Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHK7_LEIMA

TriTrypDb:

LmjF.10.0130 , LMJLV39_100006100 , LMJSD75_100006200

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.683
CLV_C14_Caspase3-7	410	414	PF00656	0.548
CLV_C14_Caspase3-7	639	643	PF00656	0.593
CLV_NRD_NRD_1	184	186	PF00675	0.481
CLV_NRD_NRD_1	209	211	PF00675	0.491
CLV_NRD_NRD_1	240	242	PF00675	0.499
CLV_NRD_NRD_1	307	309	PF00675	0.508
CLV_NRD_NRD_1	449	451	PF00675	0.611
CLV_NRD_NRD_1	512	514	PF00675	0.659
CLV_NRD_NRD_1	90	92	PF00675	0.464
CLV_PCSK_KEX2_1	183	185	PF00082	0.481
CLV_PCSK_KEX2_1	208	210	PF00082	0.473
CLV_PCSK_KEX2_1	307	309	PF00082	0.422
CLV_PCSK_KEX2_1	512	514	PF00082	0.777
CLV_PCSK_KEX2_1	90	92	PF00082	0.540
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.581
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.777
CLV_PCSK_PC7_1	86	92	PF00082	0.537
CLV_PCSK_SKI1_1	11	15	PF00082	0.368
CLV_PCSK_SKI1_1	185	189	PF00082	0.592
CLV_PCSK_SKI1_1	210	214	PF00082	0.524
CLV_PCSK_SKI1_1	340	344	PF00082	0.479
CLV_PCSK_SKI1_1	360	364	PF00082	0.529
CLV_PCSK_SKI1_1	485	489	PF00082	0.660
DEG_SPOP_SBC_1	475	479	PF00917	0.762
DOC_MAPK_gen_1	127	134	PF00069	0.467
DOC_MAPK_gen_1	225	234	PF00069	0.563
DOC_MAPK_gen_1	307	315	PF00069	0.432
DOC_MAPK_JIP1_4	528	534	PF00069	0.693
DOC_MAPK_MEF2A_6	127	134	PF00069	0.432
DOC_MAPK_MEF2A_6	167	175	PF00069	0.458
DOC_MAPK_MEF2A_6	528	536	PF00069	0.634
DOC_MAPK_MEF2A_6	685	693	PF00069	0.547
DOC_MAPK_RevD_3	171	185	PF00069	0.449
DOC_PP1_RVXF_1	73	80	PF00149	0.391
DOC_PP4_FxxP_1	634	637	PF00568	0.640
DOC_SPAK_OSR1_1	78	82	PF12202	0.399
DOC_SPAK_OSR1_1	9	13	PF12202	0.355
DOC_USP7_MATH_1	109	113	PF00917	0.389
DOC_USP7_MATH_1	436	440	PF00917	0.692
DOC_USP7_MATH_1	475	479	PF00917	0.728
DOC_USP7_MATH_1	544	548	PF00917	0.745
DOC_USP7_MATH_1	598	602	PF00917	0.669
DOC_USP7_MATH_1	603	607	PF00917	0.635
DOC_USP7_MATH_1	611	615	PF00917	0.562
DOC_USP7_MATH_1	640	644	PF00917	0.623
DOC_USP7_MATH_1	714	718	PF00917	0.718
DOC_USP7_MATH_2	695	701	PF00917	0.657
DOC_USP7_UBL2_3	349	353	PF12436	0.621
DOC_WW_Pin1_4	353	358	PF00397	0.539
DOC_WW_Pin1_4	36	41	PF00397	0.434
DOC_WW_Pin1_4	468	473	PF00397	0.651
DOC_WW_Pin1_4	480	485	PF00397	0.646
DOC_WW_Pin1_4	517	522	PF00397	0.800
DOC_WW_Pin1_4	584	589	PF00397	0.763
DOC_WW_Pin1_4	661	666	PF00397	0.628
DOC_WW_Pin1_4	691	696	PF00397	0.679
LIG_14-3-3_CanoR_1	567	575	PF00244	0.693
LIG_14-3-3_CanoR_1	715	722	PF00244	0.746
LIG_Actin_WH2_2	292	309	PF00022	0.370
LIG_Actin_WH2_2	322	339	PF00022	0.456
LIG_APCC_ABBA_1	132	137	PF00400	0.434
LIG_Clathr_ClatBox_1	174	178	PF01394	0.435
LIG_EVH1_2	140	144	PF00568	0.445
LIG_FHA_1	157	163	PF00498	0.524
LIG_FHA_1	219	225	PF00498	0.536
LIG_FHA_1	3	9	PF00498	0.487
LIG_FHA_1	318	324	PF00498	0.473
LIG_FHA_1	462	468	PF00498	0.702
LIG_FHA_1	517	523	PF00498	0.592
LIG_FHA_1	581	587	PF00498	0.631
LIG_FHA_1	650	656	PF00498	0.777
LIG_FHA_1	99	105	PF00498	0.566
LIG_FHA_2	177	183	PF00498	0.564
LIG_FHA_2	224	230	PF00498	0.538
LIG_FHA_2	275	281	PF00498	0.587
LIG_FHA_2	436	442	PF00498	0.567
LIG_FHA_2	481	487	PF00498	0.708
LIG_FHA_2	94	100	PF00498	0.376
LIG_IBAR_NPY_1	720	722	PF08397	0.602
LIG_LIR_Apic_2	632	637	PF02991	0.636
LIG_LIR_Apic_2	664	670	PF02991	0.568
LIG_LIR_Nem_3	116	122	PF02991	0.504
LIG_LIR_Nem_3	143	147	PF02991	0.451
LIG_LIR_Nem_3	574	580	PF02991	0.668
LIG_LIR_Nem_3	622	628	PF02991	0.510
LIG_LIR_Nem_3	643	649	PF02991	0.577
LIG_LIR_Nem_3	719	725	PF02991	0.738
LIG_NRBOX	176	182	PF00104	0.575
LIG_SH2_CRK	236	240	PF00017	0.466
LIG_SH2_CRK	722	726	PF00017	0.731
LIG_SH2_PTP2	667	670	PF00017	0.531
LIG_SH2_STAP1	236	240	PF00017	0.466
LIG_SH2_STAP1	26	30	PF00017	0.379
LIG_SH2_STAT3	42	45	PF00017	0.536
LIG_SH2_STAT5	236	239	PF00017	0.562
LIG_SH2_STAT5	254	257	PF00017	0.396
LIG_SH2_STAT5	26	29	PF00017	0.377
LIG_SH2_STAT5	42	45	PF00017	0.421
LIG_SH2_STAT5	667	670	PF00017	0.742
LIG_SH2_STAT5	722	725	PF00017	0.623
LIG_SH2_STAT5	76	79	PF00017	0.443
LIG_SH2_STAT5	84	87	PF00017	0.449
LIG_SH3_3	150	156	PF00018	0.647
LIG_SH3_3	523	529	PF00018	0.641
LIG_SH3_3	592	598	PF00018	0.724
LIG_SUMO_SIM_par_1	11	16	PF11976	0.433
LIG_SUMO_SIM_par_1	318	324	PF11976	0.360
LIG_TRAF2_1	197	200	PF00917	0.647
LIG_TRAF2_1	288	291	PF00917	0.509
LIG_TRAF2_1	504	507	PF00917	0.787
LIG_TRFH_1	594	598	PF08558	0.751
LIG_TYR_ITIM	234	239	PF00017	0.489
LIG_WRC_WIRS_1	655	660	PF05994	0.697
MOD_CDK_SPK_2	480	485	PF00069	0.695
MOD_CDK_SPxxK_3	353	360	PF00069	0.554
MOD_CK1_1	274	280	PF00069	0.647
MOD_CK1_1	35	41	PF00069	0.566
MOD_CK1_1	468	474	PF00069	0.663
MOD_CK1_1	476	482	PF00069	0.664
MOD_CK1_1	563	569	PF00069	0.671
MOD_CK1_1	584	590	PF00069	0.673
MOD_CK1_1	614	620	PF00069	0.715
MOD_CK2_1	163	169	PF00069	0.483
MOD_CK2_1	176	182	PF00069	0.555
MOD_CK2_1	194	200	PF00069	0.585
MOD_CK2_1	223	229	PF00069	0.539
MOD_CK2_1	274	280	PF00069	0.574
MOD_CK2_1	285	291	PF00069	0.400
MOD_CK2_1	411	417	PF00069	0.721
MOD_CK2_1	435	441	PF00069	0.647
MOD_CK2_1	50	56	PF00069	0.467
MOD_CK2_1	691	697	PF00069	0.781
MOD_GlcNHglycan	109	112	PF01048	0.461
MOD_GlcNHglycan	272	276	PF01048	0.551
MOD_GlcNHglycan	473	476	PF01048	0.748
MOD_GlcNHglycan	478	481	PF01048	0.745
MOD_GlcNHglycan	529	532	PF01048	0.650
MOD_GlcNHglycan	537	540	PF01048	0.592
MOD_GlcNHglycan	569	572	PF01048	0.690
MOD_GlcNHglycan	613	616	PF01048	0.693
MOD_GlcNHglycan	679	682	PF01048	0.690
MOD_GlcNHglycan	686	689	PF01048	0.666
MOD_GSK3_1	109	116	PF00069	0.427
MOD_GSK3_1	190	197	PF00069	0.678
MOD_GSK3_1	270	277	PF00069	0.576
MOD_GSK3_1	32	39	PF00069	0.457
MOD_GSK3_1	360	367	PF00069	0.557
MOD_GSK3_1	407	414	PF00069	0.673
MOD_GSK3_1	436	443	PF00069	0.660
MOD_GSK3_1	461	468	PF00069	0.636
MOD_GSK3_1	470	477	PF00069	0.647
MOD_GSK3_1	559	566	PF00069	0.833
MOD_GSK3_1	567	574	PF00069	0.714
MOD_GSK3_1	576	583	PF00069	0.648
MOD_GSK3_1	691	698	PF00069	0.586
MOD_GSK3_1	723	730	PF00069	0.674
MOD_N-GLC_1	285	290	PF02516	0.530
MOD_N-GLC_1	35	40	PF02516	0.553
MOD_N-GLC_1	715	720	PF02516	0.783
MOD_NEK2_1	121	126	PF00069	0.480
MOD_NEK2_1	336	341	PF00069	0.469
MOD_NEK2_1	415	420	PF00069	0.615
MOD_NEK2_1	460	465	PF00069	0.696
MOD_NEK2_1	499	504	PF00069	0.711
MOD_NEK2_1	559	564	PF00069	0.757
MOD_NEK2_1	581	586	PF00069	0.714
MOD_NEK2_2	411	416	PF00069	0.528
MOD_PIKK_1	156	162	PF00454	0.484
MOD_PIKK_1	98	104	PF00454	0.513
MOD_PKA_2	2	8	PF00069	0.549
MOD_PKA_2	560	566	PF00069	0.726
MOD_PKA_2	670	676	PF00069	0.706
MOD_PKA_2	684	690	PF00069	0.630
MOD_PKA_2	714	720	PF00069	0.658
MOD_Plk_1	285	291	PF00069	0.543
MOD_Plk_1	317	323	PF00069	0.649
MOD_Plk_1	360	366	PF00069	0.637
MOD_Plk_1	440	446	PF00069	0.518
MOD_Plk_1	632	638	PF00069	0.685
MOD_Plk_1	98	104	PF00069	0.508
MOD_Plk_4	113	119	PF00069	0.515
MOD_Plk_4	176	182	PF00069	0.532
MOD_Plk_4	24	30	PF00069	0.517
MOD_Plk_4	274	280	PF00069	0.696
MOD_Plk_4	440	446	PF00069	0.518
MOD_Plk_4	576	582	PF00069	0.795
MOD_ProDKin_1	353	359	PF00069	0.531
MOD_ProDKin_1	36	42	PF00069	0.426
MOD_ProDKin_1	468	474	PF00069	0.654
MOD_ProDKin_1	480	486	PF00069	0.643
MOD_ProDKin_1	517	523	PF00069	0.801
MOD_ProDKin_1	584	590	PF00069	0.767
MOD_ProDKin_1	661	667	PF00069	0.631
MOD_ProDKin_1	691	697	PF00069	0.679
MOD_SUMO_for_1	187	190	PF00179	0.633
MOD_SUMO_for_1	504	507	PF00179	0.563
MOD_SUMO_rev_2	193	203	PF00179	0.660
MOD_SUMO_rev_2	405	410	PF00179	0.599
MOD_SUMO_rev_2	495	504	PF00179	0.733
TRG_DiLeu_BaEn_4	301	307	PF01217	0.455
TRG_ENDOCYTIC_2	236	239	PF00928	0.581
TRG_ENDOCYTIC_2	26	29	PF00928	0.510
TRG_ENDOCYTIC_2	628	631	PF00928	0.711
TRG_ENDOCYTIC_2	646	649	PF00928	0.520
TRG_ENDOCYTIC_2	722	725	PF00928	0.735
TRG_ENDOCYTIC_2	76	79	PF00928	0.506
TRG_ER_diArg_1	183	185	PF00400	0.481
TRG_ER_diArg_1	306	308	PF00400	0.390
TRG_ER_diArg_1	89	91	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD89	Leptomonas seymouri	62%	97%
A0A1X0NRK9	Trypanosomatidae	38%	100%
A0A3Q8I7M1	Leishmania donovani	90%	100%
A0A422NRU0	Trypanosoma rangeli	37%	100%
A4H5Z4	Leishmania braziliensis	63%	97%
A4HUC0	Leishmania infantum	90%	100%
C9ZVH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9AN19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B9H5	Trypanosoma cruzi	37%	100%