DOC_MAPK_gen_1	240	250	PF00069	0.406
DOC_MAPK_MEF2A_6	150	159	PF00069	0.460
DOC_MAPK_MEF2A_6	182	191	PF00069	0.510
DOC_PP2B_LxvP_1	276	279	PF13499	0.345
DOC_PP4_FxxP_1	166	169	PF00568	0.383
DOC_USP7_MATH_1	24	28	PF00917	0.613
DOC_USP7_MATH_1	32	36	PF00917	0.586
DOC_USP7_UBL2_3	134	138	PF12436	0.574
DOC_USP7_UBL2_3	236	240	PF12436	0.452
DOC_WW_Pin1_4	100	105	PF00397	0.670
DOC_WW_Pin1_4	215	220	PF00397	0.713
DOC_WW_Pin1_4	227	232	PF00397	0.702
DOC_WW_Pin1_4	41	46	PF00397	0.635
DOC_WW_Pin1_4	48	53	PF00397	0.602
DOC_WW_Pin1_4	68	73	PF00397	0.560
DOC_WW_Pin1_4	92	97	PF00397	0.660
LIG_14-3-3_CanoR_1	125	131	PF00244	0.645
LIG_14-3-3_CanoR_1	160	168	PF00244	0.493
LIG_14-3-3_CanoR_1	243	250	PF00244	0.444
LIG_14-3-3_CanoR_1	291	297	PF00244	0.286
LIG_14-3-3_CanoR_1	88	92	PF00244	0.534
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.679
LIG_BRCT_BRCA1_1	34	38	PF00533	0.586
LIG_Clathr_ClatBox_1	174	178	PF01394	0.570
LIG_FHA_1	127	133	PF00498	0.518
LIG_FHA_1	154	160	PF00498	0.515
LIG_FHA_1	163	169	PF00498	0.484
LIG_FHA_1	179	185	PF00498	0.391
LIG_FHA_1	308	314	PF00498	0.407
LIG_FHA_1	69	75	PF00498	0.593
LIG_FHA_2	219	225	PF00498	0.711
LIG_IBAR_NPY_1	23	25	PF08397	0.515
LIG_LIR_Apic_2	163	169	PF02991	0.399
LIG_LIR_Gen_1	170	177	PF02991	0.545
LIG_LIR_Gen_1	300	309	PF02991	0.329
LIG_LIR_Gen_1	35	46	PF02991	0.591
LIG_LIR_Gen_1	63	74	PF02991	0.629
LIG_LIR_Nem_3	197	202	PF02991	0.394
LIG_LIR_Nem_3	300	306	PF02991	0.276
LIG_LIR_Nem_3	63	69	PF02991	0.561
LIG_Pex14_2	60	64	PF04695	0.520
LIG_SH2_CRK	66	70	PF00017	0.567
LIG_SH2_GRB2like	66	69	PF00017	0.530
LIG_SH2_NCK_1	66	70	PF00017	0.531
LIG_SH2_STAP1	172	176	PF00017	0.547
LIG_SH2_STAP1	25	29	PF00017	0.589
LIG_SH2_STAP1	298	302	PF00017	0.403
LIG_SH2_STAT3	73	76	PF00017	0.565
LIG_SH2_STAT5	140	143	PF00017	0.443
LIG_SH2_STAT5	266	269	PF00017	0.403
LIG_SH2_STAT5	298	301	PF00017	0.284
LIG_SH2_STAT5	303	306	PF00017	0.258
LIG_SH2_STAT5	73	76	PF00017	0.666
LIG_SH3_3	125	131	PF00018	0.626
LIG_SH3_3	143	149	PF00018	0.496
LIG_SH3_3	182	188	PF00018	0.573
LIG_SH3_3	26	32	PF00018	0.571
LIG_SH3_3	66	72	PF00018	0.624
LIG_SH3_4	236	243	PF00018	0.413
LIG_SUMO_SIM_par_1	187	192	PF11976	0.535
LIG_SUMO_SIM_par_1	277	283	PF11976	0.406
LIG_TRAF2_1	221	224	PF00917	0.732
MOD_CDK_SPK_2	215	220	PF00069	0.565
MOD_CK1_1	105	111	PF00069	0.631
MOD_CK1_1	126	132	PF00069	0.615
MOD_CK1_1	162	168	PF00069	0.399
MOD_CK1_1	218	224	PF00069	0.727
MOD_CK1_1	227	233	PF00069	0.615
MOD_CK1_1	44	50	PF00069	0.692
MOD_CK1_1	67	73	PF00069	0.659
MOD_CK1_1	77	83	PF00069	0.632
MOD_CK2_1	218	224	PF00069	0.778
MOD_CK2_1	243	249	PF00069	0.365
MOD_Cter_Amidation	337	340	PF01082	0.632
MOD_Cter_Amidation	344	347	PF01082	0.596
MOD_GlcNHglycan	11	14	PF01048	0.603
MOD_GlcNHglycan	202	205	PF01048	0.430
MOD_GlcNHglycan	245	248	PF01048	0.387
MOD_GSK3_1	102	109	PF00069	0.723
MOD_GSK3_1	211	218	PF00069	0.671
MOD_GSK3_1	274	281	PF00069	0.469
MOD_GSK3_1	292	299	PF00069	0.185
MOD_GSK3_1	37	44	PF00069	0.621
MOD_GSK3_1	5	12	PF00069	0.634
MOD_GSK3_1	60	67	PF00069	0.651
MOD_GSK3_1	68	75	PF00069	0.624
MOD_N-GLC_1	67	72	PF02516	0.522
MOD_NEK2_1	124	129	PF00069	0.750
MOD_NEK2_1	132	137	PF00069	0.424
MOD_NEK2_1	16	21	PF00069	0.637
MOD_NEK2_1	64	69	PF00069	0.635
MOD_NEK2_1	74	79	PF00069	0.674
MOD_PIKK_1	72	78	PF00454	0.657
MOD_PKA_1	292	298	PF00069	0.340
MOD_PKA_2	124	130	PF00069	0.650
MOD_PKA_2	159	165	PF00069	0.510
MOD_PKA_2	296	302	PF00069	0.403
MOD_PKA_2	327	333	PF00069	0.542
MOD_PKA_2	87	93	PF00069	0.536
MOD_Plk_1	153	159	PF00069	0.449
MOD_Plk_1	162	168	PF00069	0.470
MOD_Plk_1	307	313	PF00069	0.403
MOD_Plk_1	32	38	PF00069	0.682
MOD_Plk_4	162	168	PF00069	0.505
MOD_Plk_4	170	176	PF00069	0.532
MOD_Plk_4	37	43	PF00069	0.637
MOD_Plk_4	60	66	PF00069	0.661
MOD_ProDKin_1	100	106	PF00069	0.672
MOD_ProDKin_1	215	221	PF00069	0.716
MOD_ProDKin_1	227	233	PF00069	0.700
MOD_ProDKin_1	41	47	PF00069	0.634
MOD_ProDKin_1	48	54	PF00069	0.600
MOD_ProDKin_1	68	74	PF00069	0.559
MOD_ProDKin_1	92	98	PF00069	0.661
MOD_SUMO_for_1	206	209	PF00179	0.601
MOD_SUMO_for_1	219	222	PF00179	0.715
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.470
TRG_ENDOCYTIC_2	172	175	PF00928	0.532
TRG_ENDOCYTIC_2	303	306	PF00928	0.286
TRG_ENDOCYTIC_2	66	69	PF00928	0.667
TRG_ER_diArg_1	337	340	PF00400	0.602
TRG_ER_diArg_1	87	89	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	62%	95%
A0A0S4JEW1	Bodo saltans	27%	100%
A0A3Q8IC14	Leishmania donovani	95%	100%
A0A3Q8ILM8	Leishmania donovani	32%	100%
A0A3R7KIC4	Trypanosoma rangeli	32%	92%
A4HUB9	Leishmania infantum	95%	100%
C9ZVH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
E9AI38	Leishmania braziliensis	83%	96%
E9AN18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AUD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q051	Leishmania major	32%	100%
V5DA19	Trypanosoma cruzi	32%	92%