Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase, putative

Species:

Leishmania major

UniProt:

Q4QHK6_LEIMA

TriTrypDb:

LmjF.10.0140 , LMJLV39_100006200 , LMJSD75_100006300

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	3
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

Q4QHK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0003676	nucleic acid binding	3	22
GO:0003723	RNA binding	4	5
GO:0003724	RNA helicase activity	3	9
GO:0003824	catalytic activity	1	22
GO:0004386	helicase activity	2	22
GO:0005488	binding	1	22
GO:0005524	ATP binding	5	22
GO:0008186	ATP-dependent activity, acting on RNA	2	9
GO:0017076	purine nucleotide binding	4	22
GO:0030554	adenyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032559	adenyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	22
GO:0140657	ATP-dependent activity	1	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22
GO:0016787	hydrolase activity	2	15
GO:0003743	translation initiation factor activity	4	6
GO:0008135	translation factor activity, RNA binding	3	6
GO:0045182	translation regulator activity	1	6
GO:0090079	translation regulator activity, nucleic acid binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.580
CLV_C14_Caspase3-7	201	205	PF00656	0.625
CLV_C14_Caspase3-7	23	27	PF00656	0.664
CLV_NRD_NRD_1	144	146	PF00675	0.607
CLV_NRD_NRD_1	404	406	PF00675	0.280
CLV_NRD_NRD_1	491	493	PF00675	0.445
CLV_NRD_NRD_1	560	562	PF00675	0.307
CLV_NRD_NRD_1	583	585	PF00675	0.263
CLV_NRD_NRD_1	677	679	PF00675	0.434
CLV_NRD_NRD_1	715	717	PF00675	0.663
CLV_PCSK_FUR_1	713	717	PF00082	0.700
CLV_PCSK_KEX2_1	144	146	PF00082	0.619
CLV_PCSK_KEX2_1	321	323	PF00082	0.206
CLV_PCSK_KEX2_1	404	406	PF00082	0.266
CLV_PCSK_KEX2_1	542	544	PF00082	0.231
CLV_PCSK_KEX2_1	560	562	PF00082	0.231
CLV_PCSK_KEX2_1	585	587	PF00082	0.266
CLV_PCSK_KEX2_1	609	611	PF00082	0.296
CLV_PCSK_KEX2_1	715	717	PF00082	0.635
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.206
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.231
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.291
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.214
CLV_PCSK_PC7_1	400	406	PF00082	0.202
CLV_PCSK_PC7_1	711	717	PF00082	0.644
CLV_PCSK_SKI1_1	173	177	PF00082	0.545
CLV_PCSK_SKI1_1	225	229	PF00082	0.514
CLV_PCSK_SKI1_1	322	326	PF00082	0.218
CLV_PCSK_SKI1_1	454	458	PF00082	0.305
CLV_PCSK_SKI1_1	515	519	PF00082	0.356
DEG_APCC_DBOX_1	453	461	PF00400	0.448
DEG_APCC_DBOX_1	514	522	PF00400	0.338
DEG_APCC_KENBOX_2	467	471	PF00400	0.464
DEG_SCF_FBW7_1	651	656	PF00400	0.347
DEG_SPOP_SBC_1	344	348	PF00917	0.416
DOC_ANK_TNKS_1	143	150	PF00023	0.508
DOC_CKS1_1	413	418	PF01111	0.492
DOC_CKS1_1	650	655	PF01111	0.335
DOC_CKS1_1	693	698	PF01111	0.589
DOC_MAPK_gen_1	404	413	PF00069	0.478
DOC_MAPK_gen_1	492	500	PF00069	0.431
DOC_MAPK_gen_1	542	548	PF00069	0.475
DOC_MAPK_HePTP_8	490	502	PF00069	0.316
DOC_MAPK_MEF2A_6	493	502	PF00069	0.506
DOC_PP1_RVXF_1	223	230	PF00149	0.421
DOC_PP2B_LxvP_1	483	486	PF13499	0.318
DOC_PP2B_LxvP_1	567	570	PF13499	0.431
DOC_PP4_FxxP_1	650	653	PF00568	0.419
DOC_USP7_MATH_1	11	15	PF00917	0.687
DOC_USP7_MATH_1	294	298	PF00917	0.471
DOC_USP7_MATH_1	338	342	PF00917	0.497
DOC_USP7_MATH_1	345	349	PF00917	0.499
DOC_USP7_MATH_1	387	391	PF00917	0.475
DOC_USP7_MATH_1	486	490	PF00917	0.259
DOC_USP7_MATH_1	520	524	PF00917	0.443
DOC_USP7_MATH_1	92	96	PF00917	0.595
DOC_USP7_MATH_2	22	28	PF00917	0.514
DOC_USP7_UBL2_3	321	325	PF12436	0.398
DOC_WW_Pin1_4	166	171	PF00397	0.658
DOC_WW_Pin1_4	238	243	PF00397	0.633
DOC_WW_Pin1_4	412	417	PF00397	0.479
DOC_WW_Pin1_4	447	452	PF00397	0.480
DOC_WW_Pin1_4	493	498	PF00397	0.471
DOC_WW_Pin1_4	649	654	PF00397	0.336
DOC_WW_Pin1_4	692	697	PF00397	0.585
DOC_WW_Pin1_4	732	737	PF00397	0.684
DOC_WW_Pin1_4	95	100	PF00397	0.701
LIG_14-3-3_CanoR_1	12	20	PF00244	0.504
LIG_14-3-3_CanoR_1	196	203	PF00244	0.611
LIG_14-3-3_CanoR_1	225	230	PF00244	0.478
LIG_14-3-3_CanoR_1	364	368	PF00244	0.454
LIG_14-3-3_CanoR_1	643	653	PF00244	0.544
LIG_APCC_ABBA_1	40	45	PF00400	0.595
LIG_APCC_ABBAyCdc20_2	617	623	PF00400	0.376
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_BRCT_BRCA1_1	646	650	PF00533	0.495
LIG_Clathr_ClatBox_1	444	448	PF01394	0.426
LIG_eIF4E_1	66	72	PF01652	0.632
LIG_FHA_1	15	21	PF00498	0.743
LIG_FHA_1	226	232	PF00498	0.474
LIG_FHA_1	28	34	PF00498	0.594
LIG_FHA_1	364	370	PF00498	0.481
LIG_FHA_1	418	424	PF00498	0.438
LIG_FHA_1	497	503	PF00498	0.600
LIG_FHA_1	606	612	PF00498	0.460
LIG_FHA_1	693	699	PF00498	0.593
LIG_FHA_1	85	91	PF00498	0.567
LIG_FHA_2	110	116	PF00498	0.529
LIG_FHA_2	48	54	PF00498	0.508
LIG_FHA_2	503	509	PF00498	0.488
LIG_FHA_2	553	559	PF00498	0.508
LIG_FHA_2	650	656	PF00498	0.446
LIG_Integrin_isoDGR_2	452	454	PF01839	0.205
LIG_LIR_Apic_2	26	32	PF02991	0.655
LIG_LIR_Apic_2	516	522	PF02991	0.270
LIG_LIR_Apic_2	647	653	PF02991	0.413
LIG_LIR_Apic_2	690	696	PF02991	0.622
LIG_LIR_Gen_1	300	311	PF02991	0.411
LIG_LIR_Nem_3	300	306	PF02991	0.411
LIG_LIR_Nem_3	38	43	PF02991	0.649
LIG_PCNA_yPIPBox_3	313	327	PF02747	0.405
LIG_PCNA_yPIPBox_3	667	681	PF02747	0.369
LIG_Rb_LxCxE_1	201	220	PF01857	0.516
LIG_Rb_LxCxE_1	477	496	PF01857	0.322
LIG_Rb_pABgroove_1	529	537	PF01858	0.371
LIG_RPA_C_Fungi	139	151	PF08784	0.483
LIG_SH2_CRK	303	307	PF00017	0.353
LIG_SH2_CRK	374	378	PF00017	0.351
LIG_SH2_CRK	494	498	PF00017	0.340
LIG_SH2_CRK	622	626	PF00017	0.346
LIG_SH2_NCK_1	622	626	PF00017	0.292
LIG_SH2_SRC	66	69	PF00017	0.487
LIG_SH2_STAT5	29	32	PF00017	0.617
LIG_SH2_STAT5	49	52	PF00017	0.477
LIG_SH2_STAT5	549	552	PF00017	0.300
LIG_SH3_3	151	157	PF00018	0.539
LIG_SH3_3	332	338	PF00018	0.219
LIG_SH3_3	349	355	PF00018	0.320
LIG_SH3_3	410	416	PF00018	0.372
LIG_Sin3_3	302	309	PF02671	0.214
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.441
LIG_SUMO_SIM_par_1	30	36	PF11976	0.529
LIG_SUMO_SIM_par_1	356	362	PF11976	0.451
LIG_SUMO_SIM_par_1	365	370	PF11976	0.482
LIG_SUMO_SIM_par_1	434	439	PF11976	0.434
LIG_SUMO_SIM_par_1	443	448	PF11976	0.473
LIG_SUMO_SIM_par_1	496	501	PF11976	0.495
LIG_TRAF2_1	111	114	PF00917	0.545
LIG_TRAF2_1	198	201	PF00917	0.646
LIG_TRAF2_1	316	319	PF00917	0.224
LIG_TRAF2_1	505	508	PF00917	0.549
LIG_TRAF2_1	555	558	PF00917	0.244
LIG_TYR_ITIM	301	306	PF00017	0.214
LIG_UBA3_1	305	313	PF00899	0.198
MOD_CDK_SPxK_1	238	244	PF00069	0.547
MOD_CDK_SPxK_1	412	418	PF00069	0.334
MOD_CDK_SPxxK_3	166	173	PF00069	0.521
MOD_CDK_SPxxK_3	447	454	PF00069	0.224
MOD_CDK_SPxxK_3	692	699	PF00069	0.587
MOD_CK1_1	14	20	PF00069	0.702
MOD_CK1_1	267	273	PF00069	0.452
MOD_CK1_1	27	33	PF00069	0.494
MOD_CK1_1	297	303	PF00069	0.323
MOD_CK1_1	36	42	PF00069	0.675
MOD_CK1_1	398	404	PF00069	0.370
MOD_CK1_1	496	502	PF00069	0.416
MOD_CK1_1	568	574	PF00069	0.351
MOD_CK1_1	692	698	PF00069	0.635
MOD_CK1_1	732	738	PF00069	0.587
MOD_CK1_1	95	101	PF00069	0.574
MOD_CK2_1	109	115	PF00069	0.529
MOD_CK2_1	195	201	PF00069	0.574
MOD_CK2_1	502	508	PF00069	0.546
MOD_CK2_1	552	558	PF00069	0.373
MOD_Cter_Amidation	713	716	PF01082	0.677
MOD_GlcNHglycan	1	4	PF01048	0.642
MOD_GlcNHglycan	122	125	PF01048	0.656
MOD_GlcNHglycan	14	17	PF01048	0.676
MOD_GlcNHglycan	179	182	PF01048	0.677
MOD_GlcNHglycan	266	269	PF01048	0.437
MOD_GlcNHglycan	276	279	PF01048	0.339
MOD_GlcNHglycan	295	299	PF01048	0.337
MOD_GlcNHglycan	332	335	PF01048	0.224
MOD_GlcNHglycan	34	38	PF01048	0.521
MOD_GlcNHglycan	347	350	PF01048	0.308
MOD_GlcNHglycan	454	457	PF01048	0.461
MOD_GlcNHglycan	567	570	PF01048	0.404
MOD_GlcNHglycan	578	581	PF01048	0.447
MOD_GlcNHglycan	59	62	PF01048	0.595
MOD_GlcNHglycan	639	643	PF01048	0.577
MOD_GlcNHglycan	725	728	PF01048	0.629
MOD_GlcNHglycan	94	97	PF01048	0.790
MOD_GSK3_1	162	169	PF00069	0.594
MOD_GSK3_1	192	199	PF00069	0.559
MOD_GSK3_1	20	27	PF00069	0.723
MOD_GSK3_1	219	226	PF00069	0.648
MOD_GSK3_1	270	277	PF00069	0.387
MOD_GSK3_1	359	366	PF00069	0.277
MOD_GSK3_1	43	50	PF00069	0.566
MOD_GSK3_1	474	481	PF00069	0.373
MOD_GSK3_1	498	505	PF00069	0.473
MOD_GSK3_1	565	572	PF00069	0.351
MOD_GSK3_1	601	608	PF00069	0.340
MOD_GSK3_1	649	656	PF00069	0.338
MOD_GSK3_1	723	730	PF00069	0.618
MOD_NEK2_1	140	145	PF00069	0.548
MOD_NEK2_1	223	228	PF00069	0.583
MOD_NEK2_1	264	269	PF00069	0.471
MOD_NEK2_1	274	279	PF00069	0.278
MOD_NEK2_1	33	38	PF00069	0.682
MOD_NEK2_1	373	378	PF00069	0.337
MOD_NEK2_1	4	9	PF00069	0.692
MOD_NEK2_1	498	503	PF00069	0.462
MOD_PIKK_1	395	401	PF00454	0.184
MOD_PIKK_1	633	639	PF00454	0.224
MOD_PKA_2	109	115	PF00069	0.720
MOD_PKA_2	11	17	PF00069	0.509
MOD_PKA_2	192	198	PF00069	0.683
MOD_PKA_2	270	276	PF00069	0.504
MOD_PKA_2	363	369	PF00069	0.292
MOD_PKA_2	417	423	PF00069	0.223
MOD_PKA_2	552	558	PF00069	0.343
MOD_PKA_2	633	639	PF00069	0.328
MOD_Plk_1	25	31	PF00069	0.745
MOD_Plk_1	44	50	PF00069	0.599
MOD_Plk_1	689	695	PF00069	0.603
MOD_Plk_4	270	276	PF00069	0.413
MOD_Plk_4	363	369	PF00069	0.367
MOD_Plk_4	486	492	PF00069	0.423
MOD_Plk_4	498	504	PF00069	0.382
MOD_Plk_4	536	542	PF00069	0.426
MOD_Plk_4	569	575	PF00069	0.413
MOD_Plk_4	646	652	PF00069	0.445
MOD_ProDKin_1	166	172	PF00069	0.660
MOD_ProDKin_1	238	244	PF00069	0.636
MOD_ProDKin_1	412	418	PF00069	0.328
MOD_ProDKin_1	447	453	PF00069	0.328
MOD_ProDKin_1	493	499	PF00069	0.470
MOD_ProDKin_1	649	655	PF00069	0.332
MOD_ProDKin_1	692	698	PF00069	0.585
MOD_ProDKin_1	732	738	PF00069	0.688
MOD_ProDKin_1	95	101	PF00069	0.701
MOD_SUMO_rev_2	612	619	PF00179	0.184
TRG_DiLeu_BaEn_1	380	385	PF01217	0.244
TRG_ENDOCYTIC_2	303	306	PF00928	0.228
TRG_ENDOCYTIC_2	374	377	PF00928	0.351
TRG_ENDOCYTIC_2	388	391	PF00928	0.259
TRG_ER_diArg_1	403	405	PF00400	0.309
TRG_ER_diArg_1	559	561	PF00400	0.224
TRG_ER_diArg_1	581	584	PF00400	0.258
TRG_ER_diArg_1	710	713	PF00400	0.610
TRG_NLS_MonoExtC_3	404	410	PF00514	0.219
TRG_NLS_MonoExtN_4	404	409	PF00514	0.219
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R1	Leptomonas seymouri	59%	93%
A0A1X0NRS9	Trypanosomatidae	33%	95%
A0A1X0P7J3	Trypanosomatidae	23%	100%
A0A3Q8ID91	Leishmania donovani	28%	100%
A0A3Q8IQY6	Leishmania donovani	25%	100%
A0A3S5H6T7	Leishmania donovani	24%	100%
A0A3S7WQ33	Leishmania donovani	26%	100%
A0A3S7WR01	Leishmania donovani	91%	95%
A0A3S7X9W0	Leishmania donovani	26%	100%
A0A3S7XAT8	Leishmania donovani	23%	100%
A2QIL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	23%	91%
A4H575	Leishmania braziliensis	26%	85%
A4H5Z5	Leishmania braziliensis	69%	100%
A4HGR1	Leishmania braziliensis	28%	100%
A4HK20	Leishmania braziliensis	25%	100%
A4HK38	Leishmania braziliensis	25%	100%
A4HP82	Leishmania braziliensis	24%	100%
A4HTF8	Leishmania infantum	27%	100%
A4HUC1	Leishmania infantum	91%	95%
A4HWB0	Leishmania infantum	24%	100%
A4HZF8	Leishmania infantum	22%	100%
A4I3T6	Leishmania infantum	28%	100%
A4IBU1	Leishmania infantum	26%	100%
A4IDF6	Leishmania infantum	23%	100%
A4IDI7	Leishmania infantum	25%	100%
D0A3C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A872	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AM86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ASZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P0CQ74	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	100%
P0CQ75	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	100%
Q2UH00	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	92%
Q4Q1K8	Leishmania major	24%	100%
Q4Q1N9	Leishmania major	22%	100%
Q4Q858	Leishmania major	26%	100%
Q4QFH1	Leishmania major	24%	100%
Q4QIG1	Leishmania major	27%	100%
Q5BCU6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	94%
Q6CDS6	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
V5BII0	Trypanosoma cruzi	36%	100%